Mutagenetix > Incidental Mutation

Incidental Mutation 'R8443:Fat2'

654321

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

067825-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8443 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 55311709 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Histidine at position 180 (N180H)

Ref Sequence

ENSEMBL: ENSMUSP00000067556 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000068853
AA Change: N180H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: N180H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108864
AA Change: N180H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: N180H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	A	G	1: 37,613,456 (GRCm38)	V1090A	probably benign	Het
2410089E03Rik	A	G	15: 8,201,151 (GRCm38)	I971V	probably benign	Het
Abcc6	C	T	7: 45,980,025 (GRCm38)	V1293M	probably damaging	Het
Agt	A	G	8: 124,563,798 (GRCm38)	W257R	possibly damaging	Het
Arhgef11	T	A	3: 87,713,099 (GRCm38)	N457K	probably benign	Het
Bcl3	G	T	7: 19,820,157 (GRCm38)	H95Q	probably benign	Het
C1d	T	A	11: 17,263,662 (GRCm38)	N64K	probably damaging	Het
Casc3	C	T	11: 98,822,781 (GRCm38)	R280C	probably damaging	Het
Cd300c2	C	T	11: 115,000,640 (GRCm38)	S136N	probably benign	Het
Cdh8	A	G	8: 99,031,040 (GRCm38)	V642A	possibly damaging	Het
Cep290	A	T	10: 100,495,844 (GRCm38)	I180F	possibly damaging	Het
Copz2	A	G	11: 96,854,061 (GRCm38)	E86G	probably damaging	Het
Csf3r	A	T	4: 126,029,919 (GRCm38)	D74V	possibly damaging	Het
Cyp11b1	T	G	15: 74,838,940 (GRCm38)	E257A	possibly damaging	Het
Dlg2	A	G	7: 92,375,667 (GRCm38)	Q580R	probably damaging	Het
Dnaic2	A	T	11: 114,754,449 (GRCm38)	K570M	unknown	Het
Dock8	A	G	19: 25,155,917 (GRCm38)	K1143E	probably benign	Het
Dxo	T	C	17: 34,839,123 (GRCm38)	S394P	probably benign	Het
Etl4	A	G	2: 20,806,166 (GRCm38)	D1388G	probably benign	Het
F13a1	C	A	13: 37,025,718 (GRCm38)	R91L	probably damaging	Het
Fam35a	A	C	14: 34,267,985 (GRCm38)	N321K	probably benign	Het
Fam50b	C	T	13: 34,746,873 (GRCm38)	R111*	probably null	Het
Fitm2	A	T	2: 163,469,848 (GRCm38)	H148Q	probably benign	Het
Fjx1	A	T	2: 102,450,811 (GRCm38)	S260T	possibly damaging	Het
Fos	T	C	12: 85,475,692 (GRCm38)	L165P	probably damaging	Het
Gm39115	C	A	7: 142,135,973 (GRCm38)	C21F	unknown	Het
Gucy1a1	C	T	3: 82,097,693 (GRCm38)	C595Y	probably damaging	Het
Hectd4	G	T	5: 121,329,109 (GRCm38)	W2478L	possibly damaging	Het
I830077J02Rik	T	A	3: 105,928,744 (GRCm38)	K9N	probably damaging	Het
Ireb2	T	C	9: 54,903,981 (GRCm38)	F723L	possibly damaging	Het
Itpr1	G	A	6: 108,519,348 (GRCm38)	V2580I	probably damaging	Het
Kcnu1	G	A	8: 25,892,064 (GRCm38)	G481R	probably damaging	Het
Kdm3b	G	T	18: 34,793,076 (GRCm38)	A90S	probably benign	Het
Klra8	A	G	6: 130,128,093 (GRCm38)	V23A	probably damaging	Het
Lig4	A	G	8: 9,973,777 (GRCm38)	M1T	probably null	Het
Lpin3	C	T	2: 160,895,353 (GRCm38)	P107S	probably damaging	Het
Lrp1b	T	A	2: 41,375,855 (GRCm38)	K1100*	probably null	Het
Obscn	G	A	11: 59,038,874 (GRCm38)	H5172Y	probably damaging	Het
Olfr1181	A	G	2: 88,423,401 (GRCm38)	I208T	probably benign	Het
Olfr1348	T	A	7: 6,501,735 (GRCm38)	T170S	probably damaging	Het
Olfr290	C	T	7: 84,916,579 (GRCm38)	H267Y	probably benign	Het
Olfr512	T	A	7: 108,714,211 (GRCm38)	M286K	possibly damaging	Het
Olfr892-ps1	A	T	9: 38,190,202 (GRCm38)	H159L	possibly damaging	Het
Orc3	A	G	4: 34,593,173 (GRCm38)	L298P	probably damaging	Het
Otub1	A	G	19: 7,199,995 (GRCm38)	F96L	probably damaging	Het
Pcnx3	A	G	19: 5,686,642 (GRCm38)	S156P	probably benign	Het
Pde3b	A	G	7: 114,526,894 (GRCm38)	M788V	probably damaging	Het
Pias4	A	G	10: 81,157,010 (GRCm38)		probably null	Het
Polg	A	G	7: 79,464,995 (GRCm38)	C73R	probably benign	Het
Ptbp2	T	C	3: 119,747,818 (GRCm38)	Y190C	probably damaging	Het
Rab33b	T	A	3: 51,493,629 (GRCm38)	F175I	probably damaging	Het
Rfx1	A	G	8: 84,079,886 (GRCm38)	T108A	probably benign	Het
Ribc2	A	G	15: 85,135,260 (GRCm38)	D81G	probably benign	Het
Rnf213	T	G	11: 119,449,323 (GRCm38)	M3460R		Het
Rsf1	T	A	7: 97,616,896 (GRCm38)	S86T		Het
Rxfp2	C	A	5: 150,049,603 (GRCm38)	T181N	possibly damaging	Het
Samm50	G	A	15: 84,210,501 (GRCm38)	E365K	possibly damaging	Het
Slc22a18	T	C	7: 143,497,386 (GRCm38)	V334A	probably damaging	Het
Slc23a3	A	T	1: 75,133,441 (GRCm38)	C97S	probably benign	Het
Smchd1	T	A	17: 71,407,249 (GRCm38)	H873L	probably benign	Het
Snrpa1	G	A	7: 66,070,633 (GRCm38)	G195R	probably benign	Het
Sphkap	T	A	1: 83,278,232 (GRCm38)	I599F	probably benign	Het
Stox1	A	G	10: 62,665,764 (GRCm38)	V339A	probably damaging	Het
Tlx1	A	G	19: 45,153,597 (GRCm38)	E220G	probably damaging	Het
Tmem71	C	A	15: 66,541,572 (GRCm38)		probably null	Het
Tmprss3	T	C	17: 31,195,002 (GRCm38)	D56G	possibly damaging	Het
Trabd	A	G	15: 89,085,904 (GRCm38)	R368G	probably benign	Het
Trf	A	G	9: 103,217,476 (GRCm38)	I461T	probably damaging	Het
Trpm3	A	G	19: 22,698,862 (GRCm38)	T133A	possibly damaging	Het
Trpv3	G	A	11: 73,295,383 (GRCm38)	V667I	possibly damaging	Het
Ttc30a1	T	C	2: 75,981,175 (GRCm38)	D188G	probably benign	Het
Vps13b	T	A	15: 35,455,100 (GRCm38)	N718K	probably benign	Het
Zdbf2	T	C	1: 63,306,007 (GRCm38)	S1182P	possibly damaging	Het
Zfp13	T	C	17: 23,576,892 (GRCm38)	D235G	probably benign	Het
