Incidental Mutation 'R8425:Dennd4a'
ID 653418
Institutional Source Beutler Lab
Gene Symbol Dennd4a
Ensembl Gene ENSMUSG00000053641
Gene Name DENN/MADD domain containing 4A
Synonyms F730015K02Rik
MMRRC Submission 067819-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.432) question?
Stock # R8425 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 64811340-64919667 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 64838974 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 47 (D47E)
Ref Sequence ENSEMBL: ENSMUSP00000150918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038890] [ENSMUST00000213926]
AlphaFold E9Q8V6
Predicted Effect probably damaging
Transcript: ENSMUST00000038890
AA Change: D47E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: D47E

DomainStartEndE-ValueType
internal_repeat_1 45 93 3.26e-5 PROSPERO
uDENN 169 276 1.71e-28 SMART
DENN 309 493 2.4e-73 SMART
dDENN 559 633 4.15e-27 SMART
low complexity region 724 735 N/A INTRINSIC
low complexity region 936 950 N/A INTRINSIC
low complexity region 1176 1191 N/A INTRINSIC
low complexity region 1249 1262 N/A INTRINSIC
low complexity region 1402 1417 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000213926
AA Change: D47E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik T C 6: 124,347,786 (GRCm38) E92G possibly damaging Het
4921501E09Rik C A 17: 33,067,064 (GRCm38) A255S probably benign Het
Aasdh A T 5: 76,886,277 (GRCm38) Y476N possibly damaging Het
Abca13 G T 11: 9,314,623 (GRCm38) V3002F possibly damaging Het
Adam23 C T 1: 63,585,377 (GRCm38) T788I probably damaging Het
Adgrb2 A G 4: 130,005,057 (GRCm38) T282A possibly damaging Het
Adgrg1 T C 8: 95,008,407 (GRCm38) Y402H probably damaging Het
Agpat2 A T 2: 26,593,654 (GRCm38) L257Q probably benign Het
Agpat3 A T 10: 78,282,377 (GRCm38) V255E possibly damaging Het
Akap6 A G 12: 52,886,621 (GRCm38) I299V probably benign Het
Anapc1 A T 2: 128,669,868 (GRCm38) F468L probably damaging Het
Apob T A 12: 7,988,842 (GRCm38) N431K possibly damaging Het
Asprv1 T A 6: 86,628,869 (GRCm38) D232E probably benign Het
AW209491 A G 13: 14,637,336 (GRCm38) Y258C probably damaging Het
Bach2 C T 4: 32,562,316 (GRCm38) P261L probably benign Het
Cap2 T A 13: 46,609,732 (GRCm38) I146K probably damaging Het
Catsperb A T 12: 101,602,769 (GRCm38) Q900L probably benign Het
Ccdc187 A T 2: 26,281,536 (GRCm38) V310D probably damaging Het
Cenpe G T 3: 135,242,627 (GRCm38) G1275* probably null Het
Chd8 C T 14: 52,210,555 (GRCm38) G1663D probably damaging Het
Col6a5 T A 9: 105,945,957 (GRCm38) Y67F unknown Het
Cuzd1 G T 7: 131,317,991 (GRCm38) T132K possibly damaging Het
Ddr2 T A 1: 170,036,016 (GRCm38) probably benign Het
Ddx42 T C 11: 106,247,724 (GRCm38) I783T probably benign Het
Dirc2 A T 16: 35,735,597 (GRCm38) N164K probably benign Het
Dvl2 T G 11: 70,007,847 (GRCm38) W379G probably damaging Het
Ehbp1 A G 11: 22,013,495 (GRCm38) L1160P probably damaging Het
Eml6 A G 11: 29,755,008 (GRCm38) V1512A probably benign Het
Ephb6 T C 6: 41,618,646 (GRCm38) S780P probably damaging Het
Exo5 G A 4: 120,922,363 (GRCm38) L102F probably benign Het
Fam220a A T 5: 143,562,839 (GRCm38) K2M possibly damaging Het
Fanci A T 7: 79,433,541 (GRCm38) I731L probably benign Het
Gbp8 A G 5: 105,017,774 (GRCm38) S338P probably damaging Het
H2-M11 T C 17: 36,548,757 (GRCm38) I214T probably benign Het
Hhatl C A 9: 121,789,102 (GRCm38) A196S probably benign Het
Hspg2 C A 4: 137,550,867 (GRCm38) C2988* probably null Het
Ifi213 A G 1: 173,589,860 (GRCm38) S329P probably benign Het
Lingo3 G T 10: 80,834,982 (GRCm38) F371L probably benign Het
Maml2 C T 9: 13,620,117 (GRCm38) T209I Het
Ndufaf3 T C 9: 108,566,983 (GRCm38) probably benign Het
Nfatc2 C T 2: 168,536,296 (GRCm38) G483E probably damaging Het
Npy6r A C 18: 44,276,003 (GRCm38) T164P probably benign Het
Olfr117 T A 17: 37,660,084 (GRCm38) N83I probably damaging Het
Olfr1221 T A 2: 89,112,393 (GRCm38) N40Y probably damaging Het
Olfr132 T C 17: 38,131,036 (GRCm38) D52G possibly damaging Het
Olfr1502 T C 19: 13,862,485 (GRCm38) S231P probably benign Het
Olfr173 A G 16: 58,797,603 (GRCm38) M81T probably benign Het
Olfr659 A G 7: 104,671,295 (GRCm38) N198D probably damaging Het
Omg T C 11: 79,502,000 (GRCm38) E344G possibly damaging Het
P2rx7 A G 5: 122,670,458 (GRCm38) E301G probably damaging Het
Pkhd1l1 T C 15: 44,574,515 (GRCm38) S3569P probably benign Het
Pkn3 G A 2: 30,086,501 (GRCm38) probably null Het
Proc C T 18: 32,123,358 (GRCm38) V419M probably damaging Het
Prss37 C T 6: 40,516,118 (GRCm38) W138* probably null Het
Prss52 T A 14: 64,112,560 (GRCm38) L212* probably null Het
Rnps1 A G 17: 24,418,169 (GRCm38) K8E unknown Het
Rpf2 A T 10: 40,225,433 (GRCm38) L202* probably null Het
Saraf C T 8: 34,165,448 (GRCm38) P227L probably benign Het
Serpinb5 T A 1: 106,881,785 (GRCm38) M307K possibly damaging Het
Slc46a1 T C 11: 78,468,645 (GRCm38) S368P possibly damaging Het
Slfn8 T A 11: 83,004,615 (GRCm38) Q455L possibly damaging Het
Sv2b A G 7: 75,117,599 (GRCm38) M683T probably damaging Het
Tacc3 G T 5: 33,664,530 (GRCm38) L211F unknown Het
Tbc1d8 A G 1: 39,381,409 (GRCm38) V681A probably damaging Het
Tbkbp1 T C 11: 97,138,851 (GRCm38) E493G unknown Het
Th A T 7: 142,894,086 (GRCm38) V420E possibly damaging Het
Tmem132c T G 5: 127,564,357 (GRCm38) V115G Het
Usp40 G A 1: 87,959,836 (GRCm38) R915C probably benign Het
Wdr81 T A 11: 75,451,522 (GRCm38) H973L possibly damaging Het
Zdhhc6 A G 19: 55,314,444 (GRCm38) S42P probably benign Het
Zfp369 T A 13: 65,296,675 (GRCm38) I544N possibly damaging Het
Other mutations in Dennd4a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dennd4a APN 9 64,911,762 (GRCm38) missense probably damaging 1.00
IGL01610:Dennd4a APN 9 64,906,884 (GRCm38) missense probably damaging 0.99
IGL01788:Dennd4a APN 9 64,842,621 (GRCm38) missense probably benign 0.00
IGL01827:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01828:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01829:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01979:Dennd4a APN 9 64,894,409 (GRCm38) missense probably benign 0.00
IGL02100:Dennd4a APN 9 64,909,706 (GRCm38) splice site probably benign
IGL02339:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL02341:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL02584:Dennd4a APN 9 64,851,298 (GRCm38) missense probably damaging 1.00
IGL02607:Dennd4a APN 9 64,862,327 (GRCm38) missense probably damaging 0.99
IGL02654:Dennd4a APN 9 64,910,191 (GRCm38) splice site probably benign
IGL02701:Dennd4a APN 9 64,897,353 (GRCm38) missense possibly damaging 0.50
IGL03051:Dennd4a APN 9 64,862,414 (GRCm38) missense probably damaging 1.00
IGL03257:Dennd4a APN 9 64,871,874 (GRCm38) missense possibly damaging 0.93
IGL03346:Dennd4a APN 9 64,888,526 (GRCm38) missense possibly damaging 0.47
IGL03349:Dennd4a APN 9 64,888,974 (GRCm38) missense probably damaging 1.00
IGL03398:Dennd4a APN 9 64,871,882 (GRCm38) missense probably benign 0.32
R0010:Dennd4a UTSW 9 64,896,715 (GRCm38) missense probably benign 0.00
R0010:Dennd4a UTSW 9 64,896,715 (GRCm38) missense probably benign 0.00
R0129:Dennd4a UTSW 9 64,893,294 (GRCm38) missense probably damaging 1.00
R0220:Dennd4a UTSW 9 64,852,445 (GRCm38) missense probably damaging 1.00
R0396:Dennd4a UTSW 9 64,862,391 (GRCm38) missense probably damaging 1.00
R0881:Dennd4a UTSW 9 64,851,383 (GRCm38) critical splice donor site probably null
R1225:Dennd4a UTSW 9 64,911,675 (GRCm38) missense probably benign 0.03
R1311:Dennd4a UTSW 9 64,910,004 (GRCm38) missense probably benign 0.34
R1448:Dennd4a UTSW 9 64,906,045 (GRCm38) missense possibly damaging 0.95
R1450:Dennd4a UTSW 9 64,911,665 (GRCm38) missense probably benign 0.03
R1630:Dennd4a UTSW 9 64,871,882 (GRCm38) missense probably benign 0.32
R1709:Dennd4a UTSW 9 64,889,605 (GRCm38) missense possibly damaging 0.92
R1824:Dennd4a UTSW 9 64,859,358 (GRCm38) critical splice donor site probably null
R1851:Dennd4a UTSW 9 64,862,030 (GRCm38) missense probably damaging 1.00
R1870:Dennd4a UTSW 9 64,897,234 (GRCm38) missense probably benign 0.00
R1900:Dennd4a UTSW 9 64,897,336 (GRCm38) missense probably damaging 0.99
R1911:Dennd4a UTSW 9 64,889,086 (GRCm38) missense probably damaging 1.00
R1938:Dennd4a UTSW 9 64,842,490 (GRCm38) missense probably damaging 1.00
R1954:Dennd4a UTSW 9 64,852,467 (GRCm38) missense probably benign 0.02
R1955:Dennd4a UTSW 9 64,852,467 (GRCm38) missense probably benign 0.02
R2049:Dennd4a UTSW 9 64,889,605 (GRCm38) missense possibly damaging 0.92
R2129:Dennd4a UTSW 9 64,905,974 (GRCm38) splice site probably null
R2138:Dennd4a UTSW 9 64,889,337 (GRCm38) missense probably damaging 1.00
R2929:Dennd4a UTSW 9 64,852,417 (GRCm38) missense possibly damaging 0.85
R3083:Dennd4a UTSW 9 64,906,081 (GRCm38) missense probably benign 0.03
R3108:Dennd4a UTSW 9 64,912,387 (GRCm38) missense probably benign 0.23
R3176:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3177:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3276:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3277:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3890:Dennd4a UTSW 9 64,872,028 (GRCm38) missense probably damaging 1.00
R3953:Dennd4a UTSW 9 64,852,575 (GRCm38) missense probably damaging 1.00
R3963:Dennd4a UTSW 9 64,862,331 (GRCm38) missense probably damaging 1.00
R4059:Dennd4a UTSW 9 64,911,892 (GRCm38) missense possibly damaging 0.92
R4499:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4500:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4501:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4671:Dennd4a UTSW 9 64,894,407 (GRCm38) missense probably benign
R4701:Dennd4a UTSW 9 64,897,357 (GRCm38) missense possibly damaging 0.91
R4821:Dennd4a UTSW 9 64,897,249 (GRCm38) missense possibly damaging 0.92
R4829:Dennd4a UTSW 9 64,889,056 (GRCm38) missense probably damaging 1.00
R4876:Dennd4a UTSW 9 64,896,590 (GRCm38) missense probably benign
R4881:Dennd4a UTSW 9 64,838,844 (GRCm38) missense possibly damaging 0.77
R4962:Dennd4a UTSW 9 64,906,003 (GRCm38) missense probably benign 0.00
R5225:Dennd4a UTSW 9 64,888,928 (GRCm38) missense possibly damaging 0.94
R5557:Dennd4a UTSW 9 64,904,227 (GRCm38) missense probably benign 0.07
R5649:Dennd4a UTSW 9 64,851,209 (GRCm38) splice site probably null
R5868:Dennd4a UTSW 9 64,896,729 (GRCm38) missense probably benign 0.02
R5876:Dennd4a UTSW 9 64,911,755 (GRCm38) missense probably damaging 1.00
R6052:Dennd4a UTSW 9 64,886,945 (GRCm38) missense probably damaging 1.00
R6411:Dennd4a UTSW 9 64,871,899 (GRCm38) missense probably benign 0.04
R6596:Dennd4a UTSW 9 64,852,420 (GRCm38) missense probably damaging 1.00
R6668:Dennd4a UTSW 9 64,886,965 (GRCm38) missense probably damaging 1.00
R6915:Dennd4a UTSW 9 64,852,489 (GRCm38) nonsense probably null
R7056:Dennd4a UTSW 9 64,906,923 (GRCm38) missense possibly damaging 0.89
R7107:Dennd4a UTSW 9 64,894,399 (GRCm38) missense possibly damaging 0.79
R7203:Dennd4a UTSW 9 64,896,474 (GRCm38) missense probably benign 0.05
R7238:Dennd4a UTSW 9 64,861,956 (GRCm38) missense probably damaging 1.00
R7373:Dennd4a UTSW 9 64,897,269 (GRCm38) missense probably benign 0.01
R7454:Dennd4a UTSW 9 64,852,570 (GRCm38) missense probably damaging 1.00
R7546:Dennd4a UTSW 9 64,873,044 (GRCm38) missense probably damaging 1.00
R7590:Dennd4a UTSW 9 64,888,587 (GRCm38) missense probably benign 0.01
R7662:Dennd4a UTSW 9 64,852,431 (GRCm38) missense probably damaging 1.00
R7782:Dennd4a UTSW 9 64,906,920 (GRCm38) missense probably damaging 0.98
R7909:Dennd4a UTSW 9 64,872,993 (GRCm38) critical splice acceptor site probably null
R7976:Dennd4a UTSW 9 64,852,512 (GRCm38) missense possibly damaging 0.95
R8026:Dennd4a UTSW 9 64,873,030 (GRCm38) missense probably damaging 1.00
R8034:Dennd4a UTSW 9 64,888,568 (GRCm38) missense probably benign 0.01
R8089:Dennd4a UTSW 9 64,849,175 (GRCm38) missense probably damaging 1.00
R8298:Dennd4a UTSW 9 64,906,875 (GRCm38) missense probably benign 0.00
R8397:Dennd4a UTSW 9 64,889,109 (GRCm38) missense probably benign
R8495:Dennd4a UTSW 9 64,886,879 (GRCm38) missense probably damaging 1.00
R8855:Dennd4a UTSW 9 64,912,390 (GRCm38) missense probably benign
R9219:Dennd4a UTSW 9 64,889,094 (GRCm38) missense probably damaging 0.96
R9275:Dennd4a UTSW 9 64,842,624 (GRCm38) missense probably damaging 1.00
R9376:Dennd4a UTSW 9 64,912,692 (GRCm38) missense probably benign 0.00
R9485:Dennd4a UTSW 9 64,907,106 (GRCm38) nonsense probably null
R9672:Dennd4a UTSW 9 64,893,358 (GRCm38) missense probably benign
R9746:Dennd4a UTSW 9 64,894,511 (GRCm38) missense probably benign
X0026:Dennd4a UTSW 9 64,897,320 (GRCm38) missense possibly damaging 0.67
Z1088:Dennd4a UTSW 9 64,872,022 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAGGACTTGCATTCTTTCTGG -3'
(R):5'- TACCCCAGATCTGTAAGTGGAG -3'

Sequencing Primer
(F):5'- GACTTGCATTCTTTCTGGATTTGTAC -3'
(R):5'- CCCAGATCTGTAAGTGGAGGTTTATC -3'
Posted On 2020-10-20