Incidental Mutation 'R8447:Or6c76'
ID 654559
Institutional Source Beutler Lab
Gene Symbol Or6c76
Ensembl Gene ENSMUSG00000050251
Gene Name olfactory receptor family 6 subfamily C member 76
Synonyms GA_x6K02T2PULF-11454600-11455541, Olfr809, MOR108-4
MMRRC Submission 067902-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R8447 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129611740-129612726 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 129612371 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 211 (M211R)
Ref Sequence ENSEMBL: ENSMUSP00000151711 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059891] [ENSMUST00000203236] [ENSMUST00000203598] [ENSMUST00000218237]
AlphaFold Q8VEX8
Predicted Effect possibly damaging
Transcript: ENSMUST00000059891
AA Change: M196R

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000054949
Gene: ENSMUSG00000050251
AA Change: M196R

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 3.5e-49 PFAM
Pfam:7tm_1 54 303 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203236
SMART Domains Protein: ENSMUSP00000145315
Gene: ENSMUSG00000049894

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.8e-53 PFAM
Pfam:7tm_1 39 288 7.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203598
SMART Domains Protein: ENSMUSP00000145037
Gene: ENSMUSG00000050251

DomainStartEndE-ValueType
Pfam:7tm_4 29 148 8.1e-20 PFAM
Pfam:7tm_1 39 149 1.8e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000218237
AA Change: M211R

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A C 5: 8,957,278 (GRCm39) T136P probably damaging Het
Abcc3 A T 11: 94,254,886 (GRCm39) L639Q possibly damaging Het
Adam10 T A 9: 70,655,400 (GRCm39) N289K probably damaging Het
Akap12 A G 10: 4,306,289 (GRCm39) E1138G probably benign Het
Akr1e1 C A 13: 4,648,793 (GRCm39) L167F probably damaging Het
Cars1 T C 7: 143,123,766 (GRCm39) K506E possibly damaging Het
Castor1 T C 11: 4,170,165 (GRCm39) V81A probably damaging Het
Cfap46 C A 7: 139,260,902 (GRCm39) R65S possibly damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Clec16a C A 16: 10,559,487 (GRCm39) T920K probably benign Het
Coro2b C T 9: 62,333,842 (GRCm39) E351K probably damaging Het
Diablo T C 5: 123,655,829 (GRCm39) E163G probably damaging Het
Dnah6 A G 6: 73,115,757 (GRCm39) L1547P probably damaging Het
Dynll2 G T 11: 87,874,719 (GRCm39) D37E probably benign Het
Eml4 A T 17: 83,755,656 (GRCm39) Q408L probably damaging Het
F2rl3 T C 8: 73,489,963 (GRCm39) *397R probably null Het
Fance T A 17: 28,545,155 (GRCm39) L127Q unknown Het
Fat4 T C 3: 39,033,824 (GRCm39) V2492A possibly damaging Het
Ggta1 C T 2: 35,292,573 (GRCm39) D245N probably damaging Het
Gli1 T C 10: 127,166,106 (GRCm39) N1049S probably benign Het
Grin2c A G 11: 115,148,215 (GRCm39) V354A probably benign Het
Kank4 T A 4: 98,666,729 (GRCm39) I573F probably damaging Het
Kdm3a A G 6: 71,588,881 (GRCm39) V376A probably benign Het
Kndc1 T C 7: 139,481,121 (GRCm39) V69A probably damaging Het
Lcmt1 T A 7: 123,020,825 (GRCm39) L250Q probably damaging Het
Ldhb A T 6: 142,444,356 (GRCm39) V99D probably damaging Het
Lepr T C 4: 101,671,688 (GRCm39) V904A probably benign Het
Lipe G T 7: 25,080,017 (GRCm39) N710K probably damaging Het
Med1 C A 11: 98,060,240 (GRCm39) D230Y probably damaging Het
Mpv17l T A 16: 13,758,864 (GRCm39) I96K probably benign Het
Obox1 A T 7: 15,289,541 (GRCm39) Q110L probably damaging Het
Or11h6 T C 14: 50,880,008 (GRCm39) V84A probably benign Het
Or4f4b T A 2: 111,314,101 (GRCm39) Y137N probably damaging Het
Or4k37 T A 2: 111,159,307 (GRCm39) I181N possibly damaging Het
Or5t16 T A 2: 86,818,885 (GRCm39) I212F probably benign Het
Or9s14 C A 1: 92,535,494 (GRCm39) probably benign Het
Pah T C 10: 87,417,827 (GRCm39) probably null Het
Pate1 A T 9: 35,597,631 (GRCm39) N40K probably benign Het
Pclo C A 5: 14,731,423 (GRCm39) D182E Het
Prl7a2 A T 13: 27,849,941 (GRCm39) S44T possibly damaging Het
Pwp2 T A 10: 78,007,873 (GRCm39) D894V probably benign Het
Ripor2 T A 13: 24,907,771 (GRCm39) L1014Q probably damaging Het
Rpe G A 1: 66,740,188 (GRCm39) probably null Het
Sh2d3c A G 2: 32,642,671 (GRCm39) T706A probably damaging Het
Slc34a1 T C 13: 24,006,309 (GRCm39) F445S possibly damaging Het
Spata20 C A 11: 94,373,080 (GRCm39) L515F probably damaging Het
Tcf20 G A 15: 82,737,437 (GRCm39) S1338F possibly damaging Het
Tm9sf2 C A 14: 122,377,180 (GRCm39) P236Q probably damaging Het
Tmem135 T C 7: 88,803,240 (GRCm39) Y311C probably damaging Het
Tmem245 T C 4: 56,906,261 (GRCm39) Q548R probably benign Het
Tmem94 G T 11: 115,688,023 (GRCm39) C1190F possibly damaging Het
Tmem94 G A 11: 115,688,696 (GRCm39) R1301H probably benign Het
Zp3 G A 5: 136,013,244 (GRCm39) G192E probably damaging Het
Other mutations in Or6c76
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01884:Or6c76 APN 10 129,612,697 (GRCm39) missense probably benign 0.34
IGL02000:Or6c76 APN 10 129,611,938 (GRCm39) missense probably benign 0.03
IGL02146:Or6c76 APN 10 129,612,727 (GRCm39) utr 3 prime probably benign
IGL03087:Or6c76 APN 10 129,612,130 (GRCm39) missense probably damaging 0.98
IGL03260:Or6c76 APN 10 129,612,521 (GRCm39) missense probably damaging 1.00
G1Funyon:Or6c76 UTSW 10 129,612,709 (GRCm39) missense probably benign 0.06
PIT4466001:Or6c76 UTSW 10 129,612,142 (GRCm39) missense probably benign 0.04
R0564:Or6c76 UTSW 10 129,612,005 (GRCm39) missense probably damaging 1.00
R0613:Or6c76 UTSW 10 129,612,131 (GRCm39) missense probably damaging 1.00
R1165:Or6c76 UTSW 10 129,612,302 (GRCm39) missense probably damaging 0.99
R1556:Or6c76 UTSW 10 129,612,242 (GRCm39) missense probably benign 0.05
R5392:Or6c76 UTSW 10 129,612,184 (GRCm39) missense probably benign 0.01
R6665:Or6c76 UTSW 10 129,612,116 (GRCm39) missense probably damaging 1.00
R7519:Or6c76 UTSW 10 129,612,091 (GRCm39) missense probably benign 0.01
R7804:Or6c76 UTSW 10 129,612,091 (GRCm39) missense probably benign 0.01
R8022:Or6c76 UTSW 10 129,612,654 (GRCm39) missense possibly damaging 0.47
R8301:Or6c76 UTSW 10 129,612,709 (GRCm39) missense probably benign 0.06
R9104:Or6c76 UTSW 10 129,612,521 (GRCm39) missense probably damaging 1.00
R9216:Or6c76 UTSW 10 129,611,796 (GRCm39) missense probably benign
R9679:Or6c76 UTSW 10 129,611,882 (GRCm39) missense probably damaging 1.00
R9720:Or6c76 UTSW 10 129,612,581 (GRCm39) missense probably benign 0.07
Z1176:Or6c76 UTSW 10 129,611,911 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGATCTGCCACCAGCTCATC -3'
(R):5'- CCTTTGTTAAAGCAACTCCAGCC -3'

Sequencing Primer
(F):5'- AGCTCATCATCAGCTCCTGG -3'
(R):5'- CATGAAGATGCAGCTTCCATAG -3'
Posted On 2020-10-20