Mutagenetix > Incidental Mutation

Incidental Mutation 'R7984:Fpr-rs7'

651397

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

R7984 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20113409 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 273 (N273S)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably benign
Transcript: ENSMUST00000095637
AA Change: N273S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: N273S

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (58/58)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1e1	G	T	13: 4,595,680	H226N	probably damaging	Het
Aldh1a7	T	C	19: 20,709,400	D283G	probably damaging	Het
Angel1	T	C	12: 86,720,294	D436G	probably benign	Het
Ank1	G	A	8: 23,088,966	R314Q	probably damaging	Het
Apbb2	T	C	5: 66,307,692	E629G	probably damaging	Het
Card9	T	G	2: 26,356,772	I355L	probably benign	Het
Cdon	C	T	9: 35,503,302	P1158S	probably benign	Het
Cpne7	T	G	8: 123,119,722	V91G	possibly damaging	Het
Dlc1	T	A	8: 36,938,318	T106S	possibly damaging	Het
Dnah1	A	T	14: 31,267,815	F3248Y	probably damaging	Het
Dnah7a	A	T	1: 53,504,218	D2264E	probably benign	Het
Dock7	A	T	4: 98,989,066	N1078K	unknown	Het
Emc1	T	A	4: 139,375,449	L973H	probably damaging	Het
Fer1l5	T	A	1: 36,408,621	L955Q	possibly damaging	Het
Gle1	T	A	2: 29,938,576	Y137N	probably damaging	Het
Grik4	G	A	9: 42,671,261	Q130*	probably null	Het
Hcn1	C	T	13: 117,976,073	Q858*	probably null	Het
Heg1	A	C	16: 33,763,575	S76R	possibly damaging	Het
Ikbke	T	A	1: 131,275,786	E50V	probably null	Het
Itga5	G	A	15: 103,355,952	P297S	probably damaging	Het
Kcng1	C	A	2: 168,262,486	R480L	possibly damaging	Het
Kdm3b	G	T	18: 34,823,699	E1236*	probably null	Het
Ldlrad4	G	T	18: 68,235,669	A66S	possibly damaging	Het
Lrp5	A	G	19: 3,612,342	F894L	probably damaging	Het
Lrrk1	T	C	7: 66,300,729		probably null	Het
Man2a2	T	G	7: 80,353,308	T1018P	probably damaging	Het
Mctp2	T	C	7: 72,103,189	Q772R	possibly damaging	Het
Meioc	T	A	11: 102,674,606	N293K	possibly damaging	Het
Mrps24	A	T	11: 5,707,495	C34S	possibly damaging	Het
Nek1	G	T	8: 61,121,053	E1112*	probably null	Het
Nt5dc2	A	G	14: 31,138,818	S317G	probably damaging	Het
Obscn	G	T	11: 59,106,325	Q1492K	possibly damaging	Het
Olfr1160	T	A	2: 88,006,625	N42I	probably damaging	Het
Olfr1413	A	G	1: 92,573,422	I84V	probably benign	Het
Olfr47	T	G	6: 43,235,796	S63A	probably damaging	Het
Olfr677	T	C	7: 105,056,432	F62S	probably damaging	Het
Olfr816	A	G	10: 129,912,072	F69L	probably benign	Het
Olfr883	A	G	9: 38,025,859	T18A	probably damaging	Het
P2ry12	T	A	3: 59,217,601	I218F	probably damaging	Het
Paip1	C	T	13: 119,430,162	Q11*	probably null	Het
Pcdhga3	C	A	18: 37,676,496	D667E	probably benign	Het
Pcnx2	T	G	8: 125,759,126	E1911A	probably benign	Het
Pibf1	T	C	14: 99,221,627	L678P	probably damaging	Het
Pira2	A	T	7: 3,841,697	F445Y	probably benign	Het
Prickle2	T	C	6: 92,410,874	T516A	probably benign	Het
Prl2c1	G	A	13: 27,855,327		probably null	Het
Rnf112	A	G	11: 61,449,480	V656A	possibly damaging	Het
Siglecf	A	C	7: 43,355,231		probably null	Het
Slc24a1	A	T	9: 64,949,529	L32*	probably null	Het
Slc7a1	A	G	5: 148,342,110	V284A	possibly damaging	Het
Slco5a1	T	A	1: 12,881,384	H565L	probably damaging	Het
Slit2	A	G	5: 48,176,123		probably benign	Het
Sulf1	A	G	1: 12,859,273	T255A	probably benign	Het
Tmem130	C	T	5: 144,755,427	G56R	possibly damaging	Het
Trmt1l	A	C	1: 151,435,738	Q116H	probably benign	Het
Ttn	A	T	2: 76,723,750	W30870R	probably damaging	Het
Unc13b	A	T	4: 43,173,973	L1600F	unknown	Het
Vmn1r233	C	T	17: 20,994,155	V178M	probably damaging	Het
Vmn2r18	G	A	5: 151,562,061	P656L	probably damaging	Het
Vmn2r33	A	T	7: 7,563,863	D83E	probably benign	Het
Vps13b	G	A	15: 35,879,913	V3045I	probably benign	Het
Wdr25	A	T	12: 109,011,057		probably null	Het
Xpo6	A	G	7: 126,120,444	V591A	probably benign	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TCTCAGGTCCTATGTCTCAGAG -3'
(R):5'- TGTTGGCTTCAGCATACCAATG -3'

Sequencing Primer
(F):5'- CAGGTCCTATGTCTCAGAGTCTTAAG -3'
(R):5'- GGCTTCAGCATACCAATGATCTTC -3'

Posted On

2020-09-15