Incidental Mutation 'R8441:Flrt3'
ID 654198
Institutional Source Beutler Lab
Gene Symbol Flrt3
Ensembl Gene ENSMUSG00000051379
Gene Name fibronectin leucine rich transmembrane protein 3
Synonyms 5530600M07Rik, C430047I10Rik
MMRRC Submission 067885-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8441 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 140500118-140513396 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 140502546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 361 (V361L)
Ref Sequence ENSEMBL: ENSMUSP00000053399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056760] [ENSMUST00000078027] [ENSMUST00000110057] [ENSMUST00000110063] [ENSMUST00000110064] [ENSMUST00000110067]
AlphaFold Q8BGT1
PDB Structure FLRT3 LRR domain [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000056760
AA Change: V361L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000053399
Gene: ENSMUSG00000051379
AA Change: V361L

DomainStartEndE-ValueType
LRRNT 30 62 3.12e-6 SMART
LRR 82 105 1.03e2 SMART
LRR 127 152 8.26e1 SMART
LRR 156 176 4.58e1 SMART
LRR 198 223 4.09e1 SMART
LRR 224 247 1.33e1 SMART
LRR 248 269 4.2e0 SMART
LRR_TYP 270 293 7.9e-4 SMART
LRRCT 305 356 1.49e-9 SMART
FN3 404 486 4.56e0 SMART
transmembrane domain 530 552 N/A INTRINSIC
low complexity region 625 639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000078027
SMART Domains Protein: ENSMUSP00000077174
Gene: ENSMUSG00000068205

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
A1pp 71 201 5.72e-45 SMART
low complexity region 266 293 N/A INTRINSIC
low complexity region 307 319 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110057
AA Change: V361L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000105684
Gene: ENSMUSG00000051379
AA Change: V361L

DomainStartEndE-ValueType
LRRNT 30 62 3.12e-6 SMART
LRR 82 105 1.03e2 SMART
LRR 127 152 8.26e1 SMART
LRR 156 176 4.58e1 SMART
LRR 198 223 4.09e1 SMART
LRR 224 247 1.33e1 SMART
LRR 248 269 4.2e0 SMART
LRR_TYP 270 293 7.9e-4 SMART
LRRCT 305 356 1.49e-9 SMART
FN3 404 486 4.56e0 SMART
transmembrane domain 530 552 N/A INTRINSIC
low complexity region 625 639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110063
SMART Domains Protein: ENSMUSP00000105690
Gene: ENSMUSG00000068205

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
PDB:4IQY|B 21 107 1e-36 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000110064
SMART Domains Protein: ENSMUSP00000105691
Gene: ENSMUSG00000068205

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
A1pp 71 201 5.72e-45 SMART
low complexity region 266 293 N/A INTRINSIC
low complexity region 307 319 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110067
SMART Domains Protein: ENSMUSP00000105694
Gene: ENSMUSG00000068205

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
A1pp 71 201 5.72e-45 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A G 2: 69,087,574 (GRCm39) Y1064H possibly damaging Het
Ahrr T C 13: 74,362,182 (GRCm39) D567G probably benign Het
Aldh1b1 T A 4: 45,802,465 (GRCm39) M1K probably null Het
Ankrd12 A T 17: 66,349,546 (GRCm39) S96T probably benign Het
Arhgef10 A T 8: 15,041,237 (GRCm39) probably benign Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Cmpk2 G A 12: 26,527,204 (GRCm39) A398T probably benign Het
Cpn2 A G 16: 30,078,849 (GRCm39) L284P probably damaging Het
Cubn T C 2: 13,432,658 (GRCm39) D1221G probably damaging Het
Dnah7c A G 1: 46,572,398 (GRCm39) K957R probably damaging Het
Eif1ad2 T G 12: 87,786,384 (GRCm39) D98E probably benign Het
Flnb T A 14: 7,896,488 (GRCm38) V893E probably benign Het
Fnta G A 8: 26,501,209 (GRCm39) R104* probably null Het
Ggt1 C T 10: 75,415,185 (GRCm39) T233I possibly damaging Het
Gpr37l1 A T 1: 135,094,875 (GRCm39) V123E probably damaging Het
Grpel1 A G 5: 36,622,556 (GRCm39) R7G probably benign Het
H2-M10.5 A T 17: 37,084,199 (GRCm39) I54L probably benign Het
Mapk8ip3 A T 17: 25,139,474 (GRCm39) probably benign Het
Mcm3 T C 1: 20,884,690 (GRCm39) D271G probably benign Het
Naip6 A G 13: 100,422,265 (GRCm39) V1256A possibly damaging Het
Nipbl A G 15: 8,322,599 (GRCm39) V2604A probably benign Het
Nlrp1b T A 11: 71,073,204 (GRCm39) D213V probably damaging Het
Npbwr1 G A 1: 5,987,397 (GRCm39) A39V possibly damaging Het
Nr6a1 T C 2: 38,632,888 (GRCm39) D191G probably benign Het
Olfml1 T G 7: 107,166,977 (GRCm39) V2G probably benign Het
Or4k38 A T 2: 111,166,131 (GRCm39) Y97* probably null Het
Or5b105 T A 19: 13,080,020 (GRCm39) Y216F probably damaging Het
Otof T C 5: 30,538,200 (GRCm39) K1175E probably damaging Het
Pira13 C A 7: 3,826,301 (GRCm39) E231* probably null Het
Plekhg2 C T 7: 28,060,291 (GRCm39) V989I probably benign Het
Prkcq A G 2: 11,253,037 (GRCm39) D229G probably benign Het
Ptprf A T 4: 118,075,255 (GRCm39) probably benign Het
Rest G T 5: 77,429,766 (GRCm39) Q728H possibly damaging Het
Scube1 A T 15: 83,494,423 (GRCm39) I868N probably damaging Het
Spcs3 A G 8: 54,981,375 (GRCm39) probably null Het
Speg A G 1: 75,387,976 (GRCm39) S1445G possibly damaging Het
Spmap2 C A 10: 79,412,510 (GRCm39) R327L probably damaging Het
Tmem145 T C 7: 25,008,200 (GRCm39) F261S possibly damaging Het
Trav9d-4 A G 14: 53,221,284 (GRCm39) S93G probably benign Het
Trbv5 T A 6: 41,039,517 (GRCm39) C41S probably damaging Het
Trpm5 A G 7: 142,626,171 (GRCm39) S1131P possibly damaging Het
Ttc28 C T 5: 111,325,507 (GRCm39) R313* probably null Het
Ubap2l T C 3: 89,920,007 (GRCm39) T853A unknown Het
Xirp2 T C 2: 67,343,159 (GRCm39) V1800A possibly damaging Het
Zfhx2 A G 14: 55,303,985 (GRCm39) L1333P possibly damaging Het
Other mutations in Flrt3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02141:Flrt3 APN 2 140,502,608 (GRCm39) missense probably damaging 0.99
IGL02292:Flrt3 APN 2 140,502,045 (GRCm39) missense probably damaging 1.00
R0030:Flrt3 UTSW 2 140,502,237 (GRCm39) missense probably damaging 1.00
R1487:Flrt3 UTSW 2 140,502,854 (GRCm39) missense probably damaging 1.00
R2061:Flrt3 UTSW 2 140,503,373 (GRCm39) missense probably damaging 1.00
R2115:Flrt3 UTSW 2 140,503,423 (GRCm39) missense probably damaging 1.00
R2326:Flrt3 UTSW 2 140,503,311 (GRCm39) missense possibly damaging 0.50
R3113:Flrt3 UTSW 2 140,503,454 (GRCm39) missense probably benign 0.03
R3605:Flrt3 UTSW 2 140,503,287 (GRCm39) missense probably damaging 1.00
R4366:Flrt3 UTSW 2 140,502,327 (GRCm39) missense probably damaging 0.99
R4702:Flrt3 UTSW 2 140,503,575 (GRCm39) missense probably benign
R4799:Flrt3 UTSW 2 140,502,086 (GRCm39) missense probably damaging 1.00
R5085:Flrt3 UTSW 2 140,502,177 (GRCm39) missense probably damaging 0.99
R5100:Flrt3 UTSW 2 140,513,304 (GRCm39) start gained probably null
R5109:Flrt3 UTSW 2 140,502,663 (GRCm39) missense possibly damaging 0.51
R5635:Flrt3 UTSW 2 140,502,420 (GRCm39) missense probably damaging 1.00
R5982:Flrt3 UTSW 2 140,502,836 (GRCm39) missense possibly damaging 0.95
R6117:Flrt3 UTSW 2 140,502,365 (GRCm39) missense possibly damaging 0.46
R6213:Flrt3 UTSW 2 140,503,085 (GRCm39) missense probably damaging 1.00
R6246:Flrt3 UTSW 2 140,501,721 (GRCm39) missense probably damaging 1.00
R6746:Flrt3 UTSW 2 140,501,945 (GRCm39) missense probably damaging 0.99
R6854:Flrt3 UTSW 2 140,502,638 (GRCm39) missense probably damaging 1.00
R7000:Flrt3 UTSW 2 140,502,804 (GRCm39) nonsense probably null
R7221:Flrt3 UTSW 2 140,503,090 (GRCm39) missense probably damaging 0.99
R7388:Flrt3 UTSW 2 140,503,672 (GRCm39) critical splice acceptor site probably null
R7444:Flrt3 UTSW 2 140,502,387 (GRCm39) missense probably benign 0.00
R7526:Flrt3 UTSW 2 140,502,126 (GRCm39) missense probably damaging 1.00
R7967:Flrt3 UTSW 2 140,501,811 (GRCm39) nonsense probably null
R8272:Flrt3 UTSW 2 140,502,617 (GRCm39) missense probably damaging 1.00
R9109:Flrt3 UTSW 2 140,501,879 (GRCm39) missense probably damaging 1.00
R9257:Flrt3 UTSW 2 140,502,159 (GRCm39) missense probably benign
R9298:Flrt3 UTSW 2 140,501,879 (GRCm39) missense probably damaging 1.00
R9482:Flrt3 UTSW 2 140,503,590 (GRCm39) missense probably benign
R9629:Flrt3 UTSW 2 140,502,816 (GRCm39) missense possibly damaging 0.53
Predicted Primers PCR Primer
(F):5'- ATAGGCAGAGCAAGTCTCCAGG -3'
(R):5'- TGATTCTTCGCAACAATCCTTGG -3'

Sequencing Primer
(F):5'- TCAGGGGTGACAGATTTCAC -3'
(R):5'- CGCAACAATCCTTGGTATTGTG -3'
Posted On 2020-10-20