Incidental Mutation 'R8406:Cabyr'
ID |
652449 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cabyr
|
Ensembl Gene |
ENSMUSG00000024430 |
Gene Name |
calcium binding tyrosine phosphorylation regulated |
Synonyms |
FSP-2, 1700016C01Rik, 4933421A18Rik, CBP86 |
MMRRC Submission |
067765-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.091)
|
Stock # |
R8406 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
18 |
Chromosomal Location |
12874141-12888203 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 12883804 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Lysine
at position 97
(T97K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000111523
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074352]
[ENSMUST00000080415]
[ENSMUST00000115857]
[ENSMUST00000117361]
[ENSMUST00000118313]
[ENSMUST00000119043]
[ENSMUST00000119108]
[ENSMUST00000121018]
[ENSMUST00000121774]
[ENSMUST00000121808]
[ENSMUST00000121888]
[ENSMUST00000150758]
[ENSMUST00000186263]
[ENSMUST00000191078]
|
AlphaFold |
Q9D424 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000074352
|
SMART Domains |
Protein: ENSMUSP00000073957 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
ANK
|
47 |
76 |
2.05e-6 |
SMART |
ANK
|
80 |
109 |
1.29e-3 |
SMART |
low complexity region
|
141 |
153 |
N/A |
INTRINSIC |
ANK
|
175 |
204 |
1.31e-4 |
SMART |
PH
|
236 |
336 |
6.02e-8 |
SMART |
low complexity region
|
345 |
354 |
N/A |
INTRINSIC |
coiled coil region
|
430 |
463 |
N/A |
INTRINSIC |
Pfam:Oxysterol_BP
|
548 |
940 |
6.7e-149 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000080415
AA Change: T97K
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000079277 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115857
AA Change: T97K
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000111523 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.2e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000117361
|
SMART Domains |
Protein: ENSMUSP00000112681 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
35 |
428 |
5.1e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000118313
|
SMART Domains |
Protein: ENSMUSP00000113735 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
35 |
428 |
5.1e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119043
|
SMART Domains |
Protein: ENSMUSP00000113357 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
35 |
428 |
5.1e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119108
AA Change: T97K
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000113760 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
8.5e-13 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121018
AA Change: T97K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000113131 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
6.7e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121774
|
SMART Domains |
Protein: ENSMUSP00000113268 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
8 |
401 |
4e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121808
|
SMART Domains |
Protein: ENSMUSP00000113841 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
35 |
428 |
5.1e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121888
|
SMART Domains |
Protein: ENSMUSP00000112895 Gene: ENSMUSG00000044252
Domain | Start | End | E-Value | Type |
Pfam:Oxysterol_BP
|
35 |
428 |
5.1e-150 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000150758
AA Change: T97K
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000118330 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000186263
AA Change: T97K
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000140870 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000191078
AA Change: T97K
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000140894 Gene: ENSMUSG00000024430 AA Change: T97K
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013] PHENOTYPE: Homozygous knockout affects sperm flagellum morphology, resulting in reduced sperm motility. These mutant males are subfertile. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 65 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca8a |
A |
G |
11: 109,977,343 (GRCm39) |
F139L |
probably damaging |
Het |
Adgrg6 |
A |
T |
10: 14,343,082 (GRCm39) |
D288E |
probably benign |
Het |
Agbl1 |
A |
G |
7: 76,068,415 (GRCm39) |
E327G |
|
Het |
Aipl1 |
T |
A |
11: 71,922,332 (GRCm39) |
M126L |
possibly damaging |
Het |
Alkal2 |
G |
T |
12: 30,934,850 (GRCm39) |
G23V |
probably damaging |
Het |
Arl3 |
A |
T |
19: 46,530,823 (GRCm39) |
S157T |
probably benign |
Het |
Armc3 |
A |
T |
2: 19,240,365 (GRCm39) |
I41F |
probably damaging |
Het |
Atg9a |
A |
C |
1: 75,167,028 (GRCm39) |
Y8D |
probably damaging |
Het |
Atp10b |
T |
G |
11: 43,093,984 (GRCm39) |
H509Q |
probably benign |
Het |
Ccdc91 |
T |
C |
6: 147,438,920 (GRCm39) |
F174S |
possibly damaging |
Het |
Cep350 |
A |
T |
1: 155,798,164 (GRCm39) |
H1207Q |
probably benign |
Het |
Clstn3 |
A |
T |
6: 124,439,136 (GRCm39) |
N40K |
probably damaging |
Het |
Col4a4 |
G |
A |
1: 82,501,611 (GRCm39) |
P381S |
unknown |
Het |
Cpne5 |
A |
T |
17: 29,428,455 (GRCm39) |
F116Y |
probably benign |
Het |
Csf2rb2 |
T |
C |
15: 78,171,216 (GRCm39) |
T457A |
probably benign |
Het |
Cyb5d2 |
T |
C |
11: 72,679,959 (GRCm39) |
E112G |
probably benign |
Het |
Cyp2b13 |
T |
C |
7: 25,781,223 (GRCm39) |
F212L |
probably benign |
Het |
Dlx6 |
T |
G |
6: 6,863,779 (GRCm39) |
S134A |
probably benign |
Het |
Egln1 |
A |
G |
8: 125,638,489 (GRCm39) |
Y380H |
probably benign |
Het |
Fbxl13 |
A |
T |
5: 21,728,652 (GRCm39) |
I479N |
probably damaging |
Het |
Fhip1a |
G |
T |
3: 85,580,027 (GRCm39) |
P726Q |
probably benign |
Het |
Fis1 |
A |
G |
5: 136,991,865 (GRCm39) |
K20E |
probably benign |
Het |
Foxk1 |
G |
T |
5: 142,387,528 (GRCm39) |
V84L |
unknown |
Het |
Gdf5 |
C |
A |
2: 155,784,272 (GRCm39) |
G227W |
probably damaging |
Het |
Ghrh |
T |
A |
2: 157,175,656 (GRCm39) |
T13S |
probably benign |
Het |
Gnb2 |
A |
G |
5: 137,526,865 (GRCm39) |
L308P |
probably damaging |
Het |
Grik2 |
A |
T |
10: 49,148,863 (GRCm39) |
V574D |
probably damaging |
Het |
Hydin |
A |
T |
8: 111,336,543 (GRCm39) |
I5107F |
possibly damaging |
Het |
Kl |
A |
T |
5: 150,906,229 (GRCm39) |
Y533F |
probably benign |
Het |
Man2b1 |
G |
T |
8: 85,822,907 (GRCm39) |
R816L |
probably damaging |
Het |
Myo5c |
T |
C |
9: 75,182,823 (GRCm39) |
Y821H |
probably damaging |
Het |
Myo7b |
A |
T |
18: 32,092,866 (GRCm39) |
C2076S |
probably damaging |
Het |
Naip6 |
C |
T |
13: 100,436,784 (GRCm39) |
A580T |
possibly damaging |
Het |
Nectin2 |
A |
T |
7: 19,472,275 (GRCm39) |
V38E |
probably damaging |
Het |
Or13a24 |
A |
T |
7: 140,154,044 (GRCm39) |
|
probably benign |
Het |
Osbpl9 |
T |
C |
4: 108,921,770 (GRCm39) |
Y536C |
possibly damaging |
Het |
Pcdh18 |
T |
G |
3: 49,710,998 (GRCm39) |
I106L |
probably damaging |
Het |
Pde4dip |
T |
C |
3: 97,606,428 (GRCm39) |
K2149E |
probably benign |
Het |
Pds5a |
A |
T |
5: 65,803,681 (GRCm39) |
C588S |
probably benign |
Het |
Phf8-ps |
C |
A |
17: 33,286,038 (GRCm39) |
A255S |
probably benign |
Het |
Pop1 |
T |
C |
15: 34,529,316 (GRCm39) |
M812T |
probably benign |
Het |
Pou2f3 |
T |
C |
9: 43,051,153 (GRCm39) |
T178A |
probably damaging |
Het |
Rab44 |
C |
T |
17: 29,359,294 (GRCm39) |
A494V |
unknown |
Het |
Ros1 |
G |
C |
10: 51,977,941 (GRCm39) |
T1456S |
possibly damaging |
Het |
Rubcnl |
T |
G |
14: 75,289,425 (GRCm39) |
F644L |
probably damaging |
Het |
Saraf |
C |
T |
8: 34,632,602 (GRCm39) |
P227L |
probably benign |
Het |
Sh3glb1 |
T |
G |
3: 144,397,198 (GRCm39) |
E383D |
probably damaging |
Het |
Sh3rf3 |
T |
C |
10: 58,919,407 (GRCm39) |
