Incidental Mutation 'R8408:Cd5'
ID 652556
Institutional Source Beutler Lab
Gene Symbol Cd5
Ensembl Gene ENSMUSG00000024669
Gene Name CD5 antigen
Synonyms Ly-A, Ly-1, Ly-12, Lyt-1
MMRRC Submission 067815-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8408 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 10695471-10716390 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10700469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 345 (K345R)
Ref Sequence ENSEMBL: ENSMUSP00000025571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025571]
AlphaFold P13379
Predicted Effect possibly damaging
Transcript: ENSMUST00000025571
AA Change: K345R

PolyPhen 2 Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000025571
Gene: ENSMUSG00000024669
AA Change: K345R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
SR 34 133 7.43e-19 SMART
low complexity region 138 157 N/A INTRINSIC
SR 276 367 7.27e-4 SMART
transmembrane domain 379 401 N/A INTRINSIC
low complexity region 402 415 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,236,356 (GRCm39) T1236A possibly damaging Het
9930111J21Rik1 A T 11: 48,838,829 (GRCm39) M586K probably damaging Het
Adamts4 T C 1: 171,080,314 (GRCm39) V289A possibly damaging Het
Ankrd44 A T 1: 54,762,257 (GRCm39) D522E probably benign Het
Asb14 A G 14: 26,637,067 (GRCm39) Y603C probably damaging Het
Bcl7b A G 5: 135,197,308 (GRCm39) probably benign Het
Celsr3 T C 9: 108,708,988 (GRCm39) F1278S probably damaging Het
Cndp1 T A 18: 84,650,049 (GRCm39) T215S possibly damaging Het
Crygb T G 1: 65,119,709 (GRCm39) R90S probably damaging Het
Dlg4 T A 11: 69,933,078 (GRCm39) F555I possibly damaging Het
Dnah3 C T 7: 119,551,728 (GRCm39) V2864M probably damaging Het
Dnttip2 A G 3: 122,070,351 (GRCm39) E522G probably damaging Het
Ercc4 G C 16: 12,948,001 (GRCm39) R406P probably benign Het
Foxp1 G A 6: 98,922,543 (GRCm39) P430S unknown Het
Galnt1 A G 18: 24,400,628 (GRCm39) T245A probably benign Het
Gnl2 T A 4: 124,938,082 (GRCm39) N287K probably damaging Het
Jcad C A 18: 4,649,402 (GRCm39) A91E possibly damaging Het
Kat6a G A 8: 23,352,275 (GRCm39) V20I probably damaging Het
Kcnb2 A G 1: 15,781,777 (GRCm39) N883S probably damaging Het
Lrch3 A T 16: 32,775,750 (GRCm39) R205S probably damaging Het
Lrr1 A G 12: 69,215,825 (GRCm39) T66A probably benign Het
Lrrc37a T A 11: 103,351,635 (GRCm39) I2569F unknown Het
Maip1 A T 1: 57,449,102 (GRCm39) Q161L probably damaging Het
Neb T C 2: 52,047,923 (GRCm39) E6699G probably benign Het
Nup205 A G 6: 35,202,182 (GRCm39) R1305G probably damaging Het
Or1e19 T A 11: 73,316,794 (GRCm39) N5I probably damaging Het
Or5ac21 A T 16: 59,124,418 (GRCm39) R301* probably null Het
Pate1 G A 9: 35,596,418 (GRCm39) R116W probably damaging Het
Pcsk5 T G 19: 17,410,809 (GRCm39) E1861A probably benign Het
Peg10 C CTCA 6: 4,756,453 (GRCm39) probably benign Het
Per1 A T 11: 68,999,953 (GRCm39) D1215V possibly damaging Het
Phactr2 A G 10: 13,129,570 (GRCm39) S233P probably damaging Het
Pramel28 A G 4: 143,692,212 (GRCm39) V263A probably benign Het
Rgsl1 T A 1: 153,701,435 (GRCm39) N340Y possibly damaging Het
Rhot1 C T 11: 80,114,786 (GRCm39) P65S probably damaging Het
Scrn2 T C 11: 96,921,869 (GRCm39) L113P probably damaging Het
Sema6a T C 18: 47,381,958 (GRCm39) K863R probably benign Het
Slc15a1 A G 14: 121,715,528 (GRCm39) V337A possibly damaging Het
Slc25a1 T C 16: 17,743,720 (GRCm39) D298G probably benign Het
Slc25a22 G A 7: 141,011,737 (GRCm39) P168S probably benign Het
Slc29a4 A T 5: 142,691,109 (GRCm39) probably null Het
Slc35d1 T C 4: 103,047,007 (GRCm39) T264A Het
Spice1 T C 16: 44,205,060 (GRCm39) S789P probably damaging Het
Sprr2b CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC 3: 92,224,826 (GRCm39) probably benign Het
Tectb T C 19: 55,178,099 (GRCm39) probably null Het
Ttn T A 2: 76,544,810 (GRCm39) Y32764F probably damaging Het
Utrn T G 10: 12,545,887 (GRCm39) S1684R possibly damaging Het
Zic1 G T 9: 91,246,847 (GRCm39) A75E probably damaging Het
Zswim4 A G 8: 84,939,014 (GRCm39) V956A possibly damaging Het
Other mutations in Cd5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01705:Cd5 APN 19 10,703,659 (GRCm39) critical splice donor site probably null
IGL03392:Cd5 APN 19 10,703,653 (GRCm39) splice site probably benign
PIT4305001:Cd5 UTSW 19 10,703,750 (GRCm39) missense possibly damaging 0.72
R0732:Cd5 UTSW 19 10,700,649 (GRCm39) missense probably damaging 1.00
R1831:Cd5 UTSW 19 10,696,933 (GRCm39) missense probably damaging 1.00
R2086:Cd5 UTSW 19 10,700,620 (GRCm39) missense probably benign 0.00
R4184:Cd5 UTSW 19 10,698,638 (GRCm39) missense probably damaging 1.00
R6162:Cd5 UTSW 19 10,703,244 (GRCm39) missense probably damaging 1.00
R6894:Cd5 UTSW 19 10,716,203 (GRCm39) missense possibly damaging 0.91
R7138:Cd5 UTSW 19 10,697,668 (GRCm39) missense probably damaging 1.00
R7653:Cd5 UTSW 19 10,703,910 (GRCm39) missense probably benign 0.00
R8297:Cd5 UTSW 19 10,697,609 (GRCm39) missense probably damaging 1.00
R8411:Cd5 UTSW 19 10,697,585 (GRCm39) missense probably damaging 1.00
R8699:Cd5 UTSW 19 10,702,556 (GRCm39) missense possibly damaging 0.67
R9663:Cd5 UTSW 19 10,703,858 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TAGCTTGACAGAGGTCCACG -3'
(R):5'- TGAAGTGCGCCAGAGATCAC -3'

Sequencing Primer
(F):5'- TTGACAGAGGTCCACGTGAGC -3'
(R):5'- TGCGCCAGAGATCACAGTGG -3'
Posted On 2020-10-20