Incidental Mutation 'R7982:Klf6'
ID 651289
Institutional Source Beutler Lab
Gene Symbol Klf6
Ensembl Gene ENSMUSG00000000078
Gene Name Kruppel-like transcription factor 6
Synonyms FM6, Ierepo1, Copeb, FM2, CPBP, BCD1, Ierepo3, Zf9
MMRRC Submission 046023-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7982 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 5911488-5920392 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 5911822 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 62 (L62Q)
Ref Sequence ENSEMBL: ENSMUSP00000000080 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000080] [ENSMUST00000222857]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000000080
AA Change: L62Q

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000000080
Gene: ENSMUSG00000000078
AA Change: L62Q

DomainStartEndE-ValueType
low complexity region 107 129 N/A INTRINSIC
low complexity region 137 155 N/A INTRINSIC
low complexity region 168 187 N/A INTRINSIC
ZnF_C2H2 235 259 1.08e-1 SMART
ZnF_C2H2 265 289 1.13e-4 SMART
ZnF_C2H2 295 317 6.32e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000222857
AA Change: L62Q

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 A G 1: 75,150,284 (GRCm39) S625P probably damaging Het
Actl6b A G 5: 137,561,424 (GRCm39) N142S probably benign Het
Ank1 A T 8: 23,609,397 (GRCm39) D1363V probably damaging Het
Aox4 A C 1: 58,296,400 (GRCm39) L1032F possibly damaging Het
Atosb T C 4: 43,034,483 (GRCm39) T371A probably damaging Het
Bcl2l15 T C 3: 103,740,158 (GRCm39) M4T probably damaging Het
Cand1 A T 10: 119,052,378 (GRCm39) S242R probably damaging Het
Cant1 A T 11: 118,300,968 (GRCm39) V229D probably benign Het
Ccdc117 A G 11: 5,481,460 (GRCm39) S224P possibly damaging Het
Cdc42ep4 T C 11: 113,619,402 (GRCm39) R330G possibly damaging Het
Cep164 T C 9: 45,690,162 (GRCm39) E527G probably benign Het
Cfap58 A G 19: 47,963,006 (GRCm39) D472G probably benign Het
Cln6 A C 9: 62,756,450 (GRCm39) K198T possibly damaging Het
Col4a4 G A 1: 82,549,162 (GRCm39) probably benign Het
Cyp1b1 T C 17: 80,017,919 (GRCm39) Y412C probably damaging Het
Dhx30 A T 9: 109,914,524 (GRCm39) L991Q probably damaging Het
Dst C T 1: 34,221,621 (GRCm39) T2475I possibly damaging Het
Exoc8 A T 8: 125,623,149 (GRCm39) V406E probably damaging Het
Grk6 T A 13: 55,599,519 (GRCm39) C201S probably damaging Het
Helz T C 11: 107,517,456 (GRCm39) V664A possibly damaging Het
Hsd17b11 A G 5: 104,151,090 (GRCm39) C215R possibly damaging Het
Ift25 T C 4: 107,132,480 (GRCm39) V89A probably benign Het
Kbtbd12 T C 6: 88,595,616 (GRCm39) I71M possibly damaging Het
Khdc1a A T 1: 21,421,130 (GRCm39) H105L probably benign Het
Mc1r A G 8: 124,134,879 (GRCm39) R211G probably damaging Het
Nt5m T A 11: 59,739,157 (GRCm39) W68R possibly damaging Het
Nufip1 T C 14: 76,363,679 (GRCm39) V301A probably benign Het
Or10ac1 T A 6: 42,515,225 (GRCm39) T244S probably damaging Het
Or12d14-ps1 T G 17: 37,673,502 (GRCm39) F165V probably damaging Het
Or2b7 T C 13: 21,740,136 (GRCm39) N19D probably benign Het
Or51f5 A T 7: 102,424,310 (GRCm39) D193V probably damaging Het
Or5ac25 A G 16: 59,181,927 (GRCm39) I218T probably benign Het
Ostn T C 16: 27,140,189 (GRCm39) probably null Het
Pcdhb6 C T 18: 37,467,273 (GRCm39) R65* probably null Het
Pds5b T C 5: 150,693,406 (GRCm39) I706T probably damaging Het
Pgm2 T G 5: 64,258,302 (GRCm39) Y96D probably damaging Het
Pkd1l2 G A 8: 117,777,926 (GRCm39) T875I possibly damaging Het
Poc1b A G 10: 99,000,764 (GRCm39) S355G probably benign Het
Ppp6r1 A C 7: 4,646,157 (GRCm39) D181E probably benign Het
Pstpip2 G A 18: 77,967,073 (GRCm39) V325M probably benign Het
Rras2 A T 7: 113,658,186 (GRCm39) V92D probably damaging Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Ryr3 GTCTTCTTCTTCTTCTTC GTCTTCTTCTTCTTC 2: 112,499,594 (GRCm39) probably benign Het
Stac2 T A 11: 97,933,379 (GRCm39) M188L probably benign Het
Synrg G A 11: 83,910,644 (GRCm39) D859N probably damaging Het
Tarbp1 A T 8: 127,171,040 (GRCm39) S987T probably damaging Het
Tbx20 C A 9: 24,685,220 (GRCm39) probably benign Het
Trim30d G T 7: 104,121,817 (GRCm39) N309K possibly damaging Het
Ttc16 C T 2: 32,665,047 (GRCm39) probably benign Het
Ttc34 T A 4: 154,945,875 (GRCm39) I303N possibly damaging Het
Ubr4 T C 4: 139,155,519 (GRCm39) probably null Het
Uros A T 7: 133,294,278 (GRCm39) S168T unknown Het
Vmn2r6 C T 3: 64,467,241 (GRCm39) G86D probably damaging Het
Ybx2 C T 11: 69,831,448 (GRCm39) T295I possibly damaging Het
Zbed5 T A 5: 129,929,321 (GRCm39) C146S possibly damaging Het
Zcchc2 G A 1: 105,958,901 (GRCm39) C1124Y probably damaging Het
Zfp626 G A 7: 27,510,175 (GRCm39) probably null Het
Other mutations in Klf6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Klf6 APN 13 5,911,680 (GRCm39) missense probably benign 0.02
IGL01714:Klf6 APN 13 5,916,658 (GRCm39) missense probably benign 0.25
IGL02606:Klf6 APN 13 5,916,734 (GRCm39) missense probably damaging 1.00
H8786:Klf6 UTSW 13 5,911,790 (GRCm39) missense probably damaging 0.98
R0689:Klf6 UTSW 13 5,915,115 (GRCm39) missense probably damaging 1.00
R1174:Klf6 UTSW 13 5,911,711 (GRCm39) missense probably benign 0.06
R1175:Klf6 UTSW 13 5,911,711 (GRCm39) missense probably benign 0.06
R4706:Klf6 UTSW 13 5,911,639 (GRCm39) start codon destroyed probably null 0.66
R4949:Klf6 UTSW 13 5,914,947 (GRCm39) missense probably benign 0.01
R8781:Klf6 UTSW 13 5,915,071 (GRCm39) missense probably benign 0.00
R9021:Klf6 UTSW 13 5,915,160 (GRCm39) missense probably benign 0.02
R9072:Klf6 UTSW 13 5,917,233 (GRCm39) missense probably benign 0.28
Z1177:Klf6 UTSW 13 5,914,881 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCGCCATCCAGTTTGCATG -3'
(R):5'- CATCATTCCAGGCAGCAGAAG -3'

Sequencing Primer
(F):5'- GCATGAAACTTTCACCTGCG -3'
(R):5'- AGATGCACTTCCAAGCA -3'
Posted On 2020-09-15