V508A |
probably damaging |
Het |
Sirt6 |
A |
T |
10: 81,458,328 (GRCm39) |
H308Q |
probably benign |
Het |
Slc29a1 |
T |
A |
17: 45,900,706 (GRCm39) |
I119F |
probably damaging |
Het |
Smtnl1 |
C |
T |
2: 84,648,742 (GRCm39) |
E171K |
probably benign |
Het |
Spg11 |
T |
A |
2: 121,923,923 (GRCm39) |
E799D |
probably damaging |
Het |
Tecpr1 |
A |
T |
5: 144,137,658 (GRCm39) |
W894R |
probably damaging |
Het |
Tiam2 |
A |
C |
17: 3,558,065 (GRCm39) |
I1230L |
possibly damaging |
Het |
Tnfrsf8 |
A |
G |
4: 145,019,265 (GRCm39) |
L190P |
probably damaging |
Het |
Trim35 |
C |
T |
14: 66,534,724 (GRCm39) |
T69M |
possibly damaging |
Het |
Ttll7 |
T |
C |
3: 146,645,779 (GRCm39) |
Y546H |
probably benign |
Het |
Ubash3b |
C |
T |
9: 40,940,971 (GRCm39) |
G389R |
probably damaging |
Het |
Vma21-ps |
C |
T |
4: 52,497,034 (GRCm39) |
V71I |
probably damaging |
Het |
Vmn1r43 |
T |
A |
6: 89,847,414 (GRCm39) |
H24L |
possibly damaging |
Het |
Vps37c |
T |
A |
19: 10,687,719 (GRCm39) |
L60Q |
probably damaging |
Het |
Ythdf2 |
A |
G |
4: 131,931,946 (GRCm39) |
W405R |
probably damaging |
Het |
Zfp775 |
T |
C |
6: 48,597,637 (GRCm39) |
C504R |
probably damaging |
Het |
Zfp82 |
A |
G |
7: 29,761,652 (GRCm39) |
|
probably null |
Het |
Zpr1 |
T |
A |
9: 46,185,400 (GRCm39) |
I127N |
probably damaging |
Het |
|
Other mutations in Cabyr |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00544:Cabyr
|
APN |
18 |
12,877,667 (GRCm39) |
missense |
probably damaging |
0.99 |
R0547:Cabyr
|
UTSW |
18 |
12,884,073 (GRCm39) |
missense |
probably benign |
0.07 |
R0571:Cabyr
|
UTSW |
18 |
12,883,909 (GRCm39) |
missense |
probably damaging |
1.00 |
R1556:Cabyr
|
UTSW |
18 |
12,877,837 (GRCm39) |
missense |
probably damaging |
1.00 |
R3084:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3085:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3086:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3824:Cabyr
|
UTSW |
18 |
12,884,747 (GRCm39) |
missense |
probably benign |
0.04 |
R3898:Cabyr
|
UTSW |
18 |
12,884,580 (GRCm39) |
missense |
probably benign |
0.00 |
R4869:Cabyr
|
UTSW |
18 |
12,884,875 (GRCm39) |
makesense |
probably null |
|
R4933:Cabyr
|
UTSW |
18 |
12,877,549 (GRCm39) |
splice site |
probably benign |
|
R5036:Cabyr
|
UTSW |
18 |
12,884,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R5482:Cabyr
|
UTSW |
18 |
12,884,496 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5932:Cabyr
|
UTSW |
18 |
12,887,407 (GRCm39) |
missense |
probably damaging |
1.00 |
R6515:Cabyr
|
UTSW |
18 |
12,887,340 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6556:Cabyr
|
UTSW |
18 |
12,884,073 (GRCm39) |
missense |
probably benign |
0.07 |
R6852:Cabyr
|
UTSW |
18 |
12,887,154 (GRCm39) |
missense |
probably benign |
0.35 |
R6907:Cabyr
|
UTSW |
18 |
12,883,969 (GRCm39) |
missense |
probably benign |
0.05 |
R7193:Cabyr
|
UTSW |
18 |
12,884,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R7565:Cabyr
|
UTSW |
18 |
12,877,656 (GRCm39) |
missense |
possibly damaging |
0.50 |
R7777:Cabyr
|
UTSW |
18 |
12,877,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R7941:Cabyr
|
UTSW |
18 |
12,877,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R8243:Cabyr
|
UTSW |
18 |
12,883,759 (GRCm39) |
missense |
probably benign |
0.00 |
R8914:Cabyr
|
UTSW |
18 |
12,884,077 (GRCm39) |
missense |
probably damaging |
0.98 |
R9224:Cabyr
|
UTSW |
18 |
12,887,278 (GRCm39) |
missense |
possibly damaging |
0.64 |
R9635:Cabyr
|
UTSW |
18 |
12,883,816 (GRCm39) |
missense |
probably damaging |
1.00 |
R9697:Cabyr
|
UTSW |
18 |
12,884,407 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Predicted Primers |
PCR Primer
(F):5'- AGGTTGCACATAGATCCTTGTG -3'
(R):5'- ACATAAGCGTACTCGGCAG -3'
Sequencing Primer
(F):5'- GCACATAGATCCTTGTGTATTGG -3'
(R):5'- CGCTGGAGGTGGTGACGAG -3'
|
Posted On |
2020-10-20 |