Incidental Mutation 'R8457:Icos'
ID 655047
Institutional Source Beutler Lab
Gene Symbol Icos
Ensembl Gene ENSMUSG00000026009
Gene Name inducible T cell co-stimulator
Synonyms
MMRRC Submission 067834-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R8457 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 61017086-61039479 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 61033015 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 71 (S71R)
Ref Sequence ENSEMBL: ENSMUSP00000027162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027162] [ENSMUST00000102827]
AlphaFold Q9WVS0
Predicted Effect probably damaging
Transcript: ENSMUST00000027162
AA Change: S71R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027162
Gene: ENSMUSG00000026009
AA Change: S71R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:V-set_2 23 135 7.5e-59 PFAM
transmembrane domain 143 165 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000102827
AA Change: S71R

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000099891
Gene: ENSMUSG00000026009
AA Change: S71R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:V-set_2 23 135 3.6e-59 PFAM
transmembrane domain 143 165 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 T A 11: 46,030,939 (GRCm39) L813Q probably damaging Het
Alpk3 A G 7: 80,743,066 (GRCm39) N961S probably damaging Het
Arhgap42 A T 9: 9,016,221 (GRCm39) S403T probably benign Het
Cdkl1 T C 12: 69,794,112 (GRCm39) T342A probably benign Het
Chd2 T C 7: 73,096,985 (GRCm39) E1497G probably damaging Het
Cldn11 T C 3: 31,217,342 (GRCm39) V170A probably benign Het
Cps1 T A 1: 67,196,013 (GRCm39) F291I probably damaging Het
Cpsf2 T A 12: 101,968,929 (GRCm39) S722T probably damaging Het
Creld1 T C 6: 113,468,699 (GRCm39) probably null Het
Dgki T A 6: 36,827,891 (GRCm39) E1002V possibly damaging Het
Disp3 T A 4: 148,345,572 (GRCm39) I423F possibly damaging Het
Dysf T C 6: 84,165,227 (GRCm39) V1601A probably benign Het
E4f1 G A 17: 24,665,501 (GRCm39) A347V probably benign Het
Epb41l1 G A 2: 156,367,171 (GRCm39) R680Q probably benign Het
Fcrl5 T G 3: 87,351,567 (GRCm39) S272A probably damaging Het
Gbp7 A T 3: 142,252,133 (GRCm39) D572V probably benign Het
Gm21903 A T 17: 39,354,211 (GRCm39) F8I unknown Het
Grin2b A G 6: 135,709,197 (GRCm39) S1450P probably benign Het
Ighv1-13 T A 12: 114,594,452 (GRCm39) N51K unknown Het
Ighv1-37 C T 12: 114,860,245 (GRCm39) probably benign Het
Il36g A G 2: 24,078,661 (GRCm39) Y87C probably benign Het
Irf7 T C 7: 140,843,194 (GRCm39) N440D possibly damaging Het
Ivns1abp T A 1: 151,229,761 (GRCm39) L150M probably damaging Het
Kif16b A G 2: 142,553,828 (GRCm39) I990T probably damaging Het
Kif23 A G 9: 61,834,317 (GRCm39) probably null Het
Lca5l T G 16: 95,960,908 (GRCm39) K523T possibly damaging Het
Mast3 A G 8: 71,233,085 (GRCm39) F1076L probably benign Het
Nek11 A T 9: 105,225,191 (GRCm39) I107N probably damaging Het
Nlrp12 T C 7: 3,289,435 (GRCm39) H359R probably damaging Het
Nox3 A G 17: 3,736,198 (GRCm39) S143P probably damaging Het
Or10q12 A T 19: 13,745,721 (GRCm39) N5I probably benign Het
Or8g36 A C 9: 39,422,442 (GRCm39) N191K probably benign Het
Rnf10 C A 5: 115,410,320 (GRCm39) K51N possibly damaging Het
Scap G A 9: 110,210,354 (GRCm39) G921D probably benign Het
Slc6a13 G A 6: 121,303,063 (GRCm39) probably null Het
Tk2 A T 8: 104,963,450 (GRCm39) S140T probably damaging Het
Tmem106b A G 6: 13,084,243 (GRCm39) Y249C probably damaging Het
Ttll5 T A 12: 85,923,352 (GRCm39) S276R probably damaging Het
Ugt1a7c T C 1: 88,023,078 (GRCm39) V79A probably benign Het
Zfp410 T C 12: 84,374,086 (GRCm39) V141A possibly damaging Het
Other mutations in Icos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03109:Icos APN 1 61,036,856 (GRCm39) splice site probably benign
R1416:Icos UTSW 1 61,033,802 (GRCm39) missense probably damaging 1.00
R4416:Icos UTSW 1 61,033,849 (GRCm39) missense probably benign 0.00
R4751:Icos UTSW 1 61,032,876 (GRCm39) missense probably benign 0.01
R4998:Icos UTSW 1 61,032,941 (GRCm39) missense possibly damaging 0.74
R6598:Icos UTSW 1 61,033,856 (GRCm39) missense possibly damaging 0.78
R7169:Icos UTSW 1 61,034,705 (GRCm39) missense probably damaging 1.00
R8357:Icos UTSW 1 61,033,015 (GRCm39) missense probably damaging 1.00
R8537:Icos UTSW 1 61,033,101 (GRCm39) missense probably damaging 1.00
R9178:Icos UTSW 1 61,034,714 (GRCm39) missense probably damaging 1.00
R9517:Icos UTSW 1 61,032,894 (GRCm39) missense probably damaging 1.00
R9578:Icos UTSW 1 61,032,871 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TGTGTTCACAACATAACACACTTGC -3'
(R):5'- AGCCAATGCCTTACCATAAATATGC -3'

Sequencing Primer
(F):5'- CACAACATAACACACTTGCTTTGTTC -3'
(R):5'- TGCAAATATCCTCCACTAAGGTTC -3'
Posted On 2020-10-20