Incidental Mutation 'R8434:Zfp808'
| ID |
653914 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp808
|
| Ensembl Gene |
ENSMUSG00000074867 |
| Gene Name |
zinc finger protein 808 |
| Synonyms |
Gm7036 |
| MMRRC Submission |
067900-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R8434 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
62277674-62321752 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 62319926 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 385
(Y385C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097048
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099449]
[ENSMUST00000221772]
|
| AlphaFold |
B8JJZ4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099449
AA Change: Y385C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000097048
Gene: ENSMUSG00000074867
AA Change: Y385C
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
2.1e-17 |
SMART |
|
ZnF_C2H2
|
133 |
155 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
161 |
183 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
189 |
211 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
2.43e-4 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
413 |
435 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
441 |
463 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
469 |
491 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
497 |
519 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
525 |
547 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
553 |
575 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
581 |
603 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
609 |
631 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
637 |
659 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
665 |
687 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
693 |
715 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
721 |
743 |
1.26e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221772
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,773,021 (GRCm39) |
T737A |
probably damaging |
Het |
| 2310034C09Rik |
A |
G |
16: 88,556,260 (GRCm39) |
Y158C |
probably damaging |
Het |
| Abhd18 |
T |
A |
3: 40,885,331 (GRCm39) |
S239T |
possibly damaging |
Het |
| Ankrd13b |
G |
A |
11: 77,368,552 (GRCm39) |
T56I |
probably benign |
Het |
| Arhgef10l |
T |
A |
4: 140,291,582 (GRCm39) |
Q454L |
possibly damaging |
Het |
| Atp1a2 |
T |
C |
1: 172,112,179 (GRCm39) |
E572G |
probably benign |
Het |
| Cdk5rap2 |
T |
C |
4: 70,282,257 (GRCm39) |
H164R |
probably benign |
Het |
| Clca4b |
A |
G |
3: 144,631,917 (GRCm39) |
M196T |
probably benign |
Het |
| Cnbd1 |
T |
G |
4: 19,055,045 (GRCm39) |
K127T |
probably benign |
Het |
| Cog3 |
A |
T |
14: 75,979,836 (GRCm39) |
V165E |
probably damaging |
Het |
| Crim1 |
G |
A |
17: 78,654,686 (GRCm39) |
R654H |
probably benign |
Het |
| Ctnnb1 |
G |
A |
9: 120,786,628 (GRCm39) |
V617I |
possibly damaging |
Het |
| Dach1 |
T |
A |
14: 98,406,129 (GRCm39) |
Q206L |
probably damaging |
Het |
| Dhx30 |
C |
T |
9: 109,929,974 (GRCm39) |
V41I |
probably benign |
Het |
| Dnase2a |
T |
C |
8: 85,636,410 (GRCm39) |
L176P |
probably damaging |
Het |
| Dpp10 |
T |
C |
1: 123,360,739 (GRCm39) |
D262G |
probably damaging |
Het |
| Dsel |
T |
A |
1: 111,789,385 (GRCm39) |
E383D |
probably damaging |
Het |
| Flt1 |
T |
A |
5: 147,576,253 (GRCm39) |
Y585F |
probably damaging |
Het |
| Fubp1 |
T |
A |
3: 151,926,190 (GRCm39) |
I304N |
probably damaging |
Het |
| Gab2 |
A |
G |
7: 96,948,337 (GRCm39) |
D309G |
probably damaging |
Het |
| Gon4l |
T |
C |
3: 88,762,086 (GRCm39) |
V291A |
probably damaging |
Het |
| Gpam |
C |
T |
19: 55,070,063 (GRCm39) |
V398M |
possibly damaging |
Het |
| Grin3b |
C |
T |
10: 79,810,422 (GRCm39) |
R643C |
probably damaging |
Het |
| Hdac3 |
T |
A |
18: 38,074,475 (GRCm39) |
H339L |
possibly damaging |
Het |
| Hsdl2 |
A |
T |
4: 59,610,621 (GRCm39) |
Q326L |
unknown |
Het |
| Insr |
T |
C |
8: 3,215,514 (GRCm39) |
|
probably benign |
Het |
| Ivl |
T |
A |
3: 92,479,943 (GRCm39) |
T41S |
probably benign |
Het |
| Lama4 |
C |
T |
10: 38,902,703 (GRCm39) |
P226S |
possibly damaging |
Het |
| Lpin1 |
A |
G |
12: 16,613,621 (GRCm39) |
|
probably null |
Het |
| Lrrc42 |
A |
T |
4: 107,104,721 (GRCm39) |
N81K |
probably damaging |
Het |
| Mast4 |
A |
T |
13: 102,897,900 (GRCm39) |
H838Q |
probably damaging |
Het |
| Mcmdc2 |
A |
G |
1: 9,990,806 (GRCm39) |
M314V |
possibly damaging |
Het |
| Me3 |
A |
G |
7: 89,389,086 (GRCm39) |
E130G |
probably damaging |
Het |
| Mpnd |
A |
G |
17: 56,316,405 (GRCm39) |
D28G |
possibly damaging |
Het |
| Mtch2 |
G |
T |
2: 90,683,208 (GRCm39) |
E102* |
probably null |
Het |
| Myh13 |
A |
T |
11: 67,254,011 (GRCm39) |
|
probably null |
Het |
| Or10ag55-ps1 |
G |
A |
2: 87,114,978 (GRCm39) |
V115I |
probably benign |
Het |
| Or5ae2 |
C |
A |
7: 84,506,497 (GRCm39) |
H309N |
probably benign |
Het |
| Plch2 |
T |
A |
4: 155,074,192 (GRCm39) |
D891V |
probably damaging |
Het |
| Ppfibp2 |
T |
C |
7: 107,327,957 (GRCm39) |
|
probably null |
Het |
| Rag1 |
A |
G |
2: 101,473,009 (GRCm39) |
L711P |
probably damaging |
Het |
| Sacs |
T |
A |
14: 61,450,636 (GRCm39) |
Y4227* |
probably null |
Het |
| Sec23ip |
C |
T |
7: 128,352,151 (GRCm39) |
H176Y |
probably benign |
Het |
| Sema3a |
T |
C |
5: 13,523,487 (GRCm39) |
|
probably null |
Het |
| Serpina10 |
C |
T |
12: 103,594,563 (GRCm39) |
G219R |
probably damaging |
Het |
| Sp1 |
C |
T |
15: 102,318,118 (GRCm39) |
L546F |
probably benign |
Het |
| Syne1 |
T |
C |
10: 5,073,057 (GRCm39) |
N1256S |
probably benign |
Het |
| Tbc1d5 |
G |
T |
17: 51,089,455 (GRCm39) |
|
probably benign |
Het |
| Tns1 |
T |
C |
1: 73,964,765 (GRCm39) |
S33G |
probably benign |
Het |
| Tpsab1 |
A |
G |
17: 25,564,445 (GRCm39) |
L3P |
possibly damaging |
Het |
| Trgv3 |
A |
G |
13: 19,427,036 (GRCm39) |
T8A |
probably benign |
Het |
| Vav2 |
A |
T |
2: 27,159,050 (GRCm39) |
|
probably benign |
Het |
| Vmn1r44 |
T |
C |
6: 89,870,610 (GRCm39) |
S119P |
possibly damaging |
Het |
| Vmn2r31 |
A |
G |
7: 7,387,699 (GRCm39) |
L624P |
probably damaging |
Het |
| Vps33a |
A |
T |
5: 123,671,944 (GRCm39) |
W475R |
possibly damaging |
Het |
| Xpnpep3 |
G |
T |
15: 81,311,795 (GRCm39) |
R167L |
possibly damaging |
Het |
| Zfhx4 |
T |
A |
3: 5,463,918 (GRCm39) |
S1384T |
probably damaging |
Het |
| Zfp3 |
G |
A |
11: 70,663,384 (GRCm39) |
E448K |
probably benign |
Het |
| Zfp362 |
T |
A |
4: 128,679,769 (GRCm39) |
H299L |
probably damaging |
Het |
| Zfp664 |
C |
T |
5: 124,962,827 (GRCm39) |
L74F |
possibly damaging |
Het |
|
| Other mutations in Zfp808 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01609:Zfp808
|
APN |
13 |
62,321,023 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02517:Zfp808
|
APN |
13 |
62,321,032 (GRCm39) |
makesense |
probably null |
|
|
IGL02809:Zfp808
|
APN |
13 |
62,320,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02882:Zfp808
|
APN |
13 |
62,320,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02941:Zfp808
|
APN |
13 |
62,320,944 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03184:Zfp808
|
APN |
13 |
62,317,381 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
LCD18:Zfp808
|
UTSW |
13 |
62,314,465 (GRCm39) |
intron |
probably benign |
|
|
R0387:Zfp808
|
UTSW |
13 |
62,317,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0472:Zfp808
|
UTSW |
13 |
62,320,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0544:Zfp808
|
UTSW |
13 |
62,317,248 (GRCm39) |
splice site |
probably benign |
|
|
R0635:Zfp808
|
UTSW |
13 |
62,320,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0981:Zfp808
|
UTSW |
13 |
62,319,487 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1446:Zfp808
|
UTSW |
13 |
62,320,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1569:Zfp808
|
UTSW |
13 |
62,320,714 (GRCm39) |
nonsense |
probably null |
|
|
R1573:Zfp808
|
UTSW |
13 |
62,319,311 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1761:Zfp808
|
UTSW |
13 |
62,319,460 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1796:Zfp808
|
UTSW |
13 |
62,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Zfp808
|
UTSW |
13 |
62,320,721 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2656:Zfp808
|
UTSW |
13 |
62,320,666 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2938:Zfp808
|
UTSW |
13 |
62,319,032 (GRCm39) |
missense |
probably benign |
|
|
R3027:Zfp808
|
UTSW |
13 |
62,319,404 (GRCm39) |
missense |
probably benign |
0.33 |
|
R3777:Zfp808
|
UTSW |
13 |
62,319,717 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3779:Zfp808
|
UTSW |
13 |
62,319,717 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3801:Zfp808
|
UTSW |
13 |
62,319,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Zfp808
|
UTSW |
13 |
62,319,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3804:Zfp808
|
UTSW |
13 |
62,319,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4024:Zfp808
|
UTSW |
13 |
62,319,544 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4741:Zfp808
|
UTSW |
13 |
62,319,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4791:Zfp808
|
UTSW |
13 |
62,319,045 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4809:Zfp808
|
UTSW |
13 |
62,319,106 (GRCm39) |
nonsense |
probably null |
|
|
R4907:Zfp808
|
UTSW |
13 |
62,319,287 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5056:Zfp808
|
UTSW |
13 |
62,320,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5760:Zfp808
|
UTSW |
13 |
62,319,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5869:Zfp808
|
UTSW |
13 |
62,319,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Zfp808
|
UTSW |
13 |
62,320,136 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6372:Zfp808
|
UTSW |
13 |
62,320,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Zfp808
|
UTSW |
13 |
62,319,709 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6620:Zfp808
|
UTSW |
13 |
62,320,638 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6622:Zfp808
|
UTSW |
13 |
62,319,646 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6813:Zfp808
|
UTSW |
13 |
62,320,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Zfp808
|
UTSW |
13 |
62,320,982 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7511:Zfp808
|
UTSW |
13 |
62,320,637 (GRCm39) |
missense |
probably benign |
|
|
R7666:Zfp808
|
UTSW |
13 |
62,319,225 (GRCm39) |
missense |
probably benign |
|
|
R7747:Zfp808
|
UTSW |
13 |
62,319,319 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7763:Zfp808
|
UTSW |
13 |
62,320,478 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7779:Zfp808
|
UTSW |
13 |
62,320,571 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8147:Zfp808
|
UTSW |
13 |
62,320,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8182:Zfp808
|
UTSW |
13 |
62,319,521 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8260:Zfp808
|
UTSW |
13 |
62,320,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8822:Zfp808
|
UTSW |
13 |
62,320,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9330:Zfp808
|
UTSW |
13 |
62,319,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9564:Zfp808
|
UTSW |
13 |
62,320,661 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
RF005:Zfp808
|
UTSW |
13 |
62,319,113 (GRCm39) |
missense |
probably benign |
0.14 |
|
RF024:Zfp808
|
UTSW |
13 |
62,319,113 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATACTGGAGAGAAACCCTTCAA -3'
(R):5'- CTCTCCAGTATGTGTTCTTCTATGAG -3'
Sequencing Primer
(F):5'- GGAGAGAAACCCTTCAAATGTAATC -3'
(R):5'- ACATTTGAAGGGCTTCTCTCCAG -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation