Mutagenetix > Incidental Mutation

Incidental Mutation 'R8127:Zfp583'

651983

Institutional Source

Beutler Lab

Gene Symbol

Zfp583

Ensembl Gene

ENSMUSG00000030443

Gene Name

zinc finger protein 583

Synonyms

MMRRC Submission

067556-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R8127 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

6318659-6334284 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 6326821 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129551 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062765] [ENSMUST00000108560] [ENSMUST00000127658] [ENSMUST00000165705]

AlphaFold

Q3V080

Predicted Effect

probably null
Transcript: ENSMUST00000062765

SMART Domains

Protein: ENSMUSP00000053935
Gene: ENSMUSG00000030443

Domain	Start	End	E-Value	Type
KRAB	6	66	7.45e-32	SMART
ZnF_C2H2	211	233	2.09e-3	SMART
ZnF_C2H2	239	261	3.89e-3	SMART
ZnF_C2H2	267	289	2.95e-3	SMART
ZnF_C2H2	295	317	1.2e-3	SMART
ZnF_C2H2	323	345	7.26e-3	SMART
ZnF_C2H2	351	373	2.61e-4	SMART
ZnF_C2H2	379	401	2.75e-3	SMART
ZnF_C2H2	407	429	2.57e-3	SMART
ZnF_C2H2	435	457	2.09e-3	SMART
ZnF_C2H2	463	485	1.58e-3	SMART
ZnF_C2H2	491	513	3.44e-4	SMART
ZnF_C2H2	519	541	1.36e-2	SMART
low complexity region	545	561	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000108560

SMART Domains

Protein: ENSMUSP00000104200
Gene: ENSMUSG00000030443

Domain	Start	End	E-Value	Type
KRAB	6	66	7.45e-32	SMART
ZnF_C2H2	211	233	2.09e-3	SMART
ZnF_C2H2	239	261	3.89e-3	SMART
ZnF_C2H2	267	289	2.95e-3	SMART
ZnF_C2H2	295	317	1.2e-3	SMART
ZnF_C2H2	323	345	7.26e-3	SMART
ZnF_C2H2	351	373	2.61e-4	SMART
ZnF_C2H2	379	401	2.75e-3	SMART
ZnF_C2H2	407	429	2.57e-3	SMART
ZnF_C2H2	435	457	2.09e-3	SMART
ZnF_C2H2	463	485	1.58e-3	SMART
ZnF_C2H2	491	513	3.44e-4	SMART
ZnF_C2H2	519	541	1.36e-2	SMART
low complexity region	545	561	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000127658

SMART Domains

Protein: ENSMUSP00000118249
Gene: ENSMUSG00000030443

Domain	Start	End	E-Value	Type
KRAB	6	66	7.45e-32	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000165705

SMART Domains

Protein: ENSMUSP00000129551
Gene: ENSMUSG00000030443

Domain	Start	End	E-Value	Type
KRAB	6	66	7.45e-32	SMART
ZnF_C2H2	211	233	2.09e-3	SMART
ZnF_C2H2	239	261	3.89e-3	SMART
ZnF_C2H2	267	289	2.95e-3	SMART
ZnF_C2H2	295	317	1.2e-3	SMART
ZnF_C2H2	323	345	7.26e-3	SMART
ZnF_C2H2	351	373	2.61e-4	SMART
ZnF_C2H2	379	401	2.75e-3	SMART
ZnF_C2H2	407	429	2.57e-3	SMART
ZnF_C2H2	435	457	2.09e-3	SMART
ZnF_C2H2	463	485	1.58e-3	SMART
ZnF_C2H2	491	513	3.44e-4	SMART
ZnF_C2H2	519	541	1.36e-2	SMART
low complexity region	545	561	N/A	INTRINSIC

