Incidental Mutation 'R8458:Mroh9'
| ID |
655091 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh9
|
| Ensembl Gene |
ENSMUSG00000071890 |
| Gene Name |
maestro heat-like repeat family member 9 |
| Synonyms |
4921528O07Rik, Armc11 |
| MMRRC Submission |
067835-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8458 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
162851871-162913239 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 162883250 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 410
(T410S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096608]
|
| AlphaFold |
G5E8L9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096608
AA Change: T410S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: T410S
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5b_
|
231 |
716 |
2e-8 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts20 |
T |
A |
15: 94,251,521 (GRCm39) |
H422L |
probably benign |
Het |
| Adgra3 |
G |
T |
5: 50,145,013 (GRCm39) |
P527T |
probably damaging |
Het |
| Afg1l |
A |
G |
10: 42,302,517 (GRCm39) |
V161A |
probably damaging |
Het |
| Als2cl |
A |
C |
9: 110,714,025 (GRCm39) |
E65A |
probably damaging |
Het |
| Arl3 |
A |
C |
19: 46,546,709 (GRCm39) |
S39A |
probably benign |
Het |
| Cacna1a |
T |
C |
8: 85,276,087 (GRCm39) |
V560A |
probably damaging |
Het |
| Ccr10 |
C |
T |
11: 101,064,982 (GRCm39) |
G183R |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,306,218 (GRCm39) |
T2029S |
probably benign |
Het |
| Chkb |
A |
T |
15: 89,312,376 (GRCm39) |
V213E |
possibly damaging |
Het |
| Chst5 |
A |
G |
8: 112,617,422 (GRCm39) |
V66A |
probably damaging |
Het |
| Crx |
C |
A |
7: 15,602,031 (GRCm39) |
A216S |
possibly damaging |
Het |
| Ctnnd1 |
T |
C |
2: 84,444,287 (GRCm39) |
D556G |
probably damaging |
Het |
| Cyp4a14 |
C |
A |
4: 115,353,129 (GRCm39) |
G61V |
probably damaging |
Het |
| Cyp4f17 |
T |
A |
17: 32,739,550 (GRCm39) |
F157L |
probably damaging |
Het |
| Dnah12 |
A |
T |
14: 26,548,849 (GRCm39) |
|
probably null |
Het |
| Dnah14 |
A |
C |
1: 181,633,577 (GRCm39) |
H4P |
|
Het |
| Dnah7a |
T |
C |
1: 53,657,142 (GRCm39) |
D878G |
probably benign |
Het |
| Epb41l1 |
C |
T |
2: 156,363,684 (GRCm39) |
T731I |
probably benign |
Het |
| Epg5 |
G |
C |
18: 77,991,946 (GRCm39) |
E214D |
probably benign |
Het |
| Fam171b |
A |
G |
2: 83,690,864 (GRCm39) |
T276A |
probably benign |
Het |
| Fat4 |
G |
A |
3: 39,035,702 (GRCm39) |
R3118H |
probably benign |
Het |
| Fbrs |
C |
T |
7: 127,082,329 (GRCm39) |
R327W |
probably damaging |
Het |
| Fmo3 |
A |
G |
1: 162,794,509 (GRCm39) |
V187A |
possibly damaging |
Het |
| Gins1 |
T |
C |
2: 150,772,807 (GRCm39) |
V190A |
probably benign |
Het |
| Gm17067 |
T |
C |
7: 42,358,155 (GRCm39) |
S116G |
probably damaging |
Het |
| Gm5478 |
A |
G |
15: 101,553,862 (GRCm39) |
V250A |
probably benign |
Het |
| Gpr85 |
T |
C |
6: 13,836,848 (GRCm39) |
T19A |
probably benign |
Het |
| Hepacam2 |
T |
C |
6: 3,483,358 (GRCm39) |
N217S |
probably damaging |
Het |
| Igf1r |
T |
C |
7: 67,845,377 (GRCm39) |
Y889H |
probably benign |
Het |
| Itpr2 |
T |
G |
6: 146,135,464 (GRCm39) |
R1822S |
possibly damaging |
Het |
| Kcnk7 |
C |
T |
19: 5,754,407 (GRCm39) |
|
probably benign |
Het |
| Klk1 |
T |
C |
7: 43,874,933 (GRCm39) |
S11P |
probably damaging |
Het |
| Klra7 |
C |
T |
6: 130,201,109 (GRCm39) |
G216R |
probably damaging |
Het |
| Krt34 |
T |
C |
11: 99,930,901 (GRCm39) |
D167G |
probably damaging |
Het |
| Larp1b |
A |
C |
3: 40,930,995 (GRCm39) |
E291D |
probably benign |
Het |
| Lats1 |
T |
A |
10: 7,586,688 (GRCm39) |
L950* |
probably null |
Het |
| Lrrc2 |
A |
C |
9: 110,799,218 (GRCm39) |
D255A |
probably damaging |
Het |
| Lrrc49 |
A |
T |
9: 60,505,456 (GRCm39) |
M605K |
probably benign |
Het |
| Mocos |
A |
G |
18: 24,799,314 (GRCm39) |
K183E |
probably benign |
Het |
| Mpl |
C |
A |
4: 118,301,213 (GRCm39) |
|
probably null |
Het |
| Notch3 |
T |
C |
17: 32,375,024 (GRCm39) |
E430G |
probably damaging |
Het |
| Nsun6 |
T |
C |
2: 15,034,863 (GRCm39) |
T252A |
probably benign |
Het |
| Ntrk1 |
C |
A |
3: 87,698,976 (GRCm39) |
|
probably null |
Het |
| Nts |
G |
T |
10: 102,320,921 (GRCm39) |
T56N |
probably damaging |
Het |
| Nup210l |
A |
G |
3: 90,092,874 (GRCm39) |
D1276G |
probably null |
Het |
| Or4c12b |
G |
T |
2: 89,647,494 (GRCm39) |
V269F |
probably damaging |
Het |
| Or51a10 |
C |
A |
7: 103,698,875 (GRCm39) |
A229S |
possibly damaging |
Het |
| Or5b105 |
T |
C |
19: 13,079,840 (GRCm39) |
Y276C |
probably damaging |
Het |
| Osbpl8 |
A |
G |
10: 111,113,177 (GRCm39) |
S535G |
possibly damaging |
Het |
| Pax9 |
A |
G |
12: 56,743,550 (GRCm39) |
I66V |
possibly damaging |
Het |
| Pja2 |
A |
G |
17: 64,599,843 (GRCm39) |
V547A |
probably damaging |
Het |
| Plekhs1 |
T |
C |
19: 56,465,590 (GRCm39) |
L185S |
probably benign |
Het |
| Prkdc |
T |
A |
16: 15,608,540 (GRCm39) |
|
probably null |
Het |
| Ptgdr2 |
A |
T |
19: 10,917,785 (GRCm39) |
T101S |
possibly damaging |
Het |
| Ptprd |
T |
C |
4: 75,984,496 (GRCm39) |
D550G |
probably benign |
Het |
| Ptx3 |
G |
T |
3: 66,128,419 (GRCm39) |
R160L |
probably benign |
Het |
| Rdh16f1 |
A |
C |
10: 127,624,714 (GRCm39) |
E184A |
probably damaging |
Het |
| Rfx3 |
C |
T |
19: 27,771,072 (GRCm39) |
E560K |
possibly damaging |
Het |
| Scgb2b24 |
T |
C |
7: 33,436,779 (GRCm39) |
Q111R |
probably benign |
Het |
| Spart |
A |
G |
3: 55,032,315 (GRCm39) |
D383G |
probably damaging |
Het |
| Stpg3 |
C |
A |
2: 25,103,333 (GRCm39) |
R252L |
probably damaging |
Het |
| Tcp11l2 |
C |
T |
10: 84,449,396 (GRCm39) |
Q454* |
probably null |
Het |
| Trav10d |
A |
G |
14: 53,048,780 (GRCm39) |
Y57C |
probably damaging |
Het |
| Vmn1r170 |
T |
A |
7: 23,306,321 (GRCm39) |
M241K |
possibly damaging |
Het |
| Vwa8 |
T |
A |
14: 79,302,332 (GRCm39) |
N1000K |
probably damaging |
Het |
| Wdsub1 |
T |
C |
2: 59,692,045 (GRCm39) |
E329G |
probably benign |
Het |
| Wnk4 |
C |
A |
11: 101,166,147 (GRCm39) |
C891* |
probably null |
Het |
| Zdhhc16 |
G |
T |
19: 41,928,093 (GRCm39) |
C204F |
probably damaging |
Het |
| Zfp868 |
T |
C |
8: 70,064,559 (GRCm39) |
I259V |
possibly damaging |
Het |
| Zranb3 |
G |
T |
1: 127,920,647 (GRCm39) |
Q426K |
probably damaging |
Het |
|
| Other mutations in Mroh9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Mroh9
|
APN |
1 |
162,873,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00705:Mroh9
|
APN |
1 |
162,907,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00788:Mroh9
|
APN |
1 |
162,852,227 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00795:Mroh9
|
APN |
1 |
162,888,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00815:Mroh9
|
APN |
1 |
162,866,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01025:Mroh9
|
APN |
1 |
162,875,435 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01303:Mroh9
|
APN |
1 |
162,908,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01526:Mroh9
|
APN |
1 |
162,883,172 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01680:Mroh9
|
APN |
1 |
162,875,551 (GRCm39) |
splice site |
probably null |
|
|
IGL01823:Mroh9
|
APN |
1 |
162,883,178 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02024:Mroh9
|
APN |
1 |
162,890,071 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02213:Mroh9
|
APN |
1 |
162,885,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Mroh9
|
APN |
1 |
162,903,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02546:Mroh9
|
APN |
1 |
162,908,145 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03059:Mroh9
|
APN |
1 |
162,852,205 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03061:Mroh9
|
APN |
1 |
162,854,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Mroh9
|
APN |
1 |
162,866,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0441:Mroh9
|
UTSW |
1 |
162,888,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0629:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0751:Mroh9
|
UTSW |
1 |
162,893,693 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1301:Mroh9
|
UTSW |
1 |
162,871,552 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1481:Mroh9
|
UTSW |
1 |
162,854,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Mroh9
|
UTSW |
1 |
162,852,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1647:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Mroh9
|
UTSW |
1 |
162,852,161 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1795:Mroh9
|
UTSW |
1 |
162,884,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1796:Mroh9
|
UTSW |
1 |
162,873,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1857:Mroh9
|
UTSW |
1 |
162,866,714 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1869:Mroh9
|
UTSW |
1 |
162,854,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1923:Mroh9
|
UTSW |
1 |
162,903,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Mroh9
|
UTSW |
1 |
162,854,099 (GRCm39) |
splice site |
probably null |
|
|
R2511:Mroh9
|
UTSW |
1 |
162,866,514 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2912:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Mroh9
|
UTSW |
1 |
162,884,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Mroh9
|
UTSW |
1 |
162,884,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Mroh9
|
UTSW |
1 |
162,893,638 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4034:Mroh9
|
UTSW |
1 |
162,908,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4551:Mroh9
|
UTSW |
1 |
162,871,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4656:Mroh9
|
UTSW |
1 |
162,893,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4662:Mroh9
|
UTSW |
1 |
162,883,162 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4743:Mroh9
|
UTSW |
1 |
162,852,061 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4890:Mroh9
|
UTSW |
1 |
162,854,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5128:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5147:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5157:Mroh9
|
UTSW |
1 |
162,871,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5324:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5340:Mroh9
|
UTSW |
1 |
162,908,156 (GRCm39) |
start gained |
probably benign |
|
|
R6005:Mroh9
|
UTSW |
1 |
162,903,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6182:Mroh9
|
UTSW |
1 |
162,893,612 (GRCm39) |
nonsense |
probably null |
|
|
R6414:Mroh9
|
UTSW |
1 |
162,902,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Mroh9
|
UTSW |
1 |
162,903,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6540:Mroh9
|
UTSW |
1 |
162,866,541 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6541:Mroh9
|
UTSW |
1 |
162,885,607 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6643:Mroh9
|
UTSW |
1 |
162,903,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Mroh9
|
UTSW |
1 |
162,873,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6830:Mroh9
|
UTSW |
1 |
162,903,935 (GRCm39) |
missense |
probably benign |
|
|
R7026:Mroh9
|
UTSW |
1 |
162,888,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Mroh9
|
UTSW |
1 |
162,866,525 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7068:Mroh9
|
UTSW |
1 |
162,866,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Mroh9
|
UTSW |
1 |
162,903,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7545:Mroh9
|
UTSW |
1 |
162,902,277 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7615:Mroh9
|
UTSW |
1 |
162,873,601 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7743:Mroh9
|
UTSW |
1 |
162,852,122 (GRCm39) |
missense |
probably benign |
|
|
R7808:Mroh9
|
UTSW |
1 |
162,866,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Mroh9
|
UTSW |
1 |
162,866,802 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8062:Mroh9
|
UTSW |
1 |
162,866,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Mroh9
|
UTSW |
1 |
162,890,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8426:Mroh9
|
UTSW |
1 |
162,852,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8555:Mroh9
|
UTSW |
1 |
162,899,595 (GRCm39) |
splice site |
probably null |
|
|
R8960:Mroh9
|
UTSW |
1 |
162,883,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9040:Mroh9
|
UTSW |
1 |
162,890,069 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9125:Mroh9
|
UTSW |
1 |
162,875,412 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9154:Mroh9
|
UTSW |
1 |
162,890,030 (GRCm39) |
missense |
|
|
|
R9596:Mroh9
|
UTSW |
1 |
162,893,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9612:Mroh9
|
UTSW |
1 |
162,866,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF003:Mroh9
|
UTSW |
1 |
162,885,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGTGTCTGGATGCCTATCG -3'
(R):5'- ATTCCCAGTGCCTTGGAATCTC -3'
Sequencing Primer
(F):5'- GATGCCTATCGCCCACTGAATC -3'
(R):5'- CAGTGCCTTGGAATCTCATTACCAAG -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation