Incidental Mutation 'R8360:Wdr93'
ID 652145
Institutional Source Beutler Lab
Gene Symbol Wdr93
Ensembl Gene ENSMUSG00000039099
Gene Name WD repeat domain 93
Synonyms EG626359
MMRRC Submission 067734-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R8360 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 79392911-79435698 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79398974 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 36 (D36G)
Ref Sequence ENSEMBL: ENSMUSP00000037467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035622]
AlphaFold Q402B2
Predicted Effect probably damaging
Transcript: ENSMUST00000035622
AA Change: D36G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000037467
Gene: ENSMUSG00000039099
AA Change: D36G

DomainStartEndE-ValueType
low complexity region 240 251 N/A INTRINSIC
low complexity region 265 274 N/A INTRINSIC
SCOP:d1jofa_ 389 607 7e-4 SMART
Blast:WD40 413 451 2e-11 BLAST
Meta Mutation Damage Score 0.1135 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17b C T 19: 21,655,888 (GRCm39) Q57* probably null Het
Acad8 C T 9: 26,890,352 (GRCm39) A288T possibly damaging Het
Adamtsl3 G A 7: 82,197,187 (GRCm39) C711Y probably damaging Het
Ahcyl2 C A 6: 29,768,869 (GRCm39) D111E probably benign Het
Asxl3 T C 18: 22,649,174 (GRCm39) F388L probably benign Het
Bcr T A 10: 74,981,271 (GRCm39) S697T probably damaging Het
Catspere2 G A 1: 177,842,724 (GRCm39) V50M possibly damaging Het
Dgka C A 10: 128,563,997 (GRCm39) V451F probably damaging Het
Dnajc2 A T 5: 21,962,705 (GRCm39) C617S unknown Het
Erich3 C A 3: 154,469,991 (GRCm39) T1481K unknown Het
Golm2 A T 2: 121,697,632 (GRCm39) probably benign Het
Hdac2 T A 10: 36,874,059 (GRCm39) D396E probably benign Het
Hmgcs2 A T 3: 98,204,724 (GRCm39) D294V possibly damaging Het
Hnf1a A G 5: 115,091,391 (GRCm39) V434A possibly damaging Het
Il4ra T C 7: 125,169,138 (GRCm39) L130P probably damaging Het
Inpp5j T C 11: 3,449,767 (GRCm39) K672E probably damaging Het
Kif16b G A 2: 142,553,777 (GRCm39) A1007V probably benign Het
Kif26b T C 1: 178,743,938 (GRCm39) S1345P probably benign Het
Lrrc28 A T 7: 67,290,909 (GRCm39) D37E probably benign Het
Mlx G T 11: 100,978,140 (GRCm39) probably benign Het
Muc16 T C 9: 18,436,554 (GRCm39) H7878R probably benign Het
Mybpc1 C A 10: 88,409,359 (GRCm39) E32* probably null Het
Nebl C T 2: 17,465,298 (GRCm39) V18M probably benign Het
Nhsl3 C T 4: 129,117,995 (GRCm39) R268Q possibly damaging Het
Nlrp3 T C 11: 59,440,229 (GRCm39) V602A probably benign Het
Npepps G A 11: 97,120,665 (GRCm39) P532S probably benign Het
Or7g12 T A 9: 18,900,139 (GRCm39) M285K probably benign Het
Or8g19 C T 9: 39,055,761 (GRCm39) R122* probably null Het
Or8k53 T C 2: 86,177,668 (GRCm39) I147M possibly damaging Het
Pfdn1 G A 18: 36,584,214 (GRCm39) T40M probably benign Het
Pkd2 G T 5: 104,607,653 (GRCm39) E51* probably null Het
Prss40 T A 1: 34,599,876 (GRCm39) H37L probably benign Het
Rab11fip1 A T 8: 27,642,374 (GRCm39) C808* probably null Het
Rab3gap2 A T 1: 184,999,270 (GRCm39) probably benign Het
Sall3 C T 18: 81,017,232 (GRCm39) R232H probably benign Het
Sbk3 A G 7: 4,970,707 (GRCm39) F221L probably damaging Het
