Incidental Mutation 'R8411:Vmn2r87'
| ID |
652687 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
067881-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R8411 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130308126 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 704
(I704T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164227
AA Change: I704T
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: I704T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
A |
G |
5: 113,285,588 (GRCm39) |
S89P |
probably benign |
Het |
| Aatf |
A |
T |
11: 84,361,502 (GRCm39) |
M367K |
probably benign |
Het |
| Adam18 |
A |
T |
8: 25,142,143 (GRCm39) |
I211N |
probably damaging |
Het |
| Angpt1 |
T |
C |
15: 42,290,430 (GRCm39) |
Y478C |
probably damaging |
Het |
| Apba2 |
A |
T |
7: 64,386,674 (GRCm39) |
I434F |
probably damaging |
Het |
| Arfgef1 |
T |
A |
1: 10,286,759 (GRCm39) |
K50N |
probably benign |
Het |
| Arfgef2 |
A |
T |
2: 166,715,903 (GRCm39) |
Q1397H |
probably benign |
Het |
| Ascc2 |
G |
A |
11: 4,597,208 (GRCm39) |
R129Q |
probably damaging |
Het |
| Atxn1 |
A |
G |
13: 45,720,032 (GRCm39) |
V621A |
probably benign |
Het |
| Catsperz |
A |
T |
19: 6,899,930 (GRCm39) |
L192M |
probably benign |
Het |
| Cd5 |
G |
A |
19: 10,697,585 (GRCm39) |
P465S |
probably damaging |
Het |
| Cfap57 |
C |
T |
4: 118,472,128 (GRCm39) |
V84I |
probably benign |
Het |
| Cfap61 |
A |
G |
2: 145,789,103 (GRCm39) |
E94G |
probably benign |
Het |
| Chd1 |
A |
G |
17: 15,982,711 (GRCm39) |
H1392R |
probably damaging |
Het |
| Csnk1a1 |
A |
G |
18: 61,688,888 (GRCm39) |
I23V |
probably benign |
Het |
| Ctnnd2 |
C |
T |
15: 30,647,179 (GRCm39) |
R292C |
probably benign |
Het |
| Dcaf6 |
T |
A |
1: 165,216,244 (GRCm39) |
H453L |
probably benign |
Het |
| Dnah3 |
C |
A |
7: 119,610,253 (GRCm39) |
D1728Y |
probably damaging |
Het |
| Dtx3 |
T |
C |
10: 127,028,693 (GRCm39) |
K179E |
possibly damaging |
Het |
| Fam3b |
T |
A |
16: 97,283,053 (GRCm39) |
Y74F |
probably benign |
Het |
| Gm5464 |
T |
C |
14: 67,106,555 (GRCm39) |
L64P |
unknown |
Het |
| Gm5624 |
T |
G |
14: 44,799,347 (GRCm39) |
N70T |
|
Het |
| Kcnh7 |
T |
A |
2: 62,594,952 (GRCm39) |
H706L |
probably damaging |
Het |
| Kdm2b |
C |
T |
5: 123,018,239 (GRCm39) |
R1067H |
probably damaging |
Het |
| Klhl28 |
A |
T |
12: 64,996,864 (GRCm39) |
H492Q |
probably damaging |
Het |
| Loxl3 |
T |
A |
6: 83,027,605 (GRCm39) |
C716S |
probably damaging |
Het |
| Ltbp2 |
A |
G |
12: 84,833,187 (GRCm39) |
Y1474H |
probably damaging |
Het |
| Mcm3 |
C |
T |
1: 20,886,980 (GRCm39) |
V142I |
probably benign |
Het |
| Mmp24 |
G |
T |
2: 155,655,935 (GRCm39) |
V458L |
probably benign |
Het |
| Mpl |
C |
A |
4: 118,303,306 (GRCm39) |
S502I |
|
Het |
| Nfatc1 |
A |
T |
18: 80,710,257 (GRCm39) |
V503D |
probably damaging |
Het |
| Nim1k |
A |
G |
13: 120,175,807 (GRCm39) |
I133T |
possibly damaging |
Het |
| Nr1d2 |
T |
C |
14: 18,215,031 (GRCm38) |
Y327C |
probably damaging |
Het |
| Oma1 |
C |
T |
4: 103,186,113 (GRCm39) |
R360* |
probably null |
Het |
| Oog2 |
T |
A |
4: 143,920,743 (GRCm39) |
W59R |
probably damaging |
Het |
| Or4c109 |
T |
C |
2: 88,818,409 (GRCm39) |
T46A |
probably benign |
Het |
| Pcdh10 |
A |
G |
3: 45,333,974 (GRCm39) |
E96G |
probably damaging |
Het |
| Pcna |
T |
A |
2: 132,093,850 (GRCm39) |
T98S |
probably benign |
Het |
| Pcnx3 |
C |
T |
19: 5,729,618 (GRCm39) |
C899Y |
possibly damaging |
Het |
| Phf11d |
T |
C |
14: 59,593,883 (GRCm39) |
N97S |
probably benign |
Het |
| Plekhg4 |
G |
A |
8: 106,103,961 (GRCm39) |
W431* |
probably null |
Het |
| Plk4 |
A |
G |
3: 40,767,901 (GRCm39) |
T815A |
probably benign |
Het |
| Pnma2 |
C |
T |
14: 67,153,762 (GRCm39) |
T62I |
possibly damaging |
Het |
| Ppp1r9a |
C |
T |
6: 5,057,568 (GRCm39) |
R548W |
probably damaging |
Het |
| Ptx3 |
A |
G |
3: 66,132,201 (GRCm39) |
S241G |
probably benign |
Het |
| Repin1 |
G |
T |
6: 48,574,279 (GRCm39) |
E403* |
probably null |
Het |
| Rplp0 |
A |
T |
5: 115,698,823 (GRCm39) |
K26N |
probably damaging |
Het |
| Sec62 |
A |
C |
3: 30,872,931 (GRCm39) |
E338A |
unknown |
Het |
| Sema6a |
T |
C |
18: 47,382,022 (GRCm39) |
M842V |
probably benign |
Het |
| Serpina3j |
T |
C |
12: 104,281,043 (GRCm39) |
V72A |
probably benign |
Het |
| Siglecf |
T |
C |
7: 43,001,368 (GRCm39) |
F112S |
probably damaging |
Het |
| Slc29a4 |
A |
G |
5: 142,705,880 (GRCm39) |
N455D |
probably damaging |
Het |
| Slc6a11 |
T |
A |
6: 114,108,398 (GRCm39) |
F54Y |
probably benign |
Het |
| Spag6 |
G |
A |
2: 18,715,394 (GRCm39) |
V80M |
probably damaging |
Het |
| Spic |
T |
C |
10: 88,514,498 (GRCm39) |
E34G |
possibly damaging |
Het |
| Tecpr2 |
A |
G |
12: 110,898,154 (GRCm39) |
K469E |
possibly damaging |
Het |
| Them7 |
T |
A |
2: 105,128,190 (GRCm39) |
L57Q |
probably benign |
Het |
| Tlr3 |
G |
A |
8: 45,849,978 (GRCm39) |
A897V |
probably damaging |
Het |
| Tnp2 |
A |
G |
16: 10,606,372 (GRCm39) |
C32R |
possibly damaging |
Het |
| Trpm6 |
A |
T |
19: 18,831,332 (GRCm39) |
Q1399L |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,677,015 (GRCm39) |
E11074* |
probably null |
Het |
| Ubash3b |
G |
A |
9: 40,954,781 (GRCm39) |
A243V |
probably benign |
Het |
| Vash1 |
G |
A |
12: 86,726,952 (GRCm39) |
R64Q |
possibly damaging |
Het |
| Vmn1r167 |
T |
A |
7: 23,204,981 (GRCm39) |
M12L |
possibly damaging |
Het |
| Vmn2r111 |
T |
A |
17: 22,767,562 (GRCm39) |
H645L |
probably benign |
Het |
| Vmn2r75 |
A |
T |
7: 85,797,722 (GRCm39) |
I697K |
probably damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACCAGCATGCTGAAAGTTAG -3'
(R):5'- TTGAACATCCCAACCAGGTC -3'
Sequencing Primer
(F):5'- GCTTCATTGAATCTGTCAGGAAG -3'
(R):5'- AGGTCACCTGCATCCTGC -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation