Incidental Mutation 'R8412:Taok3'
ID 652733
Institutional Source Beutler Lab
Gene Symbol Taok3
Ensembl Gene ENSMUSG00000061288
Gene Name TAO kinase 3
Synonyms 2900006A08Rik, A430105I05Rik
MMRRC Submission 067816-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8412 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 117258194-117413284 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117404102 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 759 (D759G)
Ref Sequence ENSEMBL: ENSMUSP00000107609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092889] [ENSMUST00000111975] [ENSMUST00000111978] [ENSMUST00000179276]
AlphaFold Q8BYC6
Predicted Effect possibly damaging
Transcript: ENSMUST00000092889
AA Change: D759G

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000090565
Gene: ENSMUSG00000061288
AA Change: D759G

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000111975
AA Change: D299G

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000107606
Gene: ENSMUSG00000061288
AA Change: D299G

DomainStartEndE-ValueType
coiled coil region 1 35 N/A INTRINSIC
low complexity region 60 72 N/A INTRINSIC
low complexity region 92 106 N/A INTRINSIC
coiled coil region 158 189 N/A INTRINSIC
coiled coil region 329 409 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000111978
AA Change: D759G

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000107609
Gene: ENSMUSG00000061288
AA Change: D759G

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000179276
AA Change: D759G

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000136750
Gene: ENSMUSG00000061288
AA Change: D759G

