Incidental Mutation 'R8451:Cep162'
ID 654769
Institutional Source Beutler Lab
Gene Symbol Cep162
Ensembl Gene ENSMUSG00000056919
Gene Name centrosomal protein 162
Synonyms 4922501C03Rik
MMRRC Submission 067887-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R8451 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 87071630-87137589 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 87074903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 1360 (Q1360*)
Ref Sequence ENSEMBL: ENSMUSP00000091319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093802]
AlphaFold Q6ZQ06
Predicted Effect probably null
Transcript: ENSMUST00000093802
AA Change: Q1360*
SMART Domains Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: Q1360*

DomainStartEndE-ValueType
low complexity region 198 208 N/A INTRINSIC
low complexity region 528 539 N/A INTRINSIC
coiled coil region 630 674 N/A INTRINSIC
coiled coil region 695 899 N/A INTRINSIC
coiled coil region 953 1124 N/A INTRINSIC
coiled coil region 1235 1386 N/A INTRINSIC
Meta Mutation Damage Score 0.9754 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik G A 5: 138,561,188 (GRCm39) T158M probably benign Het
Acss3 T C 10: 106,885,265 (GRCm39) H242R probably damaging Het
Ago2 G T 15: 73,002,739 (GRCm39) D164E probably damaging Het
Arl2bp G A 8: 95,393,507 (GRCm39) E6K unknown Het
Bola1 G A 3: 96,104,573 (GRCm39) A7V probably benign Het
Ccdc18 A G 5: 108,303,663 (GRCm39) E249G probably damaging Het
Cep350 T C 1: 155,747,780 (GRCm39) I2047V probably damaging Het
Cntnap5c C T 17: 58,362,687 (GRCm39) R347W probably damaging Het
Eif4a3l1 T A 6: 136,305,542 (GRCm39) M1K probably null Het
Fmo6 C T 1: 162,748,174 (GRCm39) V297M probably damaging Het
Furin C T 7: 80,048,470 (GRCm39) V17M probably benign Het
Hs6st1 A G 1: 36,108,141 (GRCm39) T135A probably damaging Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Klk1 A G 7: 43,878,410 (GRCm39) E190G probably benign Het
Map3k21 T C 8: 126,671,472 (GRCm39) L920P probably benign Het
Mecom T A 3: 30,039,519 (GRCm39) H180L probably benign Het
Mras T C 9: 99,293,548 (GRCm39) I31V probably damaging Het
Nrxn3 A G 12: 89,477,413 (GRCm39) D532G probably damaging Het
Nufip2 A G 11: 77,583,181 (GRCm39) N365S probably damaging Het
Or12j2 T C 7: 139,916,518 (GRCm39) Y248H probably damaging Het
Or4f47 A T 2: 111,972,406 (GRCm39) M39L probably benign Het
Or6b2 T C 1: 92,407,660 (GRCm39) I228V probably benign Het
Pgbd1 A T 13: 21,607,550 (GRCm39) S215T probably benign Het
Ptcd3 A G 6: 71,885,625 (GRCm39) C34R probably benign Het
S100a7l2 A T 3: 90,995,671 (GRCm39) M77K probably benign Het
Samd4 A G 14: 47,338,888 (GRCm39) D703G probably damaging Het
Scaper A T 9: 55,724,088 (GRCm39) N623K possibly damaging Het
Slc12a9 C A 5: 137,313,737 (GRCm39) V741L probably benign Het
Slc12a9 T C 5: 137,326,710 (GRCm39) D249G probably benign Het
Slc3a1 A G 17: 85,335,924 (GRCm39) N22S possibly damaging Het
Sugct A G 13: 17,427,143 (GRCm39) L339P probably damaging Het
Tenm3 T C 8: 48,740,907 (GRCm39) D1192G probably damaging Het
Tinagl1 T A 4: 130,061,376 (GRCm39) D289V probably damaging Het
Tnrc6b C A 15: 80,807,691 (GRCm39) P1548T probably damaging Het
Trmt1l A G 1: 151,324,039 (GRCm39) K152E unknown Het
Vmn1r173 T A 7: 23,401,957 (GRCm39) L64* probably null Het
Zcchc2 T A 1: 105,958,662 (GRCm39) N1044K probably damaging Het
Zfp750 T C 11: 121,404,135 (GRCm39) I247V probably benign Het
Other mutations in Cep162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Cep162 APN 9 87,109,220 (GRCm39) missense probably benign 0.24
IGL00584:Cep162 APN 9 87,103,143 (GRCm39) splice site probably benign
IGL01387:Cep162 APN 9 87,093,864 (GRCm39) missense probably benign 0.08
IGL01862:Cep162 APN 9 87,135,986 (GRCm39) missense possibly damaging 0.90
IGL02304:Cep162 APN 9 87,109,200 (GRCm39) splice site probably benign
IGL02558:Cep162 APN 9 87,107,779 (GRCm39) missense probably benign
IGL02558:Cep162 APN 9 87,107,786 (GRCm39) missense probably benign 0.04
IGL02602:Cep162 APN 9 87,128,206 (GRCm39) missense probably benign 0.19
IGL02636:Cep162 APN 9 87,130,432 (GRCm39) missense possibly damaging 0.90
IGL02680:Cep162 APN 9 87,128,797 (GRCm39) missense possibly damaging 0.64
