Incidental Mutation 'R7993:Vmn2r14'
| ID |
651860 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
046034-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.526)
|
| Stock # |
R7993 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109363862 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 685
(M685L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170341
AA Change: M685L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: M685L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
100% (69/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
T |
A |
19: 43,803,231 (GRCm39) |
V689D |
possibly damaging |
Het |
| Adamts17 |
T |
C |
7: 66,499,612 (GRCm39) |
V53A |
possibly damaging |
Het |
| Adcy9 |
T |
C |
16: 4,235,866 (GRCm39) |
N515S |
probably damaging |
Het |
| Aoc1l3 |
T |
A |
6: 48,964,542 (GRCm39) |
N183K |
possibly damaging |
Het |
| Atp1a2 |
A |
G |
1: 172,118,878 (GRCm39) |
V88A |
possibly damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,700,406 (GRCm39) |
|
probably null |
Het |
| Baz2a |
T |
C |
10: 127,961,491 (GRCm39) |
F1706L |
probably benign |
Het |
| Cacnb2 |
A |
C |
2: 14,968,731 (GRCm39) |
N199T |
probably benign |
Het |
| Caskin1 |
T |
A |
17: 24,718,279 (GRCm39) |
Y296* |
probably null |
Het |
| Cemip |
C |
A |
7: 83,613,383 (GRCm39) |
G605V |
probably damaging |
Het |
| Ciart |
T |
A |
3: 95,786,206 (GRCm39) |
K290* |
probably null |
Het |
| Cideb |
G |
T |
14: 55,995,899 (GRCm39) |
|
probably benign |
Het |
| Copg2 |
A |
T |
6: 30,793,097 (GRCm39) |
Y413N |
probably damaging |
Het |
| Csrp1 |
T |
A |
1: 135,674,453 (GRCm39) |
|
probably null |
Het |
| Cyp2j8 |
C |
T |
4: 96,335,456 (GRCm39) |
|
probably null |
Het |
| Dcbld1 |
T |
A |
10: 52,137,884 (GRCm39) |
Y49* |
probably null |
Het |
| Dpep1 |
T |
C |
8: 123,927,460 (GRCm39) |
V338A |
possibly damaging |
Het |
| Exoc2 |
A |
G |
13: 31,090,713 (GRCm39) |
|
probably null |
Het |
| Fcho2 |
A |
T |
13: 98,888,524 (GRCm39) |
|
probably null |
Het |
| Foxd3 |
C |
T |
4: 99,544,841 (GRCm39) |
|
probably benign |
Het |
| Gabbr2 |
C |
T |
4: 46,736,349 (GRCm39) |
|
probably null |
Het |
| Gipc3 |
T |
C |
10: 81,173,805 (GRCm39) |
D269G |
probably damaging |
Het |
| Gm4861 |
G |
A |
3: 137,256,417 (GRCm39) |
T63M |
probably damaging |
Het |
| Hmga1b |
C |
A |
11: 120,653,833 (GRCm39) |
A40E |
probably damaging |
Het |
| Hydin |
T |
A |
8: 111,306,264 (GRCm39) |
M3889K |
probably benign |
Het |
| Inhca |
T |
A |
9: 103,140,332 (GRCm39) |
K462N |
probably benign |
Het |
| Klk14 |
T |
A |
7: 43,344,367 (GRCm39) |
M226K |
probably benign |
Het |
| Liph |
T |
G |
16: 21,777,562 (GRCm39) |
M413L |
probably benign |
Het |
| Lrrc37a |
T |
C |
11: 103,348,787 (GRCm39) |
D2636G |
unknown |
Het |
| Lrrk1 |
G |
A |
7: 65,912,202 (GRCm39) |
T1786M |
probably benign |
Het |
| Map1a |
A |
G |
2: 121,135,057 (GRCm39) |
S1958G |
possibly damaging |
Het |
| Msto1 |
A |
G |
3: 88,817,481 (GRCm39) |
F484S |
probably benign |
Het |
| Muc2 |
C |
T |
7: 141,308,173 (GRCm39) |
H890Y |
|
Het |
| Nectin3 |
T |
C |
16: 46,279,184 (GRCm39) |
I265V |
probably benign |
Het |
| Nectin4 |
C |
T |
1: 171,211,322 (GRCm39) |
T282I |
probably damaging |
Het |
| Nfat5 |
T |
A |
8: 108,082,134 (GRCm39) |
|
probably null |
Het |
| Nsmaf |
T |
C |
4: 6,398,647 (GRCm39) |
D819G |
probably benign |
Het |
| Or8b8 |
A |
T |
9: 37,808,633 (GRCm39) |
|
probably benign |
Het |
| Pcdhb1 |
A |
T |
18: 37,400,044 (GRCm39) |
D665V |
probably damaging |
Het |
| Pkd1l1 |
T |
C |
11: 8,895,262 (GRCm39) |
D616G |
|
Het |
| Plppr2 |
A |
T |
9: 21,858,258 (GRCm39) |
H286L |
probably damaging |
Het |
| Polrmt |
T |
C |
10: 79,572,085 (GRCm39) |
T1203A |
probably damaging |
Het |
| Ppm1d |
T |
A |
11: 85,217,777 (GRCm39) |
V180E |
probably damaging |
Het |
| Ppp1r18 |
T |
A |
17: 36,184,718 (GRCm39) |
I551N |
probably benign |
Het |
| Psg28 |
C |
T |
7: 18,160,401 (GRCm39) |
C265Y |
possibly damaging |
Het |
| Psmc1 |
A |
G |
12: 100,081,824 (GRCm39) |
D142G |
probably benign |
Het |
| Rabgap1l |
G |
T |
1: 160,528,424 (GRCm39) |
A394E |
probably damaging |
Het |
| Rbm48 |
G |
A |
5: 3,640,470 (GRCm39) |
P303L |
probably benign |
Het |
| Rnf167 |
T |
C |
11: 70,540,821 (GRCm39) |
V185A |
probably benign |
Het |
| Ros1 |
T |
A |
10: 51,999,443 (GRCm39) |
Q1169L |
probably benign |
Het |
| Rrp1b |
A |
G |
17: 32,277,541 (GRCm39) |
D607G |
probably damaging |
Het |
| Scamp1 |
A |
G |
13: 94,366,294 (GRCm39) |
Y134H |
probably damaging |
Het |
| Scfd1 |
G |
A |
12: 51,492,490 (GRCm39) |
E600K |
probably damaging |
Het |
| Scn3b |
A |
G |
9: 40,193,840 (GRCm39) |
E189G |
possibly damaging |
Het |
| Scn4b |
G |
T |
9: 45,059,007 (GRCm39) |
V93L |
probably benign |
Het |
| Serpina3i |
A |
T |
12: 104,231,407 (GRCm39) |
T15S |
possibly damaging |
Het |
| Slc2a13 |
A |
T |
15: 91,296,356 (GRCm39) |
C319* |
probably null |
Het |
| Tdrd1 |
A |
G |
19: 56,854,437 (GRCm39) |
|
probably null |
Het |
| Tep1 |
T |
A |
14: 51,067,710 (GRCm39) |
I2169F |
probably benign |
Het |
| Tm4sf19 |
A |
G |
16: 32,226,458 (GRCm39) |
D124G |
possibly damaging |
Het |
| Trim2 |
T |
C |
3: 84,098,026 (GRCm39) |
Y434C |
probably damaging |
Het |
| Usp34 |
T |
A |
11: 23,327,622 (GRCm39) |
S1056T |
|
Het |
| Vmn1r230 |
T |
A |
17: 21,067,312 (GRCm39) |
M167K |
probably benign |
Het |
| Zfhx4 |
T |
A |
3: 5,478,047 (GRCm39) |
V3554D |
probably damaging |
Het |
| Zfp1010 |
C |
T |
2: 176,957,015 (GRCm39) |
G161D |
probably damaging |
Het |
| Zfp458 |
A |
G |
13: 67,405,234 (GRCm39) |
S402P |
probably damaging |
Het |
| Zfp462 |
C |
A |
4: 55,011,907 (GRCm39) |
A1291E |
probably damaging |
Het |
| Zmat5 |
G |
A |
11: 4,672,379 (GRCm39) |
|
probably benign |
Het |
| Znfx1 |
C |
A |
2: 166,897,857 (GRCm39) |
E356* |
probably null |
Het |
| Zswim5 |
A |
G |
4: 116,808,291 (GRCm39) |
T292A |
probably benign |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1509:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5763:Vmn2r14
|
UTSW |
5 |
109,363,724 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5872:Vmn2r14
|
UTSW |
5 |
109,369,222 (GRCm39) |
missense |
probably benign |
|
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6268:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6273:Vmn2r14
|
UTSW |
5 |
109,369,133 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGCAATGACTGAGCCTTTG -3'
(R):5'- CTCCCATTGTGAAGGCCAATAAC -3'
Sequencing Primer
(F):5'- GCCTTTGTTGCAAATAATGATGGTC -3'
(R):5'- TTGTGAAGGCCAATAACCGCATTC -3'
|
| Posted On |
2020-09-15 |
Incidental Mutation