Incidental Mutation 'R0382:Fstl3'
ID 65477
Institutional Source Beutler Lab
Gene Symbol Fstl3
Ensembl Gene ENSMUSG00000020325
Gene Name follistatin-like 3
Synonyms E030038F23Rik, Flrg
MMRRC Submission 038588-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0382 (G1)
Quality Score 116
Status Validated
Chromosome 10
Chromosomal Location 79613108-79618464 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79613141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 3 (S3P)
Ref Sequence ENSEMBL: ENSMUSP00000020575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020573] [ENSMUST00000020575] [ENSMUST00000169684]
AlphaFold Q9EQC7
Predicted Effect probably benign
Transcript: ENSMUST00000020573
SMART Domains Protein: ENSMUSP00000020573
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
signal peptide 1 37 N/A INTRINSIC
Tryp_SPc 39 264 1.53e-70 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000020575
AA Change: S3P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000020575
Gene: ENSMUSG00000020325
AA Change: S3P

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
FOLN 96 118 4.13e-6 SMART
KAZAL 116 165 1.69e-11 SMART
FOLN 168 191 1.09e-5 SMART
KAZAL 197 241 1.02e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168798
Predicted Effect probably benign
Transcript: ENSMUST00000169684
SMART Domains Protein: ENSMUSP00000132215
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
signal peptide 1 37 N/A INTRINSIC
Tryp_SPc 39 264 1.53e-70 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170380
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.1%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 A T 6: 86,923,901 (GRCm39) Q266L probably benign Het
Abca13 T C 11: 9,586,650 (GRCm39) probably benign Het
Adap2 T C 11: 80,069,211 (GRCm39) probably benign Het
Adgrb2 C G 4: 129,901,624 (GRCm39) P416R probably damaging Het
Brinp1 T C 4: 68,680,545 (GRCm39) R662G possibly damaging Het
Celsr3 C A 9: 108,706,417 (GRCm39) P967T probably damaging Het
Ces1b T C 8: 93,802,680 (GRCm39) probably benign Het
Ckm T C 7: 19,155,309 (GRCm39) *382Q probably null Het
Clec14a A G 12: 58,315,403 (GRCm39) V73A probably damaging Het
Cmya5 A T 13: 93,229,256 (GRCm39) V1944E probably benign Het
Col6a6 T A 9: 105,632,754 (GRCm39) D1473V probably damaging Het
Cttnbp2 A G 6: 18,435,342 (GRCm39) M172T probably benign Het
Dcaf12 T C 4: 41,302,672 (GRCm39) N161S probably damaging Het
Dnah17 T C 11: 118,019,822 (GRCm39) Y75C probably damaging Het
Efcab7 T C 4: 99,758,966 (GRCm39) V388A possibly damaging Het
Fat3 A G 9: 15,871,052 (GRCm39) C3780R probably damaging Het
Fbxl14 T C 6: 119,458,021 (GRCm39) *401R probably null Het
Fbxo5 G T 10: 5,751,176 (GRCm39) Y270* probably null Het
Fnbp1l A T 3: 122,364,602 (GRCm39) probably benign Het
Gpatch1 T C 7: 35,001,080 (GRCm39) D309G probably damaging Het
Gstcd A T 3: 132,692,169 (GRCm39) L582H probably damaging Het
Klk6 A G 7: 43,478,669 (GRCm39) D192G probably benign Het
Lrp6 A G 6: 134,444,631 (GRCm39) S1080P probably damaging Het
Lztfl1 T C 9: 123,536,971 (GRCm39) probably null Het
Mov10l1 A G 15: 88,869,796 (GRCm39) Y59C possibly damaging Het
Natd1 C T 11: 60,797,739 (GRCm39) R62H probably damaging Het
Obscn T C 11: 58,931,132 (GRCm39) T5835A probably damaging Het
Or4c31 A T 2: 88,292,069 (GRCm39) R147S possibly damaging Het
Or5j3 A G 2: 86,128,937 (GRCm39) Y259C probably damaging Het
Or6c66b T C 10: 129,376,883 (GRCm39) I159T probably benign Het
Or7a38 T A 10: 78,752,960 (GRCm39) Y95* probably null Het
P2rx2 T A 5: 110,489,045 (GRCm39) E289V probably benign Het
Patl1 T A 19: 11,902,596 (GRCm39) probably null Het
Ptprf A G 4: 118,080,591 (GRCm39) probably benign Het
Qrfpr C T 3: 36,235,118 (GRCm39) C253Y possibly damaging Het
Rad21l A T 2: 151,487,363 (GRCm39) D540E probably damaging Het
Rbm45 T A 2: 76,200,555 (GRCm39) I28N possibly damaging Het
Rnf170 A T 8: 26,615,927 (GRCm39) probably benign Het
Sgsm3 G A 15: 80,892,515 (GRCm39) W280* probably null Het
Slc9a9 A T 9: 94,567,270 (GRCm39) H113L probably benign Het
Slc9b2 G T 3: 135,024,183 (GRCm39) C78F probably damaging Het
Slfn10-ps T A 11: 82,920,360 (GRCm39) noncoding transcript Het
Slfn8 T A 11: 82,895,382 (GRCm39) I475F probably damaging Het
Stox2 A G 8: 47,656,319 (GRCm39) probably benign Het
Strbp A T 2: 37,490,838 (GRCm39) N472K probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tmem39a A G 16: 38,411,760 (GRCm39) probably benign Het
Trpc4ap A G 2: 155,478,150 (GRCm39) L664P probably damaging Het
Uap1 T A 1: 169,989,051 (GRCm39) M124L probably benign Het
Usp48 A G 4: 137,348,529 (GRCm39) N536S probably benign Het
Usp50 T A 2: 126,619,848 (GRCm39) I155F probably damaging Het
Utp4 T C 8: 107,649,567 (GRCm39) I672T probably benign Het
Vmn1r94 A T 7: 19,901,578 (GRCm39) M242K possibly damaging Het
Vmn2r45 T G 7: 8,486,098 (GRCm39) N397H probably benign Het
Vmn2r9 T C 5: 108,995,463 (GRCm39) Y395C probably damaging Het
Vps41 C A 13: 19,011,897 (GRCm39) H335N probably benign Het
Other mutations in Fstl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02680:Fstl3 APN 10 79,614,506 (GRCm39) nonsense probably null
IGL03165:Fstl3 APN 10 79,615,799 (GRCm39) missense probably benign 0.02
R2113:Fstl3 UTSW 10 79,617,012 (GRCm39) missense probably damaging 0.96
R2964:Fstl3 UTSW 10 79,617,057 (GRCm39) missense probably benign
R2965:Fstl3 UTSW 10 79,617,057 (GRCm39) missense probably benign
R2966:Fstl3 UTSW 10 79,617,057 (GRCm39) missense probably benign
R5211:Fstl3 UTSW 10 79,616,012 (GRCm39) missense probably benign 0.01
R6225:Fstl3 UTSW 10 79,615,843 (GRCm39) missense probably benign 0.08
R7389:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R7390:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R7484:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R9245:Fstl3 UTSW 10 79,614,411 (GRCm39) missense probably damaging 1.00
T0722:Fstl3 UTSW 10 79,615,997 (GRCm39) missense probably damaging 1.00
X0003:Fstl3 UTSW 10 79,615,997 (GRCm39) missense probably damaging 1.00
X0022:Fstl3 UTSW 10 79,615,901 (GRCm39) missense probably benign 0.06
Z1176:Fstl3 UTSW 10 79,617,032 (GRCm39) missense probably benign
Z1177:Fstl3 UTSW 10 79,615,942 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTGTGACCTGACCCCATTGTGGAC -3'
(R):5'- AGACTCCTGAAACCCTCTGCCTAAG -3'

Sequencing Primer
(F):5'- GGACTGTTCTTCCTAGACAACTG -3'
(R):5'- gggaggaaaaagtacccacaag -3'
Posted On 2013-08-08