Incidental Mutation 'R8426:Or8b46'
ID 653482
Institutional Source Beutler Lab
Gene Symbol Or8b46
Ensembl Gene ENSMUSG00000060114
Gene Name olfactory receptor family 8 subfamily B member 46
Synonyms GA_x6K02T2PVTD-32239063-32239995, Olfr910, MOR165-3
MMRRC Submission 067820-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R8426 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38449178-38451125 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38450620 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 143 (Y143F)
Ref Sequence ENSEMBL: ENSMUSP00000149263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000215122]
AlphaFold Q8VG76
Predicted Effect probably damaging
Transcript: ENSMUST00000215122
AA Change: Y143F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,155,606 (GRCm39) H32R probably benign Het
Abcb1b T C 5: 8,911,632 (GRCm39) probably null Het
Aicda A T 6: 122,538,150 (GRCm39) N103Y probably damaging Het
Bsn T C 9: 108,003,772 (GRCm39) E211G probably damaging Het
Casp9 T C 4: 141,540,936 (GRCm39) Y435H probably damaging Het
Catsper2 TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT 2: 121,228,053 (GRCm39) probably benign Het
Ceacam5 T C 7: 17,493,266 (GRCm39) V763A possibly damaging Het
Cxcr6 A G 9: 123,639,071 (GRCm39) N31S probably benign Het
Elapor1 G A 3: 108,378,742 (GRCm39) A352V probably damaging Het
Gm17728 A G 17: 9,641,231 (GRCm39) T114A probably benign Het
Gnao1 A T 8: 94,622,857 (GRCm39) probably null Het
Iffo2 A T 4: 139,342,291 (GRCm39) Y451F probably damaging Het
Ints4 G A 7: 97,150,239 (GRCm39) W258* probably null Het
Ipo11 T C 13: 106,978,678 (GRCm39) D834G possibly damaging Het
Kif5a T C 10: 127,067,358 (GRCm39) D853G probably damaging Het
Lama4 A G 10: 38,979,487 (GRCm39) E1655G probably damaging Het
Lepr G A 4: 101,671,841 (GRCm39) S955N probably benign Het
Lrp1b T C 2: 41,388,318 (GRCm39) I550V Het
Mov10l1 T A 15: 88,881,608 (GRCm39) probably null Het
Mroh9 A T 1: 162,852,294 (GRCm39) D798E probably damaging Het
Myo10 A G 15: 25,799,576 (GRCm39) I1380V probably damaging Het
Neu2 C T 1: 87,524,387 (GRCm39) S124L probably damaging Het
Nol6 T C 4: 41,119,870 (GRCm39) I543V probably benign Het
Nrxn3 G A 12: 88,762,097 (GRCm39) R48H possibly damaging Het
Ogn C T 13: 49,774,567 (GRCm39) R237C possibly damaging Het
Or10aa3 T C 1: 173,878,146 (GRCm39) L69P probably damaging Het
Phf24 C T 4: 42,933,785 (GRCm39) Q19* probably null Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Plscr4 C T 9: 92,372,843 (GRCm39) R322* probably null Het
Ptch2 G T 4: 116,965,369 (GRCm39) S318I possibly damaging Het
Sart1 A G 19: 5,433,769 (GRCm39) M356T probably benign Het
Slit2 A G 5: 48,382,105 (GRCm39) N529D probably benign Het
Smchd1 A C 17: 71,755,598 (GRCm39) D261E probably damaging Het
Tcerg1 G A 18: 42,681,466 (GRCm39) V538I possibly damaging Het
Thada A T 17: 84,530,131 (GRCm39) M1746K probably benign Het
Thsd1 A G 8: 22,733,654 (GRCm39) I234V probably benign Het
Tm9sf4 G A 2: 153,045,736 (GRCm39) G536D probably damaging Het
Tmprss11c G T 5: 86,379,677 (GRCm39) N410K probably damaging Het
Ttc28 G A 5: 111,381,207 (GRCm39) D1240N probably benign Het
Unc5d G T 8: 29,210,016 (GRCm39) S440Y probably damaging Het
Vmn1r44 A G 6: 89,870,470 (GRCm39) D72G probably benign Het
Vmn1r68 T C 7: 10,261,382 (GRCm39) N239D probably benign Het
Vmn2r107 T A 17: 20,577,239 (GRCm39) H412Q possibly damaging Het
Other mutations in Or8b46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02740:Or8b46 APN 9 38,450,226 (GRCm39) missense probably damaging 1.00
R0096:Or8b46 UTSW 9 38,450,832 (GRCm39) missense probably damaging 0.96
R0550:Or8b46 UTSW 9 38,450,676 (GRCm39) missense probably damaging 0.97
R1375:Or8b46 UTSW 9 38,450,830 (GRCm39) missense possibly damaging 0.63
R1698:Or8b46 UTSW 9 38,450,552 (GRCm39) nonsense probably null
R2067:Or8b46 UTSW 9 38,450,576 (GRCm39) missense probably benign 0.09
R2111:Or8b46 UTSW 9 38,450,576 (GRCm39) missense probably benign 0.09
R2519:Or8b46 UTSW 9 38,450,281 (GRCm39) missense probably damaging 0.99
R4742:Or8b46 UTSW 9 38,450,952 (GRCm39) missense probably damaging 1.00
R4782:Or8b46 UTSW 9 38,450,371 (GRCm39) missense probably damaging 1.00
R6491:Or8b46 UTSW 9 38,558,751 (GRCm39) missense probably damaging 1.00
R7101:Or8b46 UTSW 9 38,450,966 (GRCm39) missense probably benign 0.02
R8108:Or8b46 UTSW 9 38,450,706 (GRCm39) missense probably damaging 0.97
R8270:Or8b46 UTSW 9 38,450,644 (GRCm39) missense noncoding transcript
R8446:Or8b46 UTSW 9 38,450,964 (GRCm39) missense probably benign 0.10
R9004:Or8b46 UTSW 9 38,450,530 (GRCm39) missense probably benign 0.29
R9463:Or8b46 UTSW 9 38,450,665 (GRCm39) missense probably damaging 0.97
Z1088:Or8b46 UTSW 9 38,450,445 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACCCAAATTGCTGATGAACTTTG -3'
(R):5'- CTGGGCACAGTGATATCTTTTC -3'

Sequencing Primer
(F):5'- ATGTCCTGACAGCAATGG -3'
(R):5'- AGTGATATCTTTTCCCCCTACAATG -3'
Posted On 2020-10-20