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.9%
20x: 97.0%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	T	C	5: 144,980,249 (GRCm39)	M66T	possibly damaging	Het
Acvr1	A	T	2: 58,367,638 (GRCm39)	N174K	probably benign	Het
Ago1	A	T	4: 126,348,214 (GRCm39)	C342S	possibly damaging	Het
Anapc1	A	G	2: 128,474,547 (GRCm39)	S1423P	probably damaging	Het
Antxr2	A	T	5: 98,127,876 (GRCm39)	C218*	probably null	Het
Arsa	A	G	15: 89,359,067 (GRCm39)	Y200H	probably damaging	Het
Atad3a	C	T	4: 155,838,396 (GRCm39)	R207Q	probably damaging	Het
Carmil3	A	G	14: 55,735,701 (GRCm39)	D551G	probably damaging	Het
Cdk9	A	G	2: 32,598,009 (GRCm39)	I349T	probably benign	Het
Cmya5	A	T	13: 93,231,122 (GRCm39)	V1322E	probably damaging	Het
Col4a3	T	A	1: 82,627,481 (GRCm39)	I95K	unknown	Het
Dab2ip	T	C	2: 35,534,138 (GRCm39)		probably benign	Het
Dnaaf6rt	T	C	1: 31,262,201 (GRCm39)	F61S	probably benign	Het
Dok7	A	G	5: 35,244,345 (GRCm39)	S530G	probably benign	Het
Dst	C	T	1: 34,217,310 (GRCm39)	T1250M	probably damaging	Het
Dzank1	A	C	2: 144,330,736 (GRCm39)	W439G	probably damaging	Het
Evx1	T	A	6: 52,290,902 (GRCm39)	S25T	possibly damaging	Het
Fut10	G	A	8: 31,684,999 (GRCm39)		probably benign	Het
Gatad1	T	C	5: 3,693,540 (GRCm39)	R210G	probably benign	Het
Hyal5	C	A	6: 24,891,487 (GRCm39)	R434S	probably benign	Het
Lrrc43	C	T	5: 123,630,334 (GRCm39)	P66S	probably damaging	Het
Mib1	T	A	18: 10,741,031 (GRCm39)	I93N	probably damaging	Het
Mug2	G	A	6: 122,052,567 (GRCm39)	E1038K	probably benign	Het
Nsd2	T	A	5: 34,042,834 (GRCm39)	C1033S	probably damaging	Het
Or6k4	C	T	1: 173,965,155 (GRCm39)	P282S	probably damaging	Het
Or8d4	T	A	9: 40,038,360 (GRCm39)	H299L	probably benign	Het
Otogl	A	T	10: 107,731,613 (GRCm39)	F176Y	probably damaging	Het
Polr3b	A	G	10: 84,515,653 (GRCm39)	K609E	probably benign	Het
Prdm15	T	C	16: 97,638,910 (GRCm39)	N50S	probably benign	Het
Rlf	G	T	4: 121,005,093 (GRCm39)	Q1406K	possibly damaging	Het
Rusc2	T	C	4: 43,423,747 (GRCm39)	V1023A	possibly damaging	Het
Scn11a	C	T	9: 119,633,578 (GRCm39)	G385D	probably damaging	Het
Slc44a1	T	C	4: 53,528,714 (GRCm39)	S155P	probably benign	Het
Spam1	T	A	6: 24,796,970 (GRCm39)	V307D	possibly damaging	Het
Srgap1	A	C	10: 121,691,271 (GRCm39)	M321R	probably null	Het
Stam	A	G	2: 14,122,284 (GRCm39)	I128V	probably damaging	Het
Sytl2	A	G	7: 90,024,798 (GRCm39)	D262G	possibly damaging	Het
Taf2	G	A	15: 54,923,384 (GRCm39)	R298C	probably damaging	Het
Tcl1b5	A	T	12: 105,146,262 (GRCm39)	T112S	probably benign	Het
Trim33	T	C	3: 103,239,043 (GRCm39)	S674P	possibly damaging	Het
Trip12	T	C	1: 84,716,463 (GRCm39)	N1602S	probably damaging	Het
Vmn1r44	T	C	6: 89,870,845 (GRCm39)	I197T	probably benign	Het
Wdtc1	C	T	4: 133,029,693 (GRCm39)		probably null	Het
Zfyve16	T	A	13: 92,642,185 (GRCm39)	I1213F	probably damaging	Het

Other mutations in Zfp583

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01084:Zfp583	APN	7	6,320,184 (GRCm39)	missense	probably damaging	1.00
IGL01921:Zfp583	APN	7	6,328,569 (GRCm39)	missense	possibly damaging	0.95
R1593:Zfp583	UTSW	7	6,320,008 (GRCm39)	missense	probably benign	0.03
R2188:Zfp583	UTSW	7	6,320,610 (GRCm39)	missense	probably benign
R4377:Zfp583	UTSW	7	6,320,680 (GRCm39)	missense	possibly damaging	0.61
R5000:Zfp583	UTSW	7	6,328,473 (GRCm39)	missense	probably damaging	1.00
R5031:Zfp583	UTSW	7	6,320,397 (GRCm39)	missense	probably benign
R5723:Zfp583	UTSW	7	6,326,674 (GRCm39)	missense	probably damaging	0.98
R6603:Zfp583	UTSW	7	6,328,475 (GRCm39)	missense	probably damaging	1.00
R7325:Zfp583	UTSW	7	6,319,585 (GRCm39)	missense	probably damaging	0.99
R7391:Zfp583	UTSW	7	6,319,498 (GRCm39)	missense	probably damaging	1.00
R7673:Zfp583	UTSW	7	6,320,009 (GRCm39)	missense	possibly damaging	0.91
R8035:Zfp583	UTSW	7	6,319,771 (GRCm39)	missense	probably damaging	1.00
R8331:Zfp583	UTSW	7	6,320,554 (GRCm39)	missense	probably benign
R8732:Zfp583	UTSW	7	6,320,210 (GRCm39)	nonsense	probably null
R8748:Zfp583	UTSW	7	6,319,419 (GRCm39)	missense	probably benign	0.01
R9011:Zfp583	UTSW	7	6,319,627 (GRCm39)	missense	probably damaging	1.00
R9016:Zfp583	UTSW	7	6,320,404 (GRCm39)	missense	probably benign	0.28
R9038:Zfp583	UTSW	7	6,319,543 (GRCm39)	missense	probably damaging	1.00
R9075:Zfp583	UTSW	7	6,319,870 (GRCm39)	missense	probably damaging	1.00
R9346:Zfp583	UTSW	7	6,328,542 (GRCm39)	missense	probably benign	0.01
R9652:Zfp583	UTSW	7	6,320,328 (GRCm39)	missense	probably damaging	1.00
RF024:Zfp583	UTSW	7	6,319,981 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2020-09-18