Sema7a T G 9: 57,862,974 (GRCm39) probably benign Het
Serpina3b C A 12: 104,104,962 (GRCm39) N379K probably benign Het
Ssbp4 A G 8: 71,052,039 (GRCm39) L208P probably benign Het
Stxbp5 C T 10: 9,688,003 (GRCm39) probably null Het
Tecrl A G 5: 83,448,764 (GRCm39) Y160H probably damaging Het
Tnc T C 4: 63,885,511 (GRCm39) I1773V probably benign Het
Ush2a A G 1: 188,198,468 (GRCm39) T1511A probably benign Het
Utp15 T C 13: 98,391,499 (GRCm39) N246S probably damaging Het
Vmn1r49 C T 6: 90,049,991 (GRCm39) A4T probably benign Het
Vmn2r57 A T 7: 41,049,640 (GRCm39) I703N probably damaging Het
Zfp334 A G 2: 165,225,278 (GRCm39) I8T probably benign Het
Other mutations in Wdr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00928:Wdr93 APN 7 79,425,301 (GRCm39) missense probably damaging 1.00
IGL01910:Wdr93 APN 7 79,421,321 (GRCm39) missense probably damaging 1.00
IGL01977:Wdr93 APN 7 79,402,253 (GRCm39) missense probably damaging 1.00
IGL01979:Wdr93 APN 7 79,426,400 (GRCm39) missense probably benign 0.03
IGL02191:Wdr93 APN 7 79,398,968 (GRCm39) missense probably damaging 0.98
R0008:Wdr93 UTSW 7 79,408,221 (GRCm39) missense probably damaging 1.00
R0008:Wdr93 UTSW 7 79,408,221 (GRCm39) missense probably damaging 1.00
R1136:Wdr93 UTSW 7 79,423,196 (GRCm39) missense probably damaging 1.00
R1168:Wdr93 UTSW 7 79,398,922 (GRCm39) missense probably damaging 0.99
R1586:Wdr93 UTSW 7 79,418,109 (GRCm39) missense probably damaging 0.99
R1605:Wdr93 UTSW 7 79,421,257 (GRCm39) splice site probably null
R1651:Wdr93 UTSW 7 79,399,830 (GRCm39) missense probably benign 0.00
R3078:Wdr93 UTSW 7 79,402,241 (GRCm39) missense possibly damaging 0.81
R3689:Wdr93 UTSW 7 79,421,333 (GRCm39) missense possibly damaging 0.91
R4013:Wdr93 UTSW 7 79,418,159 (GRCm39) missense possibly damaging 0.90
R4771:Wdr93 UTSW 7 79,426,511 (GRCm39) missense probably damaging 0.99
R4824:Wdr93 UTSW 7 79,399,817 (GRCm39) nonsense probably null
R4887:Wdr93 UTSW 7 79,435,522 (GRCm39) missense probably damaging 1.00
R5172:Wdr93 UTSW 7 79,402,241 (GRCm39) missense probably damaging 0.97
R5510:Wdr93 UTSW 7 79,399,779 (GRCm39) missense probably damaging 1.00
R5625:Wdr93 UTSW 7 79,420,766 (GRCm39) missense probably benign 0.00
R5648:Wdr93 UTSW 7 79,426,974 (GRCm39) missense probably benign 0.04
R5950:Wdr93 UTSW 7 79,423,179 (GRCm39) missense probably damaging 0.99
R6147:Wdr93 UTSW 7 79,408,245 (GRCm39) missense probably benign
R6530:Wdr93 UTSW 7 79,405,741 (GRCm39) missense probably damaging 1.00
R7056:Wdr93 UTSW 7 79,399,088 (GRCm39) missense probably damaging 1.00
R7079:Wdr93 UTSW 7 79,399,040 (GRCm39) missense probably damaging 1.00
R7309:Wdr93 UTSW 7 79,423,103 (GRCm39) missense possibly damaging 0.86
R7397:Wdr93 UTSW 7 79,416,172 (GRCm39) missense probably null 0.01
R7426:Wdr93 UTSW 7 79,427,055 (GRCm39) critical splice donor site probably null
R7455:Wdr93 UTSW 7 79,425,267 (GRCm39) missense probably benign 0.09
R7618:Wdr93 UTSW 7 79,435,474 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TAAGGAAGTCCAGCCTGAGG -3'
(R):5'- GCAACTGGATGGTAGATGGC -3'

Sequencing Primer
(F):5'- TGAGGCAGAAGGTCCCCAC -3'
(R):5'- CGGGCACGATCCAGTTCTTC -3'
Posted On 2020-10-20