Zfp407	T	C	18: 84,209,862 (GRCm38)	E1874G	probably damaging	Het
Zfp503	T	C	14: 21,986,209 (GRCm38)	K213R	probably benign	Het
Zkscan2	A	G	7: 123,485,428 (GRCm38)	V491A	probably damaging	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55,311,244 (GRCm38)	missense	probably benign
IGL00897:Fat2	APN	11	55,289,252 (GRCm38)	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55,284,191 (GRCm38)	missense	probably benign
IGL01306:Fat2	APN	11	55,310,872 (GRCm38)	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55,269,309 (GRCm38)	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55,282,156 (GRCm38)	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55,283,387 (GRCm38)	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55,278,930 (GRCm38)	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55,296,209 (GRCm38)	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55,262,568 (GRCm38)	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55,283,980 (GRCm38)	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55,312,005 (GRCm38)	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55,311,823 (GRCm38)	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55,270,146 (GRCm38)	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55,296,195 (GRCm38)	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55,312,245 (GRCm38)	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55,282,840 (GRCm38)	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55,289,296 (GRCm38)	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55,309,042 (GRCm38)	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55,262,419 (GRCm38)	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55,273,129 (GRCm38)	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55,281,092 (GRCm38)	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55,270,259 (GRCm38)	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55,311,124 (GRCm38)	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55,281,793 (GRCm38)	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55,311,283 (GRCm38)	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55,282,828 (GRCm38)	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55,311,096 (GRCm38)	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55,282,385 (GRCm38)	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55,256,618 (GRCm38)	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55,256,653 (GRCm38)	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55,270,194 (GRCm38)	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55,283,246 (GRCm38)	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55,311,901 (GRCm38)	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55,253,920 (GRCm38)	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55,286,043 (GRCm38)	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55,310,995 (GRCm38)	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55,284,029 (GRCm38)	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55,256,219 (GRCm38)	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55,262,595 (GRCm38)	missense	probably benign
IGL03325:Fat2	APN	11	55,282,342 (GRCm38)	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55,282,361 (GRCm38)	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55,311,164 (GRCm38)	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55,310,872 (GRCm38)	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55,282,213 (GRCm38)	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55,256,110 (GRCm38)	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55,298,605 (GRCm38)	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55,283,678 (GRCm38)	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55,289,286 (GRCm38)	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55,252,118 (GRCm38)	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55,273,211 (GRCm38)	missense	probably benign
R0158:Fat2	UTSW	11	55,296,185 (GRCm38)	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55,296,288 (GRCm38)	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55,292,093 (GRCm38)	splice site	probably benign
R0384:Fat2	UTSW	11	55,269,465 (GRCm38)	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55,310,777 (GRCm38)	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55,270,349 (GRCm38)	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55,284,134 (GRCm38)	missense	possibly damaging	0.94
R0437:Fat2	UTSW	11	55,282,799 (GRCm38)	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55,262,829 (GRCm38)	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55,283,402 (GRCm38)	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55,311,843 (GRCm38)	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55,283,128 (GRCm38)	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55,309,209 (GRCm38)	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55,256,225 (GRCm38)	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55,268,179 (GRCm38)	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55,310,773 (GRCm38)	missense	probably benign
R1428:Fat2	UTSW	11	55,296,087 (GRCm38)	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55,287,811 (GRCm38)	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55,262,673 (GRCm38)	missense	probably benign
R1506:Fat2	UTSW	11	55,284,264 (GRCm38)	missense	probably benign
R1547:Fat2	UTSW	11	55,252,255 (GRCm38)	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55,253,664 (GRCm38)	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55,309,974 (GRCm38)	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55,283,404 (GRCm38)	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55,291,870 (GRCm38)	splice site	probably null
R1601:Fat2	UTSW	11	55,282,010 (GRCm38)	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55,278,924 (GRCm38)	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55,284,719 (GRCm38)	missense	probably benign
R1634:Fat2	UTSW	11	55,267,684 (GRCm38)	missense	probably damaging	1.00
R1644:Fat2	UTSW	11	55,296,181 (GRCm38)	missense	possibly damaging	0.94
R1644:Fat2	UTSW	11	55,287,783 (GRCm38)	missense	possibly damaging	0.91
R1691:Fat2	UTSW	11	55,311,852 (GRCm38)	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55,281,371 (GRCm38)	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55,256,647 (GRCm38)	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55,310,865 (GRCm38)	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55,283,892 (GRCm38)	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55,289,259 (GRCm38)	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55,256,780 (GRCm38)	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55,311,558 (GRCm38)	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55,292,014 (GRCm38)	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55,262,178 (GRCm38)	missense	probably benign
R1954:Fat2	UTSW	11	55,311,084 (GRCm38)	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55,253,827 (GRCm38)	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55,282,757 (GRCm38)	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55,281,860 (GRCm38)	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55,309,677 (GRCm38)	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55,256,564 (GRCm38)	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55,303,716 (GRCm38)	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55,267,575 (GRCm38)	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55,282,360 (GRCm38)	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55,311,901 (GRCm38)	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55,270,096 (GRCm38)	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55,310,812 (GRCm38)	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55,281,973 (GRCm38)	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55,283,773 (GRCm38)	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55,311,305 (GRCm38)	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55,284,709 (GRCm38)	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55,252,171 (GRCm38)	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55,311,796 (GRCm38)	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55,278,998 (GRCm38)	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55,260,516 (GRCm38)	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55,281,685 (GRCm38)	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55,312,069 (GRCm38)	missense	probably benign
R3620:Fat2	UTSW	11	55,256,695 (GRCm38)	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55,281,101 (GRCm38)	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55,309,650 (GRCm38)	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55,256,186 (GRCm38)	missense	probably benign
R3889:Fat2	UTSW	11	55,281,763 (GRCm38)	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55,283,984 (GRCm38)	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55,284,301 (GRCm38)	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55,262,268 (GRCm38)	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55,309,640 (GRCm38)	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55,296,198 (GRCm38)	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55,270,097 (GRCm38)	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55,265,951 (GRCm38)	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55,284,752 (GRCm38)	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55,296,213 (GRCm38)	nonsense	probably null
R4669:Fat2	UTSW	11	55,311,615 (GRCm38)	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55,285,015 (GRCm38)	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55,281,187 (GRCm38)	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55,285,060 (GRCm38)	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55,283,979 (GRCm38)	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55,311,318 (GRCm38)	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55,279,018 (GRCm38)	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55,310,637 (GRCm38)	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55,279,033 (GRCm38)	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55,283,092 (GRCm38)	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55,310,704 (GRCm38)	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55,278,988 (GRCm38)	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55,296,333 (GRCm38)	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55,253,832 (GRCm38)	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55,281,175 (GRCm38)	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55,287,878 (GRCm38)	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55,267,656 (GRCm38)	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55,282,166 (GRCm38)	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55,262,820 (GRCm38)	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55,303,941 (GRCm38)	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55,252,226 (GRCm38)	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55,303,688 (GRCm38)	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55,310,086 (GRCm38)	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55,253,681 (GRCm38)	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55,269,361 (GRCm38)	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55,262,337 (GRCm38)	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55,253,889 (GRCm38)	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55,282,277 (GRCm38)	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55,281,130 (GRCm38)	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55,282,481 (GRCm38)	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55,310,316 (GRCm38)	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55,310,681 (GRCm38)	nonsense	probably null
R5660:Fat2	UTSW	11	55,284,176 (GRCm38)	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55,289,237 (GRCm38)	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55,252,346 (GRCm38)	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55,262,325 (GRCm38)	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55,270,382 (GRCm38)	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55,284,051 (GRCm38)	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55,296,072 (GRCm38)	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55,296,271 (GRCm38)	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55,262,581 (GRCm38)	missense	probably benign
R6307:Fat2	UTSW	11	55,281,280 (GRCm38)	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55,289,310 (GRCm38)	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55,282,216 (GRCm38)	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55,270,457 (GRCm38)	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55,296,345 (GRCm38)	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55,262,397 (GRCm38)	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55,284,988 (GRCm38)	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55,283,800 (GRCm38)	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55,296,105 (GRCm38)	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55,252,262 (GRCm38)	missense	probably benign
R6679:Fat2	UTSW	11	55,309,305 (GRCm38)	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55,310,858 (GRCm38)	nonsense	probably null
R6762:Fat2	UTSW	11	55,253,482 (GRCm38)	splice site	probably null
R6810:Fat2	UTSW	11	55,282,241 (GRCm38)	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55,309,341 (GRCm38)	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55,282,771 (GRCm38)	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55,252,474 (GRCm38)	nonsense	probably null
R6941:Fat2	UTSW	11	55,262,088 (GRCm38)	missense	probably benign
R7023:Fat2	UTSW	11	55,310,502 (GRCm38)	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55,269,433 (GRCm38)	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55,281,851 (GRCm38)	nonsense	probably null
R7095:Fat2	UTSW	11	55,311,331 (GRCm38)	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55,283,434 (GRCm38)	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55,282,336 (GRCm38)	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55,281,262 (GRCm38)	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55,285,001 (GRCm38)	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55,281,045 (GRCm38)	nonsense	probably null
R7246:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55,311,262 (GRCm38)	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55,285,030 (GRCm38)	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55,286,067 (GRCm38)	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55,282,304 (GRCm38)	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55,256,551 (GRCm38)	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55,309,101 (GRCm38)	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55,303,919 (GRCm38)	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55,278,963 (GRCm38)	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55,310,432 (GRCm38)	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55,303,653 (GRCm38)	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55,282,330 (GRCm38)	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55,309,840 (GRCm38)	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55,284,347 (GRCm38)	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55,310,763 (GRCm38)	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55,284,796 (GRCm38)	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55,310,706 (GRCm38)	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55,281,131 (GRCm38)	nonsense	probably null
R7757:Fat2	UTSW	11	55,311,421 (GRCm38)	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55,311,220 (GRCm38)	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55,253,364 (GRCm38)	splice site	probably null
R7924:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55,311,160 (GRCm38)	nonsense	probably null
R7936:Fat2	UTSW	11	55,310,167 (GRCm38)	missense	probably benign
R7938:Fat2	UTSW	11	55,273,096 (GRCm38)	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55,287,734 (GRCm38)	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55,312,066 (GRCm38)	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55,296,139 (GRCm38)	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55,252,084 (GRCm38)	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55,270,455 (GRCm38)	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55,287,812 (GRCm38)	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55,284,397 (GRCm38)	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55,273,171 (GRCm38)	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55,284,610 (GRCm38)	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55,312,209 (GRCm38)	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55,270,275 (GRCm38)	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55,284,136 (GRCm38)	missense	probably benign
R8269:Fat2	UTSW	11	55,282,709 (GRCm38)	missense	possibly damaging	0.48
R8465:Fat2	UTSW	11	55,256,704 (GRCm38)	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55,282,968 (GRCm38)	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55,309,237 (GRCm38)	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55,253,866 (GRCm38)	missense	probably benign
R8704:Fat2	UTSW	11	55,281,311 (GRCm38)	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55,268,303 (GRCm38)	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55,282,960 (GRCm38)	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55,281,103 (GRCm38)	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55,282,924 (GRCm38)	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55,310,070 (GRCm38)	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55,256,810 (GRCm38)	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55,282,903 (GRCm38)	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55,303,721 (GRCm38)	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55,262,521 (GRCm38)	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55,298,610 (GRCm38)	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55,278,937 (GRCm38)	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55,256,740 (GRCm38)	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55,310,571 (GRCm38)	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55,310,697 (GRCm38)	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55,281,301 (GRCm38)	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55,310,688 (GRCm38)	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55,253,522 (GRCm38)	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55,252,012 (GRCm38)	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55,309,926 (GRCm38)	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55,309,887 (GRCm38)	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55,284,982 (GRCm38)	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55,289,267 (GRCm38)	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55,256,779 (GRCm38)	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55,268,311 (GRCm38)	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55,303,925 (GRCm38)	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55,252,260 (GRCm38)	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55,310,431 (GRCm38)	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55,296,210 (GRCm38)	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55,309,414 (GRCm38)	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55,283,234 (GRCm38)	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55,284,991 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,282,795 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,310,121 (GRCm38)	missense	probably damaging	0.96
Z1176:Fat2	UTSW	11	55,303,700 (GRCm38)	missense	probably damaging	1.00
Z1177:Fat2	UTSW	11	55,278,966 (GRCm38)	nonsense	probably null
Z1186:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1186:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1187:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1187:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1188:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1188:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1189:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1189:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1190:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1190:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1191:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1191:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1192:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1192:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AGTTGCCAAACCCATTGCCC -3'
(R):5'- AACACGGCGCTTCTCAACAG -3'

Sequencing Primer
(F):5'- AAACCCATTGCCCTCTGAG -3'
(R):5'- GTCGTGCAAGCCTCAGACAAG -3'

Posted On

2020-10-20