Incidental Mutation 'R8458:Wnk4'
| ID |
655138 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wnk4
|
| Ensembl Gene |
ENSMUSG00000035112 |
| Gene Name |
WNK lysine deficient protein kinase 4 |
| Synonyms |
2010002J11Rik, Prkwnk4 |
| MMRRC Submission |
067835-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R8458 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
101151393-101168235 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 101166147 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 891
(C891*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099397
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017332]
[ENSMUST00000103107]
[ENSMUST00000103108]
[ENSMUST00000139487]
[ENSMUST00000147741]
[ENSMUST00000168089]
[ENSMUST00000170056]
|
| AlphaFold |
Q80UE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000017332
|
| SMART Domains |
Protein: ENSMUSP00000017332
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
106 |
1.8e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103107
|
| SMART Domains |
Protein: ENSMUSP00000099396
Gene: ENSMUSG00000078653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Cyclin_N
|
111 |
180 |
1.8e-6 |
PFAM |
|
low complexity region
|
212 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
330 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103108
AA Change: C891*
|
| SMART Domains |
Protein: ENSMUSP00000099397
Gene: ENSMUSG00000035112
AA Change: C891*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
427 |
4.7e-42 |
PFAM |
|
Pfam:Pkinase
|
171 |
429 |
9e-55 |
PFAM |
|
Pfam:OSR1_C
|
450 |
486 |
3e-18 |
PFAM |
|
low complexity region
|
503 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
627 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
660 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
877 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
921 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1093 |
1112 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139487
|
| SMART Domains |
Protein: ENSMUSP00000129666
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
242 |
4e-8 |
PFAM |
|
Pfam:Pkinase
|
171 |
252 |
1.9e-10 |
PFAM |
|
low complexity region
|
269 |
283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147741
|
| SMART Domains |
Protein: ENSMUSP00000131298
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
171 |
394 |
9.3e-50 |
PFAM |
|
Pfam:Pkinase_Tyr
|
171 |
399 |
3.7e-38 |
PFAM |
|
low complexity region
|
401 |
413 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168089
|
| SMART Domains |
Protein: ENSMUSP00000130367
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
74 |
2.7e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170056
|
| SMART Domains |
Protein: ENSMUSP00000132123
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:OSR1_C
|
13 |
49 |
8.6e-20 |
PFAM |
|
low complexity region
|
66 |
76 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170372
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts20 |
T |
A |
15: 94,251,521 (GRCm39) |
H422L |
probably benign |
Het |
| Adgra3 |
G |
T |
5: 50,145,013 (GRCm39) |
P527T |
probably damaging |
Het |
| Afg1l |
A |
G |
10: 42,302,517 (GRCm39) |
V161A |
probably damaging |
Het |
| Als2cl |
A |
C |
9: 110,714,025 (GRCm39) |
E65A |
probably damaging |
Het |
| Arl3 |
A |
C |
19: 46,546,709 (GRCm39) |
S39A |
probably benign |
Het |
| Cacna1a |
T |
C |
8: 85,276,087 (GRCm39) |
V560A |
probably damaging |
Het |
| Ccr10 |
C |
T |
11: 101,064,982 (GRCm39) |
G183R |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,306,218 (GRCm39) |
T2029S |
probably benign |
Het |
| Chkb |
A |
T |
15: 89,312,376 (GRCm39) |
V213E |
possibly damaging |
Het |
| Chst5 |
A |
G |
8: 112,617,422 (GRCm39) |
V66A |
probably damaging |
Het |
| Crx |
C |
A |
7: 15,602,031 (GRCm39) |
A216S |
possibly damaging |
Het |
| Ctnnd1 |
T |
C |
2: 84,444,287 (GRCm39) |
D556G |
probably damaging |
Het |
| Cyp4a14 |
C |
A |
4: 115,353,129 (GRCm39) |
G61V |
probably damaging |
Het |
| Cyp4f17 |
T |
A |
17: 32,739,550 (GRCm39) |
F157L |
probably damaging |
Het |
| Dnah12 |
A |
T |
14: 26,548,849 (GRCm39) |
|
probably null |
Het |
| Dnah14 |
A |
C |
1: 181,633,577 (GRCm39) |
H4P |
|
Het |
| Dnah7a |
T |
C |
1: 53,657,142 (GRCm39) |
D878G |
probably benign |
Het |
| Epb41l1 |
C |
T |
2: 156,363,684 (GRCm39) |
T731I |
probably benign |
Het |
| Epg5 |
G |
C |
18: 77,991,946 (GRCm39) |
E214D |
probably benign |
Het |
| Fam171b |
A |
G |
2: 83,690,864 (GRCm39) |
T276A |
probably benign |
Het |
| Fat4 |
G |
A |
3: 39,035,702 (GRCm39) |
R3118H |
probably benign |
Het |
| Fbrs |
C |
T |
7: 127,082,329 (GRCm39) |
R327W |
probably damaging |
Het |
| Fmo3 |
A |
G |
1: 162,794,509 (GRCm39) |
V187A |
possibly damaging |
Het |
| Gins1 |
T |
C |
2: 150,772,807 (GRCm39) |
V190A |
probably benign |
Het |
| Gm17067 |
T |
C |
7: 42,358,155 (GRCm39) |
S116G |
probably damaging |
Het |
| Gm5478 |
A |
G |
15: 101,553,862 (GRCm39) |
V250A |
probably benign |
Het |
| Gpr85 |
T |
C |
6: 13,836,848 (GRCm39) |
T19A |
probably benign |
Het |
| Hepacam2 |
T |
C |
6: 3,483,358 (GRCm39) |
N217S |
probably damaging |
Het |
| Igf1r |
T |
C |
7: 67,845,377 (GRCm39) |
Y889H |
probably benign |
Het |
| Itpr2 |
T |
G |
6: 146,135,464 (GRCm39) |
R1822S |
possibly damaging |
Het |
| Kcnk7 |
C |
T |
19: 5,754,407 (GRCm39) |
|
probably benign |
Het |
| Klk1 |
T |
C |
7: 43,874,933 (GRCm39) |
S11P |
probably damaging |
Het |
| Klra7 |
C |
T |
6: 130,201,109 (GRCm39) |
G216R |
probably damaging |
Het |
| Krt34 |
T |
C |
11: 99,930,901 (GRCm39) |
D167G |
probably damaging |
Het |
| Larp1b |
A |
C |
3: 40,930,995 (GRCm39) |
E291D |
probably benign |
Het |
| Lats1 |
T |
A |
10: 7,586,688 (GRCm39) |
L950* |
probably null |
Het |
| Lrrc2 |
A |
C |
9: 110,799,218 (GRCm39) |
D255A |
probably damaging |
Het |
| Lrrc49 |
A |
T |
9: 60,505,456 (GRCm39) |
M605K |
probably benign |
Het |
| Mocos |
A |
G |
18: 24,799,314 (GRCm39) |
K183E |
probably benign |
Het |
| Mpl |
C |
A |
4: 118,301,213 (GRCm39) |
|
probably null |
Het |
| Mroh9 |
T |
A |
1: 162,883,250 (GRCm39) |
T410S |
probably damaging |
Het |
| Notch3 |
T |
C |
17: 32,375,024 (GRCm39) |
E430G |
probably damaging |
Het |
| Nsun6 |
T |
C |
2: 15,034,863 (GRCm39) |
T252A |
probably benign |
Het |
| Ntrk1 |
C |
A |
3: 87,698,976 (GRCm39) |
|
probably null |
Het |
| Nts |
G |
T |
10: 102,320,921 (GRCm39) |
T56N |
probably damaging |
Het |
| Nup210l |
A |
G |
3: 90,092,874 (GRCm39) |
D1276G |
probably null |
Het |
| Or4c12b |
G |
T |
2: 89,647,494 (GRCm39) |
V269F |
probably damaging |
Het |
| Or51a10 |
C |
A |
7: 103,698,875 (GRCm39) |
A229S |
possibly damaging |
Het |
| Or5b105 |
T |
C |
19: 13,079,840 (GRCm39) |
Y276C |
probably damaging |
Het |
| Osbpl8 |
A |
G |
10: 111,113,177 (GRCm39) |
S535G |
possibly damaging |
Het |
| Pax9 |
A |
G |
12: 56,743,550 (GRCm39) |
I66V |
possibly damaging |
Het |
| Pja2 |
A |
G |
17: 64,599,843 (GRCm39) |
V547A |
probably damaging |
Het |
| Plekhs1 |
T |
C |
19: 56,465,590 (GRCm39) |
L185S |
probably benign |
Het |
| Prkdc |
T |
A |
16: 15,608,540 (GRCm39) |
|
probably null |
Het |
| Ptgdr2 |
A |
T |
19: 10,917,785 (GRCm39) |
T101S |
possibly damaging |
Het |
| Ptprd |
T |
C |
4: 75,984,496 (GRCm39) |
D550G |
probably benign |
Het |
| Ptx3 |
G |
T |
3: 66,128,419 (GRCm39) |
R160L |
probably benign |
Het |
| Rdh16f1 |
A |
C |
10: 127,624,714 (GRCm39) |
E184A |
probably damaging |
Het |
| Rfx3 |
C |
T |
19: 27,771,072 (GRCm39) |
E560K |
possibly damaging |
Het |
| Scgb2b24 |
T |
C |
7: 33,436,779 (GRCm39) |
Q111R |
probably benign |
Het |
| Spart |
A |
G |
3: 55,032,315 (GRCm39) |
D383G |
probably damaging |
Het |
| Stpg3 |
C |
A |
2: 25,103,333 (GRCm39) |
R252L |
probably damaging |
Het |
| Tcp11l2 |
C |
T |
10: 84,449,396 (GRCm39) |
Q454* |
probably null |
Het |
| Trav10d |
A |
G |
14: 53,048,780 (GRCm39) |
Y57C |
probably damaging |
Het |
| Vmn1r170 |
T |
A |
7: 23,306,321 (GRCm39) |
M241K |
possibly damaging |
Het |
| Vwa8 |
T |
A |
14: 79,302,332 (GRCm39) |
N1000K |
probably damaging |
Het |
| Wdsub1 |
T |
C |
2: 59,692,045 (GRCm39) |
E329G |
probably benign |
Het |
| Zdhhc16 |
G |
T |
19: 41,928,093 (GRCm39) |
C204F |
probably damaging |
Het |
| Zfp868 |
T |
C |
8: 70,064,559 (GRCm39) |
I259V |
possibly damaging |
Het |
| Zranb3 |
G |
T |
1: 127,920,647 (GRCm39) |
Q426K |
probably damaging |
Het |
|
| Other mutations in Wnk4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Wnk4
|
APN |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00535:Wnk4
|
APN |
11 |
101,155,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Wnk4
|
APN |
11 |
101,167,509 (GRCm39) |
splice site |
probably benign |
|
|
IGL01931:Wnk4
|
APN |
11 |
101,159,310 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01977:Wnk4
|
APN |
11 |
101,156,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Wnk4
|
APN |
11 |
101,166,117 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02197:Wnk4
|
APN |
11 |
101,154,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Wnk4
|
APN |
11 |
101,160,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02963:Wnk4
|
APN |
11 |
101,167,039 (GRCm39) |
unclassified |
probably benign |
|
|
ashamed
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
blushing
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Caught_dead
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lowered
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
mortification
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
shame
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Wnk4
|
UTSW |
11 |
101,156,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0317:Wnk4
|
UTSW |
11 |
101,159,630 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0628:Wnk4
|
UTSW |
11 |
101,165,849 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0630:Wnk4
|
UTSW |
11 |
101,156,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Wnk4
|
UTSW |
11 |
101,164,932 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1290:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R1482:Wnk4
|
UTSW |
11 |
101,160,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1775:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R2005:Wnk4
|
UTSW |
11 |
101,154,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2229:Wnk4
|
UTSW |
11 |
101,166,467 (GRCm39) |
unclassified |
probably benign |
|
|
R2258:Wnk4
|
UTSW |
11 |
101,165,861 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2323:Wnk4
|
UTSW |
11 |
101,159,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3081:Wnk4
|
UTSW |
11 |
101,167,717 (GRCm39) |
splice site |
probably benign |
|
|
R3763:Wnk4
|
UTSW |
11 |
101,160,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4196:Wnk4
|
UTSW |
11 |
101,160,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4447:Wnk4
|
UTSW |
11 |
101,159,277 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4614:Wnk4
|
UTSW |
11 |
101,164,937 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4751:Wnk4
|
UTSW |
11 |
101,167,188 (GRCm39) |
unclassified |
probably benign |
|
|
R4948:Wnk4
|
UTSW |
11 |
101,159,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Wnk4
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Wnk4
|
UTSW |
11 |
101,152,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5107:Wnk4
|
UTSW |
11 |
101,166,364 (GRCm39) |
unclassified |
probably benign |
|
|
R5181:Wnk4
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5205:Wnk4
|
UTSW |
11 |
101,155,964 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5252:Wnk4
|
UTSW |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5273:Wnk4
|
UTSW |
11 |
101,154,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5293:Wnk4
|
UTSW |
11 |
101,166,023 (GRCm39) |
unclassified |
probably benign |
|
|
R5609:Wnk4
|
UTSW |
11 |
101,166,462 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Wnk4
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
R5931:Wnk4
|
UTSW |
11 |
101,152,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6126:Wnk4
|
UTSW |
11 |
101,167,174 (GRCm39) |
unclassified |
probably benign |
|
|
R6164:Wnk4
|
UTSW |
11 |
101,165,894 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6191:Wnk4
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6267:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Wnk4
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6296:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Wnk4
|
UTSW |
11 |
101,152,026 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7251:Wnk4
|
UTSW |
11 |
101,155,979 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7352:Wnk4
|
UTSW |
11 |
101,155,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7404:Wnk4
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7624:Wnk4
|
UTSW |
11 |
101,155,180 (GRCm39) |
nonsense |
probably null |
|
|
R7634:Wnk4
|
UTSW |
11 |
101,153,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7780:Wnk4
|
UTSW |
11 |
101,160,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8006:Wnk4
|
UTSW |
11 |
101,159,182 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8046:Wnk4
|
UTSW |
11 |
101,164,918 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8143:Wnk4
|
UTSW |
11 |
101,153,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8735:Wnk4
|
UTSW |
11 |
101,167,092 (GRCm39) |
missense |
unknown |
|
|
R9025:Wnk4
|
UTSW |
11 |
101,153,641 (GRCm39) |
nonsense |
probably null |
|
|
R9206:Wnk4
|
UTSW |
11 |
101,164,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9295:Wnk4
|
UTSW |
11 |
101,160,078 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9610:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
R9611:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
R9674:Wnk4
|
UTSW |
11 |
101,166,874 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCCAGGTCTCTTCAAACCCC -3'
(R):5'- AGCCCGCCTTGTTTTCCTAG -3'
Sequencing Primer
(F):5'- GTCTCTTCAAACCCCTATCCACAGG -3'
(R):5'- GAAAGGCTCTCCTGGTCACAAG -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation