Incidental Mutation 'R8441:Or4k38'
ID 654197
Institutional Source Beutler Lab
Gene Symbol Or4k38
Ensembl Gene ENSMUSG00000096554
Gene Name olfactory receptor family 4 subfamily K member 38
Synonyms MOR248-16, Olfr1557, MOR248-2, Olfr1282, GA_x6K02T2Q125-72387537-72386620
MMRRC Submission 067885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R8441 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111165504-111166421 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 111166131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 97 (Y97*)
Ref Sequence ENSEMBL: ENSMUSP00000097213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099618] [ENSMUST00000208176]
AlphaFold Q7TQY5
Predicted Effect probably null
Transcript: ENSMUST00000099618
AA Change: Y97*
SMART Domains Protein: ENSMUSP00000097213
Gene: ENSMUSG00000096554
AA Change: Y97*

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 5.5e-47 PFAM
Pfam:7tm_1 41 287 2.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208176
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A G 2: 69,087,574 (GRCm39) Y1064H possibly damaging Het
Ahrr T C 13: 74,362,182 (GRCm39) D567G probably benign Het
Aldh1b1 T A 4: 45,802,465 (GRCm39) M1K probably null Het
Ankrd12 A T 17: 66,349,546 (GRCm39) S96T probably benign Het
Arhgef10 A T 8: 15,041,237 (GRCm39) probably benign Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Cmpk2 G A 12: 26,527,204 (GRCm39) A398T probably benign Het
Cpn2 A G 16: 30,078,849 (GRCm39) L284P probably damaging Het
Cubn T C 2: 13,432,658 (GRCm39) D1221G probably damaging Het
Dnah7c A G 1: 46,572,398 (GRCm39) K957R probably damaging Het
Eif1ad2 T G 12: 87,786,384 (GRCm39) D98E probably benign Het
Flnb T A 14: 7,896,488 (GRCm38) V893E probably benign Het
Flrt3 C A 2: 140,502,546 (GRCm39) V361L probably benign Het
Fnta G A 8: 26,501,209 (GRCm39) R104* probably null Het
Ggt1 C T 10: 75,415,185 (GRCm39) T233I possibly damaging Het
Gpr37l1 A T 1: 135,094,875 (GRCm39) V123E probably damaging Het
Grpel1 A G 5: 36,622,556 (GRCm39) R7G probably benign Het
H2-M10.5 A T 17: 37,084,199 (GRCm39) I54L probably benign Het
Mapk8ip3 A T 17: 25,139,474 (GRCm39) probably benign Het
Mcm3 T C 1: 20,884,690 (GRCm39) D271G probably benign Het
Naip6 A G 13: 100,422,265 (GRCm39) V1256A possibly damaging Het
Nipbl A G 15: 8,322,599 (GRCm39) V2604A probably benign Het
Nlrp1b T A 11: 71,073,204 (GRCm39) D213V probably damaging Het
Npbwr1 G A 1: 5,987,397 (GRCm39) A39V possibly damaging Het
Nr6a1 T C 2: 38,632,888 (GRCm39) D191G probably benign Het
Olfml1 T G 7: 107,166,977 (GRCm39) V2G probably benign Het
Or5b105 T A 19: 13,080,020 (GRCm39) Y216F probably damaging Het
Otof T C 5: 30,538,200 (GRCm39) K1175E probably damaging Het
Pira13 C A 7: 3,826,301 (GRCm39) E231* probably null Het
Plekhg2 C T 7: 28,060,291 (GRCm39) V989I probably benign Het
Prkcq A G 2: 11,253,037 (GRCm39) D229G probably benign Het
Ptprf A T 4: 118,075,255 (GRCm39) probably benign Het
Rest G T 5: 77,429,766 (GRCm39) Q728H possibly damaging Het
Scube1 A T 15: 83,494,423 (GRCm39) I868N probably damaging Het
Spcs3 A G 8: 54,981,375 (GRCm39) probably null Het
Speg A G 1: 75,387,976 (GRCm39) S1445G possibly damaging Het
Spmap2 C A 10: 79,412,510 (GRCm39) R327L probably damaging Het
Tmem145 T C 7: 25,008,200 (GRCm39) F261S possibly damaging Het
Trav9d-4 A G 14: 53,221,284 (GRCm39) S93G probably benign Het
Trbv5 T A 6: 41,039,517 (GRCm39) C41S probably damaging Het
Trpm5 A G 7: 142,626,171 (GRCm39) S1131P possibly damaging Het
Ttc28 C T 5: 111,325,507 (GRCm39) R313* probably null Het
Ubap2l T C 3: 89,920,007 (GRCm39) T853A unknown Het
Xirp2 T C 2: 67,343,159 (GRCm39) V1800A possibly damaging Het
Zfhx2 A G 14: 55,303,985 (GRCm39) L1333P possibly damaging Het
Other mutations in Or4k38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02677:Or4k38 APN 2 111,166,147 (GRCm39) missense probably damaging 1.00
R0798:Or4k38 UTSW 2 111,165,689 (GRCm39) missense probably benign 0.16
R0932:Or4k38 UTSW 2 111,165,543 (GRCm39) missense probably benign 0.00
R0972:Or4k38 UTSW 2 111,165,763 (GRCm39) missense probably benign 0.18
R1033:Or4k38 UTSW 2 111,166,147 (GRCm39) missense probably damaging 1.00
R1864:Or4k38 UTSW 2 111,166,052 (GRCm39) missense possibly damaging 0.95
R1879:Or4k38 UTSW 2 111,165,808 (GRCm39) missense possibly damaging 0.61
R2343:Or4k38 UTSW 2 111,166,045 (GRCm39) missense probably damaging 1.00
R2509:Or4k38 UTSW 2 111,166,076 (GRCm39) missense probably damaging 0.98
R3620:Or4k38 UTSW 2 111,165,689 (GRCm39) missense probably benign 0.06
R5589:Or4k38 UTSW 2 111,165,850 (GRCm39) missense possibly damaging 0.46
R6487:Or4k38 UTSW 2 111,166,012 (GRCm39) missense probably benign 0.00
R6818:Or4k38 UTSW 2 111,165,659 (GRCm39) missense probably benign 0.22
R7153:Or4k38 UTSW 2 111,166,246 (GRCm39) missense probably damaging 1.00
R7480:Or4k38 UTSW 2 111,165,737 (GRCm39) missense probably benign 0.22
R7589:Or4k38 UTSW 2 111,165,719 (GRCm39) missense probably damaging 1.00
R8774:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
R8774-TAIL:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGTAGATCCAAAATCAAGAGCATC -3'
(R):5'- CTACCTGATGGCTGTGGTAG -3'

Sequencing Primer
(F):5'- GCATCTGACTAATGGCATGC -3'
(R):5'- AGGCAACCTGTTTGTTGTGATATTG -3'
Posted On 2020-10-20