Incidental Mutation 'R8419:Slc37a2'
ID 653094
Institutional Source Beutler Lab
Gene Symbol Slc37a2
Ensembl Gene ENSMUSG00000032122
Gene Name solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms cI-2, ci2, G3PP, Slc37a1
MMRRC Submission 067772-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R8419 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 37227585-37255738 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37237430 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 252 (D252V)
Ref Sequence ENSEMBL: ENSMUSP00000124569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115068] [ENSMUST00000161114]
AlphaFold Q9WU81
Predicted Effect probably benign
Transcript: ENSMUST00000115068
AA Change: D252V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000110720
Gene: ENSMUSG00000032122
AA Change: D252V

DomainStartEndE-ValueType
Pfam:MFS_1 23 424 1.2e-40 PFAM
transmembrane domain 431 453 N/A INTRINSIC
transmembrane domain 460 482 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161114
AA Change: D252V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000124569
Gene: ENSMUSG00000032122
AA Change: D252V

DomainStartEndE-ValueType
Pfam:MFS_1 24 426 1.2e-40 PFAM
transmembrane domain 431 453 N/A INTRINSIC
transmembrane domain 460 482 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik G T 7: 28,143,921 G745C probably damaging Het
9930111J21Rik2 A T 11: 49,019,485 I707N probably damaging Het
Abca14 A G 7: 120,216,266 I246V probably benign Het
Adam19 G A 11: 46,125,023 A337T possibly damaging Het
Ankrd40 G T 11: 94,334,836 G231V probably damaging Het
Arhgap5 G A 12: 52,518,789 V848I probably damaging Het
Bmpr2 G A 1: 59,867,356 R536H probably damaging Het
Casz1 T A 4: 148,948,583 S1310T probably benign Het
Chil1 A T 1: 134,189,542 D367V probably damaging Het
Cltc A G 11: 86,707,566 V990A probably benign Het
Col6a3 A T 1: 90,802,213 S1790R probably damaging Het
Comt C T 16: 18,411,887 W24* probably null Het
Cyp2c70 T C 19: 40,160,580 E374G possibly damaging Het
Dach1 T C 14: 98,168,640 T224A probably damaging Het
Dapk1 G A 13: 60,740,097 E656K probably benign Het
Dicer1 A G 12: 104,702,677 S1249P probably benign Het
Dpp8 A C 9: 65,080,755 I861L probably benign Het
Enam C T 5: 88,503,350 S906L possibly damaging Het
Eral1 A T 11: 78,074,080 I429N possibly damaging Het
Fbxo10 C A 4: 45,041,809 G807C possibly damaging Het
Fsip2 G C 2: 82,978,619 E1761Q probably damaging Het
Ggnbp2 C T 11: 84,837,989 probably null Het
Gm10696 T C 3: 94,175,614 I297V probably benign Het
Gm13088 A G 4: 143,656,427 I74T probably damaging Het
Gm4353 G A 7: 116,083,549 P266S probably benign Het
Gpr84 T C 15: 103,309,536 N38S probably damaging Het
Guca1a A T 17: 47,395,555 I115N probably damaging Het
Hic1 C T 11: 75,166,270 V598M possibly damaging Het
Itga1 A T 13: 115,007,068 I309N probably damaging Het
Itga11 T C 9: 62,755,178 S478P possibly damaging Het
Kctd8 T C 5: 69,340,370 D311G probably damaging Het
Klhl32 T C 4: 24,682,203 E127G possibly damaging Het
Lama2 T A 10: 27,422,563 Y179F probably benign Het
Lamb2 G T 9: 108,488,364 R1382L probably benign Het
Mrpl1 C G 5: 96,226,367 A167G probably benign Het
Muc3 A T 5: 137,146,722 N33K Het
Myt1 A T 2: 181,782,606 R31* probably null Het
Nectin2 T C 7: 19,717,721 T463A probably benign Het
Nectin2 A T 7: 19,738,078 Y129N probably damaging Het
Olfr103 A G 17: 37,336,575 I219T possibly damaging Het
Olfr1297 A T 2: 111,621,504 M190K probably benign Het
Papolb T A 5: 142,528,541 N449I possibly damaging Het
Parn T C 16: 13,648,474 K236R probably benign Het
Prelid1 G A 13: 55,322,885 R42Q probably damaging Het
Prelp A G 1: 133,915,282 F42L probably benign Het
Pygo1 C T 9: 72,945,098 P189L probably damaging Het
Rimbp3 T A 16: 17,213,022 S1437T probably damaging Het
Socs7 A G 11: 97,363,339 K233R probably benign Het
Stat4 A G 1: 52,098,478 D476G possibly damaging Het
Tesmin A G 19: 3,389,077 D43G probably benign Het
Thap1 C A 8: 26,158,474 Y8* probably null Het
Tln1 A G 4: 43,536,397 L1965P probably damaging Het
Tmprss11d A G 5: 86,309,306 S303P probably damaging Het
Tomm40 C T 7: 19,701,834 V324M probably damaging Het
Vmn1r202 A T 13: 22,501,815 I144K probably damaging Het
Other mutations in Slc37a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01643:Slc37a2 APN 9 37235553 splice site probably benign
IGL01719:Slc37a2 APN 9 37234178 missense probably damaging 1.00
IGL02039:Slc37a2 APN 9 37233684 missense probably damaging 0.98
IGL02286:Slc37a2 APN 9 37235159 missense probably damaging 1.00
IGL02951:Slc37a2 APN 9 37255315 missense probably benign 0.00
PIT4581001:Slc37a2 UTSW 9 37237405 missense probably benign 0.00
R0547:Slc37a2 UTSW 9 37233122 splice site probably null
R0689:Slc37a2 UTSW 9 37235550 splice site probably benign
R1301:Slc37a2 UTSW 9 37236881 missense probably benign 0.05
R3927:Slc37a2 UTSW 9 37235507 missense probably damaging 1.00
R4834:Slc37a2 UTSW 9 37235108 missense probably damaging 0.97
R5154:Slc37a2 UTSW 9 37231643 makesense probably null
R5292:Slc37a2 UTSW 9 37239157 nonsense probably null
R6150:Slc37a2 UTSW 9 37238347 missense probably damaging 1.00
R6959:Slc37a2 UTSW 9 37241334 missense probably benign
R7014:Slc37a2 UTSW 9 37233887 missense probably damaging 1.00
R7605:Slc37a2 UTSW 9 37237328 missense possibly damaging 0.71
R7974:Slc37a2 UTSW 9 37239125 splice site probably null
R8342:Slc37a2 UTSW 9 37238214 critical splice donor site probably null
R9039:Slc37a2 UTSW 9 37237362 missense probably benign
R9314:Slc37a2 UTSW 9 37239186 missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- CTTGAAGCTACCTGTCACCC -3'
(R):5'- TGCCCCACAACCTGATATGC -3'

Sequencing Primer
(F):5'- GTTCCCTCGAAGCTAGTGAAAATC -3'
(R):5'- TGATATGCCTGTCAGCCCAAGAG -3'
Posted On 2020-10-20