Mutagenetix > Incidental Mutation

Incidental Mutation 'R8410:Vmn2r102'

652644

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

MMRRC Submission

067880-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8410 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19880661-19915010 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19898196 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 404 (Y404H)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171741
AA Change: Y404H

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: Y404H

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

95% (40/42)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	A	T	12: 110,635,145 (GRCm39)	M131K	probably benign	Het
Alox15	T	C	11: 70,235,753 (GRCm39)	T569A	probably benign	Het
Arfgef1	A	G	1: 10,229,867 (GRCm39)	V1278A	possibly damaging	Het
Armc5	C	T	7: 127,839,323 (GRCm39)	R214C	probably damaging	Het
Asl	A	G	5: 130,042,351 (GRCm39)	F242L	possibly damaging	Het
Atoh1	G	A	6: 64,706,634 (GRCm39)	G110S	probably benign	Het
Caskin1	T	C	17: 24,721,123 (GRCm39)	F488L	possibly damaging	Het
Chsy1	T	A	7: 65,775,211 (GRCm39)	L180Q	probably damaging	Het
D1Pas1	A	T	1: 186,700,512 (GRCm39)	Q147L	probably benign	Het
D930020B18Rik	A	G	10: 121,521,435 (GRCm39)		probably benign	Het
Dnah7b	T	A	1: 46,395,819 (GRCm39)		probably null	Het
Dsp	A	G	13: 38,380,791 (GRCm39)	E2512G	possibly damaging	Het
Eci2	T	C	13: 35,162,018 (GRCm39)	K351R	probably benign	Het
Frem2	A	G	3: 53,446,598 (GRCm39)	V2390A	possibly damaging	Het
Frmpd2	G	A	14: 33,217,624 (GRCm39)	A40T	probably damaging	Het
Gapdhs	G	A	7: 30,437,335 (GRCm39)	P77S	unknown	Het
Heatr5a	T	A	12: 51,984,903 (GRCm39)	I637F	probably benign	Het
Jakmip1	G	A	5: 37,274,828 (GRCm39)	V449M	possibly damaging	Het
Myh14	G	T	7: 44,282,907 (GRCm39)	F737L	probably damaging	Het
Nbea	A	G	3: 55,944,684 (GRCm39)	V560A	probably damaging	Het
Or13n4	T	A	7: 106,423,745 (GRCm39)		probably benign	Het
Or2v2	A	T	11: 49,004,511 (GRCm39)	I14N	possibly damaging	Het
Or4f4-ps1	T	A	2: 111,330,047 (GRCm39)	M150K	probably damaging	Het
Or6x1	C	T	9: 40,098,732 (GRCm39)	T107I	possibly damaging	Het
Prex2	G	T	1: 11,223,881 (GRCm39)	R735L	possibly damaging	Het
Rrm2	T	C	12: 24,758,622 (GRCm39)	S55P	probably benign	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,229,124 (GRCm39)		probably benign	Het
Ruvbl2	T	C	7: 45,080,756 (GRCm39)	I19V	probably benign	Het
Sall3	G	A	18: 81,016,969 (GRCm39)	P320S	probably benign	Het
Slc15a5	A	T	6: 137,989,153 (GRCm39)	M147K		Het
St3gal5	A	G	6: 72,119,281 (GRCm39)	D158G	probably benign	Het
Stac3	G	A	10: 127,339,199 (GRCm39)	D103N	probably damaging	Het
Syt2	G	A	1: 134,674,602 (GRCm39)	E347K	possibly damaging	Het
Tent5b	A	G	4: 133,214,362 (GRCm39)	Q411R	possibly damaging	Het
Ticrr	A	G	7: 79,317,423 (GRCm39)	E319G	probably damaging	Het
Ttn	A	G	2: 76,539,985 (GRCm39)	S34334P	probably damaging	Het
Uqcrb	C	A	13: 67,048,850 (GRCm39)	R100L	unknown	Het
Usp43	T	G	11: 67,747,146 (GRCm39)	T854P	probably damaging	Het
Wrn	C	T	8: 33,759,048 (GRCm39)	G970D	probably damaging	Het
Zfp456	A	G	13: 67,520,915 (GRCm39)	Y27H	probably damaging	Het
Zfp516	G	T	18: 82,974,458 (GRCm39)	G219C	probably damaging	Het
Zyx	A	T	6: 42,333,384 (GRCm39)	N437Y	probably benign	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19,899,154 (GRCm39)	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19,897,771 (GRCm39)	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19,899,185 (GRCm39)	splice site	probably null
IGL01589:Vmn2r102	APN	17	19,899,066 (GRCm39)	missense	probably benign
IGL01738:Vmn2r102	APN	17	19,898,020 (GRCm39)	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19,880,731 (GRCm39)	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19,914,191 (GRCm39)	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19,901,447 (GRCm39)	missense	probably benign
IGL02589:Vmn2r102	APN	17	19,901,480 (GRCm39)	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19,898,170 (GRCm39)	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19,914,328 (GRCm39)	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19,914,286 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19,896,958 (GRCm39)	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19,880,851 (GRCm39)	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19,898,112 (GRCm39)	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19,914,630 (GRCm39)	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19,897,043 (GRCm39)	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19,898,277 (GRCm39)	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19,899,106 (GRCm39)	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19,914,454 (GRCm39)	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19,880,887 (GRCm39)	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19,914,843 (GRCm39)	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19,899,032 (GRCm39)	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19,897,770 (GRCm39)	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19,914,755 (GRCm39)	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19,897,006 (GRCm39)	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19,896,949 (GRCm39)	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19,914,930 (GRCm39)	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19,899,093 (GRCm39)	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19,914,787 (GRCm39)	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19,898,088 (GRCm39)	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19,880,845 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4535:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4662:Vmn2r102	UTSW	17	19,901,424 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19,914,576 (GRCm39)	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19,897,795 (GRCm39)	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19,898,203 (GRCm39)	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19,880,661 (GRCm39)	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19,897,834 (GRCm39)	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19,914,393 (GRCm39)	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19,914,415 (GRCm39)	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19,897,804 (GRCm39)	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19,914,943 (GRCm39)	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19,914,402 (GRCm39)	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19,899,007 (GRCm39)	missense	probably benign
R6432:Vmn2r102	UTSW	17	19,901,483 (GRCm39)	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19,898,169 (GRCm39)	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19,914,450 (GRCm39)	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19,880,694 (GRCm39)	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19,914,456 (GRCm39)	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19,914,670 (GRCm39)	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19,897,749 (GRCm39)	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19,896,886 (GRCm39)	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19,901,405 (GRCm39)	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19,914,363 (GRCm39)	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19,898,093 (GRCm39)	missense	probably benign
R8126:Vmn2r102	UTSW	17	19,880,712 (GRCm39)	missense	probably benign	0.02
R8385:Vmn2r102	UTSW	17	19,914,088 (GRCm39)	missense	possibly damaging	0.89
R9045:Vmn2r102	UTSW	17	19,880,841 (GRCm39)	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19,896,928 (GRCm39)	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19,897,558 (GRCm39)	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19,897,614 (GRCm39)	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19,897,564 (GRCm39)	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19,914,305 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGTTAGACACATTCCATGGAAGCC -3'
(R):5'- ACAATACCTAAGTTAGTGTTGCTGC -3'

Sequencing Primer
(F):5'- CCATGGAAGCCTAATTTTTAAGCAC -3'
(R):5'- GCTGCAAATCTCTTATGCCAGAGTG -3'

Posted On

2020-10-20