Mutagenetix > Incidental Mutation

Incidental Mutation 'R8418:Vmn2r29'

653038

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r29

Ensembl Gene

ENSMUSG00000095730

Gene Name

vomeronasal 2, receptor 29

Synonyms

6430701C03Rik

MMRRC Submission

067897-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R8418 (G1)

Quality Score

114.008

Status

Not validated

Chromosome

Chromosomal Location

7234326-7250327 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 7244939 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 312 (I312L)

Ref Sequence

ENSEMBL: ENSMUSP00000131990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170922] [ENSMUST00000173842] [ENSMUST00000209325] [ENSMUST00000209833] [ENSMUST00000210333]

AlphaFold

L7N2D4

Predicted Effect

probably benign
Transcript: ENSMUST00000170922
AA Change: I312L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000131990
Gene: ENSMUSG00000095730
AA Change: I312L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2e-34	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	2e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173842

Predicted Effect

probably benign
Transcript: ENSMUST00000209325

Predicted Effect

probably benign
Transcript: ENSMUST00000209833

Predicted Effect

probably benign
Transcript: ENSMUST00000210333

Predicted Effect

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

98% (48/49)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf2	T	C	17: 43,021,477 (GRCm39)	H449R	probably benign	Het
Arfgef2	T	C	2: 166,698,468 (GRCm39)	V646A	probably benign	Het
Bean1	CT	C	8: 104,908,664 (GRCm39)		probably null	Het
Ccdc62	C	T	5: 124,084,455 (GRCm39)	R279*	probably null	Het
Cimip2b	A	G	4: 43,427,204 (GRCm39)	L76P	unknown	Het
Col6a5	G	T	9: 105,755,821 (GRCm39)	P2201Q	probably damaging	Het
Cpa3	T	C	3: 20,276,315 (GRCm39)	Y306C	probably damaging	Het
Cpne9	A	G	6: 113,260,398 (GRCm39)	N82D	possibly damaging	Het
Dcaf17	T	A	2: 70,918,717 (GRCm39)	D430E	probably damaging	Het
Dcst2	T	C	3: 89,278,901 (GRCm39)	V546A	probably benign	Het
Dennd1a	T	C	2: 37,748,403 (GRCm39)	T359A	probably benign	Het
Dgkb	C	A	12: 38,380,016 (GRCm39)	H591N	probably damaging	Het
Dnah17	G	A	11: 117,994,284 (GRCm39)	S1047F	probably benign	Het
Dock2	A	G	11: 34,609,795 (GRCm39)	I215T	probably benign	Het
Efcab12	A	G	6: 115,799,076 (GRCm39)		probably null	Het
Erich3	C	T	3: 154,415,378 (GRCm39)	R165C		Het
Gabrr1	C	T	4: 33,162,615 (GRCm39)	R394*	probably null	Het
Garnl3	G	T	2: 32,942,158 (GRCm39)	Q153K	possibly damaging	Het
Gars1	A	G	6: 55,042,446 (GRCm39)	N393S	probably damaging	Het
Gbp2b	A	T	3: 142,309,466 (GRCm39)	E192D	probably benign	Het
Gm28360	A	T	1: 117,781,357 (GRCm39)	H116L	probably benign	Het
Gm9602	T	A	14: 15,935,348 (GRCm39)		probably benign	Het
Gp1bb	T	A	16: 18,440,103 (GRCm39)	H5L	unknown	Het
Grik3	A	G	4: 125,579,835 (GRCm39)	K527E	possibly damaging	Het
Hhip	T	C	8: 80,771,714 (GRCm39)	M199V	probably damaging	Het
Irgm1	A	G	11: 48,757,166 (GRCm39)	V231A	probably damaging	Het
Itgal	A	T	7: 126,929,454 (GRCm39)	I1124F	probably benign	Het
Kash5	A	G	7: 44,843,501 (GRCm39)	L241P	probably damaging	Het
Krt1	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	15: 101,758,813 (GRCm39)		probably benign	Het
Miga1	T	G	3: 151,990,954 (GRCm39)	Y433S	probably damaging	Het
Muc16	A	T	9: 18,430,926 (GRCm39)	I8062K	possibly damaging	Het
Ntsr2	T	G	12: 16,706,662 (GRCm39)	V230G	possibly damaging	Het
Or52ab2	A	G	7: 102,970,278 (GRCm39)	Y220C		Het
Ptpn2	G	A	18: 67,814,592 (GRCm39)	T139M	probably damaging	Het
Pum2	T	A	12: 8,760,245 (GRCm39)	D145E	possibly damaging	Het
Radil	T	C	5: 142,480,676 (GRCm39)	E593G	probably benign	Het
Rdh14	T	C	12: 10,444,580 (GRCm39)	F144L	probably damaging	Het
Sec23ip	T	G	7: 128,380,187 (GRCm39)	D867E	probably damaging	Het
Serpina6	T	C	12: 103,613,187 (GRCm39)	Y371C	probably damaging	Het
Snx13	T	A	12: 35,148,233 (GRCm39)	I254N	probably damaging	Het
Tacc1	T	C	8: 25,731,532 (GRCm39)	K7E	probably damaging	Het
Thoc2l	C	A	5: 104,667,724 (GRCm39)	Q749K	possibly damaging	Het
Timeless	A	C	10: 128,086,605 (GRCm39)	N1048T	probably benign	Het
Tll2	C	A	19: 41,081,276 (GRCm39)	E732D	probably damaging	Het
Tmem171	A	G	13: 98,828,740 (GRCm39)	S137P	probably damaging	Het
Ttll3	A	T	6: 113,371,734 (GRCm39)	M44L	probably benign	Het
Vmn2r43	A	T	7: 8,258,583 (GRCm39)	L210*	probably null	Het
Vmn2r60	A	G	7: 41,844,850 (GRCm39)	I738V	probably damaging	Het
Zfp977	T	A	7: 42,229,410 (GRCm39)	M372L	probably benign	Het

