Incidental Mutation 'R8419:Gpr84'
ID 653115
Institutional Source Beutler Lab
Gene Symbol Gpr84
Ensembl Gene ENSMUSG00000063234
Gene Name G protein-coupled receptor 84
Synonyms EX33
MMRRC Submission 067772-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8419 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 103216662-103219039 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103217963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 38 (N38S)
Ref Sequence ENSEMBL: ENSMUSP00000078753 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079824] [ENSMUST00000168828] [ENSMUST00000229373] [ENSMUST00000229551]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000079824
AA Change: N38S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078753
Gene: ENSMUSG00000063234
AA Change: N38S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 28 175 5e-10 PFAM
Pfam:7TM_GPCR_Srsx 31 221 7.3e-8 PFAM
Pfam:7tm_1 37 370 7.1e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168828
SMART Domains Protein: ENSMUSP00000130176
Gene: ENSMUSG00000000552

DomainStartEndE-ValueType
ZnF_U1 71 105 1.05e-2 SMART
ZnF_C2H2 74 98 1.14e0 SMART
low complexity region 157 173 N/A INTRINSIC
ZnF_U1 198 232 2.29e-3 SMART
ZnF_C2H2 201 225 1.91e1 SMART
low complexity region 245 256 N/A INTRINSIC
ZnF_U1 258 292 5.26e-3 SMART
ZnF_C2H2 261 285 2.17e-1 SMART
low complexity region 319 361 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000229373
Predicted Effect probably benign
Transcript: ENSMUST00000229551
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 A T 11: 48,910,312 (GRCm39) I707N probably damaging Het
Abca14 A G 7: 119,815,489 (GRCm39) I246V probably benign Het
Adam19 G A 11: 46,015,850 (GRCm39) A337T possibly damaging Het
Ankrd40 G T 11: 94,225,662 (GRCm39) G231V probably damaging Het
Arhgap5 G A 12: 52,565,572 (GRCm39) V848I probably damaging Het
Bmpr2 G A 1: 59,906,515 (GRCm39) R536H probably damaging Het
Casz1 T A 4: 149,033,040 (GRCm39) S1310T probably benign Het
Chi3l1 A T 1: 134,117,280 (GRCm39) D367V probably damaging Het
Cltc A G 11: 86,598,392 (GRCm39) V990A probably benign Het
Col6a3 A T 1: 90,729,935 (GRCm39) S1790R probably damaging Het
Comt C T 16: 18,230,637 (GRCm39) W24* probably null Het
Cyp2c70 T C 19: 40,149,024 (GRCm39) E374G possibly damaging Het
Dach1 T C 14: 98,406,076 (GRCm39) T224A probably damaging Het
Dapk1 G A 13: 60,887,911 (GRCm39) E656K probably benign Het
Dicer1 A G 12: 104,668,936 (GRCm39) S1249P probably benign Het
Dpp8 A C 9: 64,988,037 (GRCm39) I861L probably benign Het
Enam C T 5: 88,651,209 (GRCm39) S906L possibly damaging Het
Eral1 A T 11: 77,964,906 (GRCm39) I429N possibly damaging Het
Fbxo10 C A 4: 45,041,809 (GRCm39) G807C possibly damaging Het
Fcgbpl1 G T 7: 27,843,346 (GRCm39) G745C probably damaging Het
Fsip2 G C 2: 82,808,963 (GRCm39) E1761Q probably damaging Het
Ggnbp2 C T 11: 84,728,815 (GRCm39) probably null Het
Gm4353 G A 7: 115,682,784 (GRCm39) P266S probably benign Het
Guca1a A T 17: 47,706,480 (GRCm39) I115N probably damaging Het
Hic1 C T 11: 75,057,096 (GRCm39) V598M possibly damaging Het
Itga1 A T 13: 115,143,604 (GRCm39) I309N probably damaging Het
Itga11 T C 9: 62,662,460 (GRCm39) S478P possibly damaging Het
Kctd8 T C 5: 69,497,713 (GRCm39) D311G probably damaging Het
Klhl32 T C 4: 24,682,203 (GRCm39) E127G possibly damaging Het
Lama2 T A 10: 27,298,559 (GRCm39) Y179F probably benign Het
Lamb2 G T 9: 108,365,563 (GRCm39) R1382L probably benign Het
Mrpl1 C G 5: 96,374,226 (GRCm39) A167G probably benign Het
Muc17 A T 5: 137,175,570 (GRCm39) N33K Het
Myt1 A T 2: 181,424,399 (GRCm39) R31* probably null Het
Nectin2 T C 7: 19,451,646 (GRCm39) T463A probably benign Het
Nectin2 A T 7: 19,472,003 (GRCm39) Y129N probably damaging Het
Or12d13 A G 17: 37,647,466 (GRCm39) I219T possibly damaging Het
Or4k47 A T 2: 111,451,849 (GRCm39) M190K probably benign Het
Papolb T A 5: 142,514,296 (GRCm39) N449I possibly damaging Het
Parn T C 16: 13,466,338 (GRCm39) K236R probably benign Het
Pramel22 A G 4: 143,382,997 (GRCm39) I74T probably damaging Het
Prelid1 G A 13: 55,470,698 (GRCm39) R42Q probably damaging Het
Prelp A G 1: 133,843,020 (GRCm39) F42L probably benign Het
Pygo1 C T 9: 72,852,380 (GRCm39) P189L probably damaging Het
Rimbp3 T A 16: 17,030,886 (GRCm39) S1437T probably damaging Het
Slc37a2 T A 9: 37,148,726 (GRCm39) D252V probably benign Het
Socs7 A G 11: 97,254,165 (GRCm39) K233R probably benign Het
Spopfm2 T C 3: 94,082,921 (GRCm39) I297V probably benign Het
Stat4 A G 1: 52,137,637 (GRCm39) D476G possibly damaging Het
Tesmin A G 19: 3,439,077 (GRCm39) D43G probably benign Het
Thap1 C A 8: 26,648,502 (GRCm39) Y8* probably null Het
Tln1 A G 4: 43,536,397 (GRCm39) L1965P probably damaging Het
Tmprss11d A G 5: 86,457,165 (GRCm39) S303P probably damaging Het
Tomm40 C T 7: 19,435,759 (GRCm39) V324M probably damaging Het
Vmn1r202 A T 13: 22,685,985 (GRCm39) I144K probably damaging Het
Other mutations in Gpr84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00479:Gpr84 APN 15 103,217,834 (GRCm39) missense probably damaging 1.00
IGL02566:Gpr84 APN 15 103,217,150 (GRCm39) missense probably benign 0.00
IGL02943:Gpr84 APN 15 103,217,316 (GRCm39) missense probably benign 0.06
R1301:Gpr84 UTSW 15 103,217,646 (GRCm39) missense probably damaging 0.98
R1762:Gpr84 UTSW 15 103,217,754 (GRCm39) missense probably damaging 1.00
R4762:Gpr84 UTSW 15 103,217,027 (GRCm39) missense probably damaging 1.00
R6362:Gpr84 UTSW 15 103,216,937 (GRCm39) missense probably damaging 1.00
R6931:Gpr84 UTSW 15 103,217,441 (GRCm39) missense probably damaging 0.99
R8846:Gpr84 UTSW 15 103,218,037 (GRCm39) missense possibly damaging 0.61
R8906:Gpr84 UTSW 15 103,217,625 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCTACAGAAGACCGCGCC -3'
(R):5'- CCAGCCAAGAATTAAAGTGAGTTC -3'

Sequencing Primer
(F):5'- GTTGGCAATGAGCAGGTT -3'
(R):5'- TTAAAGTGAGTTCTAGGAGCAGAGC -3'
Posted On 2020-10-20