Incidental Mutation 'R8414:Zc3h12d'
ID 652844
Institutional Source Beutler Lab
Gene Symbol Zc3h12d
Ensembl Gene ENSMUSG00000039981
Gene Name zinc finger CCCH type containing 12D
Synonyms TFL, D730019B10Rik
MMRRC Submission 067768-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R8414 (G1)
Quality Score 217.468
Status Not validated
Chromosome 10
Chromosomal Location 7708234-7746160 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) GCCC to GCC at 7715735 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000040217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039484]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000039484
SMART Domains Protein: ENSMUSP00000040217
Gene: ENSMUSG00000039981

DomainStartEndE-ValueType
Pfam:RNase_Zc3h12a 91 247 4e-67 PFAM
low complexity region 333 345 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit disrupted regulation of excessive inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA467197 T C 2: 122,480,237 (GRCm39) Y33H probably damaging Het
Abcc10 T C 17: 46,623,273 (GRCm39) R880G probably benign Het
Abcg2 T A 6: 58,646,221 (GRCm39) Y246N probably benign Het
Abhd18 A G 3: 40,888,061 (GRCm39) M302V probably benign Het
Ablim2 A G 5: 36,032,235 (GRCm39) D568G possibly damaging Het
Alpk2 T C 18: 65,440,542 (GRCm39) R284G possibly damaging Het
AU021092 T C 16: 5,034,649 (GRCm39) Y191C probably damaging Het
Bdp1 T A 13: 100,200,985 (GRCm39) T751S probably benign Het
Brme1 A T 8: 84,893,952 (GRCm39) E373V probably damaging Het
Ccdc136 A G 6: 29,412,929 (GRCm39) E438G probably damaging Het
Cul2 C A 18: 3,399,912 (GRCm39) N15K probably benign Het
Eml2 C A 7: 18,913,220 (GRCm39) Q73K probably damaging Het
Epha6 C A 16: 59,826,030 (GRCm39) R588S probably damaging Het
Eppk1 C T 15: 75,994,319 (GRCm39) R854Q probably benign Het
Fbxw28 C T 9: 109,155,604 (GRCm39) W389* probably null Het
Fcgbpl1 T A 7: 27,842,158 (GRCm39) C698S probably damaging Het
Gbp4 A T 5: 105,284,703 (GRCm39) V62E probably benign Het
Gtf2h1 C A 7: 46,464,768 (GRCm39) T401K possibly damaging Het
Hif1a G T 12: 73,984,428 (GRCm39) M294I probably benign Het
Irak2 A G 6: 113,663,903 (GRCm39) N484S probably benign Het
Kcnj16 A G 11: 110,916,441 (GRCm39) T368A probably benign Het
Kcnq1 G A 7: 142,917,403 (GRCm39) G588D probably damaging Het
Kcnq5 G A 1: 21,549,648 (GRCm39) R360C probably damaging Het
Nckap5 T G 1: 125,942,357 (GRCm39) E1582D probably damaging Het
Nrip3 A G 7: 109,362,735 (GRCm39) I183T possibly damaging Het
Or10g9 T A 9: 39,912,241 (GRCm39) H94L probably benign Het
Or4c117 A G 2: 88,956,058 (GRCm39) F6L probably benign Het
Pcdha2 C T 18: 37,074,619 (GRCm39) S750L probably damaging Het
Pik3r2 T C 8: 71,223,079 (GRCm39) Y447C probably damaging Het
Poteg T C 8: 27,938,068 (GRCm39) Y75H probably benign Het
Proser1 G C 3: 53,385,977 (GRCm39) G620R probably damaging Het
Prpsap1 A T 11: 116,369,439 (GRCm39) L164H probably damaging Het
Rfc3 A T 5: 151,568,381 (GRCm39) V195E possibly damaging Het
Sarm1 A T 11: 78,378,794 (GRCm39) V417D probably damaging Het
She A G 3: 89,739,174 (GRCm39) T122A probably benign Het
Spata31e1 A G 13: 49,941,273 (GRCm39) S56P probably damaging Het
Srpra A G 9: 35,126,133 (GRCm39) E442G probably benign Het
Sult2a6 T A 7: 13,984,357 (GRCm39) R124S probably damaging Het
Synm T C 7: 67,383,511 (GRCm39) T1384A probably benign Het
Tenm3 A G 8: 48,746,544 (GRCm39) V1087A probably damaging Het
Ticam1 T A 17: 56,578,340 (GRCm39) I252L probably benign Het
Trbv31 C A 6: 41,534,697 (GRCm39) D89Y possibly damaging Het
Trpc7 G A 13: 56,970,282 (GRCm39) T434I probably benign Het
Tubgcp4 T A 2: 121,024,634 (GRCm39) I603N probably benign Het
Ugt3a1 A G 15: 9,310,669 (GRCm39) N317S possibly damaging Het
Vdac1 C T 11: 52,267,330 (GRCm39) T77I possibly damaging Het
Vmn2r113 A T 17: 23,177,753 (GRCm39) R846* probably null Het
Zranb2 G T 3: 157,252,312 (GRCm39) R310S unknown Het
Other mutations in Zc3h12d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Zc3h12d APN 10 7,738,231 (GRCm39) missense probably damaging 1.00
IGL01013:Zc3h12d APN 10 7,715,720 (GRCm39) missense probably damaging 1.00
IGL02090:Zc3h12d APN 10 7,743,096 (GRCm39) missense probably benign 0.00
IGL02876:Zc3h12d APN 10 7,738,364 (GRCm39) missense probably damaging 0.99
R0040:Zc3h12d UTSW 10 7,743,678 (GRCm39) missense probably benign 0.02
R0040:Zc3h12d UTSW 10 7,743,678 (GRCm39) missense probably benign 0.02
R0242:Zc3h12d UTSW 10 7,738,330 (GRCm39) missense probably damaging 1.00
R0242:Zc3h12d UTSW 10 7,738,330 (GRCm39) missense probably damaging 1.00
R1942:Zc3h12d UTSW 10 7,729,077 (GRCm39) missense probably damaging 1.00
R2290:Zc3h12d UTSW 10 7,743,223 (GRCm39) missense probably benign 0.00
R2354:Zc3h12d UTSW 10 7,743,702 (GRCm39) missense probably benign 0.00
R4816:Zc3h12d UTSW 10 7,743,711 (GRCm39) missense probably damaging 1.00
R4932:Zc3h12d UTSW 10 7,729,014 (GRCm39) missense probably damaging 0.99
R5191:Zc3h12d UTSW 10 7,743,582 (GRCm39) missense possibly damaging 0.51
R5384:Zc3h12d UTSW 10 7,729,014 (GRCm39) missense probably damaging 1.00
R5396:Zc3h12d UTSW 10 7,742,090 (GRCm39) missense probably damaging 1.00
R6409:Zc3h12d UTSW 10 7,743,082 (GRCm39) missense probably benign 0.04
R6877:Zc3h12d UTSW 10 7,715,735 (GRCm39) missense probably damaging 0.99
R6903:Zc3h12d UTSW 10 7,743,425 (GRCm39) missense probably benign
R6967:Zc3h12d UTSW 10 7,715,644 (GRCm39) missense probably damaging 1.00
R7312:Zc3h12d UTSW 10 7,743,345 (GRCm39) missense probably benign 0.00
R7594:Zc3h12d UTSW 10 7,738,382 (GRCm39) missense probably damaging 1.00
R7622:Zc3h12d UTSW 10 7,743,033 (GRCm39) missense probably damaging 1.00
R7645:Zc3h12d UTSW 10 7,743,340 (GRCm39) missense probably benign
R7769:Zc3h12d UTSW 10 7,743,390 (GRCm39) missense probably benign 0.03
R7864:Zc3h12d UTSW 10 7,715,723 (GRCm39) missense possibly damaging 0.83
R8371:Zc3h12d UTSW 10 7,715,735 (GRCm39) frame shift probably null
R9255:Zc3h12d UTSW 10 7,729,022 (GRCm39) missense probably damaging 1.00
R9470:Zc3h12d UTSW 10 7,743,321 (GRCm39) missense possibly damaging 0.73
Z1177:Zc3h12d UTSW 10 7,743,572 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTGCCAGGAGGAAGCTTG -3'
(R):5'- CCCAGCGCTCAGTAATAAGATG -3'

Sequencing Primer
(F):5'- AAGCTTGGGGCAGGAGC -3'
(R):5'- CTACCTCATAGCCACATTGCTG -3'
Posted On 2020-10-20