IGL03195:Cep162 APN 9 87,107,839 (GRCm39) missense probably benign 0.00
circus UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
moscow UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
smiley UTSW 9 87,099,134 (GRCm39) nonsense probably null
PIT4378001:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
PIT4431001:Cep162 UTSW 9 87,126,398 (GRCm39) missense probably benign 0.00
PIT4434001:Cep162 UTSW 9 87,075,701 (GRCm39) missense probably damaging 1.00
R0060:Cep162 UTSW 9 87,119,878 (GRCm39) splice site probably benign
R0218:Cep162 UTSW 9 87,093,862 (GRCm39) missense possibly damaging 0.73
R0366:Cep162 UTSW 9 87,102,537 (GRCm39) missense probably damaging 0.96
R0468:Cep162 UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
R0764:Cep162 UTSW 9 87,083,798 (GRCm39) missense probably damaging 1.00
R1386:Cep162 UTSW 9 87,103,255 (GRCm39) missense probably benign
R1614:Cep162 UTSW 9 87,094,985 (GRCm39) missense probably damaging 1.00
R1633:Cep162 UTSW 9 87,085,736 (GRCm39) missense probably benign 0.23
R1831:Cep162 UTSW 9 87,088,985 (GRCm39) missense probably damaging 1.00
R1847:Cep162 UTSW 9 87,086,133 (GRCm39) missense probably benign 0.06
R1941:Cep162 UTSW 9 87,082,048 (GRCm39) missense probably benign 0.14
R2228:Cep162 UTSW 9 87,126,384 (GRCm39) missense probably benign 0.05
R2256:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2257:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2936:Cep162 UTSW 9 87,109,467 (GRCm39) missense probably benign
R3005:Cep162 UTSW 9 87,114,113 (GRCm39) missense probably benign 0.00
R3508:Cep162 UTSW 9 87,114,030 (GRCm39) critical splice donor site probably null
R3689:Cep162 UTSW 9 87,107,747 (GRCm39) nonsense probably null
R3743:Cep162 UTSW 9 87,099,230 (GRCm39) splice site probably benign
R4118:Cep162 UTSW 9 87,086,229 (GRCm39) missense probably benign 0.30
R4380:Cep162 UTSW 9 87,082,056 (GRCm39) missense probably damaging 0.99
R4450:Cep162 UTSW 9 87,107,861 (GRCm39) missense probably damaging 1.00
R4540:Cep162 UTSW 9 87,094,992 (GRCm39) missense probably damaging 1.00
R4598:Cep162 UTSW 9 87,085,848 (GRCm39) missense possibly damaging 0.95
R4700:Cep162 UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
R4941:Cep162 UTSW 9 87,108,022 (GRCm39) intron probably benign
R5356:Cep162 UTSW 9 87,088,948 (GRCm39) missense probably damaging 1.00
R5468:Cep162 UTSW 9 87,109,290 (GRCm39) missense probably benign 0.00
R5579:Cep162 UTSW 9 87,085,724 (GRCm39) missense probably benign 0.26
R5859:Cep162 UTSW 9 87,086,145 (GRCm39) missense probably damaging 1.00
R6114:Cep162 UTSW 9 87,085,763 (GRCm39) missense probably benign
R6143:Cep162 UTSW 9 87,094,904 (GRCm39) critical splice donor site probably null
R6422:Cep162 UTSW 9 87,114,069 (GRCm39) missense possibly damaging 0.92
R6517:Cep162 UTSW 9 87,104,227 (GRCm39) missense probably damaging 0.99
R6576:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
R6782:Cep162 UTSW 9 87,093,737 (GRCm39) missense probably benign 0.07
R6867:Cep162 UTSW 9 87,099,134 (GRCm39) nonsense probably null
R7293:Cep162 UTSW 9 87,085,836 (GRCm39) missense probably benign 0.01
R7355:Cep162 UTSW 9 87,136,008 (GRCm39) nonsense probably null
R7391:Cep162 UTSW 9 87,130,547 (GRCm39) nonsense probably null
R7426:Cep162 UTSW 9 87,074,819 (GRCm39) missense probably damaging 1.00
R7593:Cep162 UTSW 9 87,086,250 (GRCm39) missense probably benign 0.40
R7710:Cep162 UTSW 9 87,114,172 (GRCm39) missense probably damaging 1.00
R7841:Cep162 UTSW 9 87,126,369 (GRCm39) missense probably benign 0.00
R7949:Cep162 UTSW 9 87,088,901 (GRCm39) missense probably benign 0.04
R8351:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8552:Cep162 UTSW 9 87,126,361 (GRCm39) missense probably benign 0.34
R8755:Cep162 UTSW 9 87,114,064 (GRCm39) missense probably benign 0.02
R8762:Cep162 UTSW 9 87,109,314 (GRCm39) missense probably benign 0.00
R9640:Cep162 UTSW 9 87,126,352 (GRCm39) missense probably benign 0.06
X0063:Cep162 UTSW 9 87,104,095 (GRCm39) critical splice donor site probably null
Z1177:Cep162 UTSW 9 87,082,033 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAACAGCAGCAGGTTTTCATC -3'
(R):5'- CATTAAGCTTCATGGTTGGTCTGAG -3'

Sequencing Primer
(F):5'- ATCTGTCTTACAATGTGGTCACTCAG -3'
(R):5'- GTCTGAGTCTTTCCCAAGAGGC -3'
Posted On 2020-10-20