Incidental Mutation 'R0288:Slc15a5'
ID 65356
Institutional Source Beutler Lab
Gene Symbol Slc15a5
Ensembl Gene ENSMUSG00000044378
Gene Name solute carrier family 15, member 5
Synonyms 9830102E05Rik
MMRRC Submission 038507-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R0288 (G1)
Quality Score 143
Status Validated
Chromosome 6
Chromosomal Location 137960584-138056914 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 137994914 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171804]
AlphaFold Q8CBB2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000050132
SMART Domains Protein: ENSMUSP00000050794
Gene: ENSMUSG00000044378

DomainStartEndE-ValueType
transmembrane domain 26 48 N/A INTRINSIC
transmembrane domain 69 88 N/A INTRINSIC
transmembrane domain 92 114 N/A INTRINSIC
Pfam:PTR2 167 345 1.2e-8 PFAM
transmembrane domain 375 394 N/A INTRINSIC
low complexity region 417 424 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111873
SMART Domains Protein: ENSMUSP00000107504
Gene: ENSMUSG00000044378

DomainStartEndE-ValueType
transmembrane domain 7 28 N/A INTRINSIC
transmembrane domain 48 70 N/A INTRINSIC
transmembrane domain 130 152 N/A INTRINSIC
transmembrane domain 167 189 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000150278
Predicted Effect probably benign
Transcript: ENSMUST00000171804
SMART Domains Protein: ENSMUSP00000129239
Gene: ENSMUSG00000044378

