Incidental Mutation 'R8459:Cryge'
ID 655159
Institutional Source Beutler Lab
Gene Symbol Cryge
Ensembl Gene ENSMUSG00000070870
Gene Name crystallin, gamma E
Synonyms Cryg-6
MMRRC Submission 067836-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8459 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 65087713-65090308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 65087841 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 156 (D156G)
Ref Sequence ENSEMBL: ENSMUSP00000084617 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087359] [ENSMUST00000161960]
AlphaFold Q03740
Predicted Effect possibly damaging
Transcript: ENSMUST00000087359
AA Change: D156G

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000084617
Gene: ENSMUSG00000070870
AA Change: D156G

DomainStartEndE-ValueType
XTALbg 3 82 3.46e-45 SMART
XTALbg 89 170 5.4e-47 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161960
SMART Domains Protein: ENSMUSP00000124711
Gene: ENSMUSG00000070870

DomainStartEndE-ValueType
low complexity region 35 73 N/A INTRINSIC
low complexity region 121 130 N/A INTRINSIC
low complexity region 145 156 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutations in this gene produce severe, nuclear and zonular cataracts with microphthalmia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aim2 CTTGTTGT CTTGT 1: 173,289,536 (GRCm39) probably benign Het
Ank1 T C 8: 23,605,528 (GRCm39) V1132A probably damaging Het
Bpifb9a T G 2: 154,102,153 (GRCm39) S83R probably damaging Het
Cacnb3 C T 15: 98,537,393 (GRCm39) R24C probably damaging Het
Car8 C T 4: 8,189,302 (GRCm39) V171I probably benign Het
Cd200l1 T A 16: 45,238,271 (GRCm39) H294L probably benign Het
Cdk17 G C 10: 93,068,289 (GRCm39) V349L probably damaging Het
Celsr3 A G 9: 108,706,829 (GRCm39) E1104G probably damaging Het
Chml T C 1: 175,515,597 (GRCm39) D108G probably benign Het
Cluap1 T C 16: 3,755,453 (GRCm39) M356T probably damaging Het
Cmtm1 A G 8: 105,036,143 (GRCm39) V162A possibly damaging Het
Disc1 A C 8: 125,891,894 (GRCm39) D649A possibly damaging Het
Dnah8 T C 17: 30,944,221 (GRCm39) probably null Het
Dpp7 C A 2: 25,242,550 (GRCm39) V468F probably damaging Het
Ecpas A G 4: 58,821,379 (GRCm39) V1207A probably damaging Het
Ep400 A G 5: 110,856,757 (GRCm39) F1163S unknown Het
Fbrs C T 7: 127,082,329 (GRCm39) R327W probably damaging Het
Fsip2 T A 2: 82,810,022 (GRCm39) Y2114N possibly damaging Het
Gnas A T 2: 174,126,732 (GRCm39) H89L probably benign Het
Gstt1 G A 10: 75,629,943 (GRCm39) R107W probably damaging Het
Hal A G 10: 93,352,177 (GRCm39) D656G probably benign Het
Htra3 G A 5: 35,828,569 (GRCm39) probably benign Het
Ighv1-64 G A 12: 115,471,256 (GRCm39) A87V probably benign Het
Itga3 A G 11: 94,959,633 (GRCm39) V80A probably benign Het
Lrrc58 A G 16: 37,698,872 (GRCm39) N280D probably benign Het
Macf1 T C 4: 123,374,107 (GRCm39) E1501G possibly damaging Het
Madd A G 2: 90,992,871 (GRCm39) I1016T probably benign Het
Mbnl1 T G 3: 60,529,628 (GRCm39) S260R probably damaging Het
Or5h17 A T 16: 58,820,348 (GRCm39) Q100L probably damaging Het
Phip G T 9: 82,758,106 (GRCm39) A1529D probably benign Het
Pramel58 A G 5: 94,830,742 (GRCm39) D80G probably damaging Het
Prorsd1 T C 11: 29,463,286 (GRCm39) T159A probably damaging Het
Sh3tc1 C A 5: 35,878,933 (GRCm39) R67L probably benign Het
Skint5 A T 4: 113,703,481 (GRCm39) L518* probably null Het
Slc26a11 T A 11: 119,259,643 (GRCm39) I280N possibly damaging Het
Spata16 A G 3: 26,721,676 (GRCm39) T66A probably benign Het
Syne1 G A 10: 5,374,277 (GRCm39) R177* probably null Het
Vmn1r16 A C 6: 57,300,347 (GRCm39) C92G probably benign Het
Vmn1r50 A G 6: 90,084,235 (GRCm39) probably benign Het
Other mutations in Cryge
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01668:Cryge APN 1 65,087,857 (GRCm39) missense probably damaging 1.00
R1023:Cryge UTSW 1 65,089,945 (GRCm39) missense probably damaging 1.00
R1159:Cryge UTSW 1 65,089,967 (GRCm39) missense probably benign 0.00
R1463:Cryge UTSW 1 65,087,997 (GRCm39) nonsense probably null
R4850:Cryge UTSW 1 65,090,211 (GRCm39) intron probably benign
R4851:Cryge UTSW 1 65,090,211 (GRCm39) intron probably benign
R6551:Cryge UTSW 1 65,087,796 (GRCm39) missense probably benign 0.00
R8338:Cryge UTSW 1 65,087,933 (GRCm39) missense unknown
R9241:Cryge UTSW 1 65,088,018 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TCTGAGTAGCTTTGCTGCGC -3'
(R):5'- AGTCCAGTTCTCACAGGATCAAG -3'

Sequencing Primer
(F):5'- TGCGCCCTTCAATTGAGG -3'
(R):5'- GTTCTCACAGGATCAAGATCTACGAG -3'
Posted On 2020-10-20