Incidental Mutation 'R8416:Or2t29'
ID 652956
Institutional Source Beutler Lab
Gene Symbol Or2t29
Ensembl Gene ENSMUSG00000064252
Gene Name olfactory receptor family 2 subfamily T member 29
Synonyms GA_x6K02T2NKPP-882068-883006, Olfr329-ps, MOR275-6P, Olfr329
MMRRC Submission 067770-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R8416 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58433273-58434309 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58433778 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 188 (S188T)
Ref Sequence ENSEMBL: ENSMUSP00000104450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108822] [ENSMUST00000108823] [ENSMUST00000219448]
AlphaFold M9MMK4
Predicted Effect possibly damaging
Transcript: ENSMUST00000108822
AA Change: S188T

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000104450
Gene: ENSMUSG00000064252
AA Change: S188T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.6e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108823
AA Change: S175T

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000104451
Gene: ENSMUSG00000064252
AA Change: S175T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.4e-35 PFAM
Pfam:7tm_4 137 281 5.8e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219448
AA Change: S175T

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 A G 16: 20,369,023 (GRCm39) N173S probably benign Het
Agps A G 2: 75,684,547 (GRCm39) I172V probably benign Het
Amz1 G A 5: 140,737,731 (GRCm39) W330* probably null Het
Asap1 A T 15: 64,002,072 (GRCm39) M413K possibly damaging Het
Bhmt1b T C 18: 87,774,687 (GRCm39) V70A probably damaging Het
Ccdc83 A T 7: 89,885,513 (GRCm39) W291R unknown Het
Cdh19 A T 1: 110,853,610 (GRCm39) M277K probably benign Het
Clca3a1 C A 3: 144,460,914 (GRCm39) probably null Het
Cnpy1 T C 5: 28,408,423 (GRCm39) T138A probably benign Het
Csnka2ip T C 16: 64,300,295 (GRCm39) D23G Het
Cxcr5 A T 9: 44,425,583 (GRCm39) F25I probably benign Het
Defb33 T A 8: 21,387,651 (GRCm39) *63R probably null Het
Dgkz A T 2: 91,770,649 (GRCm39) S485T possibly damaging Het
Elac1 A G 18: 73,871,927 (GRCm39) I356T probably damaging Het
Fam135a C T 1: 24,067,675 (GRCm39) D1065N probably benign Het
Fbxo10 T A 4: 45,058,942 (GRCm39) D265V possibly damaging Het
Flrt2 A G 12: 95,746,331 (GRCm39) E223G probably benign Het
Gjc2 A T 11: 59,068,334 (GRCm39) D49E probably damaging Het
Hmcn2 C A 2: 31,281,088 (GRCm39) L1867I probably benign Het
Irf2 A T 8: 47,271,887 (GRCm39) Y158F probably benign Het
Jmy T C 13: 93,634,949 (GRCm39) D289G probably damaging Het
Krt1 AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC 15: 101,758,813 (GRCm39) probably benign Het
Limch1 T G 5: 67,156,649 (GRCm39) I372S probably benign Het
Lsm11 A T 11: 45,824,730 (GRCm39) W266R probably benign Het
Mboat2 G A 12: 24,984,609 (GRCm39) E147K probably damaging Het
Mctp2 T C 7: 71,852,210 (GRCm39) I439V probably benign Het
Npc2 A G 12: 84,812,131 (GRCm39) V37A probably damaging Het
Or5b119 A T 19: 13,456,764 (GRCm39) M266K possibly damaging Het
Parp4 T C 14: 56,825,271 (GRCm39) probably null Het
Pcdhga2 A T 18: 37,803,178 (GRCm39) N341Y probably damaging Het
Pde1b G A 15: 103,423,745 (GRCm39) probably benign Het
Pde1c C T 6: 56,128,276 (GRCm39) probably null Het
Plce1 G A 19: 38,761,441 (GRCm39) V2098I possibly damaging Het
Pou2f2 G T 7: 24,815,551 (GRCm39) S72* probably null Het
Ptpru C T 4: 131,535,783 (GRCm39) R398H probably damaging Het
Rps15 A G 10: 80,128,624 (GRCm39) K7E probably benign Het
Rtn4rl2 C T 2: 84,702,951 (GRCm39) G207D probably damaging Het
Scn2a A C 2: 65,511,345 (GRCm39) L130F probably benign Het
Sh3tc1 G A 5: 35,868,256 (GRCm39) R403W probably damaging Het
Slc7a9 A G 7: 35,152,858 (GRCm39) K92R probably benign Het
Slit3 A T 11: 35,399,062 (GRCm39) E142D probably benign Het
Srpk1 A G 17: 28,813,229 (GRCm39) I505T probably damaging Het
Sult1c2 A T 17: 54,269,580 (GRCm39) I216K probably benign Het
Susd6 T A 12: 80,897,997 (GRCm39) M44K probably benign Het
Thoc5 T A 11: 4,876,068 (GRCm39) V607E probably benign Het
Tiparp A G 3: 65,438,767 (GRCm39) R28G probably benign Het
Tln1 C T 4: 43,540,116 (GRCm39) V1498I probably benign Het
Tmprss11c T G 5: 86,387,276 (GRCm39) Q214P probably damaging Het
Uck1 C A 2: 32,150,153 (GRCm39) probably benign Het
Wdr11 G A 7: 129,232,403 (GRCm39) S937N possibly damaging Het
Zdhhc23 A T 16: 43,791,927 (GRCm39) I282K probably damaging Het
Zfp488 A G 14: 33,693,052 (GRCm39) M37T probably benign Het
Zmpste24 T C 4: 120,940,556 (GRCm39) S142G probably benign Het
Other mutations in Or2t29
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Or2t29 UTSW 11 58,433,988 (GRCm39) missense possibly damaging 0.76
R2426:Or2t29 UTSW 11 58,433,920 (GRCm39) nonsense probably null
R4805:Or2t29 UTSW 11 58,433,396 (GRCm39) missense probably benign 0.03
R6498:Or2t29 UTSW 11 58,433,408 (GRCm39) missense probably damaging 1.00
R7341:Or2t29 UTSW 11 58,433,533 (GRCm39) nonsense probably null
R7768:Or2t29 UTSW 11 58,433,693 (GRCm39) missense possibly damaging 0.94
R7768:Or2t29 UTSW 11 58,433,466 (GRCm39) missense probably damaging 0.99
R7957:Or2t29 UTSW 11 58,433,624 (GRCm39) missense probably damaging 1.00
R9076:Or2t29 UTSW 11 58,433,782 (GRCm39) nonsense probably null
R9606:Or2t29 UTSW 11 58,433,753 (GRCm39) missense probably damaging 1.00
Z1186:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1187:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1188:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1189:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1190:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1191:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1192:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCTCTGCTGAGTTCATCCTGAG -3'
(R):5'- GCAGATGTTCCTCTACCTGACAC -3'

Sequencing Primer
(F):5'- CTGCTGAGTTCATCCTGAGAACAG -3'
(R):5'- CCTCTACCTGACACTAGTAGGG -3'
Posted On 2020-10-20