Incidental Mutation 'R8439:Zfp988'
ID 654152
Institutional Source Beutler Lab
Gene Symbol Zfp988
Ensembl Gene ENSMUSG00000078498
Gene Name zinc finger protein 988
Synonyms Gm13151
MMRRC Submission 067883-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R8439 (G1)
Quality Score 140.008
Status Not validated
Chromosome 4
Chromosomal Location 147390131-147418191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 147416808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 414 (D414G)
Ref Sequence ENSEMBL: ENSMUSP00000120413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000148762] [ENSMUST00000166764]
AlphaFold F6VKC7
Predicted Effect probably benign
Transcript: ENSMUST00000148762
AA Change: D414G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000120413
Gene: ENSMUSG00000078498
AA Change: D414G

DomainStartEndE-ValueType
KRAB 13 76 4.74e-16 SMART
ZnF_C2H2 240 262 2.61e-4 SMART
ZnF_C2H2 268 290 1.3e-4 SMART
ZnF_C2H2 296 318 9.73e-4 SMART
ZnF_C2H2 324 346 7.78e-3 SMART
ZnF_C2H2 352 374 1.3e-4 SMART
ZnF_C2H2 380 402 8.34e-3 SMART
ZnF_C2H2 408 430 2.79e-4 SMART
ZnF_C2H2 436 458 3.74e-5 SMART
ZnF_C2H2 464 486 1.3e-4 SMART
ZnF_C2H2 492 514 1.5e-4 SMART
ZnF_C2H2 520 542 2.43e-4 SMART
ZnF_C2H2 548 570 9.73e-4 SMART
ZnF_C2H2 576 598 1.56e-2 SMART
ZnF_C2H2 604 626 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166764
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A T 10: 79,841,995 (GRCm39) T1043S probably benign Het
Acadvl T A 11: 69,902,554 (GRCm39) K410* probably null Het
Adam8 C T 7: 139,567,762 (GRCm39) G354D probably benign Het
Ahctf1 T C 1: 179,590,175 (GRCm39) E1366G possibly damaging Het
Bahcc1 C A 11: 120,165,415 (GRCm39) Q949K probably benign Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Ccdc141 T A 2: 76,889,894 (GRCm39) Y466F possibly damaging Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Cyp4a30b C A 4: 115,314,972 (GRCm39) Q185K probably benign Het
Dlx2 A T 2: 71,375,882 (GRCm39) I147K possibly damaging Het
Dnaaf6rt T A 1: 31,262,349 (GRCm39) D110E probably damaging Het
Dnaaf9 A G 2: 130,612,621 (GRCm39) L482S probably damaging Het
Dnah8 CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT 17: 30,979,841 (GRCm39) probably null Het
Dock7 C A 4: 98,971,266 (GRCm39) V100F Het
Dspp C A 5: 104,325,162 (GRCm39) D508E unknown Het
Duox2 G T 2: 122,128,636 (GRCm39) T4K probably benign Het
Ear1 T C 14: 44,056,704 (GRCm39) N55D probably damaging Het
Echdc1 G C 10: 29,210,242 (GRCm39) E179Q probably damaging Het
Ehbp1 T C 11: 22,046,109 (GRCm39) M547V possibly damaging Het
Erbb2 A G 11: 98,319,798 (GRCm39) N630S possibly damaging Het
Fam227a G A 15: 79,514,271 (GRCm39) S363L possibly damaging Het
Fam98b A G 2: 117,101,381 (GRCm39) R398G unknown Het
Fsip2 G A 2: 82,807,430 (GRCm39) D1250N probably benign Het
Gdnf G T 15: 7,864,134 (GRCm39) E182* probably null Het
Gys2 T C 6: 142,406,921 (GRCm39) H145R probably benign Het
Hcls1 A G 16: 36,767,003 (GRCm39) K69R probably benign Het
Itih5 A G 2: 10,239,869 (GRCm39) N332S probably benign Het
Kcnb2 T A 1: 15,382,934 (GRCm39) Y87N probably damaging Het
Lrriq3 A G 3: 154,893,873 (GRCm39) N525D probably damaging Het
Lsg1 A T 16: 30,380,569 (GRCm39) W623R probably damaging Het
Myo10 A G 15: 25,725,158 (GRCm39) Y243C probably benign Het
Nans T C 4: 46,492,814 (GRCm39) Y81H probably damaging Het
Nup54 T G 5: 92,573,605 (GRCm39) N199T probably benign Het
Or2h1 A G 17: 37,404,664 (GRCm39) L34P probably damaging Het
Or4c126 C T 2: 89,824,348 (GRCm39) L204F probably benign Het
Or4k15 T C 14: 50,364,604 (GRCm39) I190T probably benign Het
Or5w13 A T 2: 87,524,088 (GRCm39) I46N probably damaging Het
Or7d9 T A 9: 20,197,337 (GRCm39) L122* probably null Het
Pcnt G A 10: 76,256,039 (GRCm39) R734W probably damaging Het
Peg10 T C 6: 4,755,462 (GRCm39) F13L possibly damaging Het
Plcb1 T C 2: 135,091,972 (GRCm39) probably null Het
Ppfibp1 T C 6: 146,902,448 (GRCm39) V285A possibly damaging Het
Prpf39 T C 12: 65,102,036 (GRCm39) V371A possibly damaging Het
Psmb11 G A 14: 54,863,013 (GRCm39) C77Y probably damaging Het
Rrbp1 A G 2: 143,797,053 (GRCm39) L1133P probably benign Het
Slc16a1 G T 3: 104,560,149 (GRCm39) M151I probably benign Het
Tarm1 G T 7: 3,546,037 (GRCm39) Q89K possibly damaging Het
Tas2r116 T C 6: 132,832,540 (GRCm39) I47T probably damaging Het
Tmod3 T C 9: 75,436,680 (GRCm39) D85G probably damaging Het
Trbv14 T C 6: 41,112,299 (GRCm39) L32P probably benign Het
Trim16 T C 11: 62,741,414 (GRCm39) L486P probably benign Het
Trmt1l T G 1: 151,325,727 (GRCm39) S391A probably benign Het
Ush2a T A 1: 188,582,254 (GRCm39) N3772K probably damaging Het
Vmn1r230 G T 17: 21,066,870 (GRCm39) A20S probably benign Het
Wdr76 A G 2: 121,341,179 (GRCm39) N75D possibly damaging Het
Zfp977 A G 7: 42,230,102 (GRCm39) L141S probably benign Het
Other mutations in Zfp988
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02282:Zfp988 APN 4 147,416,125 (GRCm39) nonsense probably null
R1672:Zfp988 UTSW 4 147,415,739 (GRCm39) missense probably benign
R1834:Zfp988 UTSW 4 147,417,344 (GRCm39) missense probably damaging 0.97
R2324:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R2380:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R3795:Zfp988 UTSW 4 147,416,040 (GRCm39) missense possibly damaging 0.51
R3945:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R4024:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R5012:Zfp988 UTSW 4 147,416,060 (GRCm39) missense probably benign
R5059:Zfp988 UTSW 4 147,416,372 (GRCm39) nonsense probably null
R6008:Zfp988 UTSW 4 147,416,259 (GRCm39) missense probably benign 0.16
R6245:Zfp988 UTSW 4 147,416,470 (GRCm39) nonsense probably null
R6549:Zfp988 UTSW 4 147,416,310 (GRCm39) missense probably benign 0.03
R7658:Zfp988 UTSW 4 147,416,751 (GRCm39) missense probably damaging 1.00
R8309:Zfp988 UTSW 4 147,416,765 (GRCm39) missense probably damaging 0.99
R9159:Zfp988 UTSW 4 147,416,450 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- TGTGACAAATGCTTTACCCAAC -3'
(R):5'- GCATTTGCCACATTCACTGCATTT -3'

Sequencing Primer
(F):5'- CCTTACAAATGCAGTGAATGTGGC -3'
(R):5'- GCCACATTCACTGCATTTGTAAGG -3'
Posted On 2020-10-20