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700056E22Rik T A 1: 183,765,356 (GRCm39) R234S probably damaging Het
Ace T A 11: 105,870,092 (GRCm39) F806Y probably benign Het
Ak8 A G 2: 28,629,643 (GRCm39) T286A probably benign Het
Apba2 T A 7: 64,395,546 (GRCm39) F674Y probably damaging Het
Apob A G 12: 8,058,069 (GRCm39) I2184V probably benign Het
Arhgap23 C T 11: 97,356,854 (GRCm39) P884L probably benign Het
Atg2a T C 19: 6,294,554 (GRCm39) L90P probably damaging Het
Bhmt2 T A 13: 93,798,820 (GRCm39) I334F possibly damaging Het
Bmi1 C T 2: 18,689,114 (GRCm39) T266I probably damaging Het
Cdh26 A G 2: 178,104,517 (GRCm39) I301V probably damaging Het
Cenpx A T 11: 120,602,558 (GRCm39) H68Q unknown Het
Cnot10 T C 9: 114,439,738 (GRCm39) R524G probably benign Het
Cnpy1 A T 5: 28,414,206 (GRCm39) Y22* probably null Het
Csmd3 C T 15: 47,499,794 (GRCm39) R2114H Het
Defa29 T A 8: 21,816,062 (GRCm39) T102S probably benign Het
Fras1 T C 5: 96,744,711 (GRCm39) I582T probably benign Het
Gm14295 G A 2: 176,501,422 (GRCm39) C304Y probably damaging Het
Gucy2d T C 7: 98,093,046 (GRCm39) V141A possibly damaging Het
Ifi47 A C 11: 48,986,425 (GRCm39) Q64P probably damaging Het
Irx3 G T 8: 92,527,028 (GRCm39) S225R possibly damaging Het
Itpr1 A G 6: 108,340,581 (GRCm39) H289R probably benign Het
Lamc3 A G 2: 31,802,128 (GRCm39) D512G probably damaging Het
Mcm3 C T 1: 20,886,980 (GRCm39) V142I probably benign Het
Med23 C A 10: 24,784,632 (GRCm39) F1200L probably benign Het
Ndst4 A T 3: 125,364,439 (GRCm39) D372V possibly damaging Het
Nob1 T A 8: 108,148,230 (GRCm39) K71* probably null Het
Ntrk3 A G 7: 78,005,897 (GRCm39) I488T probably benign Het
Pds5b G T 5: 150,643,424 (GRCm39) C82F probably damaging Het
Pkd1l3 T A 8: 110,360,022 (GRCm39) V969E possibly damaging Het
Ppme1 A T 7: 99,984,298 (GRCm39) N307K probably benign Het
Pus7l C T 15: 94,425,856 (GRCm39) C515Y probably benign Het
Rpp21 T A 17: 36,568,591 (GRCm39) H22L possibly damaging Het
Scamp3 T C 3: 89,088,525 (GRCm39) F244L probably damaging Het
Scgb1b7 A T 7: 31,412,379 (GRCm39) K52* probably null Het
Slc12a3 T C 8: 95,060,695 (GRCm39) I261T probably damaging Het
Slc19a3 C T 1: 82,992,533 (GRCm39) R396H probably damaging Het
Slc22a14 T C 9: 119,009,922 (GRCm39) I58V probably benign Het
Slc9a9 A C 9: 95,111,092 (GRCm39) T637P probably damaging Het
Snrnp40 T A 4: 130,278,316 (GRCm39) C274S possibly damaging Het
Sptbn1 A G 11: 30,088,457 (GRCm39) V905A probably damaging Het
Tas1r1 T C 4: 152,117,033 (GRCm39) I200M probably benign Het
Tnfrsf25 T C 4: 152,204,139 (GRCm39) V360A possibly damaging Het
Trim12a A T 7: 103,953,544 (GRCm39) M189K possibly damaging Het
Tspan32 T C 7: 142,559,695 (GRCm39) F41L probably benign Het
Tube1 T A 10: 39,021,657 (GRCm39) S301T possibly damaging Het
Usp8 T C 2: 126,584,578 (GRCm39) S596P probably benign Het
Virma T A 4: 11,521,261 (GRCm39) probably null Het
Vmn2r58 T C 7: 41,513,722 (GRCm39) D307G probably benign Het
Zeb2 T C 2: 44,888,964 (GRCm39) K327R probably damaging Het
Zfp54 C T 17: 21,654,910 (GRCm39) T468M probably benign Het
Zfp780b A T 7: 27,662,551 (GRCm39) I668N possibly damaging Het
Other mutations in Taok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Taok3 APN 5 117,410,262 (GRCm39) missense probably benign 0.20
IGL01632:Taok3 APN 5 117,403,993 (GRCm39) missense possibly damaging 0.95
IGL02894:Taok3 APN 5 117,401,678 (GRCm39) missense probably benign 0.19
bonze UTSW 5 117,410,294 (GRCm39) nonsense probably null
daoist UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
haller UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Perseveration UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
taoist UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Three_treasures UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
PIT4366001:Taok3 UTSW 5 117,366,050 (GRCm39) missense probably benign 0.21
R0046:Taok3 UTSW 5 117,410,294 (GRCm39) nonsense probably null
R0046:Taok3 UTSW 5 117,410,294 (GRCm39) nonsense probably null
R0158:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
R0245:Taok3 UTSW 5 117,390,744 (GRCm39) splice site probably benign
R0371:Taok3 UTSW 5 117,344,752 (GRCm39) nonsense probably null
R1140:Taok3 UTSW 5 117,366,118 (GRCm39) missense possibly damaging 0.94
R1302:Taok3 UTSW 5 117,337,108 (GRCm39) missense possibly damaging 0.46
R1376:Taok3 UTSW 5 117,404,026 (GRCm39) missense probably damaging 1.00
R1376:Taok3 UTSW 5 117,404,026 (GRCm39) missense probably damaging 1.00
R1387:Taok3 UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
R1711:Taok3 UTSW 5 117,393,991 (GRCm39) missense possibly damaging 0.68
R1977:Taok3 UTSW 5 117,403,989 (GRCm39) missense probably damaging 0.98
R2898:Taok3 UTSW 5 117,338,134 (GRCm39) critical splice acceptor site probably null
R3824:Taok3 UTSW 5 117,394,002 (GRCm39) missense probably benign 0.01
R4378:Taok3 UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
R4695:Taok3 UTSW 5 117,366,131 (GRCm39) missense probably benign 0.11
R4882:Taok3 UTSW 5 117,390,695 (GRCm39) missense probably damaging 0.99
R5286:Taok3 UTSW 5 117,404,140 (GRCm39) missense probably damaging 1.00
R5522:Taok3 UTSW 5 117,411,822 (GRCm39) missense probably benign 0.00
R5562:Taok3 UTSW 5 117,389,029 (GRCm39) missense probably damaging 1.00
R5643:Taok3 UTSW 5 117,344,785 (GRCm39) missense probably benign
R6241:Taok3 UTSW 5 117,410,262 (GRCm39) missense probably benign 0.33
R6290:Taok3 UTSW 5 117,342,433 (GRCm39) missense probably damaging 1.00
R6310:Taok3 UTSW 5 117,394,003 (GRCm39) missense possibly damaging 0.48
R6339:Taok3 UTSW 5 117,366,095 (GRCm39) missense probably benign
R6717:Taok3 UTSW 5 117,379,015 (GRCm39) intron probably benign
R6721:Taok3 UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
R6755:Taok3 UTSW 5 117,344,732 (GRCm39) missense probably damaging 1.00
R7046:Taok3 UTSW 5 117,411,771 (GRCm39) missense probably damaging 1.00
R7053:Taok3 UTSW 5 117,390,627 (GRCm39) missense probably benign 0.00
R7259:Taok3 UTSW 5 117,390,608 (GRCm39) missense probably benign 0.00
R7308:Taok3 UTSW 5 117,338,216 (GRCm39) nonsense probably null
R7439:Taok3 UTSW 5 117,388,974 (GRCm39) missense probably damaging 0.99
R7732:Taok3 UTSW 5 117,331,813 (GRCm39) missense possibly damaging 0.53
R7758:Taok3 UTSW 5 117,388,972 (GRCm39) missense probably damaging 1.00
R7939:Taok3 UTSW 5 117,331,902 (GRCm39) missense probably benign 0.01
R8485:Taok3 UTSW 5 117,389,142 (GRCm39) missense possibly damaging 0.54
R8989:Taok3 UTSW 5 117,379,227 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,379,245 (GRCm39) missense possibly damaging 0.70
R9135:Taok3 UTSW 5 117,379,168 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,344,744 (GRCm39) missense probably damaging 1.00
R9182:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CTTGACTGTGTCGTATGACCC -3'
(R):5'- TACATCCCAGAGGTGTGTGG -3'

Sequencing Primer
(F):5'- GGCCCTCATGCATACTGACTCAG -3'
(R):5'- CCAGAGGTGTGTGGGGATG -3'
Posted On 2020-10-20