Mutagenetix > Incidental Mutation

Incidental Mutation 'R0330:Vmn2r98'

65195

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

038539-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R0330 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19273755-19301573 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 19286609 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Proline at position 369 (H369P)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: H369P

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: H369P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 98.8%
3x: 97.7%
10x: 94.7%
20x: 88.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaa1b	T	C	9: 118,983,038 (GRCm39)	N120S	probably damaging	Het
Acsbg3	A	T	17: 57,190,631 (GRCm39)	I400F	probably benign	Het
Acvr1c	T	C	2: 58,174,850 (GRCm39)	T313A	probably damaging	Het
Adamtsl3	A	T	7: 82,171,198 (GRCm39)	D417V	probably damaging	Het
Adgrf4	A	T	17: 42,978,204 (GRCm39)	C380S	probably damaging	Het
AI597479	T	G	1: 43,150,277 (GRCm39)	L129R	probably benign	Het
AI661453	G	A	17: 47,757,571 (GRCm39)	R76Q	probably damaging	Het
Anpep	C	T	7: 79,488,004 (GRCm39)	E518K	probably benign	Het
Anxa7	A	C	14: 20,519,566 (GRCm39)		probably null	Het
Arhgap12	T	A	18: 6,039,382 (GRCm39)	D455V	probably damaging	Het
Arhgap22	A	G	14: 33,091,374 (GRCm39)	R650G	possibly damaging	Het
Arhgef12	A	C	9: 42,931,982 (GRCm39)	H168Q	probably damaging	Het
Arhgef2	A	G	3: 88,549,808 (GRCm39)	H592R	probably damaging	Het
BC049715	A	G	6: 136,817,035 (GRCm39)	T92A	possibly damaging	Het
Bcr	C	T	10: 75,017,466 (GRCm39)	T1209I	possibly damaging	Het
Bmpr1a	C	T	14: 34,151,734 (GRCm39)	S185N	probably benign	Het
Calcoco1	A	T	15: 102,624,198 (GRCm39)	M246K	probably benign	Het
Capn8	T	A	1: 182,457,703 (GRCm39)	I689N	probably benign	Het
Ccno	T	A	13: 113,126,530 (GRCm39)	L333Q	probably damaging	Het
Cep57	G	A	9: 13,728,281 (GRCm39)	R148W	probably damaging	Het
Cftr	T	A	6: 18,226,096 (GRCm39)	M318K	probably null	Het
Chd3	T	G	11: 69,247,159 (GRCm39)	D1003A	probably damaging	Het
Ckmt2	T	A	13: 92,011,322 (GRCm39)	D96V	possibly damaging	Het
Cldn13	A	G	5: 134,944,176 (GRCm39)	V3A	probably benign	Het
Col17a1	T	C	19: 47,658,871 (GRCm39)	T413A	probably benign	Het
Cpne5	A	T	17: 29,430,634 (GRCm39)	L92H	probably damaging	Het
Dnaaf2	C	A	12: 69,244,518 (GRCm39)	R181L	probably damaging	Het
Erbin	C	A	13: 104,005,373 (GRCm39)	C114F	probably damaging	Het
Fads2b	T	A	2: 85,348,895 (GRCm39)	R72S	probably benign	Het
Fanca	A	T	8: 124,000,911 (GRCm39)	C1156*	probably null	Het
Flot2	T	A	11: 77,949,784 (GRCm39)	I322N	possibly damaging	Het
Fstl5	T	C	3: 76,615,060 (GRCm39)	V707A	possibly damaging	Het
Gli3	T	G	13: 15,898,143 (GRCm39)	L741R	probably damaging	Het
Gmip	G	T	8: 70,263,468 (GRCm39)	S70I	probably benign	Het
Gnptab	T	C	10: 88,276,171 (GRCm39)	S1153P	probably damaging	Het
Gramd1a	T	C	7: 30,837,679 (GRCm39)	D360G	possibly damaging	Het
Gtf2i	T	C	5: 134,280,740 (GRCm39)	E518G	probably damaging	Het
Hsp90b1	T	C	10: 86,530,019 (GRCm39)	E226G	probably damaging	Het
Impg2	A	G	16: 56,072,627 (GRCm39)	Y353C	probably damaging	Het
Kank1	A	G	19: 25,401,677 (GRCm39)	K1095E	probably benign	Het
Kcnh4	C	T	11: 100,648,569 (GRCm39)	C45Y	probably damaging	Het
Kif13b	A	G	14: 65,040,669 (GRCm39)	T1590A	probably benign	Het
Lpin3	T	C	2: 160,747,225 (GRCm39)	V827A	probably benign	Het
Lrp1b	A	T	2: 40,591,773 (GRCm39)	C73*	probably null	Het
Mcm8	A	G	2: 132,661,914 (GRCm39)	K83E	possibly damaging	Het
Med12l	A	G	3: 59,135,123 (GRCm39)	E757G	probably damaging	Het
Mep1a	A	G	17: 43,808,789 (GRCm39)		probably null	Het
Mtor	T	A	4: 148,568,837 (GRCm39)	V1119E	probably benign	Het
Mybpc2	C	T	7: 44,158,453 (GRCm39)	A710T	possibly damaging	Het
