Incidental Mutation 'R8445:Vmn2r26'
| ID |
654443 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
067886-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.094)
|
| Stock # |
R8445 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
124001717-124038994 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 124002995 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 135
(N135S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032238
AA Change: N135S
PolyPhen 2
Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: N135S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam10 |
T |
G |
9: 70,674,203 (GRCm39) |
S522A |
probably benign |
Het |
| Akap13 |
G |
A |
7: 75,380,213 (GRCm39) |
R462H |
probably damaging |
Het |
| Alg12 |
C |
T |
15: 88,698,689 (GRCm39) |
R212Q |
probably benign |
Het |
| C330018D20Rik |
G |
A |
18: 57,090,962 (GRCm39) |
P67L |
probably damaging |
Het |
| Col3a1 |
C |
T |
1: 45,380,340 (GRCm39) |
R955* |
probably null |
Het |
| Cyp2j12 |
T |
A |
4: 96,021,259 (GRCm39) |
I116F |
possibly damaging |
Het |
| Cyp4a10 |
T |
A |
4: 115,382,791 (GRCm39) |
W331R |
probably damaging |
Het |
| Dmbt1 |
T |
A |
7: 130,692,110 (GRCm39) |
Y959N |
unknown |
Het |
| Dytn |
T |
A |
1: 63,686,673 (GRCm39) |
K332N |
probably benign |
Het |
| E130308A19Rik |
T |
A |
4: 59,720,526 (GRCm39) |
V686D |
probably damaging |
Het |
| Epha8 |
T |
C |
4: 136,659,600 (GRCm39) |
Y792C |
probably benign |
Het |
| Fam53c |
T |
C |
18: 34,901,368 (GRCm39) |
V95A |
probably benign |
Het |
| Fbxl4 |
C |
A |
4: 22,385,983 (GRCm39) |
Q197K |
probably benign |
Het |
| Fmod |
G |
A |
1: 133,968,736 (GRCm39) |
V259I |
probably benign |
Het |
| Insrr |
T |
C |
3: 87,720,891 (GRCm39) |
S1050P |
probably damaging |
Het |
| Itga4 |
A |
G |
2: 79,112,125 (GRCm39) |
M347V |
probably benign |
Het |
| Kdm5d |
A |
G |
Y: 916,874 (GRCm39) |
E423G |
probably damaging |
Het |
| Klra7 |
A |
T |
6: 130,204,078 (GRCm39) |
I147N |
possibly damaging |
Het |
| Lbx1 |
T |
A |
19: 45,222,651 (GRCm39) |
K124I |
probably damaging |
Het |
| Map4k5 |
T |
A |
12: 69,897,741 (GRCm39) |
H138L |
probably damaging |
Het |
| Mc3r |
A |
G |
2: 172,091,237 (GRCm39) |
H153R |
probably damaging |
Het |
| Myh15 |
C |
A |
16: 48,940,381 (GRCm39) |
T777N |
probably damaging |
Het |
| Nfatc4 |
A |
C |
14: 56,063,875 (GRCm39) |
I121L |
possibly damaging |
Het |
| Nipa1 |
A |
T |
7: 55,629,466 (GRCm39) |
S216T |
probably benign |
Het |
| Nlrp4e |
A |
T |
7: 23,039,965 (GRCm39) |
I763L |
probably benign |
Het |
| Nop2 |
A |
G |
6: 125,111,567 (GRCm39) |
D100G |
probably benign |
Het |
| Or2a52 |
A |
G |
6: 43,144,231 (GRCm39) |
M80V |
probably benign |
Het |
| Or8b12i |
T |
A |
9: 20,082,394 (GRCm39) |
I158L |
probably benign |
Het |
| Prelid3a |
A |
G |
18: 67,606,848 (GRCm39) |
E80G |
probably damaging |
Het |
| Prl4a1 |
T |
C |
13: 28,205,445 (GRCm39) |
S137P |
possibly damaging |
Het |
| Rbpms2 |
C |
T |
9: 65,558,303 (GRCm39) |
A113V |
possibly damaging |
Het |
| Rph3a |
T |
C |
5: 121,111,433 (GRCm39) |
E49G |
probably damaging |
Het |
| Shisa7 |
A |
T |
7: 4,839,352 (GRCm39) |
M124K |
probably benign |
Het |
| Shprh |
C |
T |
10: 11,057,313 (GRCm39) |
P1078S |
possibly damaging |
Het |
| Slc30a7 |
C |
T |
3: 115,800,995 (GRCm39) |
|
probably benign |
Het |
| Smarca4 |
CGAGGAGGAGGAGGAGG |
CGAGGAGGAGGAGG |
9: 21,612,239 (GRCm39) |
|
probably benign |
Het |
| Smg1 |
A |
C |
7: 117,736,200 (GRCm39) |
N3563K |
possibly damaging |
Het |
| Spata31d1c |
G |
T |
13: 65,180,991 (GRCm39) |
S30I |
probably damaging |
Het |
| St6galnac6 |
A |
G |
2: 32,498,532 (GRCm39) |
|
probably benign |
Het |
| Tcp11l1 |
C |
A |
2: 104,512,278 (GRCm39) |
E451D |
probably benign |
Het |
| Tfpt |
G |
A |
7: 3,623,928 (GRCm39) |
P160S |
probably damaging |
Het |
| Thbs4 |
C |
A |
13: 92,927,349 (GRCm39) |
A47S |
probably benign |
Het |
| Trpm2 |
T |
C |
10: 77,746,086 (GRCm39) |
D1482G |
probably damaging |
Het |
| Tspyl4 |
C |
T |
10: 34,173,742 (GRCm39) |
A78V |
probably benign |
Het |
| Vmn2r87 |
A |
T |
10: 130,313,335 (GRCm39) |
V477E |
probably damaging |
Het |
| Wdr89 |
T |
C |
12: 75,679,636 (GRCm39) |
D206G |
probably damaging |
Het |
| Zfp623 |
C |
A |
15: 75,819,402 (GRCm39) |
Y119* |
probably null |
Het |
| Zfp879 |
A |
G |
11: 50,724,213 (GRCm39) |
M281T |
probably damaging |
Het |
| Zfp952 |
T |
G |
17: 33,222,552 (GRCm39) |
F344V |
possibly damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,379,854 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,038,566 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,038,715 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,030,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,027,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,038,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,038,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,003,100 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,003,091 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,016,754 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,027,778 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,016,858 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,038,992 (GRCm39) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,030,940 (GRCm39) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,038,129 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,038,603 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,030,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,027,667 (GRCm39) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,016,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,038,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,038,369 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,001,730 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,030,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,038,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,038,196 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,016,708 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,038,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,002,938 (GRCm39) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,027,697 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,038,150 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,038,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,030,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,003,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,038,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,038,285 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,027,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,016,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,002,925 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,038,633 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,016,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,016,519 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,038,444 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,038,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,003,039 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,038,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,016,057 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,016,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,038,255 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,016,727 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,038,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,002,914 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,016,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,016,606 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,016,321 (GRCm39) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,038,494 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,038,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,016,758 (GRCm39) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,001,914 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,038,887 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,001,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,038,983 (GRCm39) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,003,009 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,016,333 (GRCm39) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,002,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,038,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,016,448 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTTTATATGCCTTAGATTGCTG -3'
(R):5'- ATTAAGCCGTCCTATACCTCTTCAG -3'
Sequencing Primer
(F):5'- TCCAAAATTTGAGAGGGAGCACTG -3'
(R):5'- AGCCGTCCTATACCTCTTCAGTAAAC -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation