Mutagenetix > Incidental Mutation

Incidental Mutation 'R7984:Or8b36'

651378

Institutional Source

Beutler Lab

Gene Symbol

Or8b36

Ensembl Gene

ENSMUSG00000094461

Gene Name

olfactory receptor family 8 subfamily B member 36

Synonyms

MOR162-6, Olfr883, GA_x6K02T2PVTD-31705144-31706073

MMRRC Submission

046025-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R7984 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

37937104-37938033 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 37937155 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 18 (T18A)

Ref Sequence

ENSEMBL: ENSMUSP00000072741 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072974]

AlphaFold

Q8VF64

Predicted Effect

probably damaging
Transcript: ENSMUST00000072974
AA Change: T18A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072741
Gene: ENSMUSG00000094461
AA Change: T18A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	1.6e-48	PFAM
Pfam:7tm_1	41	288	3.7e-24	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (58/58)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1e1	G	T	13: 4,645,679 (GRCm39)	H226N	probably damaging	Het
Aldh1a7	T	C	19: 20,686,764 (GRCm39)	D283G	probably damaging	Het
Angel1	T	C	12: 86,767,068 (GRCm39)	D436G	probably benign	Het
Ank1	G	A	8: 23,578,982 (GRCm39)	R314Q	probably damaging	Het
Apbb2	T	C	5: 66,465,035 (GRCm39)	E629G	probably damaging	Het
Card9	T	G	2: 26,246,784 (GRCm39)	I355L	probably benign	Het
Cdon	C	T	9: 35,414,598 (GRCm39)	P1158S	probably benign	Het
Cpne7	T	G	8: 123,846,461 (GRCm39)	V91G	possibly damaging	Het
Dlc1	T	A	8: 37,405,472 (GRCm39)	T106S	possibly damaging	Het
Dnah1	A	T	14: 30,989,772 (GRCm39)	F3248Y	probably damaging	Het
Dnah7a	A	T	1: 53,543,377 (GRCm39)	D2264E	probably benign	Het
Dock7	A	T	4: 98,877,303 (GRCm39)	N1078K	unknown	Het
Emc1	T	A	4: 139,102,760 (GRCm39)	L973H	probably damaging	Het
Fer1l5	T	A	1: 36,447,702 (GRCm39)	L955Q	possibly damaging	Het
Fpr-rs7	T	C	17: 20,333,671 (GRCm39)	N273S	probably benign	Het
Gle1	T	A	2: 29,828,588 (GRCm39)	Y137N	probably damaging	Het
Grik4	G	A	9: 42,582,557 (GRCm39)	Q130*	probably null	Het
Hcn1	C	T	13: 118,112,609 (GRCm39)	Q858*	probably null	Het
Heg1	A	C	16: 33,583,945 (GRCm39)	S76R	possibly damaging	Het
Ikbke	T	A	1: 131,203,523 (GRCm39)	E50V	probably null	Het
Itga5	G	A	15: 103,264,379 (GRCm39)	P297S	probably damaging	Het
Kcng1	C	A	2: 168,104,406 (GRCm39)	R480L	possibly damaging	Het
Kdm3b	G	T	18: 34,956,752 (GRCm39)	E1236*	probably null	Het
Ldlrad4	G	T	18: 68,368,740 (GRCm39)	A66S	possibly damaging	Het
Lrp5	A	G	19: 3,662,342 (GRCm39)	F894L	probably damaging	Het
Lrrk1	T	C	7: 65,950,477 (GRCm39)		probably null	Het
Man2a2	T	G	7: 80,003,056 (GRCm39)	T1018P	probably damaging	Het
Mctp2	T	C	7: 71,752,937 (GRCm39)	Q772R	possibly damaging	Het
Meioc	T	A	11: 102,565,432 (GRCm39)	N293K	possibly damaging	Het
Mrps24	A	T	11: 5,657,495 (GRCm39)	C34S	possibly damaging	Het
Nek1	G	T	8: 61,574,087 (GRCm39)	E1112*	probably null	Het
Nt5dc2	A	G	14: 30,860,775 (GRCm39)	S317G	probably damaging	Het
Obscn	G	T	11: 58,997,151 (GRCm39)	Q1492K	possibly damaging	Het
Or2a57	T	G	6: 43,212,730 (GRCm39)	S63A	probably damaging	Het
Or52e4	T	C	7: 104,705,639 (GRCm39)	F62S	probably damaging	Het
Or6c69	A	G	10: 129,747,941 (GRCm39)	F69L	probably benign	Het
Or9m1b	T	A	2: 87,836,969 (GRCm39)	N42I	probably damaging	Het
Or9s23	A	G	1: 92,501,144 (GRCm39)	I84V	probably benign	Het
P2ry12	T	A	3: 59,125,022 (GRCm39)	I218F	probably damaging	Het
Paip1	C	T	13: 119,566,698 (GRCm39)	Q11*	probably null	Het
Pcdhga3	C	A	18: 37,809,549 (GRCm39)	D667E	probably benign	Het
Pcnx2	T	G	8: 126,485,865 (GRCm39)	E1911A	probably benign	Het
Pibf1	T	C	14: 99,459,063 (GRCm39)	L678P	probably damaging	Het
Pira2	A	T	7: 3,844,696 (GRCm39)	F445Y	probably benign	Het
Prickle2	T	C	6: 92,387,855 (GRCm39)	T516A	probably benign	Het
Prl2c1	G	A	13: 28,039,310 (GRCm39)		probably null	Het
Rnf112	A	G	11: 61,340,306 (GRCm39)	V656A	possibly damaging	Het
Siglecf	A	C	7: 43,004,655 (GRCm39)		probably null	Het
Slc24a1	A	T	9: 64,856,811 (GRCm39)	L32*	probably null	Het
Slc7a1	A	G	5: 148,278,920 (GRCm39)	V284A	possibly damaging	Het
Slco5a1	T	A	1: 12,951,608 (GRCm39)	H565L	probably damaging	Het
Slit2	A	G	5: 48,333,465 (GRCm39)		probably benign	Het
Sulf1	A	G	1: 12,929,497 (GRCm39)	T255A	probably benign	Het
Tmem130	C	T	5: 144,692,237 (GRCm39)	G56R	possibly damaging	Het
Trmt1l	A	C	1: 151,311,489 (GRCm39)	Q116H	probably benign	Het
Ttn	A	T	2: 76,554,094 (GRCm39)	W30870R	probably damaging	Het
Unc13b	A	T	4: 43,173,973 (GRCm39)	L1600F	unknown	Het
Vmn1r233	C	T	17: 21,214,417 (GRCm39)	V178M	probably damaging	Het
Vmn2r18	G	A	5: 151,485,526 (GRCm39)	P656L	probably damaging	Het
Vmn2r33	A	T	7: 7,566,862 (GRCm39)	D83E	probably benign	Het
Vps13b	G	A	15: 35,880,059 (GRCm39)	V3045I	probably benign	Het
Wdr25	A	T	12: 108,976,983 (GRCm39)		probably null	Het
Xpo6	A	G	7: 125,719,616 (GRCm39)	V591A	probably benign	Het

Other mutations in Or8b36

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00980:Or8b36	APN	9	37,937,107 (GRCm39)	missense	probably benign	0.02
IGL02092:Or8b36	APN	9	37,937,917 (GRCm39)	missense	possibly damaging	0.80
IGL02351:Or8b36	APN	9	37,937,332 (GRCm39)	missense	possibly damaging	0.78
IGL02358:Or8b36	APN	9	37,937,332 (GRCm39)	missense	possibly damaging	0.78
IGL02807:Or8b36	APN	9	37,937,485 (GRCm39)	missense	probably damaging	1.00
R0972:Or8b36	UTSW	9	37,937,856 (GRCm39)	missense	possibly damaging	0.88
R1016:Or8b36	UTSW	9	37,937,987 (GRCm39)	missense	probably damaging	0.98
R1818:Or8b36	UTSW	9	37,937,803 (GRCm39)	missense	probably damaging	1.00
R4466:Or8b36	UTSW	9	37,937,479 (GRCm39)	missense	probably damaging	0.99
R4871:Or8b36	UTSW	9	37,937,822 (GRCm39)	missense	probably damaging	1.00
R5977:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R5979:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6026:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6027:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6029:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6035:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6035:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6053:Or8b36	UTSW	9	37,937,837 (GRCm39)	frame shift	probably null
R6092:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6106:Or8b36	UTSW	9	37,937,762 (GRCm39)	missense	probably damaging	1.00
R6131:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6132:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6133:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6134:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6153:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,842 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,841 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,833 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,844 (GRCm39)	frame shift	probably null
R6300:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6301:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6305:Or8b36	UTSW	9	37,937,838 (GRCm39)	frame shift	probably null
R6305:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6307:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,842 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,837 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,845 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,843 (GRCm39)	nonsense	probably null
R6813:Or8b36	UTSW	9	37,937,129 (GRCm39)	missense	probably damaging	1.00
R7134:Or8b36	UTSW	9	37,937,795 (GRCm39)	missense	probably benign	0.00
R7775:Or8b36	UTSW	9	37,937,963 (GRCm39)	missense	probably damaging	1.00
R7778:Or8b36	UTSW	9	37,937,963 (GRCm39)	missense	probably damaging	1.00
R8326:Or8b36	UTSW	9	37,938,014 (GRCm39)	missense	probably benign	0.00
R9154:Or8b36	UTSW	9	37,937,690 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- ATGCTACAGAGGCGATGGTG -3'
(R):5'- TGTTCTGCTTCACAAAACCCAC -3'

Sequencing Primer
(F):5'- GCCATTGTTTTCCTGAATAATATTCC -3'
(R):5'- CAGCATTCTGGGGGTTATGACAG -3'

Posted On

2020-09-15