Incidental Mutation 'R8134:Or2bd2'
ID 651989
Institutional Source Beutler Lab
Gene Symbol Or2bd2
Ensembl Gene ENSMUSG00000090824
Gene Name olfactory receptor family 2 subfamily BD member 2
Synonyms GA_x6K02T2QGBW-3169916-3170881, MOR124-1, Olfr1344, 4930415J05Rik
MMRRC Submission 067562-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R8134 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 6442901-6443866 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) T to C at 6441922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054781] [ENSMUST00000168341] [ENSMUST00000218906]
AlphaFold Q7TQV3
Predicted Effect unknown
Transcript: ENSMUST00000054781
AA Change: L90P
SMART Domains Protein: ENSMUSP00000050428
Gene: ENSMUSG00000045929
AA Change: L90P

DomainStartEndE-ValueType
low complexity region 57 74 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168341
SMART Domains Protein: ENSMUSP00000130328
Gene: ENSMUSG00000090824

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 3e-49 PFAM
Pfam:7TM_GPCR_Srsx 37 224 1.9e-7 PFAM
Pfam:7tm_1 43 295 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218906
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.5%
  • 20x: 93.5%
Validation Efficiency 99% (71/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abce1 G A 8: 80,425,982 (GRCm39) P265L probably benign Het
Adam20 A G 8: 41,249,101 (GRCm39) T404A probably benign Het
Anp32a G T 9: 62,284,863 (GRCm39) R237L unknown Het
Ascc3 A G 10: 50,643,554 (GRCm39) D1835G probably benign Het
Atg9b A G 5: 24,590,220 (GRCm39) probably null Het
Bard1 A T 1: 71,106,297 (GRCm39) N443K probably damaging Het
Btnl1 A G 17: 34,604,647 (GRCm39) D476G possibly damaging Het
C2cd3 A T 7: 100,067,711 (GRCm39) I487F Het
Cadm4 A G 7: 24,203,030 (GRCm39) E384G possibly damaging Het
Camsap3 A G 8: 3,648,075 (GRCm39) K128E probably benign Het
Casz1 C T 4: 149,027,492 (GRCm39) P1005S probably damaging Het
Cd38 C A 5: 44,058,790 (GRCm39) L135M probably damaging Het
Cdk20 A G 13: 64,585,734 (GRCm39) E244G probably benign Het
Cfap54 A T 10: 92,714,378 (GRCm39) V2667D unknown Het
Col11a1 A G 3: 114,012,435 (GRCm39) K1792E unknown Het
Cpne9 A T 6: 113,272,003 (GRCm39) D377V probably benign Het
Csmd1 A T 8: 15,982,550 (GRCm39) C2706S probably damaging Het
Ctnnbl1 T C 2: 157,651,391 (GRCm39) V222A probably benign Het
Frmpd2 T C 14: 33,227,452 (GRCm39) S277P probably benign Het
Herc2 C T 7: 55,734,884 (GRCm39) T158I probably benign Het
Hoxa4 G T 6: 52,167,537 (GRCm39) H215N possibly damaging Het
Hpd G T 5: 123,312,443 (GRCm39) Q309K probably benign Het
Il20ra A G 10: 19,626,452 (GRCm39) T159A probably damaging Het
Ints10 T A 8: 69,255,638 (GRCm39) Y209* probably null Het
Ints2 A G 11: 86,103,486 (GRCm39) I1190T probably damaging Het
Jhy A G 9: 40,872,188 (GRCm39) V107A probably null Het
Kdm4d C T 9: 14,374,532 (GRCm39) R442H probably damaging Het
Kifbp T C 10: 62,413,756 (GRCm39) Y134C probably benign Het
Klb A T 5: 65,540,958 (GRCm39) H1017L probably benign Het
Kndc1 T A 7: 139,481,285 (GRCm39) probably null Het
Krtap4-1 GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC 11: 99,518,660 (GRCm39) probably benign Het
Lrrn3 T C 12: 41,503,047 (GRCm39) I423M probably damaging Het
Magi2 T G 5: 20,596,365 (GRCm39) F274L probably damaging Het
Magi2 T A 5: 20,596,392 (GRCm39) D283E probably benign Het
Map3k19 A C 1: 127,751,492 (GRCm39) S620A probably damaging Het
Meis2 C T 2: 115,697,369 (GRCm39) M388I probably benign Het
Ms4a3 G C 19: 11,615,613 (GRCm39) H54Q probably benign Het
Nfe2l1 A T 11: 96,710,585 (GRCm39) M548K possibly damaging Het
Ninl C T 2: 150,792,234 (GRCm39) C763Y probably benign Het
Numa1 T C 7: 101,650,834 (GRCm39) F1522L probably benign Het
Or13a25 T A 7: 140,247,680 (GRCm39) I153N possibly damaging Het
Pcdhgc3 G A 18: 37,939,916 (GRCm39) V106I probably benign Het
Phf3 A G 1: 30,863,552 (GRCm39) V152A unknown Het
Pira1 A G 7: 3,738,838 (GRCm39) S590P probably damaging Het
Plcg2 A T 8: 118,284,057 (GRCm39) D118V probably damaging Het
Pnpla1 A G 17: 29,097,443 (GRCm39) D203G probably damaging Het
Ppip5k2 A T 1: 97,672,888 (GRCm39) M474K probably benign Het
Ppp1r12b T C 1: 134,814,280 (GRCm39) E341G possibly damaging Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Rrs1 C T 1: 9,615,645 (GRCm39) probably benign Het
Scaf11 T C 15: 96,318,592 (GRCm39) N324S probably damaging Het
Spaca1 T A 4: 34,042,157 (GRCm39) probably null Het
Sun3 G T 11: 8,979,346 (GRCm39) D118E probably benign Het
Svop C T 5: 114,180,992 (GRCm39) V215I probably benign Het
Tbc1d15 A T 10: 115,045,474 (GRCm39) C497S probably damaging Het
Tdrd6 A T 17: 43,937,064 (GRCm39) I1328N probably damaging Het
Tuba8 T A 6: 121,198,381 (GRCm39) D116E probably benign Het
Ube2z A G 11: 95,949,200 (GRCm39) I213T possibly damaging Het
Ubqln4 G A 3: 88,462,797 (GRCm39) probably null Het
Vps13a A G 19: 16,631,718 (GRCm39) I2639T possibly damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp94 A T 7: 24,003,166 (GRCm39) V92E probably benign Het
Other mutations in Or2bd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02217:Or2bd2 APN 7 6,443,244 (GRCm39) missense probably damaging 0.96
IGL02689:Or2bd2 APN 7 6,443,574 (GRCm39) missense possibly damaging 0.95
IGL02935:Or2bd2 APN 7 6,443,753 (GRCm39) missense possibly damaging 0.91
R0100:Or2bd2 UTSW 7 6,443,399 (GRCm39) missense probably damaging 1.00
R0100:Or2bd2 UTSW 7 6,443,399 (GRCm39) missense probably damaging 1.00
R0108:Or2bd2 UTSW 7 6,443,399 (GRCm39) missense probably damaging 1.00
R4041:Or2bd2 UTSW 7 6,443,688 (GRCm39) missense probably damaging 1.00
R4247:Or2bd2 UTSW 7 6,441,901 (GRCm39) utr 5 prime probably benign
R5275:Or2bd2 UTSW 7 6,443,015 (GRCm39) missense probably benign 0.01
R5475:Or2bd2 UTSW 7 6,443,169 (GRCm39) missense probably benign 0.21
R6016:Or2bd2 UTSW 7 6,443,613 (GRCm39) missense probably benign
R6048:Or2bd2 UTSW 7 6,443,354 (GRCm39) missense possibly damaging 0.58
R6541:Or2bd2 UTSW 7 6,443,492 (GRCm39) missense probably benign 0.04
R7945:Or2bd2 UTSW 7 6,443,354 (GRCm39) missense probably benign
R8893:Or2bd2 UTSW 7 6,443,285 (GRCm39) missense probably damaging 1.00
R8956:Or2bd2 UTSW 7 6,442,020 (GRCm39) splice site probably benign
R9211:Or2bd2 UTSW 7 6,443,417 (GRCm39) missense probably damaging 1.00
R9639:Or2bd2 UTSW 7 6,443,290 (GRCm39) missense probably benign 0.12
X0060:Or2bd2 UTSW 7 6,443,074 (GRCm39) missense probably damaging 1.00
Z1177:Or2bd2 UTSW 7 6,443,820 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- AAGTGTGGTCCCAATGTCC -3'
(R):5'- TTTGTACAACGGGCTCTCTGG -3'

Sequencing Primer
(F):5'- GTGGTCCCAATGTCCTGACCTAG -3'
(R):5'- TACAACGGGCTCTCTGGATCAC -3'
Posted On 2020-09-18