Incidental Mutation 'R8444:Vmn2r72'
| ID |
654382 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r72
|
| Ensembl Gene |
ENSMUSG00000051877 |
| Gene Name |
vomeronasal 2, receptor 72 |
| Synonyms |
EG244114, Vmn2r72-ps |
| MMRRC Submission |
067826-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
R8444 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85386992-85404189 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 85387383 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 727
(V727A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
| AlphaFold |
D3Z4N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063425
AA Change: V727A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: V727A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610010K14Rik |
G |
T |
11: 70,127,755 (GRCm39) |
R56S |
possibly damaging |
Het |
| Abca14 |
T |
A |
7: 119,918,133 (GRCm39) |
I1545K |
probably damaging |
Het |
| Abca3 |
A |
G |
17: 24,602,959 (GRCm39) |
Y518C |
probably damaging |
Het |
| Abcd2 |
A |
G |
15: 91,058,839 (GRCm39) |
V535A |
probably benign |
Het |
| Adcy9 |
T |
C |
16: 4,106,487 (GRCm39) |
T1113A |
probably damaging |
Het |
| Afdn |
A |
T |
17: 14,104,062 (GRCm39) |
N1133Y |
probably benign |
Het |
| Aip |
T |
A |
19: 4,166,034 (GRCm39) |
D139V |
probably damaging |
Het |
| Akap13 |
G |
A |
7: 75,380,213 (GRCm39) |
R462H |
probably damaging |
Het |
| Aldh16a1 |
G |
A |
7: 44,799,115 (GRCm39) |
P56S |
probably benign |
Het |
| Alpk3 |
A |
C |
7: 80,707,468 (GRCm39) |
T31P |
probably benign |
Het |
| Aoc3 |
G |
T |
11: 101,232,573 (GRCm39) |
R466S |
unknown |
Het |
| Atoh1 |
T |
C |
6: 64,706,641 (GRCm39) |
L112P |
probably benign |
Het |
| Atp2b2 |
T |
A |
6: 113,770,772 (GRCm39) |
N424I |
probably benign |
Het |
| Brms1 |
T |
C |
19: 5,091,520 (GRCm39) |
|
probably null |
Het |
| Casc3 |
C |
T |
11: 98,713,607 (GRCm39) |
R280C |
probably damaging |
Het |
| Cd34 |
T |
A |
1: 194,640,808 (GRCm39) |
S224R |
probably benign |
Het |
| Cdh20 |
T |
A |
1: 104,898,583 (GRCm39) |
F437I |
probably benign |
Het |
| Cdkal1 |
A |
T |
13: 29,510,087 (GRCm39) |
V557E |
probably benign |
Het |
| Cfap276 |
A |
G |
3: 108,451,384 (GRCm39) |
H115R |
probably benign |
Het |
| Chst5 |
T |
C |
8: 112,617,395 (GRCm39) |
H75R |
probably damaging |
Het |
| Col5a2 |
A |
T |
1: 45,435,305 (GRCm39) |
N713K |
probably benign |
Het |
| Cpne5 |
A |
T |
17: 29,407,357 (GRCm39) |
M181K |
probably benign |
Het |
| Cpt1a |
T |
C |
19: 3,431,981 (GRCm39) |
F731S |
probably benign |
Het |
| Cyfip1 |
A |
G |
7: 55,521,902 (GRCm39) |
M69V |
possibly damaging |
Het |
| Dennd3 |
A |
G |
15: 73,442,672 (GRCm39) |
K1232E |
probably benign |
Het |
| Dennd4b |
A |
T |
3: 90,181,259 (GRCm39) |
H805L |
probably benign |
Het |
| Dnm1l |
C |
T |
16: 16,158,906 (GRCm39) |
R108Q |
probably damaging |
Het |
| Dsc1 |
T |
A |
18: 20,222,636 (GRCm39) |
D612V |
probably benign |
Het |
| Ephb2 |
C |
T |
4: 136,388,711 (GRCm39) |
G628R |
probably damaging |
Het |
| Esrrb |
G |
A |
12: 86,552,595 (GRCm39) |
R195H |
probably benign |
Het |
| Flg2 |
A |
T |
3: 93,107,585 (GRCm39) |
E23D |
probably damaging |
Het |
| Gja8 |
A |
G |
3: 96,826,990 (GRCm39) |
L224P |
probably damaging |
Het |
| Hps6 |
T |
G |
19: 45,993,867 (GRCm39) |
S601R |
possibly damaging |
Het |
| Ice1 |
T |
C |
13: 70,752,495 (GRCm39) |
E1197G |
probably damaging |
Het |
| Ifnar2 |
C |
A |
16: 91,200,857 (GRCm39) |
A366D |
possibly damaging |
Het |
| Ighm |
A |
C |
12: 113,384,813 (GRCm39) |
S347A |
|
Het |
| Immt |
C |
T |
6: 71,848,492 (GRCm39) |
R494* |
probably null |
Het |
| Irs2 |
A |
G |
8: 11,056,683 (GRCm39) |
V583A |
probably damaging |
Het |
| Kcnk4 |
T |
C |
19: 6,903,508 (GRCm39) |
E347G |
probably damaging |
Het |
| Kif5b |
T |
A |
18: 6,213,245 (GRCm39) |
I716F |
probably benign |
Het |
| Klhl1 |
T |
A |
14: 96,755,326 (GRCm39) |
D143V |
probably benign |
Het |
| Lrp1b |
T |
C |
2: 40,760,272 (GRCm39) |
T2999A |
|
Het |
| Map3k9 |
A |
G |
12: 81,768,970 (GRCm39) |
L1026P |
probably damaging |
Het |
| Mtg1 |
T |
C |
7: 139,718,283 (GRCm39) |
V54A |
probably damaging |
Het |
| Mx1 |
G |
T |
16: 97,252,687 (GRCm39) |
C231* |
probably null |
Het |
| Odad4 |
G |
T |
11: 100,452,731 (GRCm39) |
|
probably null |
Het |
| Or10ag59 |
G |
A |
2: 87,406,083 (GRCm39) |
M218I |
probably benign |
Het |
| Or56a41 |
A |
G |
7: 104,740,165 (GRCm39) |
V227A |
probably damaging |
Het |
| Or5p6 |
C |
A |
7: 107,631,070 (GRCm39) |
W160L |
probably benign |
Het |
| Or5p79 |
A |
G |
7: 108,221,027 (GRCm39) |
I3V |
probably benign |
Het |
| Or6c65 |
T |
A |
10: 129,603,794 (GRCm39) |
V143E |
probably damaging |
Het |
| Otogl |
T |
A |
10: 107,692,975 (GRCm39) |
E836D |
probably benign |
Het |
| Pde6d |
A |
G |
1: 86,471,250 (GRCm39) |
S143P |
probably damaging |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pon1 |
C |
T |
6: 5,177,327 (GRCm39) |
W194* |
probably null |
Het |
| Rbm25 |
T |
A |
12: 83,711,025 (GRCm39) |
S379R |
unknown |
Het |
| Rnf111 |
A |
T |
9: 70,365,223 (GRCm39) |
S415T |
probably benign |
Het |
| Shoc2 |
A |
G |
19: 53,976,503 (GRCm39) |
Y131C |
probably damaging |
Het |
| Slc23a1 |
T |
A |
18: 35,757,489 (GRCm39) |
M261L |
possibly damaging |
Het |
| Slc34a1 |
A |
T |
13: 24,003,061 (GRCm39) |
H237L |
probably benign |
Het |
| Slc35d1 |
G |
C |
4: 103,071,896 (GRCm39) |
I35M |
|
Het |
| Slc8b1 |
C |
T |
5: 120,651,203 (GRCm39) |
|
probably benign |
Het |
| Smr3a |
A |
C |
5: 88,152,611 (GRCm39) |
L8F |
unknown |
Het |
| Snx8 |
G |
A |
5: 140,343,929 (GRCm39) |
R96C |
possibly damaging |
Het |
| Srgap3 |
A |
G |
6: 112,752,509 (GRCm39) |
V325A |
possibly damaging |
Het |
| Stk40 |
A |
G |
4: 126,012,127 (GRCm39) |
T10A |
probably benign |
Het |
| Tmem177 |
A |
T |
1: 119,837,950 (GRCm39) |
V243D |
probably benign |
Het |
| Trim6 |
G |
A |
7: 103,881,879 (GRCm39) |
V403M |
probably damaging |
Het |
| Tysnd1 |
A |
G |
10: 61,531,950 (GRCm39) |
R201G |
probably benign |
Het |
| Vmn2r67 |
A |
T |
7: 84,785,854 (GRCm39) |
F717Y |
probably benign |
Het |
| Wdr49 |
A |
C |
3: 75,358,997 (GRCm39) |
D43E |
probably benign |
Het |
| Zbtb8b |
A |
G |
4: 129,326,424 (GRCm39) |
V247A |
probably benign |
Het |
| Zfp532 |
C |
A |
18: 65,757,330 (GRCm39) |
A421E |
possibly damaging |
Het |
|
| Other mutations in Vmn2r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00931:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01019:Vmn2r72
|
APN |
7 |
85,387,542 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01445:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02076:Vmn2r72
|
APN |
7 |
85,387,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02082:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02086:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02089:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02125:Vmn2r72
|
APN |
7 |
85,399,919 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02146:Vmn2r72
|
APN |
7 |
85,387,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02272:Vmn2r72
|
APN |
7 |
85,399,901 (GRCm39) |
missense |
probably benign |
|
|
IGL02514:Vmn2r72
|
APN |
7 |
85,387,907 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02662:Vmn2r72
|
APN |
7 |
85,387,391 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02697:Vmn2r72
|
APN |
7 |
85,387,879 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02733:Vmn2r72
|
APN |
7 |
85,401,021 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03070:Vmn2r72
|
APN |
7 |
85,401,249 (GRCm39) |
splice site |
probably benign |
|
|
IGL03150:Vmn2r72
|
APN |
7 |
85,400,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03159:Vmn2r72
|
APN |
7 |
85,404,162 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03333:Vmn2r72
|
APN |
7 |
85,400,075 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0081:Vmn2r72
|
UTSW |
7 |
85,401,044 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0090:Vmn2r72
|
UTSW |
7 |
85,404,084 (GRCm39) |
missense |
probably benign |
|
|
R0655:Vmn2r72
|
UTSW |
7 |
85,387,319 (GRCm39) |
nonsense |
probably null |
|
|
R0778:Vmn2r72
|
UTSW |
7 |
85,398,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1169:Vmn2r72
|
UTSW |
7 |
85,400,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1172:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1173:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1175:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1248:Vmn2r72
|
UTSW |
7 |
85,398,396 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1302:Vmn2r72
|
UTSW |
7 |
85,387,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1506:Vmn2r72
|
UTSW |
7 |
85,398,419 (GRCm39) |
missense |
probably benign |
|
|
R1632:Vmn2r72
|
UTSW |
7 |
85,401,000 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1775:Vmn2r72
|
UTSW |
7 |
85,387,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r72
|
UTSW |
7 |
85,398,369 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r72
|
UTSW |
7 |
85,387,444 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2290:Vmn2r72
|
UTSW |
7 |
85,387,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Vmn2r72
|
UTSW |
7 |
85,400,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2655:Vmn2r72
|
UTSW |
7 |
85,400,477 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2860:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2861:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2862:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3009:Vmn2r72
|
UTSW |
7 |
85,398,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3798:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3902:Vmn2r72
|
UTSW |
7 |
85,398,943 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R3959:Vmn2r72
|
UTSW |
7 |
85,400,339 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3974:Vmn2r72
|
UTSW |
7 |
85,399,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4399:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4421:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Vmn2r72
|
UTSW |
7 |
85,387,036 (GRCm39) |
nonsense |
probably null |
|
|
R4522:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4523:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4533:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4691:Vmn2r72
|
UTSW |
7 |
85,387,119 (GRCm39) |
nonsense |
probably null |
|
|
R4781:Vmn2r72
|
UTSW |
7 |
85,387,069 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4863:Vmn2r72
|
UTSW |
7 |
85,399,806 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4952:Vmn2r72
|
UTSW |
7 |
85,400,317 (GRCm39) |
missense |
probably benign |
|
|
R4991:Vmn2r72
|
UTSW |
7 |
85,400,338 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4995:Vmn2r72
|
UTSW |
7 |
85,387,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5095:Vmn2r72
|
UTSW |
7 |
85,387,061 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5174:Vmn2r72
|
UTSW |
7 |
85,387,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5276:Vmn2r72
|
UTSW |
7 |
85,387,462 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5395:Vmn2r72
|
UTSW |
7 |
85,400,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5560:Vmn2r72
|
UTSW |
7 |
85,401,150 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5933:Vmn2r72
|
UTSW |
7 |
85,387,058 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6354:Vmn2r72
|
UTSW |
7 |
85,399,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6362:Vmn2r72
|
UTSW |
7 |
85,400,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6594:Vmn2r72
|
UTSW |
7 |
85,398,892 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6794:Vmn2r72
|
UTSW |
7 |
85,387,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7113:Vmn2r72
|
UTSW |
7 |
85,399,011 (GRCm39) |
splice site |
probably null |
|
|
R7189:Vmn2r72
|
UTSW |
7 |
85,404,125 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7266:Vmn2r72
|
UTSW |
7 |
85,387,482 (GRCm39) |
nonsense |
probably null |
|
|
R7323:Vmn2r72
|
UTSW |
7 |
85,399,771 (GRCm39) |
missense |
probably benign |
|
|
R7426:Vmn2r72
|
UTSW |
7 |
85,400,348 (GRCm39) |
missense |
probably benign |
|
|
R7606:Vmn2r72
|
UTSW |
7 |
85,400,362 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7651:Vmn2r72
|
UTSW |
7 |
85,401,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Vmn2r72
|
UTSW |
7 |
85,404,098 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7753:Vmn2r72
|
UTSW |
7 |
85,399,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7843:Vmn2r72
|
UTSW |
7 |
85,398,838 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8157:Vmn2r72
|
UTSW |
7 |
85,400,441 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8254:Vmn2r72
|
UTSW |
7 |
85,400,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Vmn2r72
|
UTSW |
7 |
85,401,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8989:Vmn2r72
|
UTSW |
7 |
85,404,134 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9015:Vmn2r72
|
UTSW |
7 |
85,398,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9080:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Vmn2r72
|
UTSW |
7 |
85,400,411 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9317:Vmn2r72
|
UTSW |
7 |
85,404,022 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9509:Vmn2r72
|
UTSW |
7 |
85,404,075 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,398,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCATGCTGAATGTCAAGAGC -3'
(R):5'- TGCAGCAGACCACTTTTGCC -3'
Sequencing Primer
(F):5'- CATGCTGAATGTCAAGAGCTTGGC -3'
(R):5'- ACCTCTACTATTTTGGCTAAGACG -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation