Incidental Mutation 'R8417:Zeb2'
| ID | 652982 |
|---|
| Institutional Source |
Beutler Lab
|
|---|
| Gene Symbol |
Zeb2
|
|---|
| Ensembl Gene |
ENSMUSG00000026872 |
|---|
| Gene Name | zinc finger E-box binding homeobox 2 |
|---|
| Synonyms | Zfhx1b, Zfx1b, SIP1, 9130203F04Rik, D130016B08Rik |
|---|
| MMRRC Submission |
|
|---|
| Accession Numbers | |
|---|
| Is this an essential gene? |
Essential (E-score: 1.000)
|
|---|
| Stock # | R8417 (G1)
|
|---|
| Quality Score | 225.009 |
|---|
| Status |
Not validated
|
|---|
| Chromosome | 2 |
|---|
| Chromosomal Location | 44983632-45117395 bp(-) (GRCm38) |
|---|
| Type of Mutation | missense |
|---|
| DNA Base Change (assembly) |
C to T
at 45022996 bp
|
|---|
| Zygosity | Heterozygous |
|---|
| Amino Acid Change |
Serine to Asparagine
at position 105
(S105N)
|
|---|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028229
(fasta)
|
|---|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028229]
[ENSMUST00000068415]
[ENSMUST00000076836]
[ENSMUST00000127520]
[ENSMUST00000176438]
[ENSMUST00000176732]
[ENSMUST00000177302]
[ENSMUST00000200844]
[ENSMUST00000201211]
[ENSMUST00000201490]
[ENSMUST00000201623]
[ENSMUST00000201804]
[ENSMUST00000201969]
[ENSMUST00000202187]
[ENSMUST00000202935]
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028229
AA Change: S105N
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000028229
Gene: ENSMUSG00000026872
AA Change: S105N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
|
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
|
HOX
|
644 |
706 |
2.05e-3 |
SMART |
|
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
|
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000068415
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000069685
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
|
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
|
HOX
|
644 |
706 |
2.05e-3 |
SMART |
|
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
|
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076836
AA Change: S61N
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000076111
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
210 |
233 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
240 |
262 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
281 |
303 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
309 |
329 |
1.86e1 |
SMART |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
580 |
600 |
5.54e1 |
SMART |
|
HOX
|
643 |
705 |
2.05e-3 |
SMART |
|
low complexity region
|
777 |
807 |
N/A |
INTRINSIC |
|
low complexity region
|
840 |
855 |
N/A |
INTRINSIC |
|
low complexity region
|
869 |
880 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
998 |
1020 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
1026 |
1048 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1054 |
1075 |
1.89e-1 |
SMART |
|
low complexity region
|
1082 |
1096 |
N/A |
INTRINSIC |
|
low complexity region
|
1133 |
1149 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1167 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000127520
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176438
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000134849
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
|
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
|
HOX
|
644 |
706 |
2.05e-3 |
SMART |
|
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
|
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176732
AA Change: S61N
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000135393
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
26 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
60 |
83 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
90 |
112 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
4.87e-4 |
SMART |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177302
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000134747
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
|
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
|
HOX
|
644 |
706 |
2.05e-3 |
SMART |
|
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
|
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200844
AA Change: S61N
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144421
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
187 |
210 |
9.2e-6 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
4.2e-7 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
2e-6 |
SMART |
|
ZnF_C2H2
|
286 |
306 |
8e-2 |
SMART |
|
low complexity region
|
328 |
340 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
557 |
577 |
2.4e-1 |
SMART |
|
HOX
|
620 |
682 |
1.1e-5 |
SMART |
|
low complexity region
|
754 |
784 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
975 |
997 |
1.9e-5 |
SMART |
|
ZnF_C2H2
|
1003 |
1025 |
9.6e-4 |
SMART |
|
ZnF_C2H2
|
1031 |
1052 |
7.9e-4 |
SMART |
|
low complexity region
|
1059 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1126 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1144 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201211
AA Change: S61N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144406
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201490
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201623
AA Change: S61N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144075
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
187 |
210 |
9.2e-6 |
SMART |
|
|---|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000201804
AA Change: S90N
PolyPhen 2
Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144637
Gene: ENSMUSG00000026872
AA Change: S90N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
107 |
119 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
240 |
263 |
9.2e-6 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
4.2e-7 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
2e-6 |
SMART |
|
ZnF_C2H2
|
339 |
359 |
8e-2 |
SMART |
|
low complexity region
|
381 |
393 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
610 |
630 |
2.4e-1 |
SMART |
|
HOX
|
673 |
731 |
1.2e-3 |
SMART |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201969
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144141
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202187
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000144552
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
|---|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202432
|
|---|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202935
AA Change: S61N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
|---|
| SMART Domains |
Protein: ENSMUSP00000143841
Gene: ENSMUSG00000026872
AA Change: S61N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
|---|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
|---|
| Validation Efficiency |
|
|---|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
PHENOTYPE: Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5. [provided by MGI curators]
|
|---|
| Allele List at MGI | |
|---|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AB124611 |
T |
C |
9: 21,529,085 |
|
probably null |
Het |
| Adamtsl1 |
G |
A |
4: 86,156,689 |
D98N |
possibly damaging |
Het |
| Adgrb3 |
T |
C |
1: 25,488,053 |
T601A |
probably benign |
Het |
| Ankrd33 |
C |
A |
15: 101,119,449 |
Q248K |
probably benign |
Het |
| Bsn |
G |
A |
9: 108,111,452 |
A2367V |
probably benign |
Het |
| Casp12 |
G |
T |
9: 5,352,263 |
C155F |
probably benign |
Het |
| Clpp |
T |
C |
17: 56,990,661 |
V81A |
probably benign |
Het |
| Cyp3a59 |
A |
T |
5: 146,090,685 |
I89F |
possibly damaging |
Het |
| Fam227b |
C |
A |
2: 126,121,062 |
W178L |
probably damaging |
Het |
| Fcna |
C |
A |
2: 25,624,851 |
R332L |
probably damaging |
Het |
| Gdf3 |
T |
G |
6: 122,606,607 |
H267P |
probably damaging |
Het |
| Gm4450 |
G |
A |
3: 98,456,415 |
T38I |
probably benign |
Het |
| Gm5592 |
A |
G |
7: 41,288,551 |
D419G |
probably benign |
Het |
| Gm6882 |
A |
G |
7: 21,427,295 |
V216A |
probably damaging |
Het |
| Gsdma3 |
A |
G |
11: 98,629,777 |
N78S |
probably benign |
Het |
| Hydin |
T |
C |
8: 110,569,392 |
I3579T |
probably benign |
Het |
| Ighmbp2 |
T |
C |
19: 3,261,590 |
I942V |
probably damaging |
Het |
| Lamc1 |
A |
G |
1: 153,230,769 |
Y1266H |
probably damaging |
Het |
| Lgi3 |
T |
C |
14: 70,534,806 |
Y264H |
probably benign |
Het |
| Lmod2 |
G |
A |
6: 24,603,385 |
E120K |
possibly damaging |
Het |
| Mbl2 |
G |
T |
19: 30,239,484 |
C232F |
probably damaging |
Het |
| Morc1 |
T |
C |
16: 48,460,740 |
V214A |
probably damaging |
Het |
| Nlrp4b |
T |
A |
7: 10,725,953 |
C827* |
probably null |
Het |
| Olfr1086 |
A |
G |
2: 86,676,805 |
F176S |
probably damaging |
Het |
| Olfr358 |
T |
A |
2: 37,004,646 |
T323S |
probably benign |
Het |
| Pbrm1 |
T |
A |
14: 31,027,462 |
H72Q |
possibly damaging |
Het |
| Plekhm2 |
T |
C |
4: 141,627,825 |
I944V |
probably benign |
Het |
| Prdm8 |
A |
T |
5: 98,184,531 |
D97V |
probably damaging |
Het |
| Preb |
G |
A |
5: 30,960,117 |
|
probably benign |
Het |
| Prkcd |
T |
C |
14: 30,609,251 |
K56E |
probably benign |
Het |
| Slit3 |
A |
T |
11: 35,610,611 |
I391F |
probably damaging |
Het |
| Spata19 |
A |
G |
9: 27,397,970 |
S91G |
probably benign |
Het |
| Stag3 |
A |
G |
5: 138,308,588 |
T1134A |
probably benign |
Het |
| Tgfbr2 |
A |
T |
9: 116,110,129 |
M235K |
probably benign |
Het |
| Tmtc2 |
A |
T |
10: 105,413,236 |
I212N |
probably damaging |
Het |
| Tnfrsf26 |
C |
T |
7: 143,614,902 |
R133K |
probably benign |
Het |
| Trim43c |
C |
A |
9: 88,843,138 |
Q238K |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,688,743 |
D2894G |
probably benign |
Het |
| Wisp3 |
T |
A |
10: 39,151,211 |
R342* |
probably null |
Het |
|
|---|
| Other mutations in Zeb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00900:Zeb2
|
APN |
2 |
44997275 |
missense |
probably damaging |
1.00 |
|
IGL01639:Zeb2
|
APN |
2 |
44997257 |
missense |
probably benign |
|
|
IGL02016:Zeb2
|
APN |
2 |
44988874 |
missense |
possibly damaging |
0.71 |
|
IGL02337:Zeb2
|
APN |
2 |
44997230 |
missense |
probably damaging |
0.96 |
|
IGL02745:Zeb2
|
APN |
2 |
44994475 |
unclassified |
probably benign |
|
|
IGL02893:Zeb2
|
APN |
2 |
44996607 |
missense |
probably benign |
0.03 |
|
IGL03412:Zeb2
|
APN |
2 |
45002708 |
intron |
probably benign |
|
|
Dropped
|
UTSW |
2 |
45110041 |
missense |
possibly damaging |
0.66 |
|
Okapi
|
UTSW |
2 |
44997156 |
missense |
probably damaging |
1.00 |
|
sable
|
UTSW |
2 |
44997318 |
missense |
probably damaging |
1.00 |
|
R0514:Zeb2
|
UTSW |
2 |
45002647 |
missense |
possibly damaging |
0.52 |
|
R0603:Zeb2
|
UTSW |
2 |
45017426 |
missense |
probably benign |
0.45 |
|
R0608:Zeb2
|
UTSW |
2 |
44996126 |
missense |
possibly damaging |
0.87 |
|
R1236:Zeb2
|
UTSW |
2 |
44994646 |
missense |
probably damaging |
1.00 |
|
R1529:Zeb2
|
UTSW |
2 |
44997194 |
missense |
probably damaging |
1.00 |
|
R1581:Zeb2
|
UTSW |
2 |
44997000 |
missense |
probably damaging |
0.99 |
|
R1636:Zeb2
|
UTSW |
2 |
45002611 |
missense |
probably damaging |
1.00 |
|
R1924:Zeb2
|
UTSW |
2 |
45002612 |
missense |
probably damaging |
1.00 |
|
R2012:Zeb2
|
UTSW |
2 |
44997950 |
missense |
probably damaging |
1.00 |
|
R2097:Zeb2
|
UTSW |
2 |
44997156 |
missense |
probably damaging |
1.00 |
|
R2156:Zeb2
|
UTSW |
2 |
44988809 |
missense |
probably benign |
0.20 |
|
R4385:Zeb2
|
UTSW |
2 |
45023062 |
missense |
probably damaging |
1.00 |
|
R4472:Zeb2
|
UTSW |
2 |
45023011 |
missense |
probably damaging |
1.00 |
|
R4678:Zeb2
|
UTSW |
2 |
44996341 |
missense |
probably damaging |
0.99 |
|
R4769:Zeb2
|
UTSW |
2 |
44996435 |
missense |
probably damaging |
1.00 |
|
R4816:Zeb2
|
UTSW |
2 |
44997768 |
missense |
probably damaging |
0.99 |
|
R4918:Zeb2
|
UTSW |
2 |
44996882 |
missense |
probably damaging |
1.00 |
|
R4969:Zeb2
|
UTSW |
2 |
44998919 |
missense |
probably damaging |
1.00 |
|
R5191:Zeb2
|
UTSW |
2 |
45002600 |
missense |
probably benign |
0.00 |
|
R5195:Zeb2
|
UTSW |
2 |
45001635 |
missense |
probably damaging |
1.00 |
|
R5322:Zeb2
|
UTSW |
2 |
44997095 |
missense |
probably damaging |
1.00 |
|
R5699:Zeb2
|
UTSW |
2 |
44997788 |
missense |
probably damaging |
1.00 |
|
R5750:Zeb2
|
UTSW |
2 |
44997518 |
missense |
probably damaging |
0.96 |
|
R5764:Zeb2
|
UTSW |
2 |
44996919 |
missense |
possibly damaging |
0.89 |
|
R5914:Zeb2
|
UTSW |
2 |
44997052 |
missense |
probably benign |
0.00 |
|
R5918:Zeb2
|
UTSW |
2 |
45111259 |
intron |
probably benign |
|
|
R6037:Zeb2
|
UTSW |
2 |
44988640 |
nonsense |
probably null |
|
|
R6037:Zeb2
|
UTSW |
2 |
44988640 |
nonsense |
probably null |
|
|
R6302:Zeb2
|
UTSW |
2 |
44997759 |
missense |
probably benign |
0.18 |
|
R6372:Zeb2
|
UTSW |
2 |
45002539 |
missense |
probably damaging |
1.00 |
|
R6402:Zeb2
|
UTSW |
2 |
44996975 |
missense |
probably damaging |
1.00 |
|
R6492:Zeb2
|
UTSW |
2 |
45110496 |
intron |
probably benign |
|
|
R6554:Zeb2
|
UTSW |
2 |
44997512 |
missense |
probably damaging |
1.00 |
|
R6675:Zeb2
|
UTSW |
2 |
44997445 |
nonsense |
probably null |
|
|
R6735:Zeb2
|
UTSW |
2 |
45110016 |
missense |
probably null |
0.99 |
|
R6870:Zeb2
|
UTSW |
2 |
44988910 |
missense |
probably damaging |
0.98 |
|
R6925:Zeb2
|
UTSW |
2 |
44994529 |
missense |
probably damaging |
1.00 |
|
R6963:Zeb2
|
UTSW |
2 |
44988799 |
missense |
probably damaging |
0.97 |
|
R6972:Zeb2
|
UTSW |
2 |
44997318 |
missense |
probably damaging |
1.00 |
|
R7144:Zeb2
|
UTSW |
2 |
45110041 |
missense |
possibly damaging |
0.66 |
|
R7178:Zeb2
|
UTSW |
2 |
44996994 |
missense |
probably damaging |
0.97 |
|
R7379:Zeb2
|
UTSW |
2 |
45001817 |
splice site |
probably null |
|
|
R7419:Zeb2
|
UTSW |
2 |
44996347 |
missense |
probably benign |
0.20 |
|
R7580:Zeb2
|
UTSW |
2 |
44994532 |
missense |
probably damaging |
1.00 |
|
R7599:Zeb2
|
UTSW |
2 |
44994613 |
missense |
probably damaging |
1.00 |
|
R7625:Zeb2
|
UTSW |
2 |
45002572 |
missense |
probably damaging |
1.00 |
|
R7917:Zeb2
|
UTSW |
2 |
44996409 |
missense |
possibly damaging |
0.50 |
|
R8132:Zeb2
|
UTSW |
2 |
44989130 |
missense |
probably damaging |
1.00 |
|
R8412:Zeb2
|
UTSW |
2 |
44998952 |
missense |
probably damaging |
1.00 |
|
R8413:Zeb2
|
UTSW |
2 |
44996171 |
missense |
probably damaging |
0.99 |
|
|---|
| Predicted Primers |
PCR Primer
(F):5'- CGGACAGACAGACACTTACCTG -3'
(R):5'- TCCTGACATGGTTGAGTAATTCAG -3'
Sequencing Primer
(F):5'- TTACCTGGACCGGCTACAGAG -3'
(R):5'- CTATTCACCTGAATATGTGGGGGC -3'
|
|---|
| Posted On | 2020-10-20 |
|---|
