Incidental Mutation 'R7986:Or10ag52'
ID 651468
Institutional Source Beutler Lab
Gene Symbol Or10ag52
Ensembl Gene ENSMUSG00000070857
Gene Name olfactory receptor family 10 subfamily AG member 52
Synonyms GA_x6K02T2Q125-48697747-48698727, MOR264-25, Olfr1113
MMRRC Submission 046027-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R7986 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87043238-87044218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87043922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 229 (I229V)
Ref Sequence ENSEMBL: ENSMUSP00000150991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079966] [ENSMUST00000215611]
AlphaFold Q7TR54
Predicted Effect probably benign
Transcript: ENSMUST00000079966
AA Change: I229V

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078883
Gene: ENSMUSG00000070857
AA Change: I229V

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 6.7e-53 PFAM
Pfam:7tm_1 56 305 2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215611
AA Change: I229V

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts1 G T 16: 85,596,435 (GRCm39) A401D probably damaging Het
Akap10 C T 11: 61,820,890 (GRCm39) G5R probably damaging Het
Arhgap21 A C 2: 20,867,967 (GRCm39) L1023W probably damaging Het
Bpifb4 A G 2: 153,799,650 (GRCm39) N339S probably benign Het
Btbd17 A G 11: 114,683,341 (GRCm39) Y124H probably damaging Het
Cacna1a C G 8: 85,365,408 (GRCm39) R2184G probably benign Het
Cavin1 A G 11: 100,861,102 (GRCm39) I64T probably damaging Het
Cby3 A G 11: 50,250,106 (GRCm39) H9R possibly damaging Het
Ccdc141 A G 2: 76,845,461 (GRCm39) L1202P probably benign Het
Cd109 A G 9: 78,596,048 (GRCm39) I794V possibly damaging Het
Col12a1 C T 9: 79,511,674 (GRCm39) probably null Het
Col6a2 A G 10: 76,450,972 (GRCm39) L23P probably benign Het
Csf1r A G 18: 61,247,904 (GRCm39) H324R probably benign Het
D430041D05Rik A G 2: 104,087,096 (GRCm39) S627P probably damaging Het
Dffb G A 4: 154,054,504 (GRCm39) S195F probably damaging Het
Fstl5 T A 3: 76,337,097 (GRCm39) Y219N probably damaging Het
Gm29106 A T 1: 118,128,000 (GRCm39) H564L possibly damaging Het
Gpt2 T A 8: 86,235,839 (GRCm39) C158* probably null Het
Grin1 G T 2: 25,185,841 (GRCm39) A872D probably damaging Het
Hoxa1 T C 6: 52,135,018 (GRCm39) S62G probably benign Het
Krt28 T C 11: 99,257,651 (GRCm39) N397D probably benign Het
Ldlrad4 G T 18: 68,368,740 (GRCm39) A66S possibly damaging Het
Llgl1 G T 11: 60,602,221 (GRCm39) A755S probably benign Het
Lmod2 A G 6: 24,603,448 (GRCm39) E141G possibly damaging Het
Loxhd1 A T 18: 77,462,890 (GRCm39) T910S possibly damaging Het
Masp2 A G 4: 148,687,283 (GRCm39) Y55C probably damaging Het
Nek10 A C 14: 15,001,020 (GRCm38) S1067R probably benign Het
Nemp2 C T 1: 52,669,981 (GRCm39) A22V probably benign Het
Npy2r T A 3: 82,448,803 (GRCm39) probably null Het
Nr1h4 A T 10: 89,290,634 (GRCm39) S469T possibly damaging Het
Nr4a3 T C 4: 48,055,954 (GRCm39) Y327H probably damaging Het
Or5an1b C T 19: 12,300,102 (GRCm39) V30I probably benign Het
Pramel26 A T 4: 143,538,590 (GRCm39) L127* probably null Het
Prss1l T C 6: 41,373,058 (GRCm39) I110T probably damaging Het
Ptpdc1 G A 13: 48,746,046 (GRCm39) A118V probably damaging Het
Raph1 T C 1: 60,535,445 (GRCm39) Y73C Het
Rtl1 A G 12: 109,558,492 (GRCm39) S1116P possibly damaging Het
Secisbp2 T C 13: 51,819,395 (GRCm39) I325T probably damaging Het
Setd5 T C 6: 113,105,418 (GRCm39) S817P probably benign Het
Sirt6 A G 10: 81,458,344 (GRCm39) L303P probably benign Het
Slc46a2 G T 4: 59,911,858 (GRCm39) F451L probably benign Het
Sorbs1 T A 19: 40,353,449 (GRCm39) I219F probably damaging Het
Tmem178 A G 17: 81,308,273 (GRCm39) I223V possibly damaging Het
Trps1 T G 15: 50,525,132 (GRCm39) T933P probably damaging Het
Trps1 A G 15: 50,753,019 (GRCm39) F16S probably benign Het
Virma T A 4: 11,540,023 (GRCm39) S1447R probably benign Het
Vmn1r230 T C 17: 21,067,119 (GRCm39) Y103H probably damaging Het
Wdfy4 G A 14: 32,826,072 (GRCm39) P1193L Het
Ybx3 T A 6: 131,356,362 (GRCm39) R170* probably null Het
Zfp423 T C 8: 88,506,978 (GRCm39) D1122G probably benign Het
Other mutations in Or10ag52
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02325:Or10ag52 APN 2 87,043,850 (GRCm39) missense probably damaging 0.96
IGL02523:Or10ag52 APN 2 87,043,664 (GRCm39) missense probably benign 0.26
IGL03112:Or10ag52 APN 2 87,043,944 (GRCm39) missense probably damaging 1.00
IGL03137:Or10ag52 APN 2 87,043,500 (GRCm39) missense probably benign 0.42
R0393:Or10ag52 UTSW 2 87,044,037 (GRCm39) missense probably benign
R1758:Or10ag52 UTSW 2 87,043,758 (GRCm39) missense probably benign 0.13
R1920:Or10ag52 UTSW 2 87,043,721 (GRCm39) missense probably benign 0.09
R1992:Or10ag52 UTSW 2 87,043,588 (GRCm39) nonsense probably null
R3742:Or10ag52 UTSW 2 87,043,340 (GRCm39) missense probably benign 0.00
R5615:Or10ag52 UTSW 2 87,044,083 (GRCm39) missense probably benign 0.00
R5665:Or10ag52 UTSW 2 87,044,072 (GRCm39) missense probably benign 0.05
R5749:Or10ag52 UTSW 2 87,043,287 (GRCm39) missense probably benign
R6752:Or10ag52 UTSW 2 87,043,388 (GRCm39) missense probably benign
R8161:Or10ag52 UTSW 2 87,044,148 (GRCm39) missense probably damaging 0.96
R8283:Or10ag52 UTSW 2 87,043,683 (GRCm39) missense probably benign 0.04
R9185:Or10ag52 UTSW 2 87,044,174 (GRCm39) missense probably benign 0.01
Z1088:Or10ag52 UTSW 2 87,044,122 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ACCCAGTTAGTAGTTGGTTCCTG -3'
(R):5'- AGAGAAGTTTGTCTGTCCCCTC -3'

Sequencing Primer
(F):5'- TCATTGGTGTTCCCATTCAGG -3'
(R):5'- GTCCCCTCAAACTTATTGGACTTAGG -3'
Posted On 2020-09-15