Other mutations in Vmn2r29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00959:Vmn2r29	APN	7	7,244,855 (GRCm39)	missense	probably benign	0.00
IGL02232:Vmn2r29	APN	7	7,244,810 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r29	UTSW	7	7,243,085 (GRCm39)	missense	possibly damaging	0.49
R3775:Vmn2r29	UTSW	7	7,243,011 (GRCm39)	missense	probably damaging	1.00
R6173:Vmn2r29	UTSW	7	7,234,369 (GRCm39)	missense	probably benign	0.13
R6604:Vmn2r29	UTSW	7	7,234,858 (GRCm39)	missense	probably damaging	1.00
R6747:Vmn2r29	UTSW	7	7,234,421 (GRCm39)	missense	probably benign	0.00
R6878:Vmn2r29	UTSW	7	7,244,863 (GRCm39)	missense	probably benign	0.05
R6899:Vmn2r29	UTSW	7	7,244,641 (GRCm39)	missense	probably damaging	1.00
R7533:Vmn2r29	UTSW	7	7,244,656 (GRCm39)	missense	probably damaging	1.00
R7578:Vmn2r29	UTSW	7	7,234,441 (GRCm39)	missense	probably damaging	0.99
R7703:Vmn2r29	UTSW	7	7,234,864 (GRCm39)	missense	probably benign	0.01
R7917:Vmn2r29	UTSW	7	7,234,727 (GRCm39)	missense	probably damaging	1.00
R8325:Vmn2r29	UTSW	7	7,244,941 (GRCm39)	missense	probably damaging	0.98
R8335:Vmn2r29	UTSW	7	7,234,445 (GRCm39)	missense	probably damaging	1.00
R9562:Vmn2r29	UTSW	7	7,244,855 (GRCm39)	missense	probably benign	0.00
R9565:Vmn2r29	UTSW	7	7,244,855 (GRCm39)	missense	probably benign	0.00
R9734:Vmn2r29	UTSW	7	7,234,492 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCATCAGATGAATTGTTCTTCAG -3'
(R):5'- GCCTTTGTGAAAATGATCTCTGTTG -3'

Sequencing Primer
(F):5'- GTATTTTACAGTTAGATGCTGAGCC -3'
(R):5'- TTGTGATGTCATCCTCAAAT -3'

Posted On

2020-10-20