Incidental Mutation 'R8459:Lrrc58'
ID 655195
Institutional Source Beutler Lab
Gene Symbol Lrrc58
Ensembl Gene ENSMUSG00000034158
Gene Name leucine rich repeat containing 58
Synonyms C330018J07Rik, 1810012N18Rik
MMRRC Submission 067836-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.183) question?
Stock # R8459 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 37688762-37709219 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37698872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 280 (N280D)
Ref Sequence ENSEMBL: ENSMUSP00000077779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078717]
AlphaFold Q3UGP9
Predicted Effect probably benign
Transcript: ENSMUST00000078717
AA Change: N280D

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000077779
Gene: ENSMUSG00000034158
AA Change: N280D

DomainStartEndE-ValueType
LRR 39 61 1.12e2 SMART
LRR 62 85 3.02e0 SMART
LRR 114 136 1.33e2 SMART
LRR 137 159 1.16e-1 SMART
LRR 160 182 1.86e0 SMART
LRR 183 205 1.12e1 SMART
LRR_TYP 206 229 2.71e-2 SMART
low complexity region 327 354 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aim2 CTTGTTGT CTTGT 1: 173,289,536 (GRCm39) probably benign Het
Ank1 T C 8: 23,605,528 (GRCm39) V1132A probably damaging Het
Bpifb9a T G 2: 154,102,153 (GRCm39) S83R probably damaging Het
Cacnb3 C T 15: 98,537,393 (GRCm39) R24C probably damaging Het
Car8 C T 4: 8,189,302 (GRCm39) V171I probably benign Het
Cd200l1 T A 16: 45,238,271 (GRCm39) H294L probably benign Het
Cdk17 G C 10: 93,068,289 (GRCm39) V349L probably damaging Het
Celsr3 A G 9: 108,706,829 (GRCm39) E1104G probably damaging Het
Chml T C 1: 175,515,597 (GRCm39) D108G probably benign Het
Cluap1 T C 16: 3,755,453 (GRCm39) M356T probably damaging Het
Cmtm1 A G 8: 105,036,143 (GRCm39) V162A possibly damaging Het
Cryge T C 1: 65,087,841 (GRCm39) D156G possibly damaging Het
Disc1 A C 8: 125,891,894 (GRCm39) D649A possibly damaging Het
Dnah8 T C 17: 30,944,221 (GRCm39) probably null Het
Dpp7 C A 2: 25,242,550 (GRCm39) V468F probably damaging Het
Ecpas A G 4: 58,821,379 (GRCm39) V1207A probably damaging Het
Ep400 A G 5: 110,856,757 (GRCm39) F1163S unknown Het
Fbrs C T 7: 127,082,329 (GRCm39) R327W probably damaging Het
Fsip2 T A 2: 82,810,022 (GRCm39) Y2114N possibly damaging Het
Gnas A T 2: 174,126,732 (GRCm39) H89L probably benign Het
Gstt1 G A 10: 75,629,943 (GRCm39) R107W probably damaging Het
Hal A G 10: 93,352,177 (GRCm39) D656G probably benign Het
Htra3 G A 5: 35,828,569 (GRCm39) probably benign Het
Ighv1-64 G A 12: 115,471,256 (GRCm39) A87V probably benign Het
Itga3 A G 11: 94,959,633 (GRCm39) V80A probably benign Het
Macf1 T C 4: 123,374,107 (GRCm39) E1501G possibly damaging Het
Madd A G 2: 90,992,871 (GRCm39) I1016T probably benign Het
Mbnl1 T G 3: 60,529,628 (GRCm39) S260R probably damaging Het
Or5h17 A T 16: 58,820,348 (GRCm39) Q100L probably damaging Het
Phip G T 9: 82,758,106 (GRCm39) A1529D probably benign Het
Pramel58 A G 5: 94,830,742 (GRCm39) D80G probably damaging Het
Prorsd1 T C 11: 29,463,286 (GRCm39) T159A probably damaging Het
Sh3tc1 C A 5: 35,878,933 (GRCm39) R67L probably benign Het
Skint5 A T 4: 113,703,481 (GRCm39) L518* probably null Het
Slc26a11 T A 11: 119,259,643 (GRCm39) I280N possibly damaging Het
Spata16 A G 3: 26,721,676 (GRCm39) T66A probably benign Het
Syne1 G A 10: 5,374,277 (GRCm39) R177* probably null Het
Vmn1r16 A C 6: 57,300,347 (GRCm39) C92G probably benign Het
Vmn1r50 A G 6: 90,084,235 (GRCm39) probably benign Het
Other mutations in Lrrc58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03225:Lrrc58 APN 16 37,701,632 (GRCm39) missense probably damaging 1.00
R0744:Lrrc58 UTSW 16 37,698,935 (GRCm39) splice site probably benign
R2140:Lrrc58 UTSW 16 37,701,771 (GRCm39) missense probably damaging 1.00
R4995:Lrrc58 UTSW 16 37,697,418 (GRCm39) missense probably benign 0.02
R7438:Lrrc58 UTSW 16 37,689,053 (GRCm39) missense probably benign 0.33
R9219:Lrrc58 UTSW 16 37,689,180 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGTTGCATTCGCTTCGATC -3'
(R):5'- CTGAGGCGACAAAGCATCTTAC -3'

Sequencing Primer
(F):5'- GACTTACCTGCCTCGAGAGATC -3'
(R):5'- GGCGACAAAGCATCTTACTTTCTAC -3'
Posted On 2020-10-20