|Institutional Source||Beutler Lab|
|Gene Name||interleukin 1 family, member 9|
|Is this an essential gene?||Probably non essential (E-score: 0.054)|
|Stock #||R8457 (G1)|
|Chromosomal Location||24186476-24193568 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 24188649 bp|
|Amino Acid Change||Tyrosine to Cysteine at position 87 (Y87C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000053391 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000057567]|
|Predicted Effect||probably benign
AA Change: Y87C
PolyPhen 2 Score 0.450 (Sensitivity: 0.89; Specificity: 0.90)
AA Change: Y87C
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il1f9||
(F):5'- CAACAGCTAGGTCAGGATGG -3'
(R):5'- CATGAAACCCACTGCTTTATATGC -3'
(F):5'- CAGCTAGGTCAGGATGGATAGGTG -3'
(R):5'- TTTCTGGGTCACTGACCT -3'