Incidental Mutation 'R7990:Sult2a6'
ID 651686
Institutional Source Beutler Lab
Gene Symbol Sult2a6
Ensembl Gene ENSMUSG00000070810
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
Synonyms Gm6957
MMRRC Submission 046031-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7990 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 13956328-13988795 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13959795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 246 (M246K)
Ref Sequence ENSEMBL: ENSMUSP00000075884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076576] [ENSMUST00000184731]
AlphaFold B2RVI8
Predicted Effect possibly damaging
Transcript: ENSMUST00000076576
AA Change: M246K

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075884
Gene: ENSMUSG00000070810
AA Change: M246K

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 1.2e-81 PFAM
Pfam:Sulfotransfer_3 35 205 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184731
SMART Domains Protein: ENSMUSP00000138842
Gene: ENSMUSG00000070810

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 116 4.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184741
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933434E20Rik G A 3: 89,970,549 (GRCm39) V28I probably damaging Het
Abcd4 G T 12: 84,651,162 (GRCm39) probably null Het
Alg2 T C 4: 47,472,308 (GRCm39) T167A probably damaging Het
Asap1 T C 15: 64,044,586 (GRCm39) probably null Het
Atad5 T A 11: 80,024,079 (GRCm39) C1730* probably null Het
Atp8b1 T C 18: 64,671,748 (GRCm39) T1092A possibly damaging Het
C130050O18Rik A G 5: 139,400,672 (GRCm39) T242A probably benign Het
Ccdc88c A G 12: 100,934,244 (GRCm39) V211A probably damaging Het
Ccnl1 A G 3: 65,854,314 (GRCm39) S436P possibly damaging Het
Cgnl1 T C 9: 71,632,547 (GRCm39) E268G probably damaging Het
Clca4b T G 3: 144,634,103 (GRCm39) D104A probably damaging Het
Col6a3 T G 1: 90,709,577 (GRCm39) K2480T unknown Het
Cryba1 T C 11: 77,614,411 (GRCm39) T21A possibly damaging Het
Csn1s1 C T 5: 87,827,912 (GRCm39) A259V possibly damaging Het
Dap3 A C 3: 88,835,814 (GRCm39) Y206* probably null Het
Etnppl T C 3: 130,424,308 (GRCm39) I360T possibly damaging Het
Gal3st3 A T 19: 5,352,617 (GRCm39) M15L probably benign Het
Gdf5 A G 2: 155,783,749 (GRCm39) V401A probably damaging Het
Gm1110 A G 9: 26,792,137 (GRCm39) S628P possibly damaging Het
Gm9493 A T 19: 23,597,397 (GRCm39) I98F possibly damaging Het
Grin2a T C 16: 9,397,040 (GRCm39) K1016E possibly damaging Het
Hdac9 T C 12: 34,265,452 (GRCm39) N850D probably benign Het
Itsn2 C A 12: 4,685,629 (GRCm39) L466I unknown Het
Jkampl T C 6: 73,446,528 (GRCm39) Y7C probably damaging Het
Kcnj16 C A 11: 110,915,886 (GRCm39) R183S probably damaging Het
Kcnk2 A C 1: 188,942,102 (GRCm39) L389R probably damaging Het
Kdm4c A C 4: 74,309,685 (GRCm39) K949N probably damaging Het
Kif3b G A 2: 153,159,383 (GRCm39) E395K probably benign Het
Ldlrad1 G A 4: 107,066,688 (GRCm39) A8T probably benign Het
Map3k1 A T 13: 111,892,696 (GRCm39) M853K probably benign Het
Metap1 T G 3: 138,186,526 (GRCm39) T68P probably benign Het
Mfsd11 T C 11: 116,750,323 (GRCm39) V114A possibly damaging Het
Mroh1 G A 15: 76,336,475 (GRCm39) R1566H probably damaging Het
Msh4 A T 3: 153,602,529 (GRCm39) M233K probably damaging Het
Ncor1 T G 11: 62,240,321 (GRCm39) probably null Het
Npl A T 1: 153,413,230 (GRCm39) V29D possibly damaging Het
Or1e29 C T 11: 73,667,497 (GRCm39) V219I probably benign Het
Osmr T C 15: 6,881,948 (GRCm39) I65M possibly damaging Het
Rabepk C T 2: 34,670,720 (GRCm39) V247I probably benign Het
Rere C T 4: 150,699,327 (GRCm39) P804S unknown Het
Rpgrip1 A T 14: 52,366,975 (GRCm39) Y265F possibly damaging Het
Slc10a1 T C 12: 81,000,554 (GRCm39) D315G probably benign Het
Smc5 A T 19: 23,213,246 (GRCm39) N555K probably benign Het
Spata17 T A 1: 186,872,592 (GRCm39) H26L unknown Het
Sphkap C T 1: 83,245,066 (GRCm39) D1518N probably damaging Het
Tmx2 A G 2: 84,506,480 (GRCm39) F71L probably damaging Het
Ush2a T A 1: 188,274,996 (GRCm39) L1823Q probably benign Het
Virma T A 4: 11,513,983 (GRCm39) D612E probably benign Het
Wdfy4 A T 14: 32,819,752 (GRCm39) L1484Q Het
Zan A G 5: 137,391,352 (GRCm39) S4711P unknown Het
Zdhhc1 A G 8: 106,203,001 (GRCm39) probably null Het
Zfp971 C T 2: 177,675,361 (GRCm39) T320I probably damaging Het
Other mutations in Sult2a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00959:Sult2a6 APN 7 13,988,634 (GRCm39) missense probably damaging 1.00
IGL01977:Sult2a6 APN 7 13,987,411 (GRCm39) missense probably benign 0.00
IGL02524:Sult2a6 APN 7 13,970,611 (GRCm39) missense possibly damaging 0.80
IGL03209:Sult2a6 APN 7 13,959,897 (GRCm39) missense probably benign 0.36
IGL03379:Sult2a6 APN 7 13,956,511 (GRCm39) missense probably benign 0.01
R1840:Sult2a6 UTSW 7 13,988,754 (GRCm39) missense probably benign 0.03
R1893:Sult2a6 UTSW 7 13,959,814 (GRCm39) missense probably benign 0.00
R2037:Sult2a6 UTSW 7 13,988,634 (GRCm39) missense probably damaging 0.99
R2331:Sult2a6 UTSW 7 13,959,795 (GRCm39) missense possibly damaging 0.94
R3871:Sult2a6 UTSW 7 13,988,701 (GRCm39) missense probably benign 0.16
R3921:Sult2a6 UTSW 7 13,988,668 (GRCm39) missense possibly damaging 0.83
R5599:Sult2a6 UTSW 7 13,988,629 (GRCm39) nonsense probably null
R5761:Sult2a6 UTSW 7 13,984,283 (GRCm39) missense probably damaging 0.97
R6744:Sult2a6 UTSW 7 13,956,470 (GRCm39) missense probably damaging 1.00
R6956:Sult2a6 UTSW 7 13,988,748 (GRCm39) missense possibly damaging 0.50
R7152:Sult2a6 UTSW 7 13,956,445 (GRCm39) missense probably benign 0.36
R7869:Sult2a6 UTSW 7 13,988,737 (GRCm39) missense not run
R8347:Sult2a6 UTSW 7 13,959,883 (GRCm39) missense probably benign 0.15
R8369:Sult2a6 UTSW 7 13,987,327 (GRCm39) critical splice donor site probably null
R8391:Sult2a6 UTSW 7 13,956,516 (GRCm39) critical splice acceptor site probably null
R8414:Sult2a6 UTSW 7 13,984,357 (GRCm39) missense probably damaging 1.00
R9317:Sult2a6 UTSW 7 13,970,615 (GRCm39) nonsense probably null
R9654:Sult2a6 UTSW 7 13,956,445 (GRCm39) missense probably benign 0.06
Z1088:Sult2a6 UTSW 7 13,959,819 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACTATCTCCAATCCCAAGTTCG -3'
(R):5'- CTTCTTTTAGGATGCAAAGGGAAC -3'

Sequencing Primer
(F):5'- CAGTGTTTGAAACCTACATCTTCTG -3'
(R):5'- CCATAAAGAAGATCTGTGACTTCC -3'
Posted On 2020-09-15