Mutagenetix > Incidental Mutation

Incidental Mutation 'R8441:Gpr37l1'

654191

Institutional Source

Beutler Lab

Gene Symbol

Gpr37l1

Ensembl Gene

ENSMUSG00000026424

Gene Name

G protein-coupled receptor 37-like 1

Synonyms

D0Kist8, CAG-18

MMRRC Submission

067885-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R8441 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

135087988-135095419 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 135094875 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 123 (V123E)

Ref Sequence

ENSEMBL: ENSMUSP00000027682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027682]

AlphaFold

Q99JG2

Predicted Effect

probably damaging
Transcript: ENSMUST00000027682
AA Change: V123E

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000027682
Gene: ENSMUSG00000026424
AA Change: V123E

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:7tm_1	147	416	4.4e-25	PFAM
low complexity region	430	439	N/A	INTRINSIC
low complexity region	442	453	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

100% (43/43)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	A	G	2: 69,087,574 (GRCm39)	Y1064H	possibly damaging	Het
Ahrr	T	C	13: 74,362,182 (GRCm39)	D567G	probably benign	Het
Aldh1b1	T	A	4: 45,802,465 (GRCm39)	M1K	probably null	Het
Ankrd12	A	T	17: 66,349,546 (GRCm39)	S96T	probably benign	Het
Arhgef10	A	T	8: 15,041,237 (GRCm39)		probably benign	Het
Bsn	G	A	9: 107,988,651 (GRCm39)	A2367V	probably benign	Het
Cmpk2	G	A	12: 26,527,204 (GRCm39)	A398T	probably benign	Het
Cpn2	A	G	16: 30,078,849 (GRCm39)	L284P	probably damaging	Het
Cubn	T	C	2: 13,432,658 (GRCm39)	D1221G	probably damaging	Het
Dnah7c	A	G	1: 46,572,398 (GRCm39)	K957R	probably damaging	Het
Eif1ad2	T	G	12: 87,786,384 (GRCm39)	D98E	probably benign	Het
Flnb	T	A	14: 7,896,488 (GRCm38)	V893E	probably benign	Het
Flrt3	C	A	2: 140,502,546 (GRCm39)	V361L	probably benign	Het
Fnta	G	A	8: 26,501,209 (GRCm39)	R104*	probably null	Het
Ggt1	C	T	10: 75,415,185 (GRCm39)	T233I	possibly damaging	Het
Grpel1	A	G	5: 36,622,556 (GRCm39)	R7G	probably benign	Het
H2-M10.5	A	T	17: 37,084,199 (GRCm39)	I54L	probably benign	Het
Mapk8ip3	A	T	17: 25,139,474 (GRCm39)		probably benign	Het
Mcm3	T	C	1: 20,884,690 (GRCm39)	D271G	probably benign	Het
Naip6	A	G	13: 100,422,265 (GRCm39)	V1256A	possibly damaging	Het
Nipbl	A	G	15: 8,322,599 (GRCm39)	V2604A	probably benign	Het
Nlrp1b	T	A	11: 71,073,204 (GRCm39)	D213V	probably damaging	Het
Npbwr1	G	A	1: 5,987,397 (GRCm39)	A39V	possibly damaging	Het
Nr6a1	T	C	2: 38,632,888 (GRCm39)	D191G	probably benign	Het
Olfml1	T	G	7: 107,166,977 (GRCm39)	V2G	probably benign	Het
Or4k38	A	T	2: 111,166,131 (GRCm39)	Y97*	probably null	Het
Or5b105	T	A	19: 13,080,020 (GRCm39)	Y216F	probably damaging	Het
Otof	T	C	5: 30,538,200 (GRCm39)	K1175E	probably damaging	Het
Pira13	C	A	7: 3,826,301 (GRCm39)	E231*	probably null	Het
Plekhg2	C	T	7: 28,060,291 (GRCm39)	V989I	probably benign	Het
Prkcq	A	G	2: 11,253,037 (GRCm39)	D229G	probably benign	Het
Ptprf	A	T	4: 118,075,255 (GRCm39)		probably benign	Het
Rest	G	T	5: 77,429,766 (GRCm39)	Q728H	possibly damaging	Het
Scube1	A	T	15: 83,494,423 (GRCm39)	I868N	probably damaging	Het
Spcs3	A	G	8: 54,981,375 (GRCm39)		probably null	Het
Speg	A	G	1: 75,387,976 (GRCm39)	S1445G	possibly damaging	Het
Spmap2	C	A	10: 79,412,510 (GRCm39)	R327L	probably damaging	Het
Tmem145	T	C	7: 25,008,200 (GRCm39)	F261S	possibly damaging	Het
Trav9d-4	A	G	14: 53,221,284 (GRCm39)	S93G	probably benign	Het
Trbv5	T	A	6: 41,039,517 (GRCm39)	C41S	probably damaging	Het
Trpm5	A	G	7: 142,626,171 (GRCm39)	S1131P	possibly damaging	Het
Ttc28	C	T	5: 111,325,507 (GRCm39)	R313*	probably null	Het
Ubap2l	T	C	3: 89,920,007 (GRCm39)	T853A	unknown	Het
Xirp2	T	C	2: 67,343,159 (GRCm39)	V1800A	possibly damaging	Het
Zfhx2	A	G	14: 55,303,985 (GRCm39)	L1333P	possibly damaging	Het

Other mutations in Gpr37l1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Gpr37l1	APN	1	135,089,440 (GRCm39)	splice site	probably benign
IGL01362:Gpr37l1	APN	1	135,089,216 (GRCm39)	missense	probably benign	0.00
IGL01678:Gpr37l1	APN	1	135,094,791 (GRCm39)	missense	probably damaging	1.00
IGL02394:Gpr37l1	APN	1	135,094,746 (GRCm39)	missense	probably damaging	1.00
ventura	UTSW	1	135,088,922 (GRCm39)	missense	probably damaging	1.00
R0045:Gpr37l1	UTSW	1	135,088,883 (GRCm39)	missense	probably damaging	1.00
R1199:Gpr37l1	UTSW	1	135,094,710 (GRCm39)	missense	probably damaging	1.00
R1730:Gpr37l1	UTSW	1	135,089,268 (GRCm39)	nonsense	probably null
R1733:Gpr37l1	UTSW	1	135,089,273 (GRCm39)	missense	possibly damaging	0.62
R1755:Gpr37l1	UTSW	1	135,094,639 (GRCm39)	missense	probably damaging	1.00
R3930:Gpr37l1	UTSW	1	135,089,100 (GRCm39)	missense	probably benign	0.01
R4091:Gpr37l1	UTSW	1	135,089,301 (GRCm39)	missense	probably benign	0.25
R4111:Gpr37l1	UTSW	1	135,095,008 (GRCm39)	missense	possibly damaging	0.69
R4288:Gpr37l1	UTSW	1	135,088,922 (GRCm39)	missense	probably damaging	1.00
R4739:Gpr37l1	UTSW	1	135,094,783 (GRCm39)	missense	probably damaging	0.99
R5114:Gpr37l1	UTSW	1	135,094,676 (GRCm39)	missense	probably damaging	1.00
R6765:Gpr37l1	UTSW	1	135,094,860 (GRCm39)	missense	probably damaging	1.00
R8734:Gpr37l1	UTSW	1	135,095,167 (GRCm39)	missense	probably benign
R9122:Gpr37l1	UTSW	1	135,095,209 (GRCm39)	missense	probably benign	0.00
R9715:Gpr37l1	UTSW	1	135,089,391 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTCATTGAAGATGACAATTGGGAGG -3'
(R):5'- ACTATGTACCCGAGGAGTGG -3'

Sequencing Primer
(F):5'- TGACAATTGGGAGGCAGAAG -3'
(R):5'- GGGCTGAATATCCCAAGCC -3'

Posted On

2020-10-20