Incidental Mutation 'R8128:Caprin2'
ID 652003
Institutional Source Beutler Lab
Gene Symbol Caprin2
Ensembl Gene ENSMUSG00000030309
Gene Name caprin family member 2
Synonyms RNG140, C1qdc1, Eeg1
MMRRC Submission 067557-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8128 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 148743990-148797735 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 148784940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072324] [ENSMUST00000111569] [ENSMUST00000139914]
AlphaFold Q05A80
Predicted Effect probably null
Transcript: ENSMUST00000072324
SMART Domains Protein: ENSMUSP00000072165
Gene: ENSMUSG00000030309

DomainStartEndE-ValueType
coiled coil region 48 125 N/A INTRINSIC
coiled coil region 239 264 N/A INTRINSIC
Pfam:Caprin-1_C 317 618 1.2e-32 PFAM
C1Q 676 812 1.27e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000111569
SMART Domains Protein: ENSMUSP00000107195
Gene: ENSMUSG00000030309

DomainStartEndE-ValueType
coiled coil region 48 125 N/A INTRINSIC
coiled coil region 239 264 N/A INTRINSIC
low complexity region 330 344 N/A INTRINSIC
Pfam:Caprin-1_C 536 836 2.9e-106 PFAM
C1Q 895 1031 1.27e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000139914
SMART Domains Protein: ENSMUSP00000121685
Gene: ENSMUSG00000030309

DomainStartEndE-ValueType
coiled coil region 48 94 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.9%
  • 20x: 96.6%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A G 5: 9,008,395 (GRCm39) R1188G probably damaging Het
Abcc5 G A 16: 20,184,473 (GRCm39) R1036C probably damaging Het
Arhgap22 T A 14: 33,089,042 (GRCm39) F508I probably benign Het
Bahcc1 C T 11: 120,163,216 (GRCm39) Q505* probably null Het
Birc6 T A 17: 74,916,253 (GRCm39) L1723Q probably damaging Het
Cfap69 C A 5: 5,646,034 (GRCm39) M555I probably benign Het
Cgn C T 3: 94,676,691 (GRCm39) A773T probably benign Het
Cnot7 A G 8: 40,963,129 (GRCm39) V15A probably damaging Het
Col7a1 A G 9: 108,784,789 (GRCm39) R206G unknown Het
Dscam C A 16: 96,602,374 (GRCm39) probably null Het
Eif3k A T 7: 28,679,742 (GRCm39) probably benign Het
Epn2 G T 11: 61,413,321 (GRCm39) probably null Het
Fitm2 T C 2: 163,311,568 (GRCm39) D215G probably benign Het
Foxa3 A T 7: 18,757,341 (GRCm39) M1K probably null Het
Glyctk T C 9: 106,032,501 (GRCm39) H504R probably benign Het
Grin3b T C 10: 79,812,944 (GRCm39) L394P Het
Hgh1 A G 15: 76,254,581 (GRCm39) Y319C probably damaging Het
Hk1 T C 10: 62,117,622 (GRCm39) T635A probably benign Het
Igsf3 T A 3: 101,346,947 (GRCm39) N627K probably damaging Het
Lmtk3 G T 7: 45,443,598 (GRCm39) M760I Het
Lrp1b G A 2: 41,159,248 (GRCm39) A1678V probably null Het
Lrrc8c A T 5: 105,755,488 (GRCm39) N421I probably damaging Het
Mfsd13b C A 7: 120,590,495 (GRCm39) R79S possibly damaging Het
Or1q1 A T 2: 36,887,673 (GRCm39) M284L probably benign Het
Or5p50 A C 7: 107,422,632 (GRCm39) F15V probably damaging Het
Pappa2 T C 1: 158,764,234 (GRCm39) T426A possibly damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Pkhd1l1 A T 15: 44,361,449 (GRCm39) I500F possibly damaging Het
Polr3gl T A 3: 96,487,824 (GRCm39) probably null Het
Psmg3 A G 5: 139,809,788 (GRCm39) V86A probably damaging Het
Ptgs2 T A 1: 149,977,099 (GRCm39) V102E probably damaging Het
Rhpn1 T C 15: 75,583,032 (GRCm39) probably null Het
Scand1 T C 2: 156,153,961 (GRCm39) D103G probably damaging Het
Serpinb6d T C 13: 33,850,383 (GRCm39) I70T possibly damaging Het
Slco3a1 A T 7: 73,934,049 (GRCm39) S708T probably damaging Het
Sprr2d G A 3: 92,247,760 (GRCm39) C67Y unknown Het
Taf2 G A 15: 54,923,384 (GRCm39) R298C probably damaging Het
Trafd1 G T 5: 121,510,465 (GRCm39) P567Q possibly damaging Het
Trim32 A G 4: 65,531,682 (GRCm39) N80D probably damaging Het
Vmn1r193 A G 13: 22,403,113 (GRCm39) L293S probably damaging Het
Vmn2r12 A T 5: 109,239,747 (GRCm39) M272K possibly damaging Het
Vmn2r90 T A 17: 17,954,155 (GRCm39) L773Q probably damaging Het
Other mutations in Caprin2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Caprin2 APN 6 148,744,569 (GRCm39) missense probably damaging 1.00
IGL01364:Caprin2 APN 6 148,774,526 (GRCm39) missense probably benign 0.00
IGL02738:Caprin2 APN 6 148,744,360 (GRCm39) missense probably damaging 1.00
IGL02819:Caprin2 APN 6 148,749,756 (GRCm39) missense probably damaging 0.99
IGL03117:Caprin2 APN 6 148,763,964 (GRCm39) missense possibly damaging 0.91
IGL03123:Caprin2 APN 6 148,796,505 (GRCm39) missense probably damaging 1.00
IGL03378:Caprin2 APN 6 148,779,352 (GRCm39) missense probably benign 0.23
R0242:Caprin2 UTSW 6 148,744,452 (GRCm39) missense probably damaging 1.00
R0242:Caprin2 UTSW 6 148,744,452 (GRCm39) missense probably damaging 1.00
R0621:Caprin2 UTSW 6 148,760,176 (GRCm39) missense possibly damaging 0.94
R0930:Caprin2 UTSW 6 148,785,009 (GRCm39) splice site probably null
R1540:Caprin2 UTSW 6 148,777,969 (GRCm39) missense probably benign 0.01
R1591:Caprin2 UTSW 6 148,774,606 (GRCm39) missense possibly damaging 0.94
R1763:Caprin2 UTSW 6 148,744,619 (GRCm39) missense probably damaging 1.00
R1885:Caprin2 UTSW 6 148,779,383 (GRCm39) splice site probably null
R2027:Caprin2 UTSW 6 148,779,385 (GRCm39) missense probably damaging 0.98
R2867:Caprin2 UTSW 6 148,747,738 (GRCm39) synonymous silent
R4856:Caprin2 UTSW 6 148,774,509 (GRCm39) missense probably benign 0.19
R5580:Caprin2 UTSW 6 148,760,232 (GRCm39) missense possibly damaging 0.79
R5696:Caprin2 UTSW 6 148,779,316 (GRCm39) missense possibly damaging 0.49
R5765:Caprin2 UTSW 6 148,744,666 (GRCm39) missense probably damaging 1.00
R5778:Caprin2 UTSW 6 148,770,820 (GRCm39) missense probably benign
R5961:Caprin2 UTSW 6 148,765,038 (GRCm39) missense probably damaging 1.00
R6255:Caprin2 UTSW 6 148,779,390 (GRCm39) missense probably benign 0.28
R6440:Caprin2 UTSW 6 148,771,143 (GRCm39) missense probably damaging 1.00
R6997:Caprin2 UTSW 6 148,779,474 (GRCm39) missense probably damaging 1.00
R7034:Caprin2 UTSW 6 148,749,703 (GRCm39) missense possibly damaging 0.64
R7344:Caprin2 UTSW 6 148,774,565 (GRCm39) missense probably benign 0.02
R7632:Caprin2 UTSW 6 148,784,954 (GRCm39) missense probably damaging 1.00
R7808:Caprin2 UTSW 6 148,744,528 (GRCm39) missense probably damaging 1.00
R8075:Caprin2 UTSW 6 148,770,590 (GRCm39) missense probably benign 0.03
R8083:Caprin2 UTSW 6 148,744,346 (GRCm39) nonsense probably null
R8393:Caprin2 UTSW 6 148,770,650 (GRCm39) missense probably benign 0.01
R8839:Caprin2 UTSW 6 148,774,525 (GRCm39) missense probably benign 0.00
R9041:Caprin2 UTSW 6 148,771,030 (GRCm39) missense probably benign 0.03
R9188:Caprin2 UTSW 6 148,767,422 (GRCm39) missense probably benign
R9234:Caprin2 UTSW 6 148,744,337 (GRCm39) nonsense probably null
R9587:Caprin2 UTSW 6 148,770,500 (GRCm39) missense probably benign
R9605:Caprin2 UTSW 6 148,744,332 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTTAGCTAGCTGGGTGGAG -3'
(R):5'- GCAGGGGAATCACAAGTTTG -3'

Sequencing Primer
(F):5'- AGATCTCTGGGCCAGACTGTC -3'
(R):5'- TACGGGTAACTAACTGCCTGATG -3'
Posted On 2020-09-18