Mutagenetix > Incidental Mutation

Incidental Mutation 'R7991:Or5an10'

651775

Institutional Source

Beutler Lab

Gene Symbol

Or5an10

Ensembl Gene

ENSMUSG00000067513

Gene Name

olfactory receptor family 5 subfamily AN member 10

Synonyms

Olfr1436, GA_x6K02T2RE5P-2634596-2633658, MOR214-2

MMRRC Submission

046032-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R7991 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

12275547-12276494 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12275639 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 286 (I286F)

Ref Sequence

ENSEMBL: ENSMUSP00000085113 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087812]

AlphaFold

A0PK57

Predicted Effect

probably damaging
Transcript: ENSMUST00000087812
AA Change: I286F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000085113
Gene: ENSMUSG00000067513
AA Change: I286F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.4e-54	PFAM
Pfam:7tm_1	45	294	1.3e-19	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (64/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	A	G	18: 59,185,726 (GRCm39)	D1200G	probably damaging	Het
Adnp2	A	G	18: 80,172,537 (GRCm39)	L624P	probably damaging	Het
Akap9	A	G	5: 4,114,949 (GRCm39)		probably null	Het
Ap2a2	A	G	7: 141,189,760 (GRCm39)	Y249C	probably damaging	Het
Asxl2	A	T	12: 3,534,531 (GRCm39)	N243Y	probably damaging	Het
Btnl4	A	G	17: 34,693,257 (GRCm39)	S53P	probably damaging	Het
Caly	T	C	7: 139,651,513 (GRCm39)	D116G	possibly damaging	Het
Ccdc121rt2	G	A	5: 112,598,791 (GRCm39)	R446H	probably benign	Het
Ccdc168	T	A	1: 44,098,869 (GRCm39)	H743L	probably benign	Het
Ccdc81	G	A	7: 89,539,609 (GRCm39)	A209V	probably benign	Het
Cdc14a	A	G	3: 116,101,887 (GRCm39)	S347P	probably benign	Het
Cdh9	G	T	15: 16,828,489 (GRCm39)	A194S	probably damaging	Het
Clca3a2	A	G	3: 144,519,756 (GRCm39)	V206A	probably benign	Het
Clca4a	A	T	3: 144,658,500 (GRCm39)	V905E	possibly damaging	Het
Cluap1	A	G	16: 3,746,485 (GRCm39)	E282G	probably damaging	Het
Cmtm2b	T	A	8: 105,056,419 (GRCm39)	C109*	probably null	Het
Crtac1	T	C	19: 42,322,399 (GRCm39)	N114D	probably benign	Het
Dennd1b	T	C	1: 139,013,634 (GRCm39)	Y168H		Het
Dock6	T	C	9: 21,757,858 (GRCm39)	D82G	probably damaging	Het
Eps8	C	T	6: 137,505,569 (GRCm39)	R53Q	possibly damaging	Het
Erfl	G	A	7: 24,627,975 (GRCm39)	P185S	possibly damaging	Het
Fh1	T	C	1: 175,437,337 (GRCm39)	Y254C	probably damaging	Het
H2-Q1	T	A	17: 35,540,356 (GRCm39)	L147Q	probably damaging	Het
H3c8	T	A	13: 23,719,887 (GRCm39)	M91K	probably benign	Het
Hnrnpu	A	T	1: 178,159,871 (GRCm39)	D403E	unknown	Het
Il34	T	C	8: 111,476,122 (GRCm39)	K33E	probably benign	Het
Klhl20	A	G	1: 160,934,434 (GRCm39)	V195A	possibly damaging	Het
Lair1	G	T	7: 4,031,969 (GRCm39)	T46N	probably damaging	Het
Lama4	A	G	10: 38,921,805 (GRCm39)	E442G	possibly damaging	Het
Lifr	A	T	15: 7,202,963 (GRCm39)	I400F	possibly damaging	Het
Man2a1	T	C	17: 64,908,771 (GRCm39)	I14T	probably benign	Het
Or13p10	T	A	4: 118,523,489 (GRCm39)	C258*	probably null	Het
Or1ad8	T	G	11: 50,898,071 (GRCm39)	S91A	possibly damaging	Het
Or4z4	A	C	19: 12,076,190 (GRCm39)	V271G	possibly damaging	Het
Or51h7	A	G	7: 102,591,760 (GRCm39)	L8P	probably benign	Het
Or8s10	T	C	15: 98,335,419 (GRCm39)	I23T	probably benign	Het
Papss2	G	T	19: 32,629,403 (GRCm39)	V331F	possibly damaging	Het
Pcdha11	T	C	18: 37,145,909 (GRCm39)	S667P	probably damaging	Het
Pcolce	A	T	5: 137,607,390 (GRCm39)	S75T	probably benign	Het
Phf20l1	A	C	15: 66,502,768 (GRCm39)	D716A	possibly damaging	Het
Pkd1	A	G	17: 24,791,595 (GRCm39)	E1094G	possibly damaging	Het
Ppm1h	A	G	10: 122,618,152 (GRCm39)	K104E	probably benign	Het
Ppp6r3	T	C	19: 3,509,750 (GRCm39)	Y195C	probably benign	Het
Pramel6	T	A	2: 87,340,031 (GRCm39)	L265Q	probably benign	Het
Prc1	A	T	7: 79,961,969 (GRCm39)	N489I	possibly damaging	Het
Prss59	A	C	6: 40,905,444 (GRCm39)		probably null	Het
Psg22	A	C	7: 18,460,861 (GRCm39)	N497H	probably damaging	Het
Pum3	T	A	19: 27,389,620 (GRCm39)	I411F	possibly damaging	Het
Repin1	G	T	6: 48,574,279 (GRCm39)	E403*	probably null	Het
Rev3l	A	T	10: 39,739,734 (GRCm39)	I2861L	possibly damaging	Het
Rsf1	A	C	7: 97,310,540 (GRCm39)	K423N		Het
Samd4b	A	G	7: 28,103,458 (GRCm39)	I553T	probably benign	Het
Septin3	A	G	15: 82,170,654 (GRCm39)	E216G	probably benign	Het
Sppl2c	A	G	11: 104,078,189 (GRCm39)	T330A	probably benign	Het
Sppl2c	T	C	11: 104,078,640 (GRCm39)	V480A	possibly damaging	Het
Srebf2	A	G	15: 82,088,253 (GRCm39)	D1073G	probably damaging	Het
Sv2c	C	T	13: 96,224,797 (GRCm39)	V171M	probably damaging	Het
Tbc1d4	T	A	14: 101,845,715 (GRCm39)	E61V	probably damaging	Het
Tnc	T	A	4: 63,926,983 (GRCm39)	T848S	probably benign	Het
Trmt5	A	G	12: 73,329,439 (GRCm39)	Y240H	probably damaging	Het
Trpv1	T	C	11: 73,132,583 (GRCm39)	V399A	possibly damaging	Het
Tstd2	T	C	4: 46,133,646 (GRCm39)	T59A	unknown	Het
Ubash3a	T	A	17: 31,456,869 (GRCm39)	L510M	probably benign	Het
Ubr3	T	A	2: 69,783,200 (GRCm39)	I713N	probably damaging	Het
Upf3a	A	G	8: 13,842,166 (GRCm39)	E194G	probably damaging	Het
Usp22	A	T	11: 61,065,588 (GRCm39)	Y42N	probably benign	Het
Vav3	T	A	3: 109,470,478 (GRCm39)	C555S	probably damaging	Het
Vmn1r210	T	A	13: 23,011,684 (GRCm39)	M201L	probably benign	Het
Wdr64	C	A	1: 175,554,051 (GRCm39)	Q194K	probably benign	Het

Other mutations in Or5an10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00975:Or5an10	APN	19	12,276,149 (GRCm39)	missense	probably damaging	0.99
IGL02129:Or5an10	APN	19	12,275,822 (GRCm39)	missense	probably damaging	1.00
PIT4378001:Or5an10	UTSW	19	12,276,076 (GRCm39)	missense	probably damaging	1.00
R0727:Or5an10	UTSW	19	12,276,458 (GRCm39)	missense	probably benign	0.03
R1244:Or5an10	UTSW	19	12,275,860 (GRCm39)	missense	probably damaging	0.98
R1647:Or5an10	UTSW	19	12,276,023 (GRCm39)	missense	probably benign
R1648:Or5an10	UTSW	19	12,276,023 (GRCm39)	missense	probably benign
R1837:Or5an10	UTSW	19	12,275,740 (GRCm39)	missense	probably damaging	1.00
R1899:Or5an10	UTSW	19	12,275,707 (GRCm39)	missense	probably damaging	1.00
R2031:Or5an10	UTSW	19	12,275,740 (GRCm39)	missense	probably damaging	1.00
R2305:Or5an10	UTSW	19	12,276,451 (GRCm39)	missense	probably benign	0.01
R4624:Or5an10	UTSW	19	12,276,347 (GRCm39)	missense	probably benign
R4681:Or5an10	UTSW	19	12,276,413 (GRCm39)	missense	probably benign	0.05
R4790:Or5an10	UTSW	19	12,276,305 (GRCm39)	missense	possibly damaging	0.60
R4865:Or5an10	UTSW	19	12,275,944 (GRCm39)	missense	probably damaging	1.00
R4941:Or5an10	UTSW	19	12,276,260 (GRCm39)	missense	possibly damaging	0.95
R5138:Or5an10	UTSW	19	12,276,140 (GRCm39)	missense	possibly damaging	0.56
R5161:Or5an10	UTSW	19	12,276,153 (GRCm39)	missense	probably damaging	0.99
R5560:Or5an10	UTSW	19	12,276,008 (GRCm39)	nonsense	probably null
R5983:Or5an10	UTSW	19	12,276,467 (GRCm39)	missense	probably benign	0.00
R6736:Or5an10	UTSW	19	12,275,936 (GRCm39)	nonsense	probably null
R6882:Or5an10	UTSW	19	12,275,934 (GRCm39)	missense	probably damaging	1.00
R6883:Or5an10	UTSW	19	12,275,934 (GRCm39)	missense	probably damaging	1.00
R7465:Or5an10	UTSW	19	12,275,801 (GRCm39)	missense	probably benign	0.04
R7500:Or5an10	UTSW	19	12,276,041 (GRCm39)	missense	probably damaging	0.98
R7529:Or5an10	UTSW	19	12,276,086 (GRCm39)	missense	probably damaging	1.00
R7565:Or5an10	UTSW	19	12,276,212 (GRCm39)	missense	probably benign	0.09
R7611:Or5an10	UTSW	19	12,276,242 (GRCm39)	missense	probably damaging	0.99
R7850:Or5an10	UTSW	19	12,275,996 (GRCm39)	missense	probably benign
R7956:Or5an10	UTSW	19	12,275,666 (GRCm39)	missense	probably damaging	1.00
R9770:Or5an10	UTSW	19	12,276,464 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAGTCACAGTCCACATGGC -3'
(R):5'- GCACACGTAGAGCTTCTCATATTAAC -3'

Sequencing Primer
(F):5'- GTCACAGTCCACATGGCTATTATAAC -3'
(R):5'- ATTGTCTTGTCCATTCTGAAGATCAC -3'

Posted On

2020-09-15