DomainStartEndE-ValueType
Pfam:PTR2 101 485 4.3e-23 PFAM
low complexity region 536 543 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 95.1%
  • 20x: 89.7%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg3 A G 8: 95,766,568 (GRCm39) E413G possibly damaging Het
Amigo2 G T 15: 97,143,560 (GRCm39) N287K probably damaging Het
Ankle2 T A 5: 110,384,256 (GRCm39) I260K probably damaging Het
Apob C T 12: 8,040,779 (GRCm39) R635* probably null Het
Camkv A G 9: 107,823,555 (GRCm39) Y153C probably damaging Het
Capn9 A G 8: 125,327,230 (GRCm39) probably benign Het
Ces2c A G 8: 105,576,376 (GRCm39) I130V probably benign Het
Cfap44 T A 16: 44,236,257 (GRCm39) probably benign Het
Cfhr3 A G 1: 139,525,425 (GRCm39) noncoding transcript Het
Chmp1a G T 8: 123,934,745 (GRCm39) D70E probably damaging Het
Coil G A 11: 88,872,694 (GRCm39) G352R probably damaging Het
Colq T C 14: 31,265,949 (GRCm39) E188G possibly damaging Het
Cyfip2 A G 11: 46,144,799 (GRCm39) F685S possibly damaging Het
Cyp4f39 A G 17: 32,711,410 (GRCm39) N519S probably benign Het
Dennd1c A T 17: 57,383,870 (GRCm39) probably null Het
Dnah9 A T 11: 65,915,960 (GRCm39) probably null Het
Dnmbp T C 19: 43,890,898 (GRCm39) T290A possibly damaging Het
Dsc2 T C 18: 20,166,177 (GRCm39) D818G probably damaging Het
Gnptab G A 10: 88,268,967 (GRCm39) V557I probably benign Het
Hdac4 A T 1: 91,898,728 (GRCm39) H675Q probably damaging Het
Kcnk3 T C 5: 30,745,764 (GRCm39) M35T probably benign Het
Kif1b A T 4: 149,283,795 (GRCm39) I1290N probably damaging Het
Klhl14 G A 18: 21,698,620 (GRCm39) R398W probably damaging Het
Marveld1 T C 19: 42,136,265 (GRCm39) F60L probably damaging Het
Miox C T 15: 89,220,477 (GRCm39) L189F possibly damaging Het
Ncoa6 TGC TGCGC 2: 155,250,211 (GRCm39) probably null Het
Ndst3 A T 3: 123,465,843 (GRCm39) V43D probably benign Het
Nhsl1 A G 10: 18,399,794 (GRCm39) D306G probably damaging Het
Nlrp2 A G 7: 5,331,544 (GRCm39) V284A probably benign Het
Pcdhb15 T C 18: 37,608,451 (GRCm39) V561A probably damaging Het
Pdcl2 T C 5: 76,460,344 (GRCm39) I177V possibly damaging Het
Pkd1l3 G A 8: 110,373,131 (GRCm39) probably null Het
Pla2g6 A C 15: 79,171,106 (GRCm39) probably benign Het
Plekhj1 A T 10: 80,632,444 (GRCm39) I122N probably damaging Het
Pmel T C 10: 128,550,175 (GRCm39) I70T probably benign Het
Psip1 T C 4: 83,383,196 (GRCm39) D273G probably damaging Het
Rictor A G 15: 6,816,021 (GRCm39) I1098V probably benign Het
Rif1 T C 2: 52,000,025 (GRCm39) S1160P probably damaging Het
Rsbn1l T C 5: 21,125,038 (GRCm39) I255V probably damaging Het
Slc29a1 G A 17: 45,900,730 (GRCm39) R111W probably damaging Het
Slc36a1 G A 11: 55,109,913 (GRCm39) A74T probably damaging Het
Slc5a7 A T 17: 54,600,046 (GRCm39) Y122* probably null Het
Slc6a3 G T 13: 73,709,047 (GRCm39) G324W probably damaging Het
Sltm T C 9: 70,486,633 (GRCm39) S433P probably damaging Het
Spta1 T C 1: 174,070,745 (GRCm39) S2190P probably damaging Het
Sry A T Y: 2,662,818 (GRCm39) F281I unknown Het
Stk32a T A 18: 43,438,060 (GRCm39) probably null Het
Sytl2 T C 7: 90,052,228 (GRCm39) probably benign Het
Tbl3 G A 17: 24,920,781 (GRCm39) H612Y probably damaging Het
Tmem144 G A 3: 79,746,580 (GRCm39) probably benign Het
Top2a A G 11: 98,907,249 (GRCm39) probably benign Het
Usp9y A T Y: 1,333,606 (GRCm39) probably benign Het
Vldlr G A 19: 27,218,051 (GRCm39) probably benign Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vmn2r28 A G 7: 5,491,020 (GRCm39) L409P probably damaging Het
Vps13c T C 9: 67,834,648 (GRCm39) V1659A probably damaging Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zfp280d A T 9: 72,238,621 (GRCm39) K646* probably null Het
Zfp36 A G 7: 28,077,666 (GRCm39) S81P probably benign Het
Zfp618 A T 4: 63,051,171 (GRCm39) T651S possibly damaging Het
Other mutations in Slc15a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00546:Slc15a5 APN 6 138,020,536 (GRCm39) missense probably damaging 1.00
IGL02090:Slc15a5 APN 6 138,020,598 (GRCm39) missense probably benign 0.00
R0355:Slc15a5 UTSW 6 137,995,112 (GRCm39) splice site probably benign
R0825:Slc15a5 UTSW 6 137,995,087 (GRCm39) missense possibly damaging 0.84
R1470:Slc15a5 UTSW 6 138,049,992 (GRCm39) missense probably benign 0.01
R1470:Slc15a5 UTSW 6 138,049,992 (GRCm39) missense probably benign 0.01
R1721:Slc15a5 UTSW 6 138,049,845 (GRCm39) splice site probably benign
R1897:Slc15a5 UTSW 6 138,056,762 (GRCm39) missense possibly damaging 0.93
R4159:Slc15a5 UTSW 6 138,049,938 (GRCm39) missense possibly damaging 0.84
R4415:Slc15a5 UTSW 6 138,056,754 (GRCm39) missense probably benign 0.34
R4703:Slc15a5 UTSW 6 138,032,643 (GRCm39) missense probably benign 0.08
R4951:Slc15a5 UTSW 6 138,050,064 (GRCm39) missense probably damaging 1.00
R4996:Slc15a5 UTSW 6 138,020,583 (GRCm39) missense probably damaging 1.00
R5268:Slc15a5 UTSW 6 138,056,751 (GRCm39) missense probably damaging 1.00
R5310:Slc15a5 UTSW 6 138,050,034 (GRCm39) missense probably benign 0.28
R5321:Slc15a5 UTSW 6 137,964,436 (GRCm39) missense probably benign 0.08
R5963:Slc15a5 UTSW 6 138,056,691 (GRCm39) missense probably damaging 1.00
R5988:Slc15a5 UTSW 6 138,020,529 (GRCm39) missense probably benign 0.07
R7400:Slc15a5 UTSW 6 138,050,055 (GRCm39) missense probably benign 0.01
R7515:Slc15a5 UTSW 6 138,020,496 (GRCm39) missense possibly damaging 0.89
R7604:Slc15a5 UTSW 6 138,056,784 (GRCm39) missense probably damaging 1.00
R7707:Slc15a5 UTSW 6 138,056,745 (GRCm39) missense probably damaging 1.00
R8344:Slc15a5 UTSW 6 138,056,898 (GRCm39) missense probably damaging 1.00
R8410:Slc15a5 UTSW 6 137,989,153 (GRCm39) missense
R9020:Slc15a5 UTSW 6 138,032,704 (GRCm39) missense probably benign 0.00
R9157:Slc15a5 UTSW 6 137,961,456 (GRCm39) missense
R9222:Slc15a5 UTSW 6 137,961,450 (GRCm39) missense
R9526:Slc15a5 UTSW 6 138,049,954 (GRCm39) missense probably benign 0.02
R9618:Slc15a5 UTSW 6 138,032,779 (GRCm39) missense possibly damaging 0.90
Z1188:Slc15a5 UTSW 6 137,994,956 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TGGAGGGTGAATTTTCACAAAGCGG -3'
(R):5'- GGATTGAACAGAGTGACCTCAGCC -3'

Sequencing Primer
(F):5'- CTTTAATCAGGTTAGCGAGTTCC -3'
(R):5'- GGTAACATTTGTGCAGCATCC -3'
Posted On 2013-08-08