Myof	A	C	19: 37,924,326 (GRCm39)	I1297S	probably damaging	Het
Nacad	A	G	11: 6,550,903 (GRCm39)	S763P	probably benign	Het
Nbea	A	G	3: 55,550,238 (GRCm39)	V2730A	probably benign	Het
Nbeal1	A	G	1: 60,307,222 (GRCm39)	Y1684C	probably damaging	Het
Optn	A	T	2: 5,039,066 (GRCm39)	N352K	possibly damaging	Het
Or10k2	A	G	8: 84,268,142 (GRCm39)	Y123C	probably damaging	Het
Or2g1	A	T	17: 38,106,880 (GRCm39)	M182L	probably benign	Het
Or7g16	A	G	9: 18,726,937 (GRCm39)	Y218H	probably damaging	Het
Or9g4b	T	A	2: 85,616,147 (GRCm39)	C97*	probably null	Het
Pcif1	G	T	2: 164,731,364 (GRCm39)	R466L	probably damaging	Het
Phxr2	T	C	10: 98,961,979 (GRCm39)		probably benign	Het
Plaat5	T	A	19: 7,614,663 (GRCm39)		probably null	Het
Plb1	T	A	5: 32,512,701 (GRCm39)	F1353Y	probably damaging	Het
Plec	A	G	15: 76,075,618 (GRCm39)		probably null	Het
Polr1a	T	A	6: 71,943,400 (GRCm39)	C1212S	possibly damaging	Het
Primpol	A	T	8: 47,063,496 (GRCm39)	N53K	probably damaging	Het
Pygo2	T	A	3: 89,340,461 (GRCm39)	N286K	possibly damaging	Het
Rttn	G	A	18: 89,004,204 (GRCm39)		probably null	Het
Serpinb3b	G	T	1: 107,087,433 (GRCm39)	N25K	probably damaging	Het
Sidt2	A	G	9: 45,866,200 (GRCm39)	I2T	probably benign	Het
Slc12a3	A	T	8: 95,072,974 (GRCm39)	N699I	possibly damaging	Het
Slc25a30	G	A	14: 76,000,112 (GRCm39)	Q285*	probably null	Het
Slc4a9	A	T	18: 36,668,592 (GRCm39)	H724L	probably damaging	Het
Ssbp2	T	A	13: 91,828,698 (GRCm39)		probably null	Het
Stac3	C	A	10: 127,343,616 (GRCm39)		probably null	Het
Stk32a	A	G	18: 43,446,566 (GRCm39)	K339E	probably benign	Het
Stoml2	A	G	4: 43,030,238 (GRCm39)		probably null	Het
Syne2	G	T	12: 76,013,727 (GRCm39)	G2974C	probably benign	Het
Tbc1d16	A	G	11: 119,049,555 (GRCm39)		probably null	Het
Tfdp2	T	G	9: 96,188,946 (GRCm39)	F200V	probably damaging	Het
Tie1	C	A	4: 118,341,924 (GRCm39)	R175L	probably benign	Het
Trappc12	A	G	12: 28,797,259 (GRCm39)	V91A	probably benign	Het
Trim46	G	T	3: 89,143,820 (GRCm39)	P536Q	probably damaging	Het
Tshz3	T	A	7: 36,469,458 (GRCm39)	D482E	probably benign	Het
Tspan33	T	C	6: 29,711,091 (GRCm39)		probably null	Het
Unc80	T	C	1: 66,713,246 (GRCm39)	L2788P	possibly damaging	Het
Utp20	T	A	10: 88,653,841 (GRCm39)	T260S	probably benign	Het
Vmn2r118	G	T	17: 55,917,717 (GRCm39)	T265K	probably damaging	Het
Vps39	A	T	2: 120,169,268 (GRCm39)	Y245N	possibly damaging	Het
Vps4a	A	C	8: 107,769,698 (GRCm39)	I336L	probably benign	Het
Xylb	T	C	9: 119,210,653 (GRCm39)	S379P	probably damaging	Het
Zbtb37	T	C	1: 160,860,066 (GRCm39)	T80A	probably benign	Het
Zfhx3	A	G	8: 109,675,589 (GRCm39)	D2213G	probably damaging	Het
Zfp729a	G	T	13: 67,768,473 (GRCm39)	H585Q	probably damaging	Het
Zfp804b	A	T	5: 6,821,029 (GRCm39)	I642N	possibly damaging	Het
Zfp804b	A	T	5: 6,821,994 (GRCm39)	N356K	possibly damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,286,007 (GRCm39)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,285,447 (GRCm39)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,286,020 (GRCm39)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,286,713 (GRCm39)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,286,548 (GRCm39)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,300,941 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,286,113 (GRCm39)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,286,083 (GRCm39)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,301,223 (GRCm39)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,286,275 (GRCm39)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,301,283 (GRCm39)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,286,242 (GRCm39)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,290,107 (GRCm39)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,301,223 (GRCm39)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,286,662 (GRCm39)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,286,089 (GRCm39)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,273,875 (GRCm39)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,300,759 (GRCm39)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,300,782 (GRCm39)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,301,011 (GRCm39)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,286,210 (GRCm39)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,285,440 (GRCm39)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,301,170 (GRCm39)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,286,680 (GRCm39)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,285,595 (GRCm39)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,301,553 (GRCm39)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,286,213 (GRCm39)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,300,698 (GRCm39)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,286,081 (GRCm39)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,301,439 (GRCm39)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,287,664 (GRCm39)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,300,887 (GRCm39)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,286,354 (GRCm39)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,290,007 (GRCm39)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,286,602 (GRCm39)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,286,419 (GRCm39)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,286,306 (GRCm39)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,273,815 (GRCm39)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,300,981 (GRCm39)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,290,016 (GRCm39)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,290,015 (GRCm39)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,301,161 (GRCm39)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,286,260 (GRCm39)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,286,336 (GRCm39)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,286,143 (GRCm39)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,286,063 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,285,510 (GRCm39)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,286,530 (GRCm39)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,301,184 (GRCm39)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,285,575 (GRCm39)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,287,570 (GRCm39)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,300,797 (GRCm39)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,287,460 (GRCm39)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,287,493 (GRCm39)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,273,912 (GRCm39)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,301,425 (GRCm39)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,301,031 (GRCm39)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,286,532 (GRCm39)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,285,531 (GRCm39)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,301,481 (GRCm39)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,286,777 (GRCm39)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,287,517 (GRCm39)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,301,496 (GRCm39)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,285,665 (GRCm39)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,287,685 (GRCm39)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,285,398 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

Posted On

2013-08-08