Incidental Mutation 'R8405:Cyp2t4'
ID 652348
Institutional Source Beutler Lab
Gene Symbol Cyp2t4
Ensembl Gene ENSMUSG00000078787
Gene Name cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms LOC384724
MMRRC Submission 067879-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R8405 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 26853139-26857989 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 26856894 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080058] [ENSMUST00000108382] [ENSMUST00000108385] [ENSMUST00000164093]
AlphaFold E9PWV0
Predicted Effect probably benign
Transcript: ENSMUST00000080058
SMART Domains Protein: ENSMUSP00000078966
Gene: ENSMUSG00000058709

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
low complexity region 64 73 N/A INTRINSIC
Blast:P4Hc 75 136 3e-14 BLAST
low complexity region 154 174 N/A INTRINSIC
P4Hc 201 387 9.71e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108382
SMART Domains Protein: ENSMUSP00000104019
Gene: ENSMUSG00000058709

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
low complexity region 64 73 N/A INTRINSIC
Blast:P4Hc 75 136 3e-14 BLAST
low complexity region 154 174 N/A INTRINSIC
P4Hc 201 387 9.71e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108385
SMART Domains Protein: ENSMUSP00000104022
Gene: ENSMUSG00000078787

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 35 492 5.3e-130 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000164093
SMART Domains Protein: ENSMUSP00000126779
Gene: ENSMUSG00000078787

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
Pfam:p450 43 500 2.6e-130 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm T C 3: 153,635,165 (GRCm39) probably benign Het
Anxa3 C A 5: 96,978,295 (GRCm39) D226E probably benign Het
Anxa8 T C 14: 33,819,881 (GRCm39) L290P probably damaging Het
Brd4 C A 17: 32,448,505 (GRCm39) K57N unknown Het
Cpne8 T A 15: 90,456,235 (GRCm39) Q176L possibly damaging Het
Csf2rb2 T C 15: 78,172,093 (GRCm39) D439G possibly damaging Het
Csmd3 A G 15: 47,619,379 (GRCm39) S1832P probably damaging Het
Cux1 A G 5: 136,304,241 (GRCm39) S1320P possibly damaging Het
Dnah2 A T 11: 69,349,289 (GRCm39) L2449Q probably damaging Het
Dock1 A G 7: 134,379,192 (GRCm39) M640V probably benign Het
Efcab3 G A 11: 104,612,024 (GRCm39) S622N probably benign Het
Ergic1 T A 17: 26,874,096 (GRCm39) I274N probably damaging Het
Fat3 T C 9: 15,907,167 (GRCm39) D2945G probably damaging Het
Fscb T C 12: 64,520,278 (GRCm39) E396G possibly damaging Het
Gab1 T A 8: 81,501,594 (GRCm39) R581* probably null Het
Gabarapl1 A G 6: 129,514,497 (GRCm39) D45G probably null Het
Gfap C A 11: 102,782,255 (GRCm39) Q418H probably benign Het
Gfap T A 11: 102,782,256 (GRCm39) Q418L probably benign Het
Hectd1 T A 12: 51,874,178 (GRCm39) M33L probably benign Het
Kcnh7 T A 2: 62,533,446 (GRCm39) K1144N probably benign Het
Lrit3 C T 3: 129,582,301 (GRCm39) G562D probably benign Het
Mab21l1 A T 3: 55,690,659 (GRCm39) Q82L probably damaging Het
Naip6 C T 13: 100,436,784 (GRCm39) A580T possibly damaging Het
Nav1 T C 1: 135,382,508 (GRCm39) K1258R unknown Het
Nbas C A 12: 13,329,394 (GRCm39) A113E probably damaging Het
Nlrp1b A T 11: 71,073,356 (GRCm39) D162E possibly damaging Het
Nr2c1 A T 10: 94,031,155 (GRCm39) H572L probably benign Het
Or52s1 A T 7: 102,861,408 (GRCm39) I114F probably benign Het
Or56b2j T A 7: 104,353,208 (GRCm39) S145T probably benign Het
Pcdha12 T A 18: 37,154,250 (GRCm39) V323E possibly damaging Het
Pgm5 T A 19: 24,705,106 (GRCm39) H469L probably benign Het
Phf8-ps C A 17: 33,286,038 (GRCm39) A255S probably benign Het
Pja2 T C 17: 64,616,505 (GRCm39) E130G possibly damaging Het
Ppp2r2b G C 18: 42,778,805 (GRCm39) D443E probably benign Het
Prdm9 T A 17: 15,764,456 (GRCm39) T775S probably benign Het
Rbm6 A G 9: 107,730,016 (GRCm39) S211P probably benign Het
Rgl2 C T 17: 34,152,698 (GRCm39) Q408* probably null Het
Rgs14 C T 13: 55,530,962 (GRCm39) R389W probably damaging Het
Rtcb T C 10: 85,793,534 (GRCm39) D13G probably benign Het
Slc23a4 C T 6: 34,923,145 (GRCm39) C280Y probably benign Het
Slc7a5 G T 8: 122,613,661 (GRCm39) T297K possibly damaging Het
Spef2 A G 15: 9,612,643 (GRCm39) V1229A probably benign Het
Stag3 A C 5: 138,302,914 (GRCm39) T1064P probably damaging Het
Tnnt1 A G 7: 4,510,592 (GRCm39) S211P probably damaging Het
Trim26 A G 17: 37,167,095 (GRCm39) D262G possibly damaging Het
Trim30a A T 7: 104,060,749 (GRCm39) Y342* probably null Het
Trpm7 T C 2: 126,658,755 (GRCm39) I1134V probably benign Het
Tsc22d1 G A 14: 76,655,734 (GRCm39) G738S probably damaging Het
Usp39 A G 6: 72,305,521 (GRCm39) F421L probably damaging Het
Vmn2r97 G A 17: 19,134,802 (GRCm39) probably null Het
Zfat T C 15: 68,018,410 (GRCm39) Y968C probably damaging Het
Other mutations in Cyp2t4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Cyp2t4 APN 7 26,854,723 (GRCm39) missense probably benign 0.00
IGL00706:Cyp2t4 APN 7 26,854,583 (GRCm39) missense probably benign 0.01
IGL02926:Cyp2t4 APN 7 26,857,228 (GRCm39) missense probably damaging 1.00
R0560:Cyp2t4 UTSW 7 26,857,936 (GRCm39) missense probably damaging 0.99
R0632:Cyp2t4 UTSW 7 26,857,671 (GRCm39) missense possibly damaging 0.82
R0788:Cyp2t4 UTSW 7 26,854,588 (GRCm39) missense probably null
R1353:Cyp2t4 UTSW 7 26,856,055 (GRCm39) missense probably benign 0.03
R1652:Cyp2t4 UTSW 7 26,856,815 (GRCm39) missense possibly damaging 0.48
R1838:Cyp2t4 UTSW 7 26,857,841 (GRCm39) missense possibly damaging 0.92
R1997:Cyp2t4 UTSW 7 26,857,038 (GRCm39) critical splice donor site probably null
R2136:Cyp2t4 UTSW 7 26,857,585 (GRCm39) missense probably benign 0.32
R2963:Cyp2t4 UTSW 7 26,854,699 (GRCm39) missense possibly damaging 0.86
R6239:Cyp2t4 UTSW 7 26,856,900 (GRCm39) missense possibly damaging 0.73
R6634:Cyp2t4 UTSW 7 26,855,213 (GRCm39) nonsense probably null
R7251:Cyp2t4 UTSW 7 26,857,144 (GRCm39) missense possibly damaging 0.72
R7348:Cyp2t4 UTSW 7 26,856,676 (GRCm39) missense probably benign 0.01
R7436:Cyp2t4 UTSW 7 26,857,668 (GRCm39) missense probably damaging 0.99
R8350:Cyp2t4 UTSW 7 26,856,806 (GRCm39) missense possibly damaging 0.51
R8352:Cyp2t4 UTSW 7 26,857,162 (GRCm39) missense probably benign 0.04
R8450:Cyp2t4 UTSW 7 26,856,806 (GRCm39) missense possibly damaging 0.51
R8452:Cyp2t4 UTSW 7 26,857,162 (GRCm39) missense probably benign 0.04
R9366:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9370:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9447:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9451:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9495:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9496:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9497:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9499:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9500:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9516:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9553:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9554:Cyp2t4 UTSW 7 26,854,717 (GRCm39) missense possibly damaging 0.80
R9682:Cyp2t4 UTSW 7 26,857,611 (GRCm39) missense probably damaging 1.00
R9732:Cyp2t4 UTSW 7 26,854,657 (GRCm39) missense probably damaging 0.97
Z1088:Cyp2t4 UTSW 7 26,857,171 (GRCm39) missense probably damaging 1.00
Z1177:Cyp2t4 UTSW 7 26,857,665 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCAAGAGCTCCGACTCTTC -3'
(R):5'- TTTACTGAGATCCCACCCCAGC -3'

Sequencing Primer
(F):5'- CATCTCTGAGCAAATTCAGTGGC -3'
(R):5'- CCTCTCTTCACTTAGGGGGAG -3'
Posted On 2020-10-20