Incidental Mutation 'R8429:Or9k2b'
ID 653659
Institutional Source Beutler Lab
Gene Symbol Or9k2b
Ensembl Gene ENSMUSG00000059862
Gene Name olfactory receptor family 9 subfamily K member 2B
Synonyms MOR210-2, GA_x6K02T2PULF-11851623-11850682, Olfr826
MMRRC Submission 067774-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R8429 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 130015806-130016747 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130016092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 219 (V219A)
Ref Sequence ENSEMBL: ENSMUSP00000149119 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078322] [ENSMUST00000203720] [ENSMUST00000216661]
AlphaFold Q8VFU6
Predicted Effect possibly damaging
Transcript: ENSMUST00000078322
AA Change: V219A

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077436
Gene: ENSMUSG00000059862
AA Change: V219A

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.3e-52 PFAM
Pfam:7tm_1 44 291 3.7e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000203720
AA Change: V219A

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000144755
Gene: ENSMUSG00000059862
AA Change: V219A

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.3e-52 PFAM
Pfam:7tm_1 44 291 3.7e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216661
AA Change: V219A

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik A T 17: 48,347,875 (GRCm39) L143* probably null Het
2900026A02Rik T C 5: 113,331,302 (GRCm39) T971A probably benign Het
Abca6 A T 11: 110,093,208 (GRCm39) C1022S probably benign Het
Adgrf4 G T 17: 42,978,340 (GRCm39) N334K probably benign Het
Baz1b A G 5: 135,246,185 (GRCm39) K545E probably benign Het
Bin3 A G 14: 70,374,598 (GRCm39) Y209C probably damaging Het
Btbd16 G A 7: 130,397,067 (GRCm39) A223T probably benign Het
C3 A G 17: 57,529,811 (GRCm39) V555A probably damaging Het
Calm3 T A 7: 16,653,592 (GRCm39) probably null Het
Cct4 T A 11: 22,946,030 (GRCm39) L124Q probably damaging Het
Cenpf C T 1: 189,389,504 (GRCm39) D1443N possibly damaging Het
Egfem1 G A 3: 29,711,417 (GRCm39) probably null Het
Epha4 G T 1: 77,366,673 (GRCm39) Q591K probably benign Het
Fanci T C 7: 79,088,133 (GRCm39) F929L possibly damaging Het
Fnip1 A T 11: 54,366,522 (GRCm39) D95V possibly damaging Het
Foxc1 A T 13: 31,991,759 (GRCm39) H190L probably benign Het
Gm45713 T C 7: 44,785,540 (GRCm39) S2G unknown Het
Grin2b T C 6: 135,710,914 (GRCm39) I877M probably damaging Het
Hadha T C 5: 30,349,255 (GRCm39) I119V probably benign Het
Hcar2 C T 5: 124,003,538 (GRCm39) probably benign Het
Irag2 C A 6: 145,110,949 (GRCm39) D251E probably damaging Het
Krt13 A T 11: 100,011,951 (GRCm39) L124Q probably damaging Het
Larp1b A G 3: 40,931,662 (GRCm39) *336W probably null Het
Man2c1 T C 9: 57,038,445 (GRCm39) L35P probably damaging Het
Meioc A T 11: 102,565,032 (GRCm39) N160I probably benign Het
Mfsd2b G T 12: 4,916,487 (GRCm39) Q331K possibly damaging Het
Mical2 T A 7: 111,944,460 (GRCm39) V930E probably benign Het
Mrgprb4 A T 7: 47,848,173 (GRCm39) F252I probably benign Het
Nars1 A G 18: 64,634,391 (GRCm39) Y511H probably damaging Het
Naxe C A 3: 87,965,459 (GRCm39) S84I probably damaging Het
