Incidental Mutation 'R8410:Or4f4-ps1'
ID 652612
Institutional Source Beutler Lab
Gene Symbol Or4f4-ps1
Ensembl Gene ENSMUSG00000108891
Gene Name olfactory receptor family 4 subfamily F member 4, pseudogene 1
Synonyms Olfr1291-ps1, MOR245-32_p, OTTMUSG00000015084, GA_x6K02T2Q125-72550790-72551728, Olfr1291
MMRRC Submission 067880-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R8410 (G1)
Quality Score 205.009
Status Validated
Chromosome 2
Chromosomal Location 111329641-111330579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111330047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 150 (M150K)
Ref Sequence ENSEMBL: ENSMUSP00000153499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121345] [ENSMUST00000219064]
AlphaFold A0A286YE47
Predicted Effect probably damaging
Transcript: ENSMUST00000121345
AA Change: M150K

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000219064
AA Change: M122K

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 95% (40/42)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001K19Rik A T 12: 110,635,145 (GRCm39) M131K probably benign Het
Alox15 T C 11: 70,235,753 (GRCm39) T569A probably benign Het
Arfgef1 A G 1: 10,229,867 (GRCm39) V1278A possibly damaging Het
Armc5 C T 7: 127,839,323 (GRCm39) R214C probably damaging Het
Asl A G 5: 130,042,351 (GRCm39) F242L possibly damaging Het
Atoh1 G A 6: 64,706,634 (GRCm39) G110S probably benign Het
Caskin1 T C 17: 24,721,123 (GRCm39) F488L possibly damaging Het
Chsy1 T A 7: 65,775,211 (GRCm39) L180Q probably damaging Het
D1Pas1 A T 1: 186,700,512 (GRCm39) Q147L probably benign Het
D930020B18Rik A G 10: 121,521,435 (GRCm39) probably benign Het
Dnah7b T A 1: 46,395,819 (GRCm39) probably null Het
Dsp A G 13: 38,380,791 (GRCm39) E2512G possibly damaging Het
Eci2 T C 13: 35,162,018 (GRCm39) K351R probably benign Het
Frem2 A G 3: 53,446,598 (GRCm39) V2390A possibly damaging Het
Frmpd2 G A 14: 33,217,624 (GRCm39) A40T probably damaging Het
Gapdhs G A 7: 30,437,335 (GRCm39) P77S unknown Het
Heatr5a T A 12: 51,984,903 (GRCm39) I637F probably benign Het
Jakmip1 G A 5: 37,274,828 (GRCm39) V449M possibly damaging Het
Myh14 G T 7: 44,282,907 (GRCm39) F737L probably damaging Het
Nbea A G 3: 55,944,684 (GRCm39) V560A probably damaging Het
Or13n4 T A 7: 106,423,745 (GRCm39) probably benign Het
Or2v2 A T 11: 49,004,511 (GRCm39) I14N possibly damaging Het
Or6x1 C T 9: 40,098,732 (GRCm39) T107I possibly damaging Het
Prex2 G T 1: 11,223,881 (GRCm39) R735L possibly damaging Het
Rrm2 T C 12: 24,758,622 (GRCm39) S55P probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,124 (GRCm39) probably benign Het
Ruvbl2 T C 7: 45,080,756 (GRCm39) I19V probably benign Het
Sall3 G A 18: 81,016,969 (GRCm39) P320S probably benign Het
Slc15a5 A T 6: 137,989,153 (GRCm39) M147K Het
St3gal5 A G 6: 72,119,281 (GRCm39) D158G probably benign Het
Stac3 G A 10: 127,339,199 (GRCm39) D103N probably damaging Het
Syt2 G A 1: 134,674,602 (GRCm39) E347K possibly damaging Het
Tent5b A G 4: 133,214,362 (GRCm39) Q411R possibly damaging Het
Ticrr A G 7: 79,317,423 (GRCm39) E319G probably damaging Het
Ttn A G 2: 76,539,985 (GRCm39) S34334P probably damaging Het
Uqcrb C A 13: 67,048,850 (GRCm39) R100L unknown Het
Usp43 T G 11: 67,747,146 (GRCm39) T854P probably damaging Het
Vmn2r102 T C 17: 19,898,196 (GRCm39) Y404H possibly damaging Het
Wrn C T 8: 33,759,048 (GRCm39) G970D probably damaging Het
Zfp456 A G 13: 67,520,915 (GRCm39) Y27H probably damaging Het
Zfp516 G T 18: 82,974,458 (GRCm39) G219C probably damaging Het
Zyx A T 6: 42,333,384 (GRCm39) N437Y probably benign Het
Other mutations in Or4f4-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
BB002:Or4f4-ps1 UTSW 2 111,330,166 (GRCm39) missense probably damaging 0.99
BB012:Or4f4-ps1 UTSW 2 111,330,166 (GRCm39) missense probably damaging 0.99
R6322:Or4f4-ps1 UTSW 2 111,329,729 (GRCm39) missense possibly damaging 0.77
R7219:Or4f4-ps1 UTSW 2 111,330,532 (GRCm39) missense probably benign 0.00
R7394:Or4f4-ps1 UTSW 2 111,330,241 (GRCm39) missense probably damaging 0.98
R7711:Or4f4-ps1 UTSW 2 111,330,497 (GRCm39) missense probably damaging 1.00
R7768:Or4f4-ps1 UTSW 2 111,330,198 (GRCm39) missense possibly damaging 0.92
R7925:Or4f4-ps1 UTSW 2 111,330,166 (GRCm39) missense probably damaging 0.99
R8125:Or4f4-ps1 UTSW 2 111,330,332 (GRCm39) missense possibly damaging 0.91
R8427:Or4f4-ps1 UTSW 2 111,330,310 (GRCm39) missense probably damaging 1.00
R8735:Or4f4-ps1 UTSW 2 111,330,497 (GRCm39) missense probably damaging 1.00
R9634:Or4f4-ps1 UTSW 2 111,330,131 (GRCm39) missense possibly damaging 0.72
R9635:Or4f4-ps1 UTSW 2 111,330,267 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTCTGTCACAGCACCAAAGATG -3'
(R):5'- ACAGTAAGCACACCACTGTTG -3'

Sequencing Primer
(F):5'- TGTCACAGCACCAAAGATGATTGC -3'
(R):5'- CACTGTTGGCAATGACCATG -3'
Posted On 2020-10-20