Incidental Mutation 'R0350:Zfp937'
ID65377
Institutional Source Beutler Lab
Gene Symbol Zfp937
Ensembl Gene ENSMUSG00000060336
Gene Namezinc finger protein 937
SynonymsGm4979
MMRRC Submission 038557-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #R0350 (G1)
Quality Score95
Status Not validated
Chromosome2
Chromosomal Location150218073-150240725 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 150239302 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 417 (D417E)
Ref Sequence ENSEMBL: ENSMUSP00000073454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073782]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073782
AA Change: D417E

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: D417E

DomainStartEndE-ValueType
KRAB 4 66 8.19e-20 SMART
ZnF_C2H2 103 125 1.28e-3 SMART
ZnF_C2H2 131 153 2.53e-2 SMART
ZnF_C2H2 159 181 9.58e-3 SMART
ZnF_C2H2 187 209 2.09e-3 SMART
ZnF_C2H2 215 237 2.2e-2 SMART
ZnF_C2H2 243 265 2.2e-2 SMART
ZnF_C2H2 271 293 2.2e-2 SMART
ZnF_C2H2 299 321 1.82e-3 SMART
ZnF_C2H2 327 349 3.69e-4 SMART
ZnF_C2H2 355 377 4.47e-3 SMART
ZnF_C2H2 383 405 3.89e-3 SMART
ZnF_C2H2 411 433 4.79e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 490 7.26e-3 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 89.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd13 T A 8: 9,987,600 Y66N probably damaging Het
Apol6 C T 15: 77,050,947 Q139* probably null Het
Armh1 C A 4: 117,215,556 E244* probably null Het
BC052040 T C 2: 115,776,930 Y255H possibly damaging Het
Ccdc130 C T 8: 84,260,648 E99K probably damaging Het
Cd1d1 A T 3: 86,997,573 H219Q probably benign Het
Cdca2 A G 14: 67,713,119 L121P probably benign Het
Cog4 T A 8: 110,853,696 L133I possibly damaging Het
Csf1 T C 3: 107,748,606 M370V probably benign Het
Ddi2 G A 4: 141,685,523 T26M probably benign Het
Dhcr7 A G 7: 143,837,770 D32G probably damaging Het
Exd1 T C 2: 119,523,566 N337S possibly damaging Het
Flii T C 11: 60,721,857 D227G probably damaging Het
Gm11639 T C 11: 104,690,880 V16A probably benign Het
Hsf1 A G 15: 76,500,479 T485A probably benign Het
Igfn1 G A 1: 135,956,767 R2614* probably null Het
Iqch T C 9: 63,500,876 T630A probably benign Het
Itgal T A 7: 127,322,081 D770E probably damaging Het
Mroh1 T A 15: 76,432,249 V759E probably damaging Het
Mrps17 A G 5: 129,718,145 probably benign Het
Mtpap A G 18: 4,396,195 S496G possibly damaging Het
Nkd1 T A 8: 88,585,216 Y39* probably null Het
Nmd3 A G 3: 69,743,574 Y359C probably damaging Het
Nr1h3 G A 2: 91,191,825 L153F possibly damaging Het
Nuf2 T A 1: 169,513,543 probably null Het
Olfr1218 T A 2: 89,055,356 K23N probably benign Het
Olfr1272 T C 2: 90,282,582 probably null Het
Olfr870 A T 9: 20,170,736 Y278* probably null Het
Pnn T C 12: 59,067,117 probably null Het
Ppm1j A G 3: 104,783,371 D230G probably benign Het
Ppp1r15a A T 7: 45,523,018 L650Q probably damaging Het
Prss37 T C 6: 40,514,959 E229G probably damaging Het
Rbm19 T C 5: 120,128,307 V465A possibly damaging Het
Rubcnl G T 14: 75,040,891 V372F probably damaging Het
Sema6a G T 18: 47,270,718 D595E probably benign Het
Slc35c1 A G 2: 92,459,032 F43S probably damaging Het
Slc39a5 C T 10: 128,396,750 probably null Het
Slco4c1 A G 1: 96,828,849 F583L probably benign Het
Sox9 A G 11: 112,784,876 Y297C probably damaging Het
Taf1b A G 12: 24,514,885 D167G possibly damaging Het
Trpm6 T C 19: 18,883,957 probably null Het
Uba6 A C 5: 86,144,378 V402G possibly damaging Het
Usp43 T C 11: 67,876,498 Y682C probably damaging Het
Vmn1r195 A G 13: 22,279,233 D291G probably damaging Het
Xpr1 A T 1: 155,330,468 F156Y probably damaging Het
Zfp318 T A 17: 46,413,198 H2042Q probably benign Het
Other mutations in Zfp937
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0449:Zfp937 UTSW 2 150239546 missense probably benign 0.13
R1403:Zfp937 UTSW 2 150238948 nonsense probably null
R1403:Zfp937 UTSW 2 150238948 nonsense probably null
R1465:Zfp937 UTSW 2 150239047 nonsense probably null
R1465:Zfp937 UTSW 2 150239047 nonsense probably null
R4510:Zfp937 UTSW 2 150238511 missense probably damaging 0.98
R4511:Zfp937 UTSW 2 150238511 missense probably damaging 0.98
R4689:Zfp937 UTSW 2 150236786 missense probably damaging 1.00
R5290:Zfp937 UTSW 2 150238309 nonsense probably null
R6287:Zfp937 UTSW 2 150238341 missense possibly damaging 0.89
R6701:Zfp937 UTSW 2 150239216 missense probably damaging 1.00
R6746:Zfp937 UTSW 2 150239423 nonsense probably null
R6838:Zfp937 UTSW 2 150239346 missense probably benign 0.01
R7162:Zfp937 UTSW 2 150239519 missense probably benign 0.35
R7213:Zfp937 UTSW 2 150239465 missense probably damaging 1.00
R7441:Zfp937 UTSW 2 150238710 frame shift probably null
R7481:Zfp937 UTSW 2 150239346 missense probably benign 0.01
R7694:Zfp937 UTSW 2 150239348 missense probably damaging 1.00
R7856:Zfp937 UTSW 2 150239547 missense probably benign 0.23
R7902:Zfp937 UTSW 2 150238761 missense probably damaging 1.00
R7956:Zfp937 UTSW 2 150239156 missense probably benign 0.03
R8058:Zfp937 UTSW 2 150239501 missense probably benign 0.00
R8468:Zfp937 UTSW 2 150238714 missense probably benign 0.02
X0017:Zfp937 UTSW 2 150218161 splice site probably null
Predicted Primers
Posted On2013-08-08