Ncam2 A T 16: 81,386,523 (GRCm39) D634V probably damaging Het
Npat C T 9: 53,481,909 (GRCm39) Q1206* probably null Het
Nr1d2 G A 14: 18,215,409 (GRCm38) T201I probably benign Het
Nt5el A G 13: 105,255,296 (GRCm39) Y459C probably damaging Het
Nup155 C T 15: 8,141,904 (GRCm39) H99Y probably damaging Het
Or10ag60 G T 2: 87,437,868 (GRCm39) L45F probably benign Het
Or4f4b G A 2: 111,313,840 (GRCm39) V50I possibly damaging Het
Or5ac25 A G 16: 59,181,990 (GRCm39) V197A possibly damaging Het
Pcnx3 C T 19: 5,715,412 (GRCm39) G1946E probably damaging Het
Pde6a T A 18: 61,365,916 (GRCm39) Y214N probably damaging Het
Pex7 T C 10: 19,770,074 (GRCm39) T145A probably damaging Het
Plekhj1 C T 10: 80,632,304 (GRCm39) S146N probably benign Het
Ralgapb C T 2: 158,268,217 (GRCm39) P107S probably damaging Het
Satb1 A G 17: 52,074,978 (GRCm39) M506T probably damaging Het
Sh3gl1 T C 17: 56,325,821 (GRCm39) N203D possibly damaging Het
Slc7a12 A T 3: 14,562,342 (GRCm39) I240F probably benign Het
Spata31h1 G T 10: 82,125,301 (GRCm39) Q2570K possibly damaging Het
Syt17 T A 7: 118,033,564 (GRCm39) Y144F probably benign Het
Thbd G T 2: 148,249,457 (GRCm39) T137K possibly damaging Het
Tmem114 A G 16: 8,230,031 (GRCm39) F124L probably damaging Het
Ubtd1 G T 19: 42,020,556 (GRCm39) probably null Het
Zfp458 A G 13: 67,406,152 (GRCm39) Y96H possibly damaging Het
Zfp78 T C 7: 6,381,492 (GRCm39) S181P probably benign Het
Other mutations in Or9k2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Or9k2b APN 10 130,016,083 (GRCm39) missense probably benign 0.06
R0627:Or9k2b UTSW 10 130,016,557 (GRCm39) missense probably damaging 1.00
R1672:Or9k2b UTSW 10 130,016,261 (GRCm39) missense probably benign 0.00
R1834:Or9k2b UTSW 10 130,016,701 (GRCm39) missense probably benign 0.01
R1957:Or9k2b UTSW 10 130,015,847 (GRCm39) missense possibly damaging 0.77
R3717:Or9k2b UTSW 10 130,016,369 (GRCm39) missense possibly damaging 0.63
R5106:Or9k2b UTSW 10 130,016,177 (GRCm39) missense probably benign 0.37
R5837:Or9k2b UTSW 10 130,016,266 (GRCm39) missense probably damaging 1.00
R6348:Or9k2b UTSW 10 130,016,166 (GRCm39) missense probably benign 0.12
R6971:Or9k2b UTSW 10 130,016,638 (GRCm39) missense possibly damaging 0.95
R7181:Or9k2b UTSW 10 130,016,626 (GRCm39) missense possibly damaging 0.78
R7394:Or9k2b UTSW 10 130,016,123 (GRCm39) missense probably damaging 1.00
R8372:Or9k2b UTSW 10 130,016,656 (GRCm39) missense probably damaging 0.99
R8679:Or9k2b UTSW 10 130,016,702 (GRCm39) missense probably benign 0.01
R8746:Or9k2b UTSW 10 130,016,086 (GRCm39) missense probably damaging 1.00
R9043:Or9k2b UTSW 10 130,016,154 (GRCm39) missense probably benign 0.00
R9204:Or9k2b UTSW 10 130,016,566 (GRCm39) missense probably damaging 1.00
R9254:Or9k2b UTSW 10 130,016,605 (GRCm39) missense possibly damaging 0.85
R9379:Or9k2b UTSW 10 130,016,605 (GRCm39) missense possibly damaging 0.85
R9568:Or9k2b UTSW 10 130,015,814 (GRCm39) missense probably benign
Z1176:Or9k2b UTSW 10 130,015,834 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- ATCAGAGGGTTCAGCATAGGTG -3'
(R):5'- TCAGCTCTGTTCTCCAGACTAG -3'

Sequencing Primer
(F):5'- TCAGCATAGGTGTGACTAGGG -3'
(R):5'- TGTTCTCCAGACTAGCATGAC -3'
Posted On 2020-10-20