Incidental Mutation 'R8444:Mx1'
ID 654412
Institutional Source Beutler Lab
Gene Symbol Mx1
Ensembl Gene ENSMUSG00000000386
Gene Name MX dynamin-like GTPase 1
Synonyms Mx-1, myxovirus (influenza) resistance 1 polypeptide, Mx
MMRRC Submission 067826-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8444 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 97248235-97264106 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 97252687 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 231 (C231*)
Ref Sequence ENSEMBL: ENSMUSP00000109397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023655] [ENSMUST00000113768] [ENSMUST00000135184] [ENSMUST00000155233] [ENSMUST00000232193] [ENSMUST00000232282]
AlphaFold Q3UD61
Predicted Effect probably null
Transcript: ENSMUST00000023655
AA Change: C461*
SMART Domains Protein: ENSMUSP00000023655
Gene: ENSMUSG00000000386
AA Change: C461*

DomainStartEndE-ValueType
DYNc 12 255 3.52e-134 SMART
low complexity region 309 325 N/A INTRINSIC
Pfam:Dynamin_M 428 509 8.1e-12 PFAM
GED 534 625 5.58e-38 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113768
AA Change: C231*
SMART Domains Protein: ENSMUSP00000109397
Gene: ENSMUSG00000000386
AA Change: C231*

DomainStartEndE-ValueType
DYNc 12 241 1.34e-98 SMART
low complexity region 279 289 N/A INTRINSIC
GED 304 395 5.58e-38 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000135184
SMART Domains Protein: ENSMUSP00000138813
Gene: ENSMUSG00000000386

DomainStartEndE-ValueType
DYNc 2 111 2.62e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000155233
SMART Domains Protein: ENSMUSP00000138532
Gene: ENSMUSG00000000386

DomainStartEndE-ValueType
DYNc 12 255 3.52e-134 SMART
Predicted Effect probably null
Transcript: ENSMUST00000232193
AA Change: C133*
Predicted Effect probably benign
Transcript: ENSMUST00000232282
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]
PHENOTYPE: A2G, SL/NiA, T9 and CAST/Ei strains produce the MX1 protein (Mx1+ allele) conferring resistance to myxoviruses, whereas no protein is made by the Mx1- susceptible alleles of C57BL/6J and many other inbred strains with an exon 9-11 deletion; or CBA/J, CE/J, I/LnJ and PERA/Ei with a nonsense mutation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010K14Rik G T 11: 70,127,755 (GRCm39) R56S possibly damaging Het
Abca14 T A 7: 119,918,133 (GRCm39) I1545K probably damaging Het
Abca3 A G 17: 24,602,959 (GRCm39) Y518C probably damaging Het
Abcd2 A G 15: 91,058,839 (GRCm39) V535A probably benign Het
Adcy9 T C 16: 4,106,487 (GRCm39) T1113A probably damaging Het
Afdn A T 17: 14,104,062 (GRCm39) N1133Y probably benign Het
Aip T A 19: 4,166,034 (GRCm39) D139V probably damaging Het
Akap13 G A 7: 75,380,213 (GRCm39) R462H probably damaging Het
Aldh16a1 G A 7: 44,799,115 (GRCm39) P56S probably benign Het
Alpk3 A C 7: 80,707,468 (GRCm39) T31P probably benign Het
Aoc3 G T 11: 101,232,573 (GRCm39) R466S unknown Het
Atoh1 T C 6: 64,706,641 (GRCm39) L112P probably benign Het
Atp2b2 T A 6: 113,770,772 (GRCm39) N424I probably benign Het
Brms1 T C 19: 5,091,520 (GRCm39) probably null Het
Casc3 C T 11: 98,713,607 (GRCm39) R280C probably damaging Het
Cd34 T A 1: 194,640,808 (GRCm39) S224R probably benign Het
Cdh20 T A 1: 104,898,583 (GRCm39) F437I probably benign Het
Cdkal1 A T 13: 29,510,087 (GRCm39) V557E probably benign Het
Cfap276 A G 3: 108,451,384 (GRCm39) H115R probably benign Het
Chst5 T C 8: 112,617,395 (GRCm39) H75R probably damaging Het
Col5a2 A T 1: 45,435,305 (GRCm39) N713K probably benign Het
Cpne5 A T 17: 29,407,357 (GRCm39) M181K probably benign Het
Cpt1a T C 19: 3,431,981 (GRCm39) F731S probably benign Het
Cyfip1 A G 7: 55,521,902 (GRCm39) M69V possibly damaging Het
Dennd3 A G 15: 73,442,672 (GRCm39) K1232E probably benign Het
Dennd4b A T 3: 90,181,259 (GRCm39) H805L probably benign Het
Dnm1l C T 16: 16,158,906 (GRCm39) R108Q probably damaging Het
Dsc1 T A 18: 20,222,636 (GRCm39) D612V probably benign Het
Ephb2 C T 4: 136,388,711 (GRCm39) G628R probably damaging Het
Esrrb G A 12: 86,552,595 (GRCm39) R195H probably benign Het
Flg2 A T 3: 93,107,585 (GRCm39) E23D probably damaging Het
Gja8 A G 3: 96,826,990 (GRCm39) L224P probably damaging Het
Hps6 T G 19: 45,993,867 (GRCm39) S601R possibly damaging Het
Ice1 T C 13: 70,752,495 (GRCm39) E1197G probably damaging Het
Ifnar2 C A 16: 91,200,857 (GRCm39) A366D possibly damaging Het
Ighm A C 12: 113,384,813 (GRCm39) S347A Het
Immt C T 6: 71,848,492 (GRCm39) R494* probably null Het
Irs2 A G 8: 11,056,683 (GRCm39) V583A probably damaging Het
Kcnk4 T C 19: 6,903,508 (GRCm39) E347G probably damaging Het
Kif5b T A 18: 6,213,245 (GRCm39) I716F probably benign Het
Klhl1 T A 14: 96,755,326 (GRCm39) D143V probably benign Het
Lrp1b T C 2: 40,760,272 (GRCm39) T2999A Het
Map3k9 A G 12: 81,768,970 (GRCm39) L1026P probably damaging Het
Mtg1 T C 7: 139,718,283 (GRCm39) V54A probably damaging Het
Odad4 G T 11: 100,452,731 (GRCm39) probably null Het
Or10ag59 G A 2: 87,406,083 (GRCm39) M218I probably benign Het
Or56a41 A G 7: 104,740,165 (GRCm39) V227A probably damaging Het
Or5p6 C A 7: 107,631,070 (GRCm39) W160L probably benign Het
Or5p79 A G 7: 108,221,027 (GRCm39) I3V probably benign Het
Or6c65 T A 10: 129,603,794 (GRCm39) V143E probably damaging Het
Otogl T A 10: 107,692,975 (GRCm39) E836D probably benign Het
Pde6d A G 1: 86,471,250 (GRCm39) S143P probably damaging Het
Peg10 CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG CCACATCAGGATCCACATCAGGATGCACATCAG 6: 4,756,398 (GRCm39) probably benign Het
Pon1 C T 6: 5,177,327 (GRCm39) W194* probably null Het
Rbm25 T A 12: 83,711,025 (GRCm39) S379R unknown Het
Rnf111 A T 9: 70,365,223 (GRCm39) S415T probably benign Het
Shoc2 A G 19: 53,976,503 (GRCm39) Y131C probably damaging Het
Slc23a1 T A 18: 35,757,489 (GRCm39) M261L possibly damaging Het
Slc34a1 A T 13: 24,003,061 (GRCm39) H237L probably benign Het
Slc35d1 G C 4: 103,071,896 (GRCm39) I35M Het
Slc8b1 C T 5: 120,651,203 (GRCm39) probably benign Het
Smr3a A C 5: 88,152,611 (GRCm39) L8F unknown Het
Snx8 G A 5: 140,343,929 (GRCm39) R96C possibly damaging Het
Srgap3 A G 6: 112,752,509 (GRCm39) V325A possibly damaging Het
Stk40 A G 4: 126,012,127 (GRCm39) T10A probably benign Het
Tmem177 A T 1: 119,837,950 (GRCm39) V243D probably benign Het
Trim6 G A 7: 103,881,879 (GRCm39) V403M probably damaging Het
Tysnd1 A G 10: 61,531,950 (GRCm39) R201G probably benign Het
Vmn2r67 A T 7: 84,785,854 (GRCm39) F717Y probably benign Het
Vmn2r72 A G 7: 85,387,383 (GRCm39) V727A probably benign Het
Wdr49 A C 3: 75,358,997 (GRCm39) D43E probably benign Het
Zbtb8b A G 4: 129,326,424 (GRCm39) V247A probably benign Het
Zfp532 C A 18: 65,757,330 (GRCm39) A421E possibly damaging Het
Other mutations in Mx1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00553:Mx1 APN 16 97,258,632 (GRCm39) missense probably damaging 1.00
IGL01328:Mx1 APN 16 97,256,832 (GRCm39) missense probably damaging 0.99
IGL03105:Mx1 APN 16 97,257,554 (GRCm39) missense possibly damaging 0.94
PIT4585001:Mx1 UTSW 16 97,257,454 (GRCm39) missense probably benign 0.07
R0003:Mx1 UTSW 16 97,252,788 (GRCm39) intron probably benign
R1597:Mx1 UTSW 16 97,256,329 (GRCm39) missense probably damaging 1.00
R1753:Mx1 UTSW 16 97,255,358 (GRCm39) missense probably damaging 1.00
R1780:Mx1 UTSW 16 97,252,712 (GRCm39) makesense probably null
R1826:Mx1 UTSW 16 97,256,837 (GRCm39) missense possibly damaging 0.95
R1851:Mx1 UTSW 16 97,249,403 (GRCm39) missense probably damaging 1.00
R1852:Mx1 UTSW 16 97,249,403 (GRCm39) missense probably damaging 1.00
R2059:Mx1 UTSW 16 97,255,379 (GRCm39) nonsense probably null
R2223:Mx1 UTSW 16 97,256,432 (GRCm39) splice site probably benign
R3441:Mx1 UTSW 16 97,257,431 (GRCm39) missense probably damaging 1.00
R3442:Mx1 UTSW 16 97,257,431 (GRCm39) missense probably damaging 1.00
R3782:Mx1 UTSW 16 97,253,195 (GRCm39) missense possibly damaging 0.75
R4460:Mx1 UTSW 16 97,255,281 (GRCm39) missense probably damaging 0.99
R4659:Mx1 UTSW 16 97,256,439 (GRCm39) splice site probably null
R5116:Mx1 UTSW 16 97,258,679 (GRCm39) missense possibly damaging 0.67
R5186:Mx1 UTSW 16 97,256,694 (GRCm39) missense probably benign 0.09
R5215:Mx1 UTSW 16 97,249,560 (GRCm39) missense possibly damaging 0.72
R5249:Mx1 UTSW 16 97,258,628 (GRCm39) missense probably damaging 1.00
R5450:Mx1 UTSW 16 97,255,347 (GRCm39) nonsense probably null
R5806:Mx1 UTSW 16 97,255,351 (GRCm39) missense possibly damaging 0.81
R5894:Mx1 UTSW 16 97,255,406 (GRCm39) missense probably damaging 1.00
R5916:Mx1 UTSW 16 97,252,933 (GRCm39) missense probably benign 0.00
R5981:Mx1 UTSW 16 97,255,405 (GRCm39) missense probably damaging 1.00
R7111:Mx1 UTSW 16 97,256,376 (GRCm39) missense probably damaging 0.99
R7207:Mx1 UTSW 16 97,253,398 (GRCm39) missense probably benign
R7238:Mx1 UTSW 16 97,249,496 (GRCm39) missense unknown
R7318:Mx1 UTSW 16 97,253,286 (GRCm39) missense probably benign 0.06
R7699:Mx1 UTSW 16 97,249,521 (GRCm39) missense unknown
R7856:Mx1 UTSW 16 97,256,735 (GRCm39) missense probably damaging 1.00
R8012:Mx1 UTSW 16 97,258,572 (GRCm39) missense probably damaging 1.00
R8560:Mx1 UTSW 16 97,253,987 (GRCm39) missense probably damaging 0.99
R8750:Mx1 UTSW 16 97,252,917 (GRCm39) missense probably damaging 1.00
R9245:Mx1 UTSW 16 97,252,753 (GRCm39) critical splice acceptor site probably null
R9642:Mx1 UTSW 16 97,256,376 (GRCm39) missense probably damaging 0.99
R9645:Mx1 UTSW 16 97,253,409 (GRCm39) missense probably benign 0.01
R9797:Mx1 UTSW 16 97,252,893 (GRCm39) missense probably benign 0.01
X0028:Mx1 UTSW 16 97,251,621 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCAAACCCGTTTTAACCAGAAG -3'
(R):5'- CTGTCTTCACAAGGGGAAAAGG -3'

Sequencing Primer
(F):5'- ACCAGAAGGCCTGTTGTTAC -3'
(R):5'- TGTCTTCACAAGGGGAAAAGGAAAAC -3'
Posted On 2020-10-20