Incidental Mutation 'R8436:Vmn1r86'
ID 653996
Institutional Source Beutler Lab
Gene Symbol Vmn1r86
Ensembl Gene ENSMUSG00000070816
Gene Name vomeronasal 1 receptor 86
Synonyms Gm10301
MMRRC Submission 067777-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8436 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 12835924-12836874 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12836771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 35 (F35S)
Ref Sequence ENSEMBL: ENSMUSP00000092423 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094828] [ENSMUST00000226604] [ENSMUST00000227220] [ENSMUST00000227700]
AlphaFold L7N213
Predicted Effect probably benign
Transcript: ENSMUST00000094828
AA Change: F35S

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000092423
Gene: ENSMUSG00000070816
AA Change: F35S

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.1e-14 PFAM
Pfam:V1R 35 301 4e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226604
AA Change: F35S

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000227220
AA Change: F35S

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000227700
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,949,936 (GRCm39) I1278V possibly damaging Het
Baz1b A G 5: 135,266,821 (GRCm39) H1210R probably damaging Het
Cdt1 C T 8: 123,296,070 (GRCm39) S128L probably benign Het
Cfap54 A T 10: 92,800,398 (GRCm39) N1603K unknown Het
Cfap99 A G 5: 34,469,026 (GRCm39) N300S possibly damaging Het
Chrdl2 G A 7: 99,676,940 (GRCm39) probably null Het
Cpb2 C A 14: 75,510,015 (GRCm39) F258L probably damaging Het
Csmd3 A T 15: 47,868,218 (GRCm39) D767E probably damaging Het
Dennd3 C T 15: 73,434,198 (GRCm39) T956I probably damaging Het
Emcn A G 3: 137,129,228 (GRCm39) T245A possibly damaging Het
Gm4353 A G 7: 115,682,864 (GRCm39) V239A probably damaging Het
Gm4884 G A 7: 40,692,810 (GRCm39) A260T probably damaging Het
Hectd4 A G 5: 121,446,421 (GRCm39) D205G possibly damaging Het
Hectd4 A G 5: 121,481,210 (GRCm39) S3005G probably benign Het
Ifngr1 T C 10: 19,479,553 (GRCm39) L148P probably damaging Het
Irf2 C T 8: 47,271,929 (GRCm39) T172M probably damaging Het
Irs1 T C 1: 82,267,970 (GRCm39) H82R possibly damaging Het
Kcnc4 G T 3: 107,366,084 (GRCm39) N41K probably damaging Het
Lig3 C T 11: 82,682,870 (GRCm39) A490V possibly damaging Het
Megf6 G A 4: 154,349,649 (GRCm39) E946K probably damaging Het
Mpi A T 9: 57,452,200 (GRCm39) Y359N probably damaging Het
Nf1 A G 11: 79,349,709 (GRCm39) S1365G probably damaging Het
P3h3 C A 6: 124,828,041 (GRCm39) probably null Het
Pdk2 A T 11: 94,930,259 (GRCm39) V59D probably damaging Het
Ppip5k2 T C 1: 97,683,613 (GRCm39) K168R probably benign Het
Prg4 G T 1: 150,331,318 (GRCm39) P452T unknown Het
Prl2b1 T C 13: 27,567,442 (GRCm39) N234S possibly damaging Het
Rnd1 T A 15: 98,574,455 (GRCm39) T41S possibly damaging Het
Sall4 G A 2: 168,597,830 (GRCm39) P337S probably damaging Het
Slc1a2 G A 2: 102,586,298 (GRCm39) A301T possibly damaging Het
Sorcs3 C T 19: 48,194,913 (GRCm39) R99W possibly damaging Het
Svep1 G A 4: 58,044,053 (GRCm39) T3531I possibly damaging Het
Sycp2 T C 2: 178,004,761 (GRCm39) D894G probably benign Het
Syne1 T C 10: 5,178,659 (GRCm39) N4605S probably benign Het
Syt4 A C 18: 31,573,472 (GRCm39) C348G possibly damaging Het
Tceanc2 G A 4: 107,034,778 (GRCm39) T28M probably damaging Het
Tmco1 A G 1: 167,136,254 (GRCm39) D5G Het
Tnfsf12 T C 11: 69,577,713 (GRCm39) K235E probably damaging Het
Trank1 T C 9: 111,220,450 (GRCm39) S2396P possibly damaging Het
Vipas39 T A 12: 87,304,191 (GRCm39) D125V probably damaging Het
Vmn2r16 A G 5: 109,511,649 (GRCm39) N619D probably damaging Het
Vps13a A G 19: 16,718,157 (GRCm39) V521A probably benign Het
Wdr20rt T A 12: 65,273,035 (GRCm39) L166Q probably damaging Het
Zbtb11 T A 16: 55,821,022 (GRCm39) C706* probably null Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Zscan21 A T 5: 138,116,178 (GRCm39) Y30F unknown Het
Other mutations in Vmn1r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Vmn1r86 APN 7 12,836,468 (GRCm39) missense possibly damaging 0.91
IGL01124:Vmn1r86 APN 7 12,836,856 (GRCm39) missense probably benign 0.04
IGL01291:Vmn1r86 APN 7 12,836,433 (GRCm39) missense probably benign 0.14
IGL02347:Vmn1r86 APN 7 12,836,574 (GRCm39) missense probably damaging 0.99
IGL02457:Vmn1r86 APN 7 12,836,707 (GRCm39) missense probably benign
IGL02983:Vmn1r86 APN 7 12,836,741 (GRCm39) missense probably damaging 1.00
ANU05:Vmn1r86 UTSW 7 12,836,433 (GRCm39) missense probably benign 0.14
R0304:Vmn1r86 UTSW 7 12,836,707 (GRCm39) missense probably benign
R0525:Vmn1r86 UTSW 7 12,836,088 (GRCm39) missense probably benign 0.13
R1958:Vmn1r86 UTSW 7 12,836,621 (GRCm39) missense possibly damaging 0.94
R2227:Vmn1r86 UTSW 7 12,836,847 (GRCm39) missense probably benign 0.00
R3149:Vmn1r86 UTSW 7 12,836,358 (GRCm39) nonsense probably null
R3896:Vmn1r86 UTSW 7 12,836,093 (GRCm39) missense probably benign 0.18
R4735:Vmn1r86 UTSW 7 12,836,221 (GRCm39) missense probably damaging 1.00
R5219:Vmn1r86 UTSW 7 12,836,382 (GRCm39) missense probably damaging 1.00
R6003:Vmn1r86 UTSW 7 12,836,125 (GRCm39) nonsense probably null
R6457:Vmn1r86 UTSW 7 12,836,279 (GRCm39) missense possibly damaging 0.70
R7442:Vmn1r86 UTSW 7 12,835,983 (GRCm39) missense possibly damaging 0.70
R7622:Vmn1r86 UTSW 7 12,836,685 (GRCm39) missense probably benign 0.07
R9141:Vmn1r86 UTSW 7 12,836,789 (GRCm39) nonsense probably null
R9374:Vmn1r86 UTSW 7 12,836,781 (GRCm39) missense possibly damaging 0.86
R9398:Vmn1r86 UTSW 7 12,836,261 (GRCm39) missense probably damaging 0.98
R9551:Vmn1r86 UTSW 7 12,836,781 (GRCm39) missense possibly damaging 0.86
R9552:Vmn1r86 UTSW 7 12,836,781 (GRCm39) missense possibly damaging 0.86
R9606:Vmn1r86 UTSW 7 12,836,741 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTTAGAACAGAGGTGGTGC -3'
(R):5'- CCTGAGCTGTCACTAAGTATATTTTCC -3'

Sequencing Primer
(F):5'- TGGTGCAGATGGACAGACCC -3'
(R):5'- CATGCTTCCAAGTGACAC -3'
Posted On 2020-10-20