Incidental Mutation 'R8427:Olfr747'
ID 653548
Institutional Source Beutler Lab
Gene Symbol Olfr747
Ensembl Gene ENSMUSG00000057179
Gene Name olfactory receptor 747
Synonyms GA_x6K02T2PMLR-6420220-6419279, MOR106-7, MOR106-16
MMRRC Submission 067821-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R8427 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50680657-50693206 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50681149 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 162 (I162F)
Ref Sequence ENSEMBL: ENSMUSP00000149081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078075] [ENSMUST00000205373] [ENSMUST00000205897] [ENSMUST00000213238]
AlphaFold E9PXH6
Predicted Effect probably damaging
Transcript: ENSMUST00000078075
AA Change: I162F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077220
Gene: ENSMUSG00000057179
AA Change: I162F

Pfam:7tm_4 30 307 2.2e-53 PFAM
Pfam:7tm_1 40 289 2.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205373
AA Change: I162F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000205897
Predicted Effect probably damaging
Transcript: ENSMUST00000213238
AA Change: I162F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik G T 12: 72,903,286 (GRCm38) S271R possibly damaging Het
Adrb2 A G 18: 62,179,274 (GRCm38) V160A possibly damaging Het
Atp13a5 T C 16: 29,349,002 (GRCm38) D113G possibly damaging Het
B4galt7 T A 13: 55,609,325 (GRCm38) V312D possibly damaging Het
Bccip A G 7: 133,709,491 (GRCm38) D45G probably benign Het
Bcl2l2 A G 14: 54,885,403 (GRCm38) Y151C probably damaging Het
Ccdc146 T C 5: 21,399,792 (GRCm38) E16G unknown Het
Cdr2l C A 11: 115,394,039 (GRCm38) D400E probably damaging Het
Celsr2 A C 3: 108,392,633 (GRCm38) *2920E probably null Het
Cib1 A G 7: 80,228,001 (GRCm38) F183L probably damaging Het
Cnot1 A G 8: 95,734,324 (GRCm38) Y1716H probably benign Het
Copb1 A G 7: 114,226,754 (GRCm38) V665A probably benign Het
Crmp1 C T 5: 37,291,195 (GRCm38) T683I probably damaging Het
Cubn G C 2: 13,428,756 (GRCm38) F1114L probably benign Het
Dab2 A T 15: 6,429,359 (GRCm38) R251* probably null Het
Ddx28 A G 8: 106,010,280 (GRCm38) V382A probably benign Het
Eml1 C A 12: 108,530,321 (GRCm38) T612K probably damaging Het
Hoxb3 CGGCGGTGGCGG CGGCGGTGGCGGTGGCGG 11: 96,345,589 (GRCm38) probably benign Het
Hoxb3 TGGCGG TGGCGGAGGCGG 11: 96,345,595 (GRCm38) probably benign Het
Iapp T A 6: 142,298,886 (GRCm38) I13N probably damaging Het
Ifit1bl1 A T 19: 34,599,266 (GRCm38) probably null Het
Itgb4 T A 11: 115,991,718 (GRCm38) probably null Het
Kcnh3 T C 15: 99,227,053 (GRCm38) V128A probably benign Het
Kmt2a A G 9: 44,845,423 (GRCm38) F1176L probably damaging Het
Lifr A G 15: 7,190,981 (GRCm38) T1031A probably benign Het
Lrp2 T C 2: 69,451,297 (GRCm38) D3910G probably damaging Het
Man1a2 A T 3: 100,684,685 (GRCm38) S60T probably benign Het
Mdh1 C T 11: 21,564,138 (GRCm38) R93K probably benign Het
Mical1 G T 10: 41,478,595 (GRCm38) K142N probably damaging Het
Nf2 T A 11: 4,791,118 (GRCm38) E365D probably benign Het
Nfrkb A G 9: 31,419,027 (GRCm38) M1192V probably benign Het
Npas4 A C 19: 4,986,080 (GRCm38) D685E probably benign Het
Olfr1291-ps1 A G 2: 111,499,965 (GRCm38) T238A probably damaging Het
Olfr358 G T 2: 37,004,782 (GRCm38) Y277* probably null Het
Ovch2 G A 7: 107,794,000 (GRCm38) T222I probably damaging Het
Plat G T 8: 22,772,232 (GRCm38) G91W probably damaging Het
Pld1 A T 3: 28,088,646 (GRCm38) I668F probably damaging Het
Plscr4 C T 9: 92,490,790 (GRCm38) R322* probably null Het
Ppa1 A G 10: 61,660,925 (GRCm38) D64G possibly damaging Het
Rnf133 T C 6: 23,649,406 (GRCm38) I175V probably benign Het
Rpp30 A G 19: 36,094,412 (GRCm38) I127V probably benign Het
Scube2 T A 7: 109,800,590 (GRCm38) H913L probably damaging Het
Sema6d T A 2: 124,665,277 (GRCm38) S1045T probably benign Het
Skida1 A T 2: 18,046,591 (GRCm38) N496K unknown Het
Slc29a2 A T 19: 5,030,420 (GRCm38) I397F probably benign Het
Slc38a2 G T 15: 96,692,413 (GRCm38) R316S probably damaging Het
Slc40a1 A C 1: 45,912,338 (GRCm38) Y220D probably damaging Het
Strc T G 2: 121,377,531 (GRCm38) H453P probably damaging Het
Tmprss3 T A 17: 31,188,384 (GRCm38) I312F probably damaging Het
Tnn G A 1: 160,130,686 (GRCm38) T529I probably damaging Het
Tnr A T 1: 159,886,231 (GRCm38) D743V possibly damaging Het
Trim42 A T 9: 97,363,121 (GRCm38) F542Y probably benign Het
Trpm2 A T 10: 77,911,402 (GRCm38) Y1421N possibly damaging Het
Ttn T C 2: 76,746,557 (GRCm38) E24664G probably damaging Het
Ube2q2 T C 9: 55,184,966 (GRCm38) probably null Het
Unc79 A T 12: 103,079,038 (GRCm38) R824S probably benign Het
V1ra8 A G 6: 90,203,577 (GRCm38) D254G probably damaging Het
Vmn1r173 A T 7: 23,702,534 (GRCm38) I65F probably damaging Het
Vmn2r16 T A 5: 109,340,272 (GRCm38) M337K probably benign Het
Wfs1 C A 5: 36,968,087 (GRCm38) G487C probably damaging Het
Xdh T C 17: 73,935,931 (GRCm38) Y127C probably damaging Het
Zfp229 T C 17: 21,746,834 (GRCm38) S682P probably damaging Het
Zscan4-ps1 A T 7: 11,068,520 (GRCm38) D117E possibly damaging Het
Other mutations in Olfr747
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02437:Olfr747 APN 14 50,681,200 (GRCm38) missense probably benign 0.04
R0349:Olfr747 UTSW 14 50,681,254 (GRCm38) missense probably benign 0.00
R0613:Olfr747 UTSW 14 50,681,404 (GRCm38) missense probably benign 0.06
R1023:Olfr747 UTSW 14 50,681,016 (GRCm38) missense probably damaging 1.00
R1126:Olfr747 UTSW 14 50,681,263 (GRCm38) missense possibly damaging 0.94
R1298:Olfr747 UTSW 14 50,680,880 (GRCm38) nonsense probably null
R1344:Olfr747 UTSW 14 50,680,858 (GRCm38) missense probably benign
R1775:Olfr747 UTSW 14 50,681,166 (GRCm38) missense possibly damaging 0.66
R1928:Olfr747 UTSW 14 50,681,415 (GRCm38) missense probably benign 0.00
R2208:Olfr747 UTSW 14 50,681,563 (GRCm38) missense probably benign 0.01
R4181:Olfr747 UTSW 14 50,681,050 (GRCm38) missense probably benign 0.07
R4183:Olfr747 UTSW 14 50,681,050 (GRCm38) missense probably benign 0.07
R4184:Olfr747 UTSW 14 50,681,050 (GRCm38) missense probably benign 0.07
R5104:Olfr747 UTSW 14 50,680,702 (GRCm38) nonsense probably null
R6144:Olfr747 UTSW 14 50,680,935 (GRCm38) missense probably benign 0.01
R6768:Olfr747 UTSW 14 50,681,592 (GRCm38) missense probably damaging 1.00
R7026:Olfr747 UTSW 14 50,681,259 (GRCm38) missense probably damaging 0.98
R7454:Olfr747 UTSW 14 50,680,824 (GRCm38) missense possibly damaging 0.94
R7777:Olfr747 UTSW 14 50,680,804 (GRCm38) missense probably damaging 1.00
R7851:Olfr747 UTSW 14 50,681,458 (GRCm38) missense probably damaging 1.00
X0067:Olfr747 UTSW 14 50,681,529 (GRCm38) missense possibly damaging 0